{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T02:06:42Z","timestamp":1790215602019,"version":"4.1.0"},"reference-count":43,"publisher":"Springer Science and Business Media LLC","issue":"9","license":[{"start":{"date-parts":[[2014,7,8]],"date-time":"2014-07-08T00:00:00Z","timestamp":1404777600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Assist Reprod Genet"],"published-print":{"date-parts":[[2014,9]]},"DOI":"10.1007\/s10815-014-0290-4","type":"journal-article","created":{"date-parts":[[2014,7,7]],"date-time":"2014-07-07T10:42:02Z","timestamp":1404729722000},"page":"1167-1174","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Meiotic segregation and sperm DNA fragmentation in Tunisian men with dysplasia of the fibrous sheath (DFS) associated with head abnormalities"],"prefix":"10.1007","volume":"31","author":[{"given":"H.","family":"Ghedir","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Mehri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Mehdi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S","family":"Brahem","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Saad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Ibala-Romdhane","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2014,7,8]]},"reference":[{"issue":"4","key":"290_CR1","doi-asserted-by":"crossref","first-page":"664","DOI":"10.1016\/S0015-0282(16)59482-5","volume":"48","author":"HE Chemes","year":"1987","unstructured":"Chemes HE, Brugo S, Zanchetti F, Carrere C, Lavieri JC. Dysplasia of the fibrous sheath: an ultrastructural defect of human spermatozoa associated with sperm immotility and primary sterility. Fertil Steril. 1987;48(4):664\u20139.","journal-title":"Fertil Steril"},{"issue":"9","key":"290_CR2","doi-asserted-by":"crossref","first-page":"2521","DOI":"10.1093\/humrep\/13.9.2521","volume":"13","author":"HE Chemes","year":"1998","unstructured":"Chemes HE, Olmedo SB, Carrere C, Oses R, Carizza C, Leisner M, et al. Ultrastructural pathology of the sperm flagellum: association between flagellar pathology and fertility prognosis in severely asthenozoospermic men. Hum Reprod. 1998;13(9):2521\u20136.","journal-title":"Hum Reprod"},{"issue":"6","key":"290_CR3","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1002\/j.1939-4640.2000.tb03409.x","volume":"21","author":"HE Chemes","year":"2000","unstructured":"Chemes HE. Phenotypes of sperm pathology: genetic and acquired forms in infertile men. J Androl. 2000;21(6):799\u2013808.","journal-title":"J Androl"},{"issue":"5","key":"290_CR4","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1093\/humupd\/dmg034","volume":"9","author":"EH Chemes","year":"2003","unstructured":"Chemes EH, Rawe YV. Sperm pathology: a step beyond descriptive morphology. origin, characterization and fertility potential of abnormal sperm phenotypes in infertile men. Hum Reprod Update. 2003;9(5):405\u201328.","journal-title":"Hum Reprod Update"},{"issue":"7","key":"290_CR5","doi-asserted-by":"crossref","first-page":"1365","DOI":"10.1093\/humrep\/16.7.1365","volume":"16","author":"B Baccetti","year":"2001","unstructured":"Baccetti B, Capitani S, Collodel G, Di Cairano G, Gambera L, Moretti E, et al. Genetic sperm defects and consanguinity. Hum Reprod. 2001;16(7):1365\u201371.","journal-title":"Hum Reprod"},{"issue":"1","key":"290_CR6","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1093\/oxfordjournals.humrep.a137566","volume":"7","author":"A Jassim","year":"1992","unstructured":"Jassim A, Gillott DJ, al-Zuhdi Y, Gray A, Foxon R, Bottazzo GF. Isolation and biochemical characterization of the human sperm tail fibrous sheath. Hum Reprod. 1992;7(1):86\u201394.","journal-title":"Hum Reprod"},{"key":"290_CR7","doi-asserted-by":"crossref","first-page":"69","DOI":"10.2741\/2049","volume":"12","author":"S Francavilla","year":"2007","unstructured":"Francavilla S, Cordeschi G, Pelliccione F, Bocchio M, Francavilla F. Isolated teratozoospermia: a cause of male sterility in the era of ICSI? Front Biosci. 