{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,16]],"date-time":"2026-03-16T14:57:08Z","timestamp":1773673028556,"version":"3.50.1"},"reference-count":29,"publisher":"Springer Science and Business Media LLC","issue":"11","license":[{"start":{"date-parts":[[2012,10,13]],"date-time":"2012-10-13T00:00:00Z","timestamp":1350086400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Assist Reprod Genet"],"published-print":{"date-parts":[[2012,11]]},"DOI":"10.1007\/s10815-012-9869-9","type":"journal-article","created":{"date-parts":[[2012,10,12]],"date-time":"2012-10-12T06:12:39Z","timestamp":1350022359000},"page":"1249-1254","source":"Crossref","is-referenced-by-count":29,"title":["Follicular flushing during oocyte retrieval: a systematic review and meta-analysis"],"prefix":"10.1007","volume":"29","author":[{"given":"Matheus","family":"Roque","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcos","family":"Sampaio","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Selmo","family":"Geber","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2012,10,13]]},"reference":[{"key":"9869_CR1","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1080\/01443610500118970","volume":"25","author":"S Bagtharia","year":"2005","unstructured":"Bagtharia S, Haloob ARK. Is there a benefit from routine follicular flushing for oocyte retrieval? J Obstet Gynaecol. 2005;25:374\u20136.","journal-title":"J Obstet Gynaecol"},{"key":"9869_CR2","doi-asserted-by":"crossref","first-page":"1262","DOI":"10.1093\/humrep\/14.5.1262","volume":"14","author":"S Bassil","year":"1999","unstructured":"Bassil S, Godin PA, Donnez J. Outcome of in-vitro fertilization through natural cycles in poor responders. Hum Reprod. 1999;14:1262\u20135.","journal-title":"Hum Reprod"},{"key":"9869_CR3","doi-asserted-by":"crossref","first-page":"1132","DOI":"10.1016\/S0015-0282(97)00391-9","volume":"68","author":"MM Biljan","year":"1997","unstructured":"Biljan MM, Dean N, Hemmings R, Bissonnette F, Tan SL. Prospective randomized trial of the effect of two flushing media on oocyte collection and fertilization rates after in vitro fertilization. Fertil Steril. 1997;68:1132\u20134.","journal-title":"Fertil Steril"},{"key":"9869_CR4","doi-asserted-by":"crossref","first-page":"1719","DOI":"10.1093\/HUMREP\/10.6.1392","volume":"10","author":"S Daya","year":"1995","unstructured":"Daya S, Gunby J, Hughes EG, Collins JA, Sagle MA, YoungLai EV. Natural cycles for in-vitro fertilization: cost-effectiveness analysis and factors influencing outcome. Hum Reprod. 1995;10:1719\u201324.","journal-title":"Hum Reprod"},{"key":"9869_CR5","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1111\/j.1471-0528.1992.tb14417.x","volume":"99","author":"E Hussein El","year":"1992","unstructured":"El Hussein E, Balen AH, Tan SL. A prospective study comparing the outcome of oocytes retrieved in the aspirate with those retrieved in the flush during transvaginal ultrasound directed oocyte recovery for in-vitro fertilization. Br J Obstet Gynaecol. 1992;99:841\u20134.","journal-title":"Br J Obstet Gynaecol"},{"issue":"Suppl 1","key":"9869_CR6","first-page":"163","volume":"17","author":"AC Gordon","year":"2002","unstructured":"Gordon AC, Gadd SC, Kendrew H, Spearman P, Williams C, Walker D, Sharp NC. Prospective randomized comparison of two commercially prepared flushing media for IVF\/ICSI. Hum Reprod. 2002;17 Suppl 1:163.","journal-title":"Hum Reprod"},{"issue":"7650","key":"9869_CR7","doi-asserted-by":"crossref","first-page":"924","DOI":"10.1136\/bmj.39489.470347.AD","volume":"336","author":"GH Guyatt","year":"2008","unstructured":"Guyatt GH, Oxman AD, Vist GE, Kunz R, Falck-Ytter Y, Alonso-Coello P, Sch\u00fcnemann HJ. GRADE working group: an emerging consensus on rating quality of evidence and strength of recommendations. BMJ. 2008;336(7650):924\u20136.","journal-title":"BMJ"},{"key":"9869_CR8","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1007\/BF01130737","volume":"6","author":"CJ Haines","year":"1989","unstructured":"Haines CJ, Emes AL, O\u2019Shea RT, Weiss TJ. Choice of needle for ovum pickup. J In Vitro Fert Embryo Transf. 