{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,12]],"date-time":"2025-09-12T19:45:09Z","timestamp":1757706309303},"reference-count":30,"publisher":"Springer Science and Business Media LLC","issue":"9","license":[{"start":{"date-parts":[[2015,7,24]],"date-time":"2015-07-24T00:00:00Z","timestamp":1437696000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Assist Reprod Genet"],"published-print":{"date-parts":[[2015,9]]},"DOI":"10.1007\/s10815-015-0532-0","type":"journal-article","created":{"date-parts":[[2015,7,23]],"date-time":"2015-07-23T03:34:31Z","timestamp":1437622471000},"page":"1379-1384","update-policy":"http:\/\/dx.doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Is the presence of an uncleaved embryo on day 3 a useful predictor of outcomes following day 5 transfer?"],"prefix":"10.1007","volume":"32","author":[{"given":"Clara J.","family":"Men","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charles L.","family":"Bormann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brian W.","family":"Walsh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Catherine","family":"Racowsky","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2015,7,24]]},"reference":[{"issue":"9","key":"532_CR1","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1111\/j.1471-0528.1980.tb04610.x","volume":"87","author":"RG Edwards","year":"1980","unstructured":"Edwards RG, Steptoe PC, Purdy JM. Establishing full-term human pregnancies using cleaving embryos grown in vitro. Br J Obstet Gynaecol. 1980;87(9):737\u201356.","journal-title":"Br J Obstet Gynaecol"},{"key":"532_CR2","doi-asserted-by":"crossref","first-page":"830","DOI":"10.1016\/S0015-0282(16)54257-5","volume":"55","author":"VN Bolton","year":"1991","unstructured":"Bolton VN, Wren ME, Parsons JH. Pregnancies after in vitro fertilization and transfer of human blastocysts. Fertil Steril. 1991;55:830\u20132.","journal-title":"Fertil Steril"},{"key":"532_CR3","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/S0015-0282(97)00438-X","volume":"69","author":"DK Gardner","year":"1998","unstructured":"Gardner DK, Vella P, Lane M, Wagley L, Schlenker T, Schoolcraft WB. Culture and transfer of human blastocysts increases implantation rates and reduces the need for multiple embryo transfers. Fertil Steril. 1998;69:84\u20138.","journal-title":"Fertil Steril"},{"issue":"4","key":"532_CR4","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1016\/j.rbmo.2013.11.018","volume":"28","author":"A Adler","year":"2014","unstructured":"Adler A, Lee HL, McCulloh DH, Ampeloquio E, Clarke-Williams M, Wertz BH, et al. Blastocyst culture selects for euploid embryos: comparison of blastomere and trophectoderm biopsies. Reprod Biomed Online. 2014;28(4):485\u201391.","journal-title":"Reprod Biomed Online"},{"issue":"2","key":"532_CR5","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1016\/j.fertnstert.2014.04.026","volume":"102","author":"M Vega","year":"2014","unstructured":"Vega M, Breborowicz A, Moshier EL, McGovern PG, Keltz MD. Blastulation rates decline in a linear fashion from euploid to aneuploid embryos with single versus multiple chromosomal errors. Fertil Steril. 2014;102(2):394\u20138.","journal-title":"Fertil Steril"},{"key":"532_CR6","doi-asserted-by":"crossref","first-page":"2119","DOI":"10.1093\/oxfordjournals.humrep.a137993","volume":"8","author":"A Dokras","year":"1993","unstructured":"Dokras A, Sargent IL, Barlow DH. Human blastocyst grading: an indicator of developmental potential? Hum Reprod. 1993;8:2119\u201327.","journal-title":"Hum Reprod"},{"key":"532_CR7","first-page":"378","volume-title":"Towards reproductive certainty: fertility and genetics beyond","author":"DK Gardner","year":"1999","unstructured":"Gardner DK, Schoolcraft WB. In vitro culture of human blastocysts. In: Jansen R, Mortimer D, editors. Towards reproductive certainty: fertility and genetics beyond. London: Parthenon Publishing; 1999. p. 378\u201388."},{"key":"532_CR8","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1097\/00001703-199906000-00013","volume":"11","author":"DK Gardner","year":"1999","unstructured":"Gardner DK, Schoolcraft WB. Culture and transfer of human blastocysts. Curr Opin Obstet Gynecol. 1999;11:307\u201311.","journal-title":"Curr Opin Obstet Gynecol"},{"key":"532_CR9","doi-asserted-by":"crossref","first-page":"1155","DOI":"10.1016\/S0015-0282(00)00518-5","volume":"73","author":"D Gardner","year":"2000","unstructured":"Gardner D, Lane M, Stevens J, Schlenker T, Schoolcraft WB. Blastocyst score affects implantation and pregnancy outcome: towards a single blastocyst transfer. Fertil Steril. 