{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T19:42:28Z","timestamp":1789501348743,"version":"build-2803163510"},"reference-count":105,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2024,10,12]],"date-time":"2024-10-12T00:00:00Z","timestamp":1728691200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2024,10,12]],"date-time":"2024-10-12T00:00:00Z","timestamp":1728691200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"Erasmus MC Fellowship","award":["Erasmus MC Fellowship"],"award-info":[{"award-number":["Erasmus MC Fellowship"]}]},{"DOI":"10.13039\/501100009480","name":"Stichting Vrienden van het Sophia","doi-asserted-by":"publisher","award":["S16-14"],"award-info":[{"award-number":["S16-14"]}],"id":[{"id":"10.13039\/501100009480","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009480","name":"Stichting Vrienden van het Sophia","doi-asserted-by":"publisher","award":["B17-04"],"award-info":[{"award-number":["B17-04"]}],"id":[{"id":"10.13039\/501100009480","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009480","name":"Stichting Vrienden van het Sophia","doi-asserted-by":"publisher","award":["B14-02"],"award-info":[{"award-number":["B14-02"]}],"id":[{"id":"10.13039\/501100009480","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Autism Dev Disord"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Studying Autism Spectrum Disorder (ASD) heterogeneity in biologically homogeneous samples may increase our knowledge of ASD etiology. Fragile X syndrome (FXS), Angelman syndrome (AS), Tuberous Sclerosis Complex (TSC), and Neurofibromatosis type 1 (NF1) are monogenic disorders with high a prevalence of ASD symptomatology. This study aimed to identify ASD symptom profiles in a large group of children and adolescents (0;9\u201328 years) with FXS, AS, TSC, and NF1. Data on ASD symptomatology (Autism Diagnostic Observation Scale (ADOS-2) &amp; Social Responsiveness Scale (SRS-2)) were collected from children and adolescents with FXS (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u200954), AS (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u200993), TSC (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u2009112), and NF1 (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u2009278). To identify groups of individuals with similar ASD profiles, we performed two latent profile analyses. We identified a four-profile model based on the ADOS-2, with a (1) \u2018Non-spectrum symptom profile\u2019, (2) \u2018Social Affect symptom profile\u2019, (3)\u2018Restricted\/Repetitive Behaviors symptom profile\u2019, and (4)\u2018ASD symptom profile\u2019. We also identified a four-profile model based on the SRS, with a (1)\u2018Non-clinical symptom profile\u2019, (2)\u2018Mild symptom profile\u2019, (3)\u2018Moderate symptom profile\u2019, and (4)\u2018Severe symptom profile\u2019. Although each syndrome group exhibited varying degrees of severity, they also displayed heterogeneity in the profiles in which they were classified. We found distinct ASD symptom profiles in a population consisting of children and adolescents with FXS, AS, TSC, and NF1. Our study highlights the importance of a personalized approach to the identification and management of ASD symptoms in rare genetic syndromes. Future studies should aim to include more domains of functioning and investigate the stability of latent profiles over time.\n                  <\/jats:p>","DOI":"10.1007\/s10803-024-06557-2","type":"journal-article","created":{"date-parts":[[2024,10,12]],"date-time":"2024-10-12T01:02:05Z","timestamp":1728694925000},"page":"793-807","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Autism Spectrum Disorder Symptom Profiles in Fragile X Syndrome, Angelman Syndrome, Tuberous Sclerosis Complex and Neurofibromatosis Type 1"],"prefix":"10.1007","volume":"56","author":[{"given":"Kyra","family":"Lubbers","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kamil R.","family":"Hiralal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gwendolyn C.","family":"Dieleman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Doesjka A.","family":"Hagenaar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bram","family":"Dierckx","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeroen S.","family":"Legerstee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pieter F.A.","family":"de Nijs","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andr\u00e9 B.","family":"Rietman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rianne","family":"Oostenbrink","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen G.C.B.","family":"Bindels-de Heus","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie-Claire Y.","family":"de Wit","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manon H.J.","family":"Hillegers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leontine W.","family":"ten Hoopen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9088-8095","authenticated-orcid":false,"given":"Sabine E.","family":"Mous","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,10,12]]},"reference":[{"key":"6557_CR1","doi-asserted-by":"publisher","unstructured":"Abbeduto, L., Thurman, A. J., McDuffie, A., Klusek, J., Feigles, R. T., Brown, T., Harvey, W., Adayev, D. J., LaFauci, T., Dobkins, G., C., & Roberts, J. E. (2019). ASD Comorbidity in Fragile X Syndrome: Symptom Profile and predictors of Symptom Severity in adolescent and young adult males. Journal of Autism and Developmental Disorders, 49(3), 960\u2013977. https:\/\/doi.org\/10.1007\/s10803-018-3796-2","DOI":"10.1007\/s10803-018-3796-2"},{"key":"6557_CR2","doi-asserted-by":"publisher","first-page":"102033","DOI":"10.1016\/j.cpr.2021.102033","volume":"87","author":"JA van Agelink","year":"2021","unstructured":"Agelink, J. A., Deserno, M. K., & Geurts, H. M. (2021). Validation strategies for subtypes in psychiatry: A systematic review of research on autism spectrum disorder. Clinical Psychology Review, 87, 102033.","journal-title":"Clinical Psychology Review"},{"issue":"4","key":"6557_CR3","doi-asserted-by":"publisher","first-page":"1269","DOI":"10.1007\/s10803-019-04353-x","volume":"50","author":"GF Azad","year":"2020","unstructured":"Azad, G. F., Dillon, E., Feuerstein, J., Kalb, L., Neely, J., & Landa, R. (2020). Quality of life in school-aged youth referred to an Autism Specialty Clinic: A Latent Profile Analysis. Journal of Autism and Developmental Disorders, 50(4), 1269\u20131280. https:\/\/doi.org\/10.1007\/s10803-019-04353-x","journal-title":"Journal