1989;6:111\u20132.","journal-title":"J In Vitro Fert Embryo Transf"},{"key":"9869_CR9","doi-asserted-by":"crossref","first-page":"812","DOI":"10.1016\/j.fertnstert.2010.09.013","volume":"95","author":"B Haydardedeoglu","year":"2011","unstructured":"Haydardedeoglu B, Cok T, Kilicdag EB, Parlakgumus AH, Simsek E, Bagis T. In vitro fertilization-intracytoplasmic sperm injection outcomes in single- versus double-lumen oocyte retrieval needles in normally responding patients: a randomized trial. Fertil Steril. 2011;95:812\u20134.","journal-title":"Fertil Steril"},{"issue":"7414","key":"9869_CR10","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1136\/bmj.327.7414.557","volume":"327","author":"JP Higgins","year":"2003","unstructured":"Higgins JP, Thompson SG, Deeks JJ, Altmann DG. Measuring inconsistency in meta-analyses. BMJ. 2003;327(7414):557\u201360.","journal-title":"BMJ"},{"key":"9869_CR11","volume-title":"Cochrane handbook for systematic reviews of interventions version 5.1.0","author":"JPT Higgins","year":"2011","unstructured":"Higgins JPT, Green S. Cochrane handbook for systematic reviews of interventions version 5.1.0. London: The Cochrane Colaboration; 2011."},{"key":"9869_CR12","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1097\/GCO.0b013e3283373bfe","volume":"22","author":"MJ Hill","year":"2010","unstructured":"Hill MJ, Levens ED. Is there a benefit in follicular flushing in assisted reproductive technology? Curr Opin Obstet Gynecol. 2010;22:208\u201312.","journal-title":"Curr Opin Obstet Gynecol"},{"issue":"Suppl1","key":"9869_CR13","first-page":"193","volume":"72","author":"EAM Khalifa","year":"1999","unstructured":"Khalifa EAM, Buraidah KFSH. Routine use of normal saline as flushing media has no impact on fertilization, embryo development and pregnancy rates in assisted reproductive technologies. Fert Stert. 1999;72(Suppl1):193\u20134.","journal-title":"Fert Stert"},{"key":"9869_CR14","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1093\/humrep\/6.suppl_1.382","volume":"6","author":"CR Kingsland","year":"1991","unstructured":"Kingsland CR, Taylor CT, Aziz N, Bickerton N. Is follicular flushing necessary for oocyte retrieval? A randomized trial. Hum Reprod. 1991;6:382\u20133.","journal-title":"Hum Reprod"},{"key":"9869_CR15","doi-asserted-by":"crossref","unstructured":"Knight DC, Tyler JP, Driscoll GL. Follicular flushing at oocyte retrieval: a reappraisal. Aust N Z J Obstet Gynaecol 2001; 41: 210-3.","DOI":"10.1111\/j.1479-828X.2001.tb01212.x"},{"key":"9869_CR16","doi-asserted-by":"crossref","first-page":"1163","DOI":"10.1016\/S0140-6736(81)92335-7","volume":"1","author":"S Lenz","year":"1981","unstructured":"Lenz S, Lauristen JG, Kjellow M. Collection of human oocytes for in vitro fertilization by ultrasonically guided follicular puncture. Lancet. 1981;1:1163\u20134.","journal-title":"Lancet"},{"key":"9869_CR17","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1007\/BF01555463","volume":"4","author":"S Lenz","year":"1987","unstructured":"Lenz S, Lindenberg S, Fehilly C, Petersen K. Are ultrasonic-guided follicular aspiration and flushing safe for the oocyte? J In Vitro Fert Embryo Transf. 1987;4:159\u201361.","journal-title":"J In Vitro Fert Embryo Transf"},{"key":"9869_CR18","doi-asserted-by":"crossref","first-page":"1381","DOI":"10.1016\/j.fertnstert.2008.04.034","volume":"91","author":"ED Levens","year":"2009","unstructured":"Levens ED, Whitcomb BW, Payson MD, Larsen FW. Ovarian follicular flushing among low-responding patients undergoing assisted reproductive technology. Fertil Steril. 2009;91:1381\u20134.","journal-title":"Fertil Steril"},{"key":"9869_CR19","first-page":"423","volume":"104","author":"DH Lozano","year":"2006","unstructured":"Lozano DH, Fanchin R, Chevalier N, Feyereisen E, Hesters L, Frydman N, Frydman R. Optimising the semi natural cycle IVF: the importance of follicular flushing. J Indian Med Assoc. 2006;104:423\u20137.","journal-title":"J Indian Med Assoc"},{"key":"9869_CR20","doi-asserted-by":"crossref","first-page":"3235","DOI":"10.1093\/humrep\/del278","volume":"21","author":"AK Ludwig","year":"2006","unstructured":"Ludwig AK, Glawatz M, Griesinger G, Diedrich K, Ludwig M. Perioperative and post-operative complications of transvaginal ultrasound-guided oocyte retrieval: prospective study of >1000 oocyte retrievals. Hum Reprod. 