{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T07:25:38Z","timestamp":1791876338568,"version":"4.3.4"},"reference-count":38,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2013,7,4]],"date-time":"2013-07-04T00:00:00Z","timestamp":1372896000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Autism Dev Disord"],"published-print":{"date-parts":[[2014,2]]},"DOI":"10.1007\/s10803-013-1860-5","type":"journal-article","created":{"date-parts":[[2013,7,3]],"date-time":"2013-07-03T14:01:18Z","timestamp":1372860078000},"page":"310-320","source":"Crossref","is-referenced-by-count":69,"title":["The Social Behavioral Phenotype in Boys and Girls with an Extra X Chromosome (Klinefelter Syndrome and Trisomy X): A Comparison with Autism Spectrum Disorder"],"prefix":"10.1007","volume":"44","author":[{"given":"Sophie","family":"van Rijn","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lex","family":"Stockmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martine","family":"Borghgraef","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hilgo","family":"Bruining","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Conny","family":"van Ravenswaaij-Arts","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lutgarde","family":"Govaerts","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kerstin","family":"Hansson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanna","family":"Swaab","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2013,7,4]]},"reference":[{"key":"1860_CR1","volume-title":"Manual for the Child Behaviour Checklist\/4\u201318 and 1991 profile","author":"TM Achenbach","year":"1991","unstructured":"Achenbach, T. M. (1991). Manual for the Child Behaviour Checklist\/4\u201318 and 1991 profile. Burlington, VT: University of Vermont Department of Psychiatry."},{"key":"1860_CR2","volume-title":"Diagnostic and statistical manual of mental disorders IV","author":"A.P.A.","year":"1994","unstructured":"A.P.A. (1994). Diagnostic and statistical manual of mental disorders IV (4th ed.). Washington, DC: American Psychiatric Association Press.","edition":"4"},{"key":"1860_CR3","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1016\/j.gde.2004.04.005","volume":"14","author":"CE Bearden","year":"2004","unstructured":"Bearden, C. E., Reus, V. I., & Freimer, N. B. (2004). Why genetic investigation of psychiatric disorders is so difficult. Current Opinion in Genetics & Development, 14, 280.","journal-title":"Current Opinion in Genetics & Development"},{"key":"1860_CR4","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1002\/(SICI)1096-8628(19990416)88:2<200::AID-AJMG18>3.0.CO;2-3","volume":"88","author":"BG Bender","year":"1999","unstructured":"Bender, B. G., Harmon, R. J., Linden, M. G., Bucher-Bartelson, B., & Robinson, A. (1999). Psychosocial competence of unselected young adults with sex chromosome abnormalities. American Journal of Medical Genetics-Neuropsychiatric Genetics, 88, 200\u2013206.","journal-title":"American Journal of Medical Genetics-Neuropsychiatric Genetics"},{"key":"1860_CR5","doi-asserted-by":"crossref","first-page":"954","DOI":"10.1136\/adc.2009.179747","volume":"10","author":"DV Bishop","year":"2011","unstructured":"Bishop, D. V., et al. (2011). Autism, language and communication in children with sex chromosome trisomies. Archives of Disease in Childhood, 10, 954\u2013959. doi: 10.1136\/adc.2009.179747 .","journal-title":"Archives of Disease in Childhood"},{"key":"1860_CR6","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1002\/ddrr.83","volume":"15","author":"R Boada","year":"2009","unstructured":"Boada, R., Janusz, J., Hutaff-Lee, C., & Tartaglia, N. (2009). The cognitive phenotype in Klinefelter syndrome: A review of the literature including genetic and hormonal factors. Developmental Disabilities Research Reviews, 15, 284\u2013294.","journal-title":"Developmental Disabilities Research Reviews"},{"key":"1860_CR7","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1017\/S1355617701744013","volume":"7","author":"KB Boone","year":"2001","unstructured":"Boone, K. B., et al. (2001). Neuropsychological profiles of adults with Klinefelter syndrome. Journal of International Neuropsychological Society, 7, 446\u2013456.","journal-title":"Journal of International Neuropsychological Society"},{"key":"1860_CR8","doi-asserted-by":"crossref","first-page":"e865","DOI":"10.1542\/peds.2008-1954","volume":"123","author":"H