2007;12:69\u201388.","journal-title":"Front Biosci"},{"issue":"6","key":"290_CR8","doi-asserted-by":"crossref","first-page":"2241","DOI":"10.1095\/biolreprod.102.013466","volume":"68","author":"PR Brown","year":"2003","unstructured":"Brown PR, Miki K, Harper DB, Eddy EM. A-kinase anchoring protein 4 binding proteins in the fibrous sheath of the sperm flagellum. Biol Reprod. 2003;68(6):2241\u20138.","journal-title":"Biol Reprod"},{"issue":"1","key":"290_CR9","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1002\/jemt.10320","volume":"61","author":"EM Eddy","year":"2003","unstructured":"Eddy EM, Toshimori K, O\u2019Brien DA. Fibrous sheath of mammalian spermatozoa. Microsc Res Tech. 2003;61(1):103\u201315.","journal-title":"Microsc Res Tech"},{"issue":"2","key":"290_CR10","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1006\/dbio.2002.0728","volume":"248","author":"K Miki","year":"2002","unstructured":"Miki K, Willis WD, Brown PR, Goulding EH, Fulcher KD, Eddy EM. Targeted disruption of the Akap4 gene causes defects in sperm flagellum and motility. Dev Biol. 2002;248(2):331\u201342.","journal-title":"Dev Biol"},{"issue":"10","key":"290_CR11","doi-asserted-by":"crossref","first-page":"2790","DOI":"10.1093\/humrep\/dei126","volume":"20","author":"B Baccetti","year":"2005","unstructured":"Baccetti B, Collodel G, Estenoz M, Manca D, Moretti E, Piomboni P. Gene deletions in an infertile man with sperm fibrous sheath dysplasia. Hum Reprod. 2005;20(10):2790\u20134.","journal-title":"Hum Reprod"},{"issue":"6","key":"290_CR12","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1111\/j.1439-0272.2006.00742.x","volume":"38","author":"G Collodel","year":"2006","unstructured":"Collodel G, Moretti E. Sperm morphology and aneuploidies: defects of supposed genetic origin. Andrologia. 2006;38(6):208\u201315.","journal-title":"Andrologia"},{"issue":"12","key":"290_CR13","doi-asserted-by":"crossref","first-page":"2563","DOI":"10.1093\/humrep\/15.12.2563","volume":"15","author":"S Viville","year":"2000","unstructured":"Viville S, Mollard R, Bach ML, Falquet C, Gerlinger P, Warter S. Do morphological anomalies reflect chromosomal aneuploidies? Hum Reprod. 2000;15(12):2563\u20136.","journal-title":"Hum Reprod"},{"issue":"1","key":"290_CR14","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/j.fertnstert.2005.01.128","volume":"84","author":"B Baccetti","year":"2005","unstructured":"Baccetti B, Collodel G, Gambera L, Moretti E, Serafini F, Piomboni P. Fluorescence in situ hybridization and molecular studies in infertile men with dysplasia of the fibrous sheath. Fertil Steril. 2005;84(1):123\u20139.","journal-title":"Fertil Steril"},{"issue":"1","key":"290_CR15","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1002\/j.1939-4640.2005.tb02873.x","volume":"26","author":"N Rives","year":"2005","unstructured":"Rives N, Mousset-Simeon N, Mazurier S, Mace B. Primary flagellar abnormality is associated with an increased rate of spermatozoa aneuploidy. J Androl. 2005;26(1):61\u20139.","journal-title":"J Androl"},{"issue":"2\u20133","key":"290_CR16","first-page":"137","volume":"38","author":"E Moretti","year":"2006","unstructured":"Moretti E, Collodel G. Three cases of genetic defects affecting sperm tail: a FISH study. J Submicrosc Cytol Pathol. 2006;38(2\u20133):137\u201341.","journal-title":"J Submicrosc Cytol Pathol"},{"key":"290_CR17","volume-title":"Laboratory manual for the examination and processing of human semen","author":"WHO. (World Health Organization)","year":"2010","unstructured":"WHO. (World Health Organization). Laboratory manual for the examination and processing of human semen. 