{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T22:17:44Z","timestamp":1762899464802,"version":"3.37.3"},"reference-count":38,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2017,9,13]],"date-time":"2017-09-13T00:00:00Z","timestamp":1505260800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["MA-6288\/1-1"],"award-info":[{"award-number":["MA-6288\/1-1"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Assist Reprod Genet"],"published-print":{"date-parts":[[2018,1]]},"DOI":"10.1007\/s10815-017-1041-0","type":"journal-article","created":{"date-parts":[[2017,9,12]],"date-time":"2017-09-12T22:41:57Z","timestamp":1505256117000},"page":"157-163","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Assessment of M2\/ANXA5 haplotype as a risk factor in couples with placenta-mediated pregnancy complications"],"prefix":"10.1007","volume":"35","author":[{"given":"Nina","family":"Rogenhofer","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lara R. M.","family":"Nienaber","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lea C.","family":"Amshoff","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nadia","family":"Bogdanova","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Petroff","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"Wieacker","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christian J.","family":"Thaler","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7134-3452","authenticated-orcid":false,"given":"Arseni","family":"Markoff","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2017,9,13]]},"reference":[{"key":"1041_CR1","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/S1521-6926(02)00099-3","volume":"16","author":"JS Younis","year":"2003","unstructured":"Younis JS, Samueloff A. Gestational vascular complications. Best Pract Res Clin Haematol. 2003;16:135\u201351.","journal-title":"Best Pract Res Clin Haematol."},{"key":"1041_CR2","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1016\/S1521-6926(03)00017-3","volume":"16","author":"E Grandone","year":"2003","unstructured":"Grandone E, Margaglione M. Inherited thrombophilia and gestational vascular complications. Best Pract Res Clin Haematol. 2003;16:321\u201332.","journal-title":"Best Pract Res Clin Haematol"},{"key":"1041_CR3","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1160\/TH09-02-0123","volume":"102","author":"G Tiscia","year":"2009","unstructured":"Tiscia G, Colaizzo D, Chinni E, et al. Haplotype M2 in the annexin A5 (ANXA5) gene and the occurrence of obstetric complications. Thromb Haemost. 2009;102:309\u201313.","journal-title":"Thromb Haemost"},{"key":"1041_CR4","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1007\/s12687-010-0011-3","volume":"1","author":"N Bogdanova","year":"2010","unstructured":"Bogdanova N, Markoff A. Hereditary thrombophilic risk factors for recurrent pregnancy loss. J Community Genet. 2010;1:47\u201353.","journal-title":"J Community Genet"},{"key":"1041_CR5","doi-asserted-by":"crossref","first-page":"901","DOI":"10.1016\/S0140-6736(03)12771-7","volume":"361","author":"E Rey","year":"2003","unstructured":"Rey E, Kahn SR, David M, Shrier I. Thrombophilic disorders and fetal loss: a meta-analysis. Lancet. 2003;361:901\u20138.","journal-title":"Lancet"},{"key":"1041_CR6","doi-asserted-by":"crossref","first-page":"e1000292","DOI":"10.1371\/journal.pmed.1000292","volume":"7","author":"MA Rodger","year":"2010","unstructured":"Rodger MA, Betancourt MT, Clark P, et al. The association of factor V Leiden and prothrombin gene mutation and placenta-mediated pregnancy complications: a systematic review and meta-analysis of prospective cohort studies. PLoS Med. 2010;7:e1000292.","journal-title":"PLoS Med"},{"key":"1041_CR7","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1093\/hmg\/ddm017","volume":"16","author":"N Bogdanova","year":"2007","unstructured":"Bogdanova N, Horst J, Chlystun M, et al. A common haplotype of the annexin A5 (ANXA5) gene promoter is associated with recurrent pregnancy loss. Hum Mol Genet. 