2006;21:3235\u201340.","journal-title":"Hum Reprod"},{"key":"9869_CR21","first-page":"119","volume":"16","author":"DH Mendez Lozano","year":"2008","unstructured":"Mendez Lozano DH, Scheffer JB, Frydman N, Fay S, Fanchin R, Frydman R. Optimal reproductive competence of oocytes retrieved through follicular flushing in minimal stimulation IVF. RBM Online. 2008;16:119\u201323.","journal-title":"RBM Online"},{"key":"9869_CR22","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1136\/bmj.b2535","volume":"339","author":"D Moher","year":"2009","unstructured":"Moher D, Liberati A, Tetzlaff J, Altman DG. Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. BMJ. 2009;339:332\u20139.","journal-title":"BMJ"},{"key":"9869_CR23","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1093\/humupd\/8.2.129","volume":"8","author":"MJ Pelinck","year":"2002","unstructured":"Pelinck MJ, Hoek A, Simons AH, Heineman MJ. Efficacy of natural cycle IVF: a review of the literature. Hum Reprod Update. 2002;8:129\u201339.","journal-title":"Hum Reprod Update"},{"key":"9869_CR24","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1055\/s-2008-1076145","volume":"26","author":"MB Porter","year":"2008","unstructured":"Porter MB. Ultrasound in assisted reproductive technology. Semin Reprod Med. 2008;26:266\u201376.","journal-title":"Semin Reprod Med"},{"key":"9869_CR25","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1007\/BF01130734","volume":"6","author":"RT Scott","year":"1989","unstructured":"Scott RT, Hofmann GE, Muasher SJ, Acosta AA, Kreiner DK, Rosenwaks Z. A prospective randomized comparison of single- and double-lumenneedles for transvaginal follicular aspiration. J In Vitro Fert Embryo Transf. 1989;6:98\u2013100.","journal-title":"J In Vitro Fert Embryo Transf"},{"key":"9869_CR26","first-page":"747","volume":"281","author":"SL Tan","year":"1992","unstructured":"Tan SL, Waterstone J, Wren M, Parsons J. A prospective randomized study comparing aspiration only with aspiration and flushing for transvaginal ultrasound-directed oocyte recovery. Fertil Steril. 1992;281:747\u201352.","journal-title":"Fertil Steril"},{"key":"9869_CR27","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/S0015-0282(16)54806-7","volume":"57","author":"JJ Waterstone","year":"1992","unstructured":"Waterstone JJ, Parsons JH. A prospective study to investigate the value of flushing follicles during transvaginal ultrasound-directed follicle aspiration. Fertil Steril. 1992;57:221\u20133.","journal-title":"Fertil Steril"},{"issue":"9","key":"9869_CR28","first-page":"CD004634","volume":"8","author":"S Wongtra-ngan","year":"2010","unstructured":"Wongtra-ngan S, Vutyavanich T, Brown J. Follicular flushing during oocyte retrieval in assisted reproductive techniques. Cochrane Database Syst Rev. 2010;8(9):CD004634.","journal-title":"Cochrane Database Syst Rev"},{"key":"9869_CR29","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1093\/humrep\/15.suppl_1.74","volume":"15","author":"S Ziebe","year":"2000","unstructured":"Ziebe S, Sunde A, Erb K. Evaluation of a new fully synthetic flushing medium in a prospective randomized multi-centre study. Hum Reprod. 2000;15:74.","journal-title":"Hum Reprod"}],"container-title":["Journal of Assisted Reproduction and Genetics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10815-012-9869-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s10815-012-9869-9\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10815-012-9869-9","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,31]],"date-time":"2019-05-31T01:19:53Z","timestamp":1559265593000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s10815-012-9869-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,10,13]]},"references-count":29,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2012,11]]}},"alternative-id":["9869"],"URL":"https:\/\/doi.org\/10.1007\/s10815-012-9869-9","relation":{},"ISSN":["1058-0468","1573-7330"],"issn-type":[{"value":"1058-0468","type":"print"},{"value":"1573-7330","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,10,13]]}}}