of Autism and Developmental Disorders"},{"issue":"6","key":"6557_CR4","doi-asserted-by":"publisher","first-page":"1070","DOI":"10.1016\/j.neuron.2019.02.041","volume":"101","author":"C Bagni","year":"2019","unstructured":"Bagni, C., & Zukin, R. S. (2019). A synaptic perspective of Fragile X Syndrome and Autism Spectrum disorders. Neuron, 101(6), 1070\u20131088. https:\/\/doi.org\/10.1016\/j.neuron.2019.02.041","journal-title":"Neuron"},{"issue":"1","key":"6557_CR5","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1023\/A:1005412111706","volume":"30","author":"DB Bailey Jr","year":"2000","unstructured":"Bailey, D. B. Jr., Hatton, D. D., Mesibov, G., Ament, N., & Skinner, M. (2000). Early development, temperament, and functional impairment in autism and fragile X syndrome. Journal of Autism and Developmental Disorders, 30(1), 49\u201359.","journal-title":"Journal of Autism and Developmental Disorders"},{"key":"6557_CR6","doi-asserted-by":"crossref","unstructured":"Bayley, N. (2006). Bayley scales of infant and toddler development (3 edn). Harcourt Assessment.","DOI":"10.1037\/t14978-000"},{"issue":"2","key":"6557_CR7","doi-asserted-by":"publisher","first-page":"174","DOI":"10.1093\/jpepsy\/jst084","volume":"39","author":"KS Berlin","year":"2014","unstructured":"Berlin, K. S., Williams, N. A., & Parra, G. R. (2014). An introduction to latent variable mixture modeling (part 1): Overview and cross-sectional latent class and latent profile analyses. Journal of Pediatric Psychology, 39(2), 174\u2013187.","journal-title":"Journal of Pediatric Psychology"},{"issue":"10","key":"6557_CR8","doi-asserted-by":"publisher","first-page":"2333","DOI":"10.1007\/s00381-020-04710-7","volume":"36","author":"P Bernardo","year":"2020","unstructured":"Bernardo, P., Cinalli, G., & Santoro, C. (2020). Epilepsy in NF1: A systematic review of the literature. Child\u2019s Nervous System, 36(10), 2333\u20132350. https:\/\/doi.org\/10.1007\/s00381-020-04710-7","journal-title":"Child\u2019s Nervous System"},{"issue":"11","key":"6557_CR9","doi-asserted-by":"publisher","first-page":"724","DOI":"10.1017\/s0012162201002833","volume":"44","author":"E Berry-Kravis","year":"2002","unstructured":"Berry-Kravis, E. (2002). Epilepsy in fragile X syndrome. Developmental Medicine and Child Neurology, 44(11), 724\u2013728. https:\/\/doi.org\/10.1017\/s0012162201002833","journal-title":"Developmental Medicine and Child Neurology"},{"issue":"1","key":"6557_CR10","doi-asserted-by":"publisher","first-page":"66","DOI":"10.1007\/s10803-010-1024-9","volume":"41","author":"S B\u00f6lte","year":"2011","unstructured":"B\u00f6lte, S., Westerwald, E., Holtmann, M., Freitag, C., & Poustka, F. (2011). Autistic traits and autism spectrum disorders: The clinical validity of two measures presuming a continuum of social communication skills. Journal of Autism and Developmental Disorders, 41(1), 66\u201372.","journal-title":"Journal of Autism and Developmental Disorders"},{"issue":"3","key":"6557_CR11","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1007\/s10048-007-0086-0","volume":"8","author":"MT Bonati","year":"2007","unstructured":"Bonati, M. T., Russo, S., Finelli, P., Valsecchi, M. R., Cogliati, F., Cavalleri, F., Roberts, W., Elia, M., & Larizza, L. (2007). Evaluation of autism traits in Angelman syndrome: A resource to unfold autism genes. Neurogenetics, 8(3), 169\u2013178.","journal-title":"Neurogenetics"},{"issue":"1","key":"6557_CR12","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1186\/s13229-022-00530-5","volume":"14","author":"N Bozhilova","year":"2023","unstructured":"Bozhilova, N., Welham, A., Adams, D., Bissell, S., Bruining, H., Crawford, H., Eden, K., Nelson, L., Oliver, C., Powis, L., Richards, C., Waite, J., Watson, P., Rhys, H., Wilde, L., Woodcock, K., & Moss, J. (2023). Profiles of autism characteristics in thirteen genetic syndromes: A machine learning approach. Molecular Autism, 14(1), 3. https:\/\/doi.org\/10.1186\/s13229-022-00530-5","journal-title":"Molecular Autism"},{"issue":"4","key":"6557_CR13","doi-asserted-by":"publisher","first-page":"365","DOI":"10.1177\/0734282913517525","volume":"32","author":"TP Bruni","year":"2014","unstructured":"Bruni, T. P. (2014). Test review: Social responsiveness scale-second edition (SRS-2) [Test Review]. Journal of Psychoeducational Assessment, 32(4), 365\u2013369.","journal-title":"Journal of Psychoeducational Assessment"},{"issue":"10","key":"6557_CR14","doi-asserted-by":"publisher","first-page":"694","DOI":"10.3390\/brainsci10100694","volume":"10","author":"DB Budimirovic","year":"2020","unstructured":"Budimirovic, D. B., Schlageter, A., Filipovic-Sadic, S., Protic, D. D., Bram, E., Mahone, E. M., Nicholson, K., Culp, K., Javanmardi, K., Kemppainen, J., Hadd, A., Sharp, K., Adayev, T., LaFauci, G., Dobkin, C., Zhou, L., Brown, W. T., Berry-Kravis, E., Kaufmann, W. E., & Latham, G. J. (2020). A genotype-phenotype study of high-resolution FMR1 nucleic acid and protein analyses in fragile x patients with neurobehavioral assessments. Brain Sciences, 10(10), 694. https:\/\/doi.org\/10.3390\/brainsci10100694","journal-title":"Brain Sciences"},{"issue":"6","key":"6557_CR15","doi-asserted-by":"publisher","first-page":"1","DOI":"10.18637\/jss.v061.i06","volume":"61","author":"M Charrad","year":"2014","unstructured":"Charrad, M., Ghazzali, N., Boiteau, V., & Niknafs, A. (2014). NbClust: An R Package for determining the relevant number of clusters in a Data Set. Journal of Statistical Software, 61(6), 1\u201336. https:\/\/doi.org\/10.18637\/jss.v061.i06","journal-title":"Journal of Statistical Software"},{"key":"6557_CR16","unstructured":"Constantino, J. N., & Gruber, C. P. (2012). Social responsiveness scale second edition (SRS-2): Manual. Western Psychological Services (WPS)."