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Although maternal depression is a well-established risk factor for psychopathology in offspring, less is known about protective factors that may mitigate this risk. Peer social support, particularly during the transition to adolescence, may play a critical role in reducing risk for SITBs, yet limited research has examined the potential impact of different domains of peer influence (e.g., close friends versus classmates) as specific and distinct facets of the peer environment.\u00a0In a two-year longitudinal study, we assessed SITBs in 215 children (ages 8\u201314), half of whom had mothers with a history of major depressive disorder (MDD) during their child\u2019s life. We hypothesized that maternal MDD would predict increased risk of SITBs in children but that higher levels of peer social support would buffer this effect.\u00a0Survival analyses confirmed that children of mothers with MDD were over twice as likely to develop SITBs during the follow-up. Importantly, higher levels of social support from classmates uniquely predicted reduced risk for SITBs in children, even after accounting for the influence of maternal MDD history.\u00a0Our findings highlight the role of broad peer environments in protecting against SITBs in youth. These results underscore the importance of school-based interventions that foster social inclusion as potential preventive measures for SITBs.<\/jats:p>","DOI":"10.1007\/s10802-025-01363-5","type":"journal-article","created":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T09:12:00Z","timestamp":1756717920000},"page":"1611-1619","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Maternal History of Major Depression, Social Support from Peers, and Children\u2019s Risk for Self-Injurious Thoughts and Behaviors"],"prefix":"10.1007","volume":"53","author":[{"given":"Sara I.","family":"Buseman","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9482-067X","authenticated-orcid":false,"given":"Brandon E.","family":"Gibb","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,9,1]]},"reference":[{"issue":"2","key":"1363_CR1","doi-asserted-by":"publisher","first-page":"354","DOI":"10.1037\/0022-006X.61.2.354","volume":"61","author":"C Adrian","year":"1993","unstructured":"Adrian, C., & Hammen, C. 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Buseman and Brandon E. Gibb, was originally published without open access. Following the author\u2019s\/authors\u2019 decision to opt for open access, the copyright of the chapter changed on May 08, 2026 to \u00a9 The Author(s) 2025 and the chapter is now distributed under the terms of the Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article\u2019s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article\u2019s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http:\/\/creativecommons.org\/licenses\/by\/4.0\/.","order":6,"name":"change_details","label":"Change Details","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors have no conflicts of interest to disclose.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"All study procedures were approved by the university Institutional Review Board. This study was conducted in accordance with the ethical standards as laid down in the\u00a01964 Declaration of Helsinki\u00a0and its later amendments or comparable ethical standards. Informed consent\/assent was collected from all participants.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical Approval"}}]}}