Bruining","year":"2009","unstructured":"Bruining, H., Swaab, H., Kas, M., & Van Engeland, H. (2009). Psychiatric characteristics in a self-selected sample of boys with klinefelter syndrome. Pediatrics, 123, e865\u2013e870.","journal-title":"Pediatrics"},{"key":"1860_CR9","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1371\/journal.pone.0010887","volume":"5","author":"H Bruining","year":"2010","unstructured":"Bruining, H., et al. (2010). Dissecting the clinical heterogeneity of autism spectrum disorders through defined genotypes. PLoS One, 5, 7. doi: 10.1371\/journal.pone.0010887 .","journal-title":"PLoS One"},{"key":"1860_CR10","volume-title":"The social responsiveness scale","author":"JN Constantino","year":"2005","unstructured":"Constantino, J. N., & Gruber, C. P. (2005). The social responsiveness scale. Los Angeles: Western Psychological Services."},{"key":"1860_CR11","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1023\/A:1025014929212","volume":"33","author":"JN Constantino","year":"2003","unstructured":"Constantino, J. N., et al. (2003). Validation of a brief quantitative measure of autistic traits: Comparison of the social responsiveness scale with the autism diagnostic interview-revised. Journal of Autism and Developmental Disorders, 33, 427.","journal-title":"Journal of Autism and Developmental Disorders"},{"key":"1860_CR12","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1111\/1469-7610.00488","volume":"40","author":"A Cox","year":"1999","unstructured":"Cox, A., et al. (1999). Autism spectrum disorders at 20 and 42\u00a0months of age: Stability of clinical and ADI-R diagnosis. Journal of Child Psychology and Psychiatry, 40, 719\u2013732. doi: 10.1017\/s002196309900400x .","journal-title":"Journal of Child Psychology and Psychiatry"},{"key":"1860_CR13","volume-title":"[Handleiding sociale angst schaal voor kinderen] Manual social anxiety scale for children","author":"YM Dekking","year":"1983","unstructured":"Dekking, Y. M. (1983). [Handleiding sociale angst schaal voor kinderen] Manual social anxiety scale for children. Lisse, The Netherlands: Swets & Zeitlinger."},{"key":"1860_CR14","volume-title":"Amsterdam","author":"A Evers","year":"1992","unstructured":"Evers, A., Van Vliet-Mulder, J. C., & Ter Laak, J. (1992). Amsterdam. The Netherlands: Van Gorcum."},{"key":"1860_CR15","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1111\/j.1540-5826.2004.00100.x","volume":"19","author":"DH Geschwind","year":"2004","unstructured":"Geschwind, D. H., & Dykens, E. (2004). Neurobehavioral and psychosocial issues in Klinefelter syndrome. Learning Disabilities Research & Practice, 19, 166\u2013173. doi: 10.1111\/j.1540-5826.2004.00100.x .","journal-title":"Learning Disabilities Research & Practice"},{"key":"1860_CR16","doi-asserted-by":"crossref","first-page":"636","DOI":"10.1176\/appi.ajp.160.4.636","volume":"160","author":"II Gottesman","year":"2003","unstructured":"Gottesman, I. I., & Gould, T. D. (2003). The endophenotype concept in psychiatry: etymology and strategic intentions. American Journal of Psychiatry, 160, 636\u2013645.","journal-title":"American Journal of Psychiatry"},{"key":"1860_CR17","volume-title":"Social skills rating system manual","author":"FM Gresham","year":"1990","unstructured":"Gresham, F. M., & Elliott, S. N. (1990). Social skills rating system manual. Circle Pines, MN: American Guidance Service."},{"key":"1860_CR18","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1097\/00004583-199803000-00013","volume":"37","author":"RJ Harmon","year":"1998","unstructured":"Harmon, R. J., Bender, B. G., Linden, M. G., & Robinson, A. (1998). Transition from adolescence to early adulthood: Adaptation and psychiatric status of women with 47, XXX. Journal of the American Academy of Child and Adolescent Psychiatry, 37, 286\u2013291.","journal-title":"Journal of the American Academy of Child and Adolescent Psychiatry"},{"key":"1860_CR19","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1016\/j.brat.2004.07.002","volume":"43","author":"SG Hofmann","year":"2005","unstructured":"Hofmann, S. G. (2005). Perception of control over anxiety mediates the relation between catastrophic thinking and social anxiety in social phobia. Behaviour Research and Therapy, 43, 885\u2013895. doi: 10.1016\/j.brat.2004.07.002 .","journal-title":"Behaviour Research and