2000;73:1155\u201358.","journal-title":"Fertil Steril"},{"key":"532_CR10","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1016\/S0015-0282(00)00645-2","volume":"74","author":"B Balaban","year":"2000","unstructured":"Balaban B, Urman B, Sertac A, Alatas C, Aksoy S, Mercan R. Blastocyst quality affects the success of blastocyst-stage embryo transfer. Fertil Steril. 2000;74:282\u20137.","journal-title":"Fertil Steril"},{"key":"532_CR11","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1016\/j.fertnstert.2005.11.013","volume":"85","author":"B Balaban","year":"2006","unstructured":"Balaban B, Yakin K, Urman B. Randomized comparison of two different blastocyst grading systems. Fertil Steril. 2006;85:559\u201363.","journal-title":"Fertil Steril"},{"key":"532_CR12","doi-asserted-by":"crossref","first-page":"1157","DOI":"10.1016\/S0015-0282(01)02870-9","volume":"76","author":"K Richter","year":"2001","unstructured":"Richter K, Harris D, Daneshmand S, Shapiro B. Quantitative grading of a human blastocyst: optimal inner cell mass size and shape. Fertil Steril. 2001;76:1157\u201367.","journal-title":"Fertil Steril"},{"issue":"4","key":"532_CR13","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1016\/j.fertnstert.2012.01.115","volume":"97","author":"NR Treff","year":"2012","unstructured":"Treff NR, Tao X, Ferry KM, Su J, Taylor D, Scott Jr RT. Development and validation of an accurate quantitative real-time polymerase chain reaction-based assay for human blastocyst comprehensive chromosomal aneuploidy screening. Fertil Steril. 2012;97(4):819\u201324.","journal-title":"Fertil Steril"},{"issue":"3","key":"532_CR14","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1016\/j.fertnstert.2013.04.035","volume":"100","author":"RT Scott Jr","year":"2013","unstructured":"Scott Jr RT, Upham KM, Forman EJ, Hong KH, Scott KL, Taylor D, et al. Blastocyst biopsy with comprehensive chromosome screening and fresh embryo transfer significantly increases in vitro fertilization implantation and delivery rates: a randomized controlled trial. Fertil Steril. 2013;100(3):697\u2013703.","journal-title":"Fertil Steril"},{"issue":"8","key":"532_CR15","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1136\/jmedgenet-2014-102497","volume":"51","author":"D Wells","year":"2014","unstructured":"Wells D, Kaur K, Grifo J, Glassner M, Taylor JC, Fragouli E, et al. Clinical utilization of a rapid low-pass whole genome sequencing technique for the diagnosis of aneuploidy in human embryos prior to implantation. J Med Genet. 2014;51(8):553\u201362.","journal-title":"J Med Genet"},{"issue":"5","key":"532_CR16","doi-asserted-by":"crossref","first-page":"962","DOI":"10.1016\/S0015-0282(01)02018-0","volume":"76","author":"D Valbuena","year":"2001","unstructured":"Valbuena D, Martin J, de Pablo JL, Remohi J, Pellicer A, Simon C. Increasing levels of estradiol are deleterious to embryonic implantation because they directly affect the embryo. Fertil Steril. 2001;76(5):962\u20138.","journal-title":"Fertil Steril"},{"issue":"Suppl 2","key":"532_CR17","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/S1472-6483(10)60450-6","volume":"18","author":"R Fanchin","year":"2009","unstructured":"Fanchin R, Ayoubi JM. Uterine dynamics: impact on the human reproduction process. Reprod Biomed Online. 2009;18 Suppl 2:57\u201362.","journal-title":"Reprod Biomed Online"},{"issue":"6","key":"532_CR18","doi-asserted-by":"crossref","first-page":"2140","DOI":"10.1016\/j.fertnstert.2010.12.018","volume":"95","author":"S Kawachiya","year":"2011","unstructured":"Kawachiya S, Bodri D, Shimada N, Kato K, Takehara Y, Kato O. Blastocyst culture is associated with an elevated incidence of monozygotic twinning after single embryo transfer. Fertil Steril. 2011;95(6):2140\u20132.","journal-title":"Fertil Steril"},{"key":"532_CR19","first-page":"CD002118","volume":"7","author":"D Glujovsky","year":"2012","unstructured":"Glujovsky D, Blake D, Bardach A, Farquhar C. Cleavage stage versus blastocyst stage embryo transfer in assisted reproductive technology. Cochrane Database Syst Rev. 2012;7:CD002118.","journal-title":"Cochrane Database Syst Rev"},{"issue":"6","key":"532_CR20","doi-asserted-by":"crossref","first-page":"1366","DOI":"10.1093\/humrep\/den045","volume":"23","author":"CC Skiadas","year":"2008","unstructured":"Skiadas CC, Missmer SA, Benson CB, Gee RE, Racowsky C. Risk factors associated with pregnancies containing a monochorionic pair following assisted reproductive technologies. Hum Reprod. 2008;23(6):1366\u201371.","journal-title":"Hum Reprod"},{"key":"532_CR21","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1093\/humrep\/dem339","volume":"23","author":"EG Papanikolaou","year":"2008","unstructured":"Papanikolaou EG, Kolibianakis EM, Tournaye H, Venetis C, Fatemi H, Tarlatzis B, et al. Live birth rates after transfer of equal number of blastocysts and cleavage stage embryos in IVF. A systematic review and meta-analysis. Hum Reprod. 