5th ed. New York: Cambridge University Press; 2010.","edition":"5"},{"issue":"5","key":"290_CR18","doi-asserted-by":"crossref","first-page":"1018","DOI":"10.1093\/humrep\/deg197","volume":"18","author":"F Eustache","year":"2003","unstructured":"Eustache F, Auger J. Inter-individual variability in the morphological assessment of human sperm: effect of the level of experience and the use of standard methods. Hum Reprod. 2003;18(5):1018\u201322.","journal-title":"Hum Reprod"},{"issue":"9","key":"290_CR19","doi-asserted-by":"crossref","first-page":"2344","DOI":"10.1093\/humrep\/17.9.2344","volume":"17","author":"VY Rawe","year":"2002","unstructured":"Rawe VY, Terada Y, Nakamura S, Chillik CF, Olmedo SB, Chemes HE. A pathology of the sperm centriole responsible for defective sperm aster formation, syngamy and cleavage. Hum Reprod. 2002;17(9):2344\u20139.","journal-title":"Hum Reprod"},{"issue":"5","key":"290_CR20","doi-asserted-by":"crossref","first-page":"e19","DOI":"10.1016\/j.fertnstert.2010.11.027","volume":"95","author":"E Moretti","year":"2011","unstructured":"Moretti E, Geminiani M, Terzuoli G, Renieri T, Pascarelli N, Collodel G. Two cases of sperm immotility: a mosaic of flagellar alterations related to dysplasia of the fibrous sheath and abnormalities of head-neck attachment. Fertil Steril. 2011;95(5):e19\u201323.","journal-title":"Fertil Steril"},{"issue":"6","key":"290_CR21","doi-asserted-by":"crossref","first-page":"1172","DOI":"10.1093\/humrep\/16.6.1172","volume":"16","author":"AE Calogero","year":"2001","unstructured":"Calogero AE, De Palma A, Grazioso C, Barone N, Romeo R, Rappazzo G, et al. Aneuploidy rate in spermatozoa of selected men with abnormal semen parameters. Hum Reprod. 2001;16(6):1172\u20139.","journal-title":"Hum Reprod"},{"issue":"5","key":"290_CR22","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1002\/j.1939-4640.2001.tb02578.x","volume":"22","author":"LA Gole","year":"2001","unstructured":"Gole LA, Wong PF, Ng PL, Wang XQ, Ng SC, Bongso A. Does sperm morphology play a significant role in increased sex chromosomal disomy? a comparison between patients with teratozoospermia and OAT by FISH. J Androl. 2001;22(5):759\u201363.","journal-title":"J Androl"},{"issue":"4","key":"290_CR23","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1046\/j.1365-2605.2001.00280.x","volume":"24","author":"K Harkonen","year":"2001","unstructured":"Harkonen K, Suominen J, Lahdetie J. Aneuploidy in spermatozoa of infertile men with teratozoospermia. Int J Androl. 2001;24(4):197\u2013205.","journal-title":"Int J Androl"},{"issue":"2","key":"290_CR24","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1002\/mrd.1148","volume":"61","author":"C Templado","year":"2002","unstructured":"Templado C, Hoang T, Greene C, Rademaker A, Chernos J, Martin R. Aneuploid spermatozoa in infertile men: teratozoospermia. Mol Reprod Dev. 2002;61(2):200\u20134.","journal-title":"Mol Reprod Dev"},{"issue":"1","key":"290_CR25","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1016\/S0015-0282(02)04411-4","volume":"79","author":"I Lewis-Jones","year":"2003","unstructured":"Lewis-Jones I, Aziz N, Seshadri S, Douglas A, Howard P. Sperm chromosomal abnormalities are linked to sperm morphologic deformities. Fertil Steril. 2003;79(1):212\u20135.","journal-title":"Fertil Steril"},{"issue":"1","key":"290_CR26","doi-asserted-by":"crossref","first-page":"e163","DOI":"10.1111\/j.1365-2605.2009.00982.x","volume":"33","author":"SS Tang","year":"2010","unstructured":"Tang SS, Gao H, Zhao Y, Ma S. Aneuploidy and DNA fragmentation in morphologically abnormal sperm. Int J Androl. 