Therapy"},{"key":"1860_CR20","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1023\/A:1022155201662","volume":"29","author":"MM Konstantareas","year":"1999","unstructured":"Konstantareas, M. M., & Homatidis, S. (1999). Chromosomal abnormalities in a series of children with autistic disorder. Journal of Autism and Developmental Disorders, 29, 275\u2013285.","journal-title":"Journal of Autism and Developmental Disorders"},{"key":"1860_CR21","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1111\/j.1469-8749.2009.03545.x","volume":"52","author":"V Leggett","year":"2010","unstructured":"Leggett, V., Jacobs, P., Nation, K., Scerif, G., & Bishop, D. V. M. (2010). Neurocognitive outcomes of individuals with a sex chromosome trisomy: XXX, XYY, or XXY: a systematic review. Developmental Medicine and Child Neurology, 52, 119\u2013129. doi: 10.1111\/j.1469-8749.2009.03545.x .","journal-title":"Developmental Medicine and Child Neurology"},{"key":"1860_CR22","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1111\/j.1751-2409.2010.01019.x","volume":"4","author":"JK Maner","year":"2010","unstructured":"Maner, J. K., & Kenrick, D. T. (2010). When adaptations go awry: Functional and dysfunctional aspects of social anxiety. Social Issues and Policy Review, 4, 111\u2013142.","journal-title":"Social Issues and Policy Review"},{"key":"1860_CR23","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1038\/ejhg.2009.109","volume":"18","author":"M Otter","year":"2010","unstructured":"Otter, M., Schrander-Stumpel, C., & Curfs, L. M. G. (2010). Triple X syndrome: A review of the literature. European Journal of Human Genetics, 18, 265\u2013271. doi: 10.1038\/ejhg.2009.109 .","journal-title":"European Journal of Human Genetics"},{"key":"1860_CR24","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1017\/S0033291704003496","volume":"35","author":"S Palmen","year":"2005","unstructured":"Palmen, S., et al. (2005). Increased gray-matter volume in medication-naive high-functioning children with autism spectrum disorder. Psychological Medicine, 35, 561\u2013570. doi: 10.1017\/s0033291704003496 .","journal-title":"Psychological Medicine"},{"key":"1860_CR25","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1136\/adc.80.2.192","volume":"80","author":"S Ratcliffe","year":"1999","unstructured":"Ratcliffe, S. (1999). Long-term outcome in children of sex chromosome abnormalities. Archives of Disease in Childhood, 80, 192\u2013195.","journal-title":"Archives of Disease in Childhood"},{"key":"1860_CR26","first-page":"1","volume":"26","author":"S Ratcliffe","year":"1991","unstructured":"Ratcliffe, S., Butler, G. E., & Jones, M. (1991). Edinburgh study of growth and development of children with sex chromosome abnormalities. IV. Birth Defects: Original Articles Series, 26, 1\u201344.","journal-title":"Birth Defects: Original Articles Series"},{"key":"1860_CR27","first-page":"59","volume":"26","author":"A Robinson","year":"1991","unstructured":"Robinson, A., Bender, B., Linden, M., & Salbenblatt, J. (1991). Sex chromosome aneuploidy: The Denver prospective study. Birth Defects: Original Articles Series, 26, 59\u2013115.","journal-title":"Birth Defects: Original Articles Series"},{"key":"1860_CR28","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1192\/bjp.175.6.559","volume":"175","author":"J Scourfield","year":"1999","unstructured":"Scourfield, J., Martin, N., Lewis, G., & McGuffin, P. (1999). Heritability of social cognitive skills in children and adolescents. British Journal of Psychiatry, 175, 559\u2013564.","journal-title":"British Journal of Psychiatry"},{"key":"1860_CR29","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1212\/WNL.59.2.184","volume":"59","author":"BF Sparks","year":"2002","unstructured":"Sparks, B. F., et al. (2002). Brain structural abnormalities in young children with autism spectrum disorder. Neurology, 59, 184\u2013192.","journal-title":"Neurology"},{"key":"1860_CR30","first-page":"131","volume":"26","author":"D Stewart","year":"1991","unstructured":"Stewart, D., Bailey, J., Netley, C., & Park, E. (1991). Growth, development and behavioral outcome from mid-adolescence to adulthood in subjects with chromosome aneuploidy: the Toronto study. Birth Defects: Original Articles Series, 26, 131\u2013188.","journal-title":"Birth Defects: Original Articles Series"},{"issue":"Suppl 1","key":"1860_CR31","first-page":"151","volume":"8","author":"N