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R.S. also has equity in ehave. EA has received consultation fees from Roche and Takeda, royalties from APPI and Springer, and funding from SynapDx and Sanofi-Aventis. P.S. has received royalties from Guilford Press and Simon & Schuster. C.B. has received grant support from the US Department of Defense, NIH, Muscular Dystrophy Canada, MGNet, Grifols and Octapharma. She has participated in an advisory board for Alexion, argenx, UCB, Janssen and been a consultant for Alexion, argenx, Janssen, Novartis and UCB. None of these are related to this work. The remaining authors have declared that they have no competing or potential conflicts of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing Interests"}},{"value":"This study was approved by the Research Ethics Board at the Hospital for Sick Children (#100002432, October 2010). \u2018Informed consent\/assent\u2019 has been appropriately obtained (or parental consent\/assent if required).","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical Approval"}}]}}