2008;23:91\u20139.","journal-title":"Hum Reprod"},{"key":"532_CR22","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1016\/j.fertnstert.2009.03.051","volume":"94","author":"MR Thomas","year":"2010","unstructured":"Thomas MR, Sparks AE, Ryan GL, van Voorhis BJ. Clinical predictors of human blastocyst formation and pregnancy after extended culture and transfer. Fertil Steril. 2010;94:543\u20138.","journal-title":"Fertil Steril"},{"key":"532_CR23","doi-asserted-by":"crossref","first-page":"598","DOI":"10.1093\/humrep\/dep439","volume":"25","author":"L Dessolle","year":"2010","unstructured":"Dessolle L, Freour T, Barriere P, Darai E, Ravel C, Jean M, et al. A cycle-based model to predict blastocyst transfer cancellation. Hum Reprod. 2010;25:598\u2013604.","journal-title":"Hum Reprod"},{"issue":"12","key":"532_CR24","doi-asserted-by":"crossref","first-page":"1357","DOI":"10.1007\/s10815-012-9875-y","volume":"29","author":"DP Braga","year":"2012","unstructured":"Braga DP, Setti AS, de C\u00e1ssia S, Figueira R, Machado RB, Iaconelli Jr A, et al. Patient selection criteria for blastocyst transfers in extended embryo culture programs. J Assist Reprod Genet. 2012;29(12):1357\u201362.","journal-title":"J Assist Reprod Genet"},{"issue":"5","key":"532_CR25","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1093\/humupd\/dmu023","volume":"20","author":"DJ Kaser","year":"2014","unstructured":"Kaser DJ, Racowsky C. Clinical outcomes following selection of human preimplantation embryos with time-lapse monitoring: a systematic review. Hum Reprod Update. 2014;20(5):617\u201331.","journal-title":"Hum Reprod Update"},{"issue":"2","key":"532_CR26","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1016\/j.fertnstert.2014.11.003","volume":"103","author":"K Kirkegaard","year":"2015","unstructured":"Kirkegaard K, Ahlstrom A, Ingerslev HJ, Hardarson T. Choosing the best embryo by time lapse versus standard morphology. Fertil Steril. 2015;103(2):323\u201332.","journal-title":"Fertil Steril"},{"issue":"8","key":"532_CR27","doi-asserted-by":"crossref","first-page":"1105","DOI":"10.1007\/s10815-014-0266-4","volume":"31","author":"DP Braga","year":"2014","unstructured":"Braga DP, Setti AS, Figueira RC, Iaconelli Jr A, Borges Jr E. The importance of the cleavage stage morphology evaluation for blastocyst transfer in patients with good prognosis. J Assist Reprod Genet. 2014;31(8):1105\u201310.","journal-title":"J Assist Reprod Genet"},{"key":"532_CR28","doi-asserted-by":"crossref","first-page":"965","DOI":"10.1016\/j.fertnstert.2009.04.018","volume":"94","author":"DE Reichman","year":"2010","unstructured":"Reichman DE, Jackson KV, Racowsky C. Incidence and development of zygotes exhibiting abnormal pronuclear disposition after identification of two pronuclei at the fertilization check. Fertil Steril. 2010;94:965\u201370.","journal-title":"Fertil Steril"},{"issue":"3","key":"532_CR29","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1016\/S0015-0282(99)00565-8","volume":"73","author":"C Racowsky","year":"2000","unstructured":"Racowsky C, Jackson KV, Cekleniak NA, Fox JH, Hornstein MD, Ginsburg ES. The number of eight-cell embryos is a key determinant for selecting day 3 or day 5 transfer. Fertil Steril. 2000;73(3):558\u201364.","journal-title":"Fertil Steril"},{"key":"532_CR30","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1007\/978-1-60327-392-3_10","volume-title":"Biennial Review of Infertility","author":"ST Ceyhan","year":"2009","unstructured":"Ceyhan ST, Jackson KV, Racowsky C. Selecting the most competent embryo. In: Carrell DT, Racowsky C, Schlegel PN, Van Voorhis BJ, editors. Biennial Review of Infertility, vol. 1. New York: Humana Press; 2009. p. 143\u201369."}],"container-title":["Journal of Assisted Reproduction and Genetics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10815-015-0532-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s10815-015-0532-0\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10815-015-0532-0","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,30]],"date-time":"2019-05-30T21:21:26Z","timestamp":1559251286000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s10815-015-0532-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,7,24]]},"references-count":30,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2015,9]]}},"alternative-id":["532"],"URL":"https:\/\/doi.org\/10.1007\/s10815-015-0532-0","relation":{},"ISSN":["1058-0468","1573-7330"],"issn-type":[{"value":"1058-0468","type":"print"},{"value":"1573-7330","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,7,24]]}}}