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The aims of this investigation were: (1) to examine the proportion of CHR-P individuals with past contact with mental healthcare services enrolled within a specialized CHR-P service, and (2) to longitudinally compare sociodemographic, clinical, and treatment parameters between CHR-P subjects with and without psychiatric antecedents across 2 years of follow-up.\u00a0All participants (aged 12\u201325 years) were recruited within the \u201cParma At Risk Mental States\u201d (PARMS) program. Across the follow-up, they completed the Health of the Nation Outcome Scale (HoNOS) and the Positive And Negative Syndrome Scale (PANSS). A mixed-design ANOVA and a Kaplan-Meier survival analysis were also used.\u00a0Of the 170 CHR-P subjects, 95 (55.9%) had previous contact with mental health services. In 85.2% of cases, a care discontinuity was observed. Main psychiatric antecedents were learning disorders (7.4%), anxiety disorder (23.1%), conduct disorder (22.1%), and depressive disorder (14.7%). CHR-P youths with psychiatric antecedents had longer duration of untreated psychosis and a higher 2-year incidence rate of psychosis transition. Having previous contact with psychiatric services also resulted to be a associated with poorer social functioning over time.\u00a0Carefully monitor mental health suffering and related help-seeking-behavior in youths typically manifested in their early 20\u2019s is crucial, also in terms of psychosis prevention. Moreover, special attention should be given to service engagement as care continuity within adolescent-adult transition.<\/jats:p>","DOI":"10.1007\/s10802-025-01368-0","type":"journal-article","created":{"date-parts":[[2025,8,30]],"date-time":"2025-08-30T00:58:02Z","timestamp":1756515482000},"page":"1713-1730","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Psychiatric Antecedents in Adolescents at Clinical High Risk for Psychosis: Insights from the \u201cParma At-Risk Mental States\u201d Follow-up Program"],"prefix":"10.1007","volume":"53","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4746-2061","authenticated-orcid":false,"given":"Lorenzo","family":"Pelizza","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabio","family":"Catalano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emanuela","family":"Leuci","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emanuela","family":"Quattrone","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Derna","family":"Palmisano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simona","family":"Pupo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppina","family":"Paulillo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clara","family":"Pellegrini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pietro","family":"Pellegrini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Menchetti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,8,30]]},"reference":[{"key":"1368_CR1","doi-asserted-by":"publisher","first-page":"656","DOI":"10.1177\/0706743717719895","volume":"62","author":"J Addington","year":"2017","unstructured":"Addington, J., Addington, D., Abidi, S., Raedler, T., & Remington, G. 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