},{"issue":"1","key":"6557_CR17","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1186\/s13023-019-1123-4","volume":"14","author":"S Courbier","year":"2019","unstructured":"Courbier, S., Dimond, R., & Bros-Facer, V. (2019). Share and protect our health data: An evidence based approach to rare disease patients\u2019 perspectives on data sharing and data protection - quantitative survey and recommendations. Orphanet Journal of Rare Diseases, 14(1), 175. https:\/\/doi.org\/10.1186\/s13023-019-1123-4","journal-title":"Orphanet Journal of Rare Diseases"},{"key":"6557_CR18","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1111\/j.1749-6632.1991.tb37743.x","volume":"615","author":"P Curatolo","year":"1991","unstructured":"Curatolo, P., Cusmai, R., Cortesi, F., Chiron, C., Jambaque, I., & Dulac, O. (1991). Neuropsychiatric aspects of tuberous sclerosis. Annals of the New York Acadamy of Sciences, 615, 8\u201316.","journal-title":"Annals of the New York Acadamy of Sciences"},{"issue":"9","key":"6557_CR19","doi-asserted-by":"publisher","first-page":"1350","DOI":"10.1007\/s10803-009-0749-9","volume":"39","author":"A de Bildt","year":"2009","unstructured":"de Bildt, A., Sytema, S., van Lang, N. D., Minderaa, R. B., van Engeland, H., & de Jonge, M. V. (2009). Evaluation of the ADOS revised algorithm: The applicability in 558 Dutch children and adolescents. Journal of Autism and Developmental Disorders, 39(9), 1350\u20131358.","journal-title":"Journal of Autism and Developmental Disorders"},{"issue":"1","key":"6557_CR21","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1007\/s00787-006-0570-3","volume":"16","author":"PJ de Vries","year":"2007","unstructured":"de Vries, P. J., Hunt, A., & Bolton, P. F. (2007). The psychopathologies of children and adolescents with tuberous sclerosis complex (TSC): A postal survey of UK families. European Child & Adolescent Psychiatry, 16(1), 16\u201324.","journal-title":"European Child & Adolescent Psychiatry"},{"key":"6557_CR20","first-page":"603","volume":"11","author":"PJ de Vries","year":"2020","unstructured":"de Vries, P. J., Belousova, E., Benedik, M. P., Carter, T., Cottin, V., Curatolo, P., Dahlin, M., D\u2019Amato, L., d\u2019Aug\u00e8res, B., Ferreira, G., Feucht, J. C., Fladrowski, M., Hertzberg, C., Jozwiak, C., Lawson, S., Macaya, J. A., Marques, A., Nabbout, R., O\u2019Callaghan, R., & Investigators, F., T (2020). Tuberous sclerosis Complex-Associated Neuropsychiatric disorders (TAND): New findings on Age, Sex, and genotype in relation to intellectual phenotype. Frontiers in Neurology, 11, 603.","journal-title":"Frontiers in Neurology"},{"key":"6557_CR22","doi-asserted-by":"crossref","unstructured":"Duis, J., Nespeca, M., Summers, J., Bird, L., Bindels-de Heus, K., Valstar, M. J., de Wit, M. Y., Navis, C., Hooven-Radstaake, T., van Iperen-Kolk, M., Ernst, B. M., Dendrinos, S., Katz, M., Diaz-Medina, T., Katyayan, G., Nangia, A., Thibert, S., Glaze, R., Keary, D., & Anderson, C., A (2022). A multidisciplinary approach and consensus statement to establish standards of care for Angelman syndrome (Vol. 10). Molecular Genetics & Genomic Medicine. 3e1843.","DOI":"10.1002\/mgg3.1843"},{"issue":"7","key":"6557_CR23","doi-asserted-by":"publisher","first-page":"2278","DOI":"10.1007\/s10803-018-3478-0","volume":"48","author":"S Eijk","year":"2018","unstructured":"Eijk, S., Mous, S. E., Dieleman, G. C., Dierckx, B., Rietman, A. B., de Nijs, P. F. A., Hoopen, T., van Minkelen, L. W., Elgersma, R., Catsman-Berrevoets, Y., Oostenbrink, C. E., R., & Legerstee, J. S. (2018). Autism spectrum disorder in an unselected cohort of children with neurofibromatosis type 1 (NF1). Journal of Autism and Developmental Disorders, 48(7), 2278\u20132285.","journal-title":"Journal of Autism and Developmental Disorders"},{"issue":"2","key":"6557_CR24","doi-asserted-by":"publisher","first-page":"104172","DOI":"10.4172\/2165-7890.1000143","volume":"5","author":"M Fahnestock","year":"2015","unstructured":"Fahnestock, M., & Nicolini, C. (2015). Bridging the gap between genes and behavior: Brain-derived neurotrophic factor and the mTOR pathway in idiopathic autism. Autism Open Access, 5(2), 104172.","journal-title":"Autism Open Access"},{"key":"6557_CR25","doi-asserted-by":"publisher","first-page":"39","DOI":"10.3389\/fnana.2020.00039","volume":"14","author":"DM Feliciano","year":"2020","unstructured":"Feliciano, D. M. (2020). The neurodevelopmental pathogenesis of Tuberous Sclerosis Complex (TSC). Frontiers in Neuroanatomy, 14, 39.","journal-title":"Frontiers in Neuroanatomy"},{"issue":"12","key":"6557_CR26","doi-asserted-by":"publisher","first-page":"4520","DOI":"10.1007\/s10803-021-04892-2","volume":"51","author":"H Fielding-Gebhardt","year":"2021","unstructured":"Fielding-Gebhardt, H., Bredin-Oja, S. L., Warren, S. F., & Brady, N. C. (2021). Rethinking measurement standards of Autism Symptomology in adolescents with Fragile X Syndrome. Journal of Autism and Developmental Disorders, 51(12), 4520\u20134533. https:\/\/doi.org\/10.1007\/s10803-021-04892-2","journal-title":"Journal of Autism and Developmental Disorders"},{"issue":"11","key":"6557_CR27","doi-asserted-by":"publisher","first-page":"1339","DOI":"10.1111\/jcpp.13510","volume":"62","author":"V Frewer","year":"2021","unstructured":"Frewer, V., Gilchrist, C. P., Collins, S. E., Williams, K., Seal, M. L., Leventer, R. J., & Amor, D. J. (2021). A systematic review of brain MRI findings in monogenic disorders strongly associated with autism spectrum disorder. Journal of Child Psychology and Psychiatry, 62(11), 1339\u20131352.","journal-title":"Journal of Child Psychology and Psychiatry"},{"issue":"1","key":"6557_CR28","doi-asserted-by":"publisher","first-page":"392","DOI":"10.1007\/s10803-021-04949-2","volume":"52","author":"S Georgiades","year":"2022","unstructured":"Georgiades, S., Tait, P. A., McNicholas, P. D., Duku, E., Zwaigenbaum, L., Smith, I. M., Bennett, T., Elsabbagh, M., Kerns, C. M., Mirenda, P., Ungar, W. J., Vaillancourt, T., Volden, J., Waddell, C., Zaidman-Zait, A., Gentles, S., & Szatmari, P. (2022). Trajectories of Symptom Severity in Children with Autism: Variability and turning points through the transition to School. Journal of Autism and Developmental Disorders, 52(1), 392\u2013401.","journal-title":"Journal of Autism and Developmental Disorders"},{"issue":"4","key":"6557_CR30","doi-asserted-by":"publisher","first-page":"613","DOI":"10.1007\/s10803-006-0280-1","volume":"37","author":"K Gotham","year":"2007","unstructured":"Gotham, K., Risi, S., Pickles, A., & Lord, C. (2007). The Autism Diagnostic Observation schedule: Revised algorithms for improved diagnostic validity. Journal of Autism and Developmental Disorders, 37(4), 613\u2013627. https:\/\/doi.org\/10.1007\/s10803-006-0280-1","journal-title":"Journal of Autism and Developmental Disorders"},{"issue":"5","key":"6557_CR29","doi-asserted-by":"publisher","first-page":"e1278","DOI":"10.1542\/peds.2011-3668","volume":"130","author":"K Gotham","year":"2012","unstructured":"Gotham, K., Pickles, A., & Lord, C. (2012). Trajectories of autism severity in children using standardized ADOS scores. Pediatrics, 