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However, the full spectrum of behavioral phenotypes associated with 3q29del is still evolving. Individuals with 3q29del (n\u2009=\u200996, 60.42% male) or their guardian completed the Achenbach Child or Adult Behavior Checklist (CBCL\/ABCL) via the online 3q29 registry (3q29deletion.org). Typically developing controls (n\u2009=\u200957, 49.12% male) were ascertained as a comparison group. We analyzed mean performance on the CBCL\/ABCL for individuals with 3q29del and controls across composite, DSM-keyed, and developmental scales; and the relationship between CBCL\/ABCL performance and clinical and developmental phenotypes for individuals with 3q29del. Individuals with 3q29del showed significantly elevated behavioral and developmental impairment relative to controls across CBCL\/ABCL domains. A substantial proportion of study participants with 3q29del scored in the Borderline or Clinical range for composite and DSM-keyed scales, indicating significant behavioral problems that may require clinical evaluation. We found that the preschool CBCL DSM-keyed autism spectrum problems scale is a potential screening tool for autism spectrum disorder (ASD) for individuals with 3q29del; CBCL\/ABCL DSM-keyed scales were not accurate screeners for anxiety disorders or attention-deficit\/hyperactivity disorder (ADHD) in our study sample. We identified a high degree of psychiatric comorbidity in individuals with 3q29del, with 60.42% (n\u2009=\u200958) of individuals with 3q29del scoring in the Borderline or Clinical range on two or more DSM-keyed CBCL\/ABCL scales. Finally, we found that the degree of developmental delay in participants with 3q29del does not explain the increased behavioral problems observed on the CBCL\/ABCL. The CBCL\/ABCL can be used as screening tools in populations such as 3q29del, even in the presence of substantial psychiatric comorbidity. These results expand our understanding of the phenotypic spectrum of 3q29del and demonstrate an effective method for recruiting and phenotyping a large sample of individuals with a rare genetic disorder.<\/jats:p>","DOI":"10.1007\/s10803-023-06218-w","type":"journal-article","created":{"date-parts":[[2024,1,12]],"date-time":"2024-01-12T18:02:28Z","timestamp":1705082548000},"page":"667-677","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Behavioral Phenotypes and Comorbidity in 3q29 Deletion Syndrome: Results from the 3q29 Registry"],"prefix":"10.1007","volume":"55","author":[{"given":"Rebecca M.","family":"Pollak","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Mortillo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Melissa M.","family":"Murphy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jennifer G.","family":"Mulle","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2024,1,12]]},"reference":[{"key":"6218_CR1","volume-title":"Manual for the ASEBA preschool forms and profiles","author":"TM Achenbach","year":"2000","unstructured":"Achenbach, T. 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