2010;33(1):e163\u201379.","journal-title":"Int J Androl"},{"issue":"6","key":"290_CR27","doi-asserted-by":"crossref","first-page":"1313","DOI":"10.1016\/j.urology.2011.08.064","volume":"78","author":"S Brahem","year":"2011","unstructured":"Brahem S, Elghezal H, Ghedir H, Landolsi H, Amara A, Ibala S, et al. Cytogenetic and molecular aspects of absolute teratozoospermia: comparison between polymorphic and monomorphic forms. Urology. 2011;78(6):1313\u20139.","journal-title":"Urology"},{"issue":"Suppl 1","key":"290_CR28","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1111\/j.1439-0272.2010.01152.x","volume":"44","author":"M Mehdi","year":"2012","unstructured":"Mehdi M, Gmidene A, Brahem S, Guerin JF, Elghezal H, Saad A. Aneuploidy rate in spermatozoa of selected men with severe teratozoospermia. Andrologia. 2012;44 Suppl 1:139\u201343.","journal-title":"Andrologia"},{"issue":"2","key":"290_CR29","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/j.rbmo.2010.10.006","volume":"22","author":"A Perrin","year":"2011","unstructured":"Perrin A, Louanjli N, Ziane Y, Louanjli T, Le Roy C, Gueganic N, et al. Study of aneuploidy and DNA fragmentation in gametes of patients with severe teratozoospermia. Reprod BioMed Online. 2011;22(2):148\u201354.","journal-title":"Reprod BioMed Online"},{"issue":"1","key":"290_CR30","doi-asserted-by":"crossref","first-page":"6","DOI":"10.2164\/jandrol.05033","volume":"27","author":"E Mateu","year":"2006","unstructured":"Mateu E, Rodrigo L, Prados N, Gil-Salom M, Remohi J, Pellicer A, et al. High incidence of chromosomal abnormalities in large-headed and multiple-tailed spermatozoa. J Androl. 2006;27(1):6\u201310.","journal-title":"J Androl"},{"issue":"2","key":"290_CR31","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1111\/j.1439-0272.2010.01115.x","volume":"44","author":"S Brahem","year":"2012","unstructured":"Brahem S, Mehdi M, Elghezal H, Saad A. Study of aneuploidy rate and sperm DNA fragmentation in large-headed, multiple-tailed spermatozoa. Andrologia. 2012;44(2):130\u20135.","journal-title":"Andrologia"},{"issue":"Suppl 3","key":"290_CR32","doi-asserted-by":"crossref","first-page":"1662","DOI":"10.1016\/S0015-0282(03)00401-1","volume":"79","author":"RH Martin","year":"2003","unstructured":"Martin RH, Greene C, Rademaker AW. Sperm chromosome aneuploidy analysis in a man with globozoospermia. Fertil Steril. 2003;79 Suppl 3:1662\u20134.","journal-title":"Fertil Steril"},{"issue":"6","key":"290_CR33","doi-asserted-by":"crossref","first-page":"1343","DOI":"10.1016\/j.urology.2010.12.015","volume":"77","author":"S Brahem","year":"2011","unstructured":"Brahem S, Mehdi M, Elghezal H, Saad A. Analysis of sperm aneuploidies and DNA fragmentation in patients with globozoospermia or with abnormal acrosomes. Urology. 2011;77(6):1343\u20138.","journal-title":"Urology"},{"issue":"1","key":"290_CR34","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1093\/humrep\/17.1.5","volume":"17","author":"S Egozcue","year":"2002","unstructured":"Egozcue S, Blanco J, Vidal F, Egozcue J. Diploid sperm and the origin of triploidy. Hum Reprod. 2002;17(1):5\u20137.","journal-title":"Hum Reprod"},{"issue":"3","key":"290_CR35","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1016\/S0015-0282(97)00536-0","volume":"69","author":"S Lopes","year":"1998","unstructured":"Lopes S, Sun JG, Jurisicova A, Meriano J, Casper RF. Sperm deoxyribonucleic acid fragmentation is increased in poor-quality semen samples and correlates with failed fertilization in intracytoplasmic sperm injection. Fertil Steril. 1998;69(3):528\u201332.","journal-title":"Fertil Steril"},{"issue":"6","key":"290_CR36","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1016\/S1472-6483(10)60676-1","volume":"14","author":"RJ Aitken","year":"2007","unstructured":"Aitken RJ, De Iuliis GN. Origins and consequences of DNA damage in male germ cells. Reprod BioMed Online. 