Tartaglia","year":"2010","unstructured":"Tartaglia, N., Cordeiro, L., Howell, S., Wilson, R., & Janusz, J. (2010a). The spectrum of the behavioral phenotype in boys and adolescents 47, XXY (Klinefelter syndrome). Pediatric Endocrinology Reviews: PER, 8(Suppl 1), 151\u2013159.","journal-title":"Pediatric Endocrinology Reviews: PER"},{"key":"1860_CR32","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1186\/1750-1172-5-8","volume":"5","author":"NR Tartaglia","year":"2010","unstructured":"Tartaglia, N. R., Howell, S., Sutherland, A., Wilson, R., & Wilson, L. (2010b). A review of trisomy X (47, XXX). Orphanet Journal of Rare Diseases, 5, 9. doi: 10.1186\/1750-1172-5-8 .","journal-title":"Orphanet Journal of Rare Diseases"},{"key":"1860_CR33","doi-asserted-by":"crossref","first-page":"1065","DOI":"10.1017\/S1355617707071044","volume":"13","author":"S Rijn van","year":"2007","unstructured":"van Rijn, S., Aleman, A., Swaab, H., Krijn, T., Vingerhoets, G., & Kahn, R. (2007). What it is said versus how it is said: comprehension of affective prosody in men with Klinefelter (47, XXY) syndrome. Journal of International Neuropsychological Society, 13, 1065\u20131070. doi: 10.1017\/S1355617707071044 .","journal-title":"Journal of International Neuropsychological Society"},{"key":"1860_CR34","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1016\/j.schres.2006.02.020","volume":"84","author":"S Rijn van","year":"2006","unstructured":"van Rijn, S., Swaab, H., Aleman, A., & Kahn, R. S. (2006). X Chromosomal effects on social cognitive processing and emotion regulation: A study with Klinefelter men (47, XXY). Schizophrenia Research, 84, 194\u2013203. doi: 10.1016\/j.schres.2006.02.020 .","journal-title":"Schizophrenia Research"},{"key":"1860_CR35","doi-asserted-by":"crossref","first-page":"1634","DOI":"10.1007\/s10803-008-0542-1","volume":"38","author":"S Rijn van","year":"2008","unstructured":"van Rijn, S., Swaab, H., Aleman, A., & Kahn, R. S. (2008). Social behavior and autism traits in a sex chromosomal disorder: Klinefelter (47XXY) syndrome. Journal of Autism and Developmental Disorders, 38, 1634\u20131641. doi: 10.1007\/s10803-008-0542-1 .","journal-title":"Journal of Autism and Developmental Disorders"},{"key":"1860_CR36","doi-asserted-by":"crossref","first-page":"e5581","DOI":"10.1371\/journal.pone.0005581","volume":"4","author":"M Wout van\u2019t","year":"2009","unstructured":"van\u2019t Wout, M., van Rijn, S., Jellema, T., Kahn, R. S., & Aleman, A. (2009). Deficits in implicit attention to social signals in schizophrenia and high risk groups: Behavioural evidence from a new illusion. PloS one, 4, e5581. doi: 10.1371\/journal.pone.0005581 .","journal-title":"PloS one"},{"key":"1860_CR37","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1002\/ddrr.76","volume":"15","author":"J Visootsak","year":"2009","unstructured":"Visootsak, J., & Graham, J. M. (2009). Social function in multiple X and Y chromosome disorders: XXY, XYY, XXYY, XXXY. Developmental Disabilities Research Reviews, 15, 328\u2013332.","journal-title":"Developmental Disabilities Research Reviews"},{"key":"1860_CR38","doi-asserted-by":"crossref","unstructured":"Zechner, U., Wilda, M., Kehrer-Sawatzki, H., Vogel, W., Fundele, R., & Hameister, H. (2001). A high density of X-linked genes for general cognitive ability: A run-away process shaping human evolution? Trends in Genetics, 17, 697\u2013701. doi: 10.1016\/S0168-9525(01)02446-5 .","DOI":"10.1016\/S0168-9525(01)02446-5"}],"container-title":["Journal of Autism and Developmental Disorders"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10803-013-1860-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s10803-013-1860-5\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10803-013-1860-5","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,31]],"date-time":"2019-05-31T00:51:32Z","timestamp":1559263892000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s10803-013-1860-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,7,4]]},"references-count":38,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2014,2]]}},"alternative-id":["1860"],"URL":"https:\/\/doi.org\/10.1007\/s10803-013-1860-5","relation":{},"ISSN":["0162-3257","1573-3432"],"issn-type":[{"value":"0162-3257","type":"print"},{"value":"1573-3432","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,7,4]]}}}