130(5), e1278\u20131284. https:\/\/doi.org\/10.1542\/peds.2011-3668","journal-title":"Pediatrics"},{"issue":"12","key":"6557_CR31","doi-asserted-by":"publisher","first-page":"e2029068","DOI":"10.1001\/jamanetworkopen.2020.29068","volume":"3","author":"RW Grant","year":"2020","unstructured":"Grant, R. W., McCloskey, J., Hatfield, M., Uratsu, C., Ralston, J. D., Bayliss, E., & Kennedy, C. J. (2020). Use of Latent Class Analysis and k-Means clustering to identify Complex patient profiles. JAMA Network Open, 3(12), e2029068.","journal-title":"JAMA Network Open"},{"issue":"1","key":"6557_CR32","doi-asserted-by":"publisher","first-page":"16035","DOI":"10.1038\/nrdp.2016.35","volume":"2","author":"EP Henske","year":"2016","unstructured":"Henske, E. P., J\u00f3\u017awiak, S., Kingswood, J. C., Sampson, J. R., & Thiele, E. A. (2016). Tuberous sclerosis complex. Nature Reviews Disease Primers, 2(1), 16035. https:\/\/doi.org\/10.1038\/nrdp.2016.35","journal-title":"Nature Reviews Disease Primers"},{"key":"6557_CR35","doi-asserted-by":"crossref","unstructured":"Hus, V., & Lord, C. (2014). The autism diagnostic observation schedule, module 4: revised algorithm and standardized severity scores. Journal of autism and developmental disorders, 44(8), 1996\u20132012. https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10803-014-2080-3.pdf","DOI":"10.1007\/s10803-014-2080-3"},{"key":"6557_CR33","doi-asserted-by":"publisher","unstructured":"Hus, V., Bishop, S., Gotham, K., Huerta, M., & Lord, C. (2013). Factors influencing scores on the social responsiveness scale. Journal of Child Psychology and Psychiatry, 54(2), 216\u2013224. https:\/\/doi.org\/10.1111\/j.1469-7610.2012.02589.x?download=true. https:\/\/acamh.onlinelibrary.wiley.com\/doi\/pdfdirect\/","DOI":"10.1111\/j.1469-7610.2012.02589.x?download=true"},{"issue":"10","key":"6557_CR34","doi-asserted-by":"publisher","first-page":"2400","DOI":"10.1007\/s10803-012-1719-1","volume":"44","author":"V Hus","year":"2014","unstructured":"Hus, V., Gotham, K., & Lord, C. (2014). Standardizing ADOS domain scores: Separating severity of social affect and restricted and repetitive behaviors. Journal of Autism and Developmental Disorders, 44(10), 2400\u20132412.","journal-title":"Journal of Autism and Developmental Disorders"},{"key":"6557_CR36","doi-asserted-by":"publisher","first-page":"3712","DOI":"10.1007\/s10803-016-2897-z","volume":"46","author":"RJE James","year":"2016","unstructured":"James, R. J. E., Dubey, I., Smith, D., Ropar, D., & Tunney, R. J. (2016). The latent structure of autistic traits: A taxometric, latent class and latent profile analysis of the adult autism spectrum quotient. Journal of Autism and Developmental Disorders, 46, 3712\u20133728.","journal-title":"Journal of Autism and Developmental Disorders"},{"issue":"8","key":"6557_CR37","doi-asserted-by":"publisher","first-page":"766","DOI":"10.1212\/WNL.0000000000003002","volume":"87","author":"SS Jeste","year":"2016","unstructured":"Jeste, S. S., Varcin, K. J., Hellemann, G. S., Gulsrud, A. C., Bhatt, R., Kasari, C., Wu, J. Y., Sahin, M., & Nelson, C. A. (2016). Symptom profiles of autism spectrum disorder in tuberous sclerosis complex. Neurology, 87(8), 766\u2013772. 3rd.","journal-title":"Neurology"},{"key":"6557_CR38","unstructured":"Kassambra, A. (2021). rstatix: Pipe-Friendly Framework for Basic Statistical Tests. In [R package version 0.7.0]. https:\/\/CRAN.R-project.org\/package=rstatix"},{"issue":"3","key":"6557_CR39","doi-asserted-by":"publisher","first-page":"401","DOI":"10.1016\/j.cell.2008.10.017","volume":"135","author":"RJ Kelleher","year":"2008","unstructured":"Kelleher, R. J., & Bear, M. F. (2008). The autistic neuron: Troubled translation? Cell, 135(3), 401\u2013406. https:\/\/doi.org\/10.1016\/j.cell.2008.10.017","journal-title":"Cell"},{"issue":"3","key":"6557_CR40","doi-asserted-by":"publisher","first-page":"525","DOI":"10.1016\/j.pcl.2020.02.007","volume":"67","author":"T Kodak","year":"2020","unstructured":"Kodak, T., & Bergmann, S. (2020). Autism spectrum disorder: Characteristics, Associated Behaviors, and early intervention. Pediatric Clinics of North America, 67(3), 525\u2013535. https:\/\/doi.org\/10.1016\/j.pcl.2020.02.007","journal-title":"Pediatric Clinics of North America"},{"issue":"10","key":"6557_CR41","doi-asserted-by":"publisher","first-page":"819","DOI":"10.1016\/S2215-0366(19)30289-5","volume":"6","author":"MC Lai","year":"2019","unstructured":"Lai, M. C., Kassee, C., Besney, R., Bonato, S., Hull, L., Mandy, W., Szatmari, P., & Ameis, S. H. (2019). Prevalence of co-occurring mental health diagnoses in the autism population: A systematic review and meta-analysis. Lancet Psychiatry, 6(10), 819\u2013829.","journal-title":"Lancet Psychiatry"},{"issue":"3","key":"6557_CR42","doi-asserted-by":"publisher","first-page":"753","DOI":"10.1002\/ajmg.a.38072","volume":"173","author":"A Le Fevre","year":"2017","unstructured":"Le Fevre, A., Beygo, J., Silveira, C., Kamien, B., Clayton-Smith, J., Colley, A., Buiting, K., & Dudding-Byth, T. (2017). Atypical Angelman syndrome due to a mosaic imprinting defect: Case reports and review of the literature. American Journal of Medical Genetics Part A, 173(3), 753\u2013757. https:\/\/doi.org\/10.1002\/ajmg.a.38072","journal-title":"American Journal of Medical Genetics Part A"},{"key":"6557_CR43","doi-asserted-by":"publisher","first-page":"104293","DOI":"10.1016\/j.ridd.2022.104293","volume":"128","author":"G Leader","year":"2022","unstructured":"Leader, G., Gilligan, R., Whelan, S., Coyne, R., Caher, A., White, K., Traina, I., Muchenje, S., Machaka, R. L., & Mannion, A. (2022). Relationships between challenging behavior and gastrointestinal symptoms, sleep problems, and internalizing and externalizing symptoms in children and adolescents with Angelman syndrome. Research in Developmental Disabilities, 128, 104293.","journal-title":"Research in Developmental Disabilities"},{"key":"6557_CR44","doi-asserted-by":"publisher","first-page":"1104","DOI":"10.1016\/j.phpro.2012.03.206","volume":"25","author":"Y Li","year":"2012","unstructured":"Li, Y., & Wu, H. (2012). A clustering method based on K-Means Algorithm. Physics Procedia, 25, 1104\u20131109. https:\/\/doi.org\/10.1016\/j.phpro.2012.03.206","journal-title":"Physics Procedia"},{"issue":"1","key":"6557_CR45","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1186\/s12888-021-03648-7","volume":"22","author":"F Liu","year":"2022","unstructured":"Liu, F., Yang, D., Liu, Y., Zhang, Q., Chen, S., Li, W., Ren, J., Tian, X., & Wang, X. (2022). Use of latent