2007;14(6):727\u201333.","journal-title":"Reprod BioMed Online"},{"issue":"6","key":"290_CR37","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1111\/j.1439-0272.2009.00953.x","volume":"41","author":"M Mehdi","year":"2009","unstructured":"Mehdi M, Khantouche L, Ajina M, Saad A. Detection of DNA fragmentation in human spermatozoa: correlation with semen parameters. Andrologia. 2009;41(6):383\u20136.","journal-title":"Andrologia"},{"issue":"1","key":"290_CR38","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1007\/s10815-010-9482-8","volume":"28","author":"S Brahem","year":"2011","unstructured":"Brahem S, Mehdi M, Elghezal H, Saad A. Detection of DNA fragmentation and meiotic segregation in human with isolated teratozoospermia. J Assist Reprod Genet. 2011;28(1):41\u20138.","journal-title":"J Assist Reprod Genet"},{"issue":"6","key":"290_CR39","doi-asserted-by":"crossref","first-page":"903","DOI":"10.1002\/j.1939-4640.2000.tb03421.x","volume":"21","author":"M Muratori","year":"2000","unstructured":"Muratori M, Piomboni P, Baldi E, Filimberti E, Pecchioli P, Moretti E, et al. Functional and ultrastructural features of DNA-fragmented human sperm. J Androl. 2000;21(6):903\u201312.","journal-title":"J Androl"},{"issue":"1","key":"290_CR40","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1002\/j.1939-4640.2002.tb02599.x","volume":"23","author":"DP Evenson","year":"2002","unstructured":"Evenson DP, Larson KL, Jost LK. Sperm chromatin structure assay: its clinical use for detecting sperm DNA fragmentation in male infertility and comparisons with other techniques. J Androl. 2002;23(1):25\u201343.","journal-title":"J Androl"},{"issue":"3","key":"290_CR41","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1097\/GCO.0b013e32835faae5","volume":"25","author":"SAD Garza","year":"2013","unstructured":"Garza SAD, Patrizio P. Reproductive outcomes in patients with male infertility because of Klinefelter\u2019s syndrome, Kartagener\u2019s syndrome, round-head sperm, dysplasia fibrous sheath, and \u2018stump\u2019 tail sperm: an updated literature review. Curr Opin Obstet Gynecol. 2013;25(3):229\u201346.","journal-title":"Curr Opin Obstet Gynecol"},{"issue":"7","key":"290_CR42","doi-asserted-by":"crossref","first-page":"1497","DOI":"10.1093\/humrep\/12.7.1497","volume":"12","author":"SB Olmedo","year":"1997","unstructured":"Olmedo SB, Nodar F, Chillik C, Chemes HE. Successful intracytoplasmic sperm injection with spermatozoa from a patient with dysplasia of the fibrous sheath and chronic respiratory disease. Hum Reprod. 1997;12(7):1497\u20139.","journal-title":"Hum Reprod"},{"issue":"8","key":"290_CR43","doi-asserted-by":"crossref","first-page":"2065","DOI":"10.1093\/humrep\/del130","volume":"21","author":"V Mitchell","year":"2006","unstructured":"Mitchell V, Rives N, Albert M, Peers MC, Selva J, Clavier B, et al. Outcome of ICSI with ejaculated spermatozoa in a series of men with distinct ultrastructural flagellar abnormalities. Hum Reprod. 2006;21(8):2065\u201374.","journal-title":"Hum Reprod"}],"container-title":["Journal of Assisted Reproduction and Genetics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10815-014-0290-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s10815-014-0290-4\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10815-014-0290-4","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,29]],"date-time":"2024-05-29T05:28:19Z","timestamp":1716960499000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s10815-014-0290-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,7,8]]},"references-count":43,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2014,9]]}},"alternative-id":["290"],"URL":"https:\/\/doi.org\/10.1007\/s10815-014-0290-4","relation":{},"ISSN":["1058-0468","1573-7330"],"issn-type":[{"value":"1058-0468","type":"print"},{"value":"1573-7330","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,7,8]]}}}