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Children with IQ\u2009\u2265\u200970 were analyzed for baseline deficits and treatment-effects on the intention-to-treat-population with generalized-linear-models, principal component analysis and network analysis. Ninety-two children were allocated to treatment and 83 eligible for analyses. Heterogeneous neurocognitive impairments were found that were unaffected by bumetanide treatment. Network analysis showed higher modularity after treatment (mean difference:-0.165, 95%CI:-0.317 to \u2212\u20090.013,p\u2009=\u2009.034) and changes in the relative importance of response inhibition in the neurocognitive network (mean difference:-0.037, 95%CI:-0.073 to \u2212\u20090.001,p\u2009=\u2009.042). This study offers perspectives to include neurocognitive tests in ASD trials.<\/jats:p>","DOI":"10.1007\/s10803-022-05841-3","type":"journal-article","created":{"date-parts":[[2023,1,10]],"date-time":"2023-01-10T08:03:11Z","timestamp":1673337791000},"page":"894-904","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Effects of Bumetanide on Neurocognitive Functioning in Children with Autism Spectrum Disorder: Secondary Analysis of a Randomized Placebo-Controlled Trial"],"prefix":"10.1007","volume":"54","author":[{"given":"Dorinde M","family":"van Andel","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5418-9791","authenticated-orcid":false,"given":"Jan J","family":"Sprengers","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marsh","family":"K\u00f6nigs","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maretha V","family":"de Jonge","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hilgo","family":"Bruining","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2023,1,10]]},"reference":[{"issue":"12","key":"5841_CR1","doi-asserted-by":"publisher","first-page":"1624","DOI":"10.1002\/jnr.24503","volume":"97","author":"C Cepeda","year":"2019","unstructured":"Cepeda, C., Oikonomou, K. 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Transl Psychiatry, 10(1), 9. doi:https:\/\/doi.org\/10.1038\/s41398-020-0692-2.","journal-title":"Transl Psychiatry"}],"container-title":["Journal of Autism and Developmental Disorders"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10803-022-05841-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10803-022-05841-3\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10803-022-05841-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,3,5]],"date-time":"2024-03-05T06:08:03Z","timestamp":1709618883000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10803-022-05841-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,1,10]]},"references-count":41,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2024,3]]}},"alternative-id":["5841"],"URL":"https:\/\/doi.org\/10.1007\/s10803-022-05841-3","relation":{},"ISSN":["0162-3257","1573-3432"],"issn-type":[{"value":"0162-3257","type":"print"},{"value":"1573-3432","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,1,10]]},"assertion":[{"value":"18 November 2022","order":1,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 January 2023","order":2,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and\/or national research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards. The study was approved by the Ethics Committee of the University Medical Centre Utrecht. All participants or their legal guardians provided informed consent.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with Ethical Standards"}},{"value":"Dr Bruining reports being shareholder of Aspect Neuroprofiles BV, which provides EEG-analysis services for clinical trials. The other authors have no biomedical financial interests or potential conflicts of interest to report.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of Interest"}}]}}