profile analysis and k-means clustering to identify student anxiety profiles. Bmc Psychiatry, 22(1), 12. https:\/\/doi.org\/10.1186\/s12888-021-03648-7","journal-title":"Bmc Psychiatry"},{"issue":"3","key":"6557_CR46","doi-asserted-by":"publisher","first-page":"439","DOI":"10.1016\/j.beem.2010.02.002","volume":"24","author":"MB Lodish","year":"2010","unstructured":"Lodish, M. B., & Stratakis, C. A. (2010). Endocrine tumours in neurofibromatosis type 1, tuberous sclerosis and related syndromes. Best Practice & Research Clinical Endocrinology & Metabolism, 24(3), 439\u2013449. https:\/\/doi.org\/10.1016\/j.beem.2010.02.002","journal-title":"Best Practice & Research Clinical Endocrinology & Metabolism"},{"issue":"6","key":"6557_CR47","first-page":"466","volume":"56","author":"R Loomes","year":"2017","unstructured":"Loomes, R., Hull, L., & Mandy, W. P. L. (2017). What is the male-to-female ratio in Autism Spectrum Disorder? A systematic review and Meta-analysis. Journal of the American Academy of Child and Adolescent Psychiatry, 56(6), 466\u2013474.","journal-title":"Journal of the American Academy of Child and Adolescent Psychiatry"},{"key":"6557_CR48","doi-asserted-by":"crossref","unstructured":"Lord, C., Rutter, M., Dilavore, P., & Risi, S. (1999). The Autism Diagnostic Observation Schedule (ADOS). Los Angeles, Western Psychological Corporation.","DOI":"10.1037\/t17256-000"},{"key":"6557_CR49","unstructured":"Lord, C. R., DiLavore, M., Risi, P. C., Gotham, S., & Bishop, K., S (2012). Autism diagnostic observation schedule, second edition. Western Psychological Services."},{"key":"6557_CR50","doi-asserted-by":"publisher","first-page":"852208","DOI":"10.3389\/fpsyt.2022.852208","volume":"13","author":"K Lubbers","year":"2022","unstructured":"Lubbers, K., Stijl, E. M., Dierckx, B., Hagenaar, D. A., Hoopen, T., Legerstee, L. W., de Nijs, J. S., Rietman, P. F. A., Greaves-Lord, A. B., Hillegers, K., Dieleman, M. H. J., Mous, G. C., S. E., & Center, E. E. (2022). Autism symptoms in children and young adults with fragile X syndrome, Angelman Syndrome, Tuberous Sclerosis Complex, and neurofibromatosis type 1: A Cross-syndrome comparison. Frontiers in Psychiatry, 13, 852208.","journal-title":"Frontiers in Psychiatry"},{"key":"6557_CR51","unstructured":"Maechler, M., Rousseeuw, P., Struyf, A., Hubert, M., & Hornik, K. (2021). cluster: Cluster Analysis Basics and Extensions. In [R package version 2.1.2.]."},{"key":"6557_CR52","doi-asserted-by":"crossref","unstructured":"Magidson, J., & Vermunt, J. K. (2004). Latent class models. The Sage handbook of quantitative methodology for the social sciences, 175\u2013198.","DOI":"10.4135\/9781412986311.n10"},{"issue":"11","key":"6557_CR53","doi-asserted-by":"publisher","first-page":"2154","DOI":"10.1111\/febs.15258","volume":"287","author":"C Maranga","year":"2020","unstructured":"Maranga, C., Fernandes, T. G., Bekman, E., & da Rocha, S. T. (2020). Angelman syndrome: A journey through the brain. The FEBS Journal, 287(11), 2154\u20132175. https:\/\/doi.org\/10.1111\/febs.15258. https:\/\/febs.onlinelibrary.wiley.com\/doi\/","journal-title":"The FEBS Journal"},{"issue":"1","key":"6557_CR54","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1186\/s11689-021-09362-5","volume":"13","author":"M Marlborough","year":"2021","unstructured":"Marlborough, M., Welham, A., Jones, C., Reckless, S., & Moss, J. (2021). Autism spectrum disorder in females with fragile X syndrome: A systematic review and meta-analysis of prevalence. Journal of Neurodevelopmental Disorders, 13(1), 28.","journal-title":"Journal of Neurodevelopmental Disorders"},{"issue":"7","key":"6557_CR55","doi-asserted-by":"publisher","first-page":"1925","DOI":"10.1007\/s10803-013-2013-6","volume":"45","author":"A McDuffie","year":"2015","unstructured":"McDuffie, A., Thurman, A. J., Hagerman, R. J., & Abbeduto, L. (2015). Symptoms of Autism in males with fragile X syndrome: A comparison to nonsyndromic ASD using current ADI-R scores. Journal of Autism and Developmental Disorders, 45(7), 1925\u20131937.","journal-title":"Journal of Autism and Developmental Disorders"},{"issue":"2","key":"6557_CR56","doi-asserted-by":"publisher","first-page":"750","DOI":"10.1007\/s10803-018-3750-3","volume":"49","author":"JE Medda","year":"2019","unstructured":"Medda, J. E., Cholemkery, H., & Freitag, C. M. (2019). Sensitivity and specificity of the ADOS-2 Algorithm in a large German sample. Journal of Autism and Developmental Disorders, 49(2), 750\u2013761.","journal-title":"Journal of Autism and Developmental Disorders"},{"key":"6557_CR57","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1016\/j.neuropharm.2012.11.015","volume":"68","author":"MJ Millan","year":"2013","unstructured":"Millan, M. J. (2013). An epigenetic framework for neurodevelopmental disorders: From pathogenesis to potential therapy. Neuropharmacology, 68, 2\u201382. https:\/\/doi.org\/10.1016\/j.neuropharm.2012.11.015","journal-title":"Neuropharmacology"},{"issue":"3","key":"6557_CR58","doi-asserted-by":"publisher","first-page":"1080","DOI":"10.1007\/s10803-018-3810-8","volume":"49","author":"LE Miller","year":"2019","unstructured":"Miller, L. E., Burke, J. D., Robins, D. L., & Fein, D. A. (2019). Diagnosing Autism Spectrum Disorder in Children with Low Mental Age. Journal of Autism and Developmental Disorders, 49(3), 1080\u20131095.","journal-title":"Journal of Autism and Developmental Disorders"},{"issue":"02","key":"6557_CR59","doi-asserted-by":"publisher","first-page":"064","DOI":"10.1055\/s-0035-1570070","volume":"5","author":"R Moavero","year":"2016","unstructured":"Moavero, R., Bombardieri, R., Marciano, S., Cerminara, C., & Curatolo, P. (2016). Epilepsy in Tuberous Sclerosis Complex. Journal of Pediatric Epilepsy, 5(02), 064\u2013069.","journal-title":"Journal of Pediatric Epilepsy"},{"issue":"2","key":"6557_CR60","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1177\/1362361310379241","volume":"15","author":"CA Molloy","year":"2011","unstructured":"Molloy, C. A., Murray, D. S., Akers, R., Mitchell, T., & Manning-Courtney, P. (2011). Use of the Autism Diagnostic Observation schedule (ADOS) in a clinical setting. Autism, 15(2), 143\u2013162. https:\/\/doi.org\/10.1177\/1362361310379241","journal-title":"Autism"},{"issue":"12","key":"6557_CR61","doi-asserted-by":"publisher","first-page":"1276","DOI":"10.1001\/jamapsychiatry.2016.2600","volume":"73","author":"SM Morris","year":"2016","unstructured":"Morris, S. M., Acosta, M. T., Garg, S., Green, J., Huson, S., Legius, E., North, K. N., Payne, J. M., Plasschaert, E., Frazier, T. W., Weiss, L. A., Zhang, Y., Gutmann, D. H., & Constantino, J. N. (2016). Disease Burden and Symptom structure of Autism in neurofibromatosis type 1: A study of the International NF1-ASD Consortium Team (INFACT). JAMA Psychiatry, 73(12), 1276\u20131284.","journal-title":"JAMA Psychiatry"},{"issue":"10","key":"6557_CR62","doi-asserted-by":"publisher","first-page":"852","DOI":"10.1111\/j.1365-2788.2009.01197.x","volume":"53","author":"J Moss","year":"2009","unstructured":"Moss, J., & Howlin, P. (2009). Autism spectrum disorders in genetic syndromes: Implications for diagnosis, intervention and understanding the wider autism spectrum disorder population. Journal of Intellectual Disability Research, 53(10), 852\u2013873. https:\/\/doi.org\/10.1111\/j.1365-2788.2009.01197.x. https:\/\/onlinelibrary.wiley.com\/doi\/","journal-title":"Journal of Intellectual Disability Research"},{"key":"6557_CR63","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1037\/1082-989x.4.2.139","volume":"4","author":"DS Nagin","year":"1999","unstructured":"Nagin, D. S. (1999). Analyzing developmental trajectories: A semiparametric, group-based approach [doi:10.1037\/1082-989X.4.2.139]. Psychological Methods, 4, 139\u2013157. https:\/\/doi.org\/10.1037\/1082-989x.4.2.139","journal-title":"Psychological Methods"},{"key":"6557_CR64","doi-asserted-by":"publisher","first-page":"e5","DOI":"10.1017\/S2045796018000483","volume":"29","author":"A Narzisi","year":"2018","unstructured":"Narzisi, A., Posada, M., Barbieri, F., Chericoni, N., Ciuffolini, D., Pinzino, M., Romano, R., Scattoni, M. L., Tancredi, R., Calderoni, S., & Muratori, F. (2018). Prevalence of Autism Spectrum Disorder in a large Italian catchment area: A school-based population study within the ASDEU project. Epidemiology and Psychiatric Sciences, 29, e5.","journal-title":"Epidemiology and Psychiatric Sciences"},{"key":"6557_CR65","unstructured":"Northrup, H., Koenig, M. K., Pearson, D. A., & Au, K. S. (1993). Tuberous Sclerosis Complex."},{"issue":"3","key":"6557_CR66","doi-asserted-by":"publisher","first-page":"280","DOI":"10.1080\/09540261.2021.1872506","volume":"33","author":"B Oakley","year":"2021","unstructured":"Oakley, B., Loth, E., & Murphy, D. G. (2021). Autism and mood disorders. International Review of Psychiatry, 33(3), 280\u2013299.","journal-title":"International Review of Psychiatry"},{"key":"6557_CR67","doi-asserted-by":"publisher","first-page":"102017","DOI":"10.1016\/j.rasd.2022.102017","volume":"97","author":"I Pr\u00e9fontaine","year":"2022","unstructured":"Pr\u00e9fontaine, I., Morizot, J., Lanovaz, M. J., & Rivard, M. (2022). A person-centered perspective on differential efficacy of early behavioral intervention in children with autism: A latent profile analysis. Research in Autism Spectrum Disorders, 97, 102017.","journal-title":"Research in Autism Spectrum Disorders"},{"key":"6557_CR68","doi-asserted-by":"crossref","unstructured":"Protic, D. D., Aishworiya, R., Salcedo-Arellano, M. J., Tang, S. J., Milisavljevic, J., Mitrovic, F., Hagerman, R. J., & Budimirovic, D. B. (2022). Fragile X syndrome: From molecular aspect to clinical treatment. International Journal of Molecular Sciences, 23(4), 1935.","DOI":"10.3390\/ijms23041935"},{"key":"6557_CR69","unstructured":"R Development Core Team (2022). R: A language and environment for statistical ## computing.In R Foundation for Statistical Computing."},{"issue":"10","key":"6557_CR71","doi-asserted-by":"publisher","first-page":"909","DOI":"10.1016\/S2215-0366(15)00376-4","volume":"2","author":"C Richards","year":"2015","unstructured":"Richards, C., Jones, C., Groves, L., Moss, J., & Oliver, C. (2015). Prevalence of autism spectrum disorder phenomenology in genetic disorders: A systematic review and meta-analysis. Lancet Psychiatry, 2(10), 909\u2013916.","journal-title":"Lancet Psychiatry"},{"key":"6557_CR72","doi-asserted-by":"crossref","unstructured":"Rinehart, N. J., Cornish, K. M., & Tonge, B. J. (2010). Gender differences in neurodevelopmental disorders: Autism and fragile X syndrome. In J. Neill, & J. Kulkarni (Eds.), Biological Basis of Sex Differences in Psychopharmacology. Current Topics in Behavioral Neurosciences, (pp. 209\u2013229). Springer","DOI":"10.1007\/7854_2010_96"},{"issue":"3","key":"6557_CR73","doi-asserted-by":"publisher","first-page":"957","DOI":"10.1016\/j.rasd.2010.12.003","volume":"5","author":"TT Rivet","year":"2011","unstructured":"Rivet, T. T., & Matson, J. L. (2011). Review of gender differences in core symptomatology in autism spectrum disorders. Research in Autism Spectrum Disorders, 5(3), 957\u2013976.","journal-title":"Research in Autism Spectrum Disorders"},{"issue":"1","key":"6557_CR74","doi-asserted-by":"publisher","first-page":"256","DOI":"10.1038\/s41398-021-01378-8","volume":"11","author":"C Rodriguez-Fontenla","year":"2021","unstructured":"Rodriguez-Fontenla, C., & Carracedo, A. (2021). UTMOST, a single and cross-tissue TWAS (transcriptome wide association study), reveals new ASD (autism spectrum disorder) associated genes. Translational Psychiatry, 11(1), 256.","journal-title":"Translational Psychiatry"},{"issue":"6","key":"6557_CR75","doi-asserted-by":"publisher","first-page":"512","DOI":"10.1136\/jmg.2005.036913","volume":"43","author":"T Sahoo","year":"2006","unstructured":"Sahoo, T., Peters, S. U., Madduri, N. S., Glaze, D. G., German, J. R., Bird, L. M., Barbieri-Welge, R., Bichell, T. J., Beaudet, A. L., & Bacino, C. A. (2006). Microarray based comparative genomic hybridization testing in deletion bearing patients with Angelman syndrome: Genotype-phenotype correlations. Journal of Medical Genetics, 43(6), 512\u2013516.","journal-title":"Journal of Medical Genetics"},{"issue":"1","key":"6557_CR76","doi-asserted-by":"publisher","first-page":"289","DOI":"10.32614\/RJ-2016-021","volume":"8","author":"L Scrucca","year":"2016","unstructured":"Scrucca, L., Fop, M., Murphy, T. B., & Raftery, A. E. (2016). Mclust 5: Clustering, classification and density estimation using Gaussian Finite Mixture models. R J, 8(1), 289\u2013317.","journal-title":"R J"},{"issue":"Suppl 3","key":"6557_CR77","doi-asserted-by":"publisher","first-page":"S183","DOI":"10.1542\/peds.2016-1159E","volume":"139","author":"SL Sherman","year":"2017","unstructured":"Sherman, S. L., Kidd, S. A., Riley, C., Berry-Kravis, E., Andrews, H. F., Miller, R. M., Lincoln, S., Swanson, M., Kaufmann, W. E., & Brown, W. T. (2017). FORWARD: A Registry and Longitudinal Clinical Database to Study Fragile X Syndrome. Pediatrics, 139(Suppl 3), S183\u2013S193.","journal-title":"Pediatrics"},{"key":"6557_CR78","unstructured":"Sparrow, S. S., Carter, A. S., & Cicchetti, D. V. (1993). Vineland Screener: Overview, reliability, validity, administration, and scoring. Yale University Child Study Center."},{"key":"6557_CR79","doi-asserted-by":"publisher","unstructured":"Spurk, D., Hirschi, A., Wang, M., Valero, D., & Kauffeld, S. (2020). Latent profile analysis: A review and how to guide of its application within vocational behavior research [doi:10.1016\/j.jvb.2020.103445]. Journal of Vocational Behavior, 120. https:\/\/doi.org\/10.1016\/j.jvb.2020.103445","DOI":"10.1016\/j.jvb.2020.103445"},{"key":"6557_CR80","doi-asserted-by":"publisher","first-page":"4209","DOI":"10.1007\/s10803-019-04129-3","volume":"49","author":"MO Sullivan","year":"2019","unstructured":"Sullivan, M. O., Gallagher, L., & Heron, E. A. (2019). Gaining insights into aggressive behaviour in autism spectrum disorder using latent profile analysis. Journal of Autism and Developmental Disorders, 49, 4209\u20134218.","journal-title":"Journal of Autism and Developmental Disorders"},{"issue":"1","key":"6557_CR81","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1080\/20473869.2018.1542561","volume":"66","author":"CK Syriopoulou-Delli","year":"2020","unstructured":"Syriopoulou-Delli, C. K., & Papaefstathiou, E. (2020). Review of cluster analysis of phenotypic data in Autism Spectrum disorders: Distinct subtypes or a severity gradient model? [doi: 10.1080\/20473869.2018.1542561]. International Journal of Developmental Disabilities, 66(1), 13\u201321. https:\/\/doi.org\/10.1080\/20473869.2018.1542561","journal-title":"International Journal of Developmental Disabilities"},{"issue":"3","key":"6557_CR82","doi-asserted-by":"publisher","first-page":"276","DOI":"10.1001\/jamapsychiatry.2014.2463","volume":"72","author":"P Szatmari","year":"2015","unstructured":"Szatmari, P., Georgiades, S., Duku, E., Bennett, T. A., Bryson, S., Fombonne, E., Mirenda, P., Roberts, W., Smith, I. M., Vaillancourt, T., Volden, J., Waddell, C., Zwaigenbaum, L., Elsabbagh, M., & Thompson, A. (2015). Developmental trajectories of symptom severity and adaptive functioning in an inception cohort of preschool children with autism spectrum disorder. JAMA Psychiatry, 72(3), 276\u2013283. https:\/\/doi.org\/10.1001\/jamapsychiatry.2014.2463. D. S. T.","journal-title":"JAMA Psychiatry"},{"key":"6557_CR83","unstructured":"Tellegen, P. J., L. J. A (2011). Snijders-Oomen Niet-Verbale intelligentietest: Verantwoording. Hogrefe."},{"issue":"11","key":"6557_CR84","doi-asserted-by":"publisher","first-page":"2369","DOI":"10.1111\/j.1528-1167.2009.02108.x","volume":"50","author":"RL Thibert","year":"2009","unstructured":"Thibert, R. L., Conant, K. D., Braun, E. K., Bruno, P., Said, R. R., Nespeca, M. P., & Thiele, E. A. (2009). Epilepsy in Angelman syndrome: A questionnaire-based assessment of the natural history and current treatment options. Epilepsia, 50(11), 2369\u20132376.","journal-title":"Epilepsia"},{"issue":"5","key":"6557_CR85","doi-asserted-by":"publisher","first-page":"585","DOI":"10.1111\/jcpp.12499","volume":"57","author":"B Tick","year":"2016","unstructured":"Tick, B., Bolton, P., Happ\u00e9, F., Rutter, M., & Rijsdijk, F. (2016). Heritability of autism spectrum disorders: A meta-analysis of twin studies. Journal of Child Psychology and Psychiatry, 57(5), 585\u2013595.","journal-title":"Journal of Child Psychology and Psychiatry"},{"key":"6557_CR86","doi-asserted-by":"publisher","first-page":"227","DOI":"10.3389\/fped.2017.00227","volume":"5","author":"MM Torres Nupan","year":"2017","unstructured":"Torres Nupan, M. M., Van Meerbeke, V., L\u00f3pez Cabra, A., C. A., & Gomez, H., P. M (2017). Cognitive and behavioral disorders in children with neurofibromatosis type 1. Frontiers in Pediatrics, 5, 227.","journal-title":"Frontiers in Pediatrics"},{"issue":"2","key":"6557_CR87","doi-asserted-by":"publisher","first-page":"163","DOI":"10.1177\/1362361304042720","volume":"8","author":"A Trillingsgaard","year":"2004","unstructured":"Trillingsgaard, A., & \u00d8Stergaard, J. R. (2004). Autism in Angelman syndrome: An exploration of comorbidity. Autism, 8(2), 163\u2013174.","journal-title":"Autism"},{"issue":"5","key":"6557_CR88","doi-asserted-by":"publisher","first-page":"510","DOI":"10.1038\/ejhg.2011.241","volume":"20","author":"AM van Eeghen","year":"2012","unstructured":"van Eeghen, A. M., Black, M. E., Pulsifer, M. B., Kwiatkowski, D. J., & Thiele, E. A. (2012). Genotype and cognitive phenotype of patients with tuberous sclerosis complex. European Journal of Human Genetics, 20(5), 510\u2013515. https:\/\/doi.org\/10.1038\/ejhg.2011.241","journal-title":"European Journal of Human Genetics"},{"issue":"2","key":"6557_CR89","doi-asserted-by":"publisher","first-page":"146","DOI":"10.1111\/dmcn.12044","volume":"55","author":"AM van Eeghen","year":"2013","unstructured":"van Eeghen, A. M., Pulsifer, M. B., Merker, V. L., Neumeyer, A. M., van Eeghen, E. E., Thibert, R. L., Cole, A. J., Leigh, F. A., Plotkin, S. R., & Thiele, E. A. (2013). Understanding relationships between autism, intelligence, and epilepsy: A cross-disorder approach. Developmental Medicine & Child Neurology, 55(2), 146\u2013153.","journal-title":"Developmental Medicine & Child Neurology"},{"issue":"4","key":"6557_CR90","doi-asserted-by":"publisher","first-page":"243","DOI":"10.1097\/00041444-200512000-00006","volume":"15","author":"MW Veltman","year":"2005","unstructured":"Veltman, M. W., Craig, E. E., & Bolton, P. F. (2005). Autism spectrum disorders in Prader-Willi and Angelman syndromes: A systematic review. Psychiatric Genetics, 15(4), 243\u2013254.","journal-title":"Psychiatric Genetics"},{"issue":"3","key":"6557_CR91","doi-asserted-by":"publisher","first-page":"546","DOI":"10.1007\/s10803-013-1903-y","volume":"44","author":"CE Venker","year":"2014","unstructured":"Venker, C. E., Ray-Subramanian, C. E., Bolt, D. M., & Weismer, E., S (2014). Trajectories of autism severity in early childhood. Journal of Autism and Developmental Disorders, 44(3), 546\u2013563. https:\/\/doi.org\/10.1007\/s10803-013-1903-y","journal-title":"Journal of Autism and Developmental Disorders"},{"issue":"8","key":"6557_CR92","doi-asserted-by":"publisher","first-page":"659","DOI":"10.1016\/j.jaac.2017.05.022","volume":"56","author":"JC Visser","year":"2017","unstructured":"Visser, J. C., Rommelse, N. N. J., Lappenschaar, M., Servatius-Oosterling, I. J., Greven, C. U., & Buitelaar, J. K. (2017). Variation in the early trajectories of autism symptoms is related to the Development of Language, Cognition, and behavior problems. Journal of the American Academy of Child & Adolescent Psychiatry, 56(8), 659\u2013668.","journal-title":"Journal of the American Academy of Child & Adolescent Psychiatry"},{"issue":"4","key":"6557_CR93","doi-asserted-by":"publisher","first-page":"687","DOI":"10.1002\/aur.2674","volume":"15","author":"E Waizbard-Bartov","year":"2022","unstructured":"Waizbard-Bartov, E., Ferrer, E., Heath, B., Rogers, S. J., Nordahl, C. W., Solomon, M., & Amaral, D. G. (2022). Identifying autism symptom severity trajectories across childhood. Autism Research, 15(4), 687\u2013701.","journal-title":"Autism Research"},{"key":"6557_CR94","unstructured":"Wechsler, D. (1991). Weschler Intelligence Scale for children: Third Edition manual. The Psychological Corporation."},{"key":"6557_CR99","doi-asserted-by":"crossref","unstructured":"Wechsler, D. P. C. (1997). WAIS-III: Administration and scoring manual: Wechsler Adult Intelligence Scale. Psychological Corporation.","DOI":"10.1037\/t49755-000"},{"key":"6557_CR95","doi-asserted-by":"crossref","unstructured":"Wechsler, D. (2002). Wechsler Preschool and Primary Scales of Intelligence\u2013Third Edition.","DOI":"10.1037\/t15177-000"},{"key":"6557_CR98","doi-asserted-by":"crossref","unstructured":"Wechsler, D. N. J. A. (2006). WNV: Wechsler nonverbal scale of ability. Pearson.","DOI":"10.1037\/t15176-000"},{"key":"6557_CR96","unstructured":"Wechsler, D. (2012). Wechsler preschool and primary scale of intelligence\u2014fourth edition. The Psychological Corporation San Antonio, TX."},{"key":"6557_CR97","unstructured":"Wechsler, D. (2014). WISC\u200b-V: Technical and Interpretive Manual\u200b. Pearson."},{"issue":"3","key":"6557_CR100","doi-asserted-by":"publisher","first-page":"816","DOI":"10.1007\/s10803-014-2246-z","volume":"45","author":"AC Wheeler","year":"2015","unstructured":"Wheeler, A. C., Mussey, J., Villagomez, A., Bishop, E., Raspa, M., Edwards, A., Bodfish, J., Bann, C., & Bailey, D. B. Jr (2015). DSM-5 changes and the prevalence of parent-reported autism spectrum symptoms in Fragile X syndrome. Journal of Autism and Developmental Disorders, 45(3), 816\u2013829.","journal-title":"Journal of Autism and Developmental Disorders"},{"issue":"1","key":"6557_CR101","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1146\/annurev-neuro-080317-061747","volume":"41","author":"KD Winden","year":"2018","unstructured":"Winden, K. D., Darius, E. F., & Mustafa, S. (2018). Abnormal mTOR activation in Autism. Annual Review of Neuroscience, 41(1), 1\u201323. https:\/\/doi.org\/10.1146\/annurev-neuro-080317-061747","journal-title":"Annual Review of Neuroscience"},{"key":"6557_CR102","doi-asserted-by":"publisher","first-page":"856084","DOI":"10.3389\/fpsyt.2022.856084","volume":"13","author":"N Wolff","year":"2022","unstructured":"Wolff, N., Stroth, S., Kamp-Becker, I., Roepke, S., & Roessner, V. (2022). Autism spectrum disorder and IQ\u2013A complex interplay. Frontiers in Psychiatry, 13, 856084.","journal-title":"Frontiers in Psychiatry"},{"key":"6557_CR103","doi-asserted-by":"publisher","first-page":"920","DOI":"10.3389\/fpsyg.2014.00920","volume":"5","author":"IC Wurpts","year":"2014","unstructured":"Wurpts, I. C., & Geiser, C. (2014). Is adding more indicators to a latent class analysis beneficial or detrimental? Results of a Monte-Carlo study. Frontiers in Psychology, 5, 920.","journal-title":"Frontiers in Psychology"},{"issue":"7","key":"6557_CR104","doi-asserted-by":"publisher","first-page":"987","DOI":"10.3390\/genes12070987","volume":"12","author":"L Yang","year":"2021","unstructured":"Yang, L., Shy, X., Mao, S., Wang, Y., Du, X., & Zou, C. (2021). Genotype-phenotype correlations in Angelman syndrome. Genes, 12(7), 987. https:\/\/doi.org\/10.3390\/genes12070987","journal-title":"Genes"},{"issue":"12","key":"6557_CR105","doi-asserted-by":"publisher","first-page":"513","DOI":"10.1016\/j.paed.2016.08.004","volume":"26","author":"K Yates","year":"2016","unstructured":"Yates, K., & Le Couteur, A. (2016). Diagnosing autism\/autism spectrum disorders. Paediatrics and Child Health, 26(12), 513\u2013518. https:\/\/doi.org\/10.1016\/j.paed.2016.08.004","journal-title":"Paediatrics and Child Health"},{"key":"6557_CR106","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1016\/j.rasd.2018.10.003","volume":"57","author":"L Zheng","year":"2019","unstructured":"Zheng, L., Grove, R., & Eapen, V. (2019). Spectrum or subtypes? A latent profile analysis of restricted and repetitive behaviours in autism. Research in Autism Spectrum Disorders, 57, 46\u201354. https:\/\/doi.org\/10.1016\/j.rasd.2018.10.003","journal-title":"Research in Autism Spectrum Disorders"}],"container-title":["Journal of Autism and Developmental Disorders"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10803-024-06557-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10803-024-06557-2","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10803-024-06557-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,2]],"date-time":"2026-02-02T08:03:36Z","timestamp":1770019416000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10803-024-06557-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,10,12]]},"references-count":105,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026,2]]}},"alternative-id":["6557"],"URL":"https:\/\/doi.org\/10.1007\/s10803-024-06557-2","relation":{},"ISSN":["0162-3257","1573-3432"],"issn-type":[{"value":"0162-3257","type":"print"},{"value":"1573-3432","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,10,12]]},"assertion":[{"value":"4 September 2024","order":1,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 October 2024","order":2,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and\/or national research committee and with the 1964 Helsinki declaration and its later amendments. This retrospective study was approved by the Medical Ethics Committee of the Erasmus Medical Center, Rotterdam, the Netherlands (MEC-2015-203).","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical Approval"}},{"value":"Written informed consent was formally waived as data was collected as part of routine clinical care.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed Consent"}},{"value":"The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of Interest"}}]}}