2007;16:573\u20138.","journal-title":"Hum Mol Genet"},{"key":"1041_CR8","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1093\/molehr\/gas023","volume":"18","author":"G Tiscia","year":"2012","unstructured":"Tiscia G, Colaizzo D, Favuzzi G, et al. The M2 haplotype in the ANXA5 gene is an independent risk factor for idiopathic small-for-gestational age newborns. Mol Hum Reprod. 2012;18:510\u20133.","journal-title":"Mol Hum Reprod"},{"key":"1041_CR9","doi-asserted-by":"crossref","first-page":"1321","DOI":"10.1016\/j.fertnstert.2013.06.046","volume":"100","author":"F T\u00fcttelmann","year":"2013","unstructured":"T\u00fcttelmann F, Ivanov P, Dietzel C, et al. Further insights into the role of the annexin A5 M2 haplotype as recurrent pregnancy loss factor, assessing timing of miscarriage and partner risk. Fertil Steril. 2013;100:1321\u20135.","journal-title":"Fertil Steril"},{"key":"1041_CR10","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1016\/j.rbmo.2015.07.004","volume":"31","author":"C Demetriou","year":"2015","unstructured":"Demetriou C, Abu-Amero S, White S, et al. Investigation of the Annexin A5 M2 haplotype in 500 white European couples who have experienced recurrent spontaneous abortion. Reprod BioMed Online. 2015;31:681\u20138.","journal-title":"Reprod BioMed Online"},{"key":"1041_CR11","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1093\/molehr\/gar008","volume":"17","author":"H Miyamura","year":"2011","unstructured":"Miyamura H, Nishizawa H, Ota S, et al. Polymorphisms in the annexin A5 gene promoter in Japanese women with recurrent pregnancy loss. Mol Hum Reprod. 2011;17:447\u201352.","journal-title":"Mol Hum Reprod"},{"key":"1041_CR12","doi-asserted-by":"crossref","first-page":"1202","DOI":"10.1016\/j.placenta.2013.09.010","volume":"34","author":"S Ota","year":"2013","unstructured":"Ota S, Miyamura H, Nishizawa H, et al. Contribution of fetal ANXA5 gene promoter polymorphisms to the onset of pre-eclampsia. Placenta. 2013;34:1202\u201310.","journal-title":"Placenta"},{"key":"1041_CR13","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1016\/j.rbmo.2014.12.014","volume":"30","author":"T Thean Hock","year":"2015","unstructured":"Thean Hock T, Bogdanova N, Kai Cheen A, et al. M2\/ANXA5 haplotype as a predisposition factor in Malay women and couples experiencing recurrent spontaneous abortion: a pilot study. Reprod BioMed Online. 2015;30:431\u20139.","journal-title":"Reprod BioMed Online"},{"key":"1041_CR14","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1007\/s10815-017-0871-0","volume":"34","author":"KC Ang","year":"2017","unstructured":"Ang KC, Kathirgamanathan S, Ch'ng ES, et al. Genetic analysis of the M2\/ANXA5 haplotype as recurrent pregnancy loss predisposition in the Malay population. J Assist Reprod Genet. 2017;34:517\u201324.","journal-title":"J Assist Reprod Genet"},{"key":"1041_CR15","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.thromres.2016.06.009","volume":"144","author":"GL Tiscia","year":"2016","unstructured":"Tiscia GL, D\u00f8rum E, Myklebust CF, Grandone E, Sandset PM, Skretting G. Functional characterization of annexin A5 gene promoter allelic variants. Thromb Res. 2016;144:93\u20139.","journal-title":"Thromb Res"},{"key":"1041_CR16","doi-asserted-by":"crossref","first-page":"940","DOI":"10.1016\/j.fertnstert.2007.12.056","volume":"91","author":"E Chinni","year":"2009","unstructured":"Chinni E, Tiscia GL, Colaizzo D, Vergura P, Margaglione M, Grandone E. Annexin V expression in human placenta is influenced by the carriership of the common haplotype M2. Fertil Steril. 2009;91:940\u20132.","journal-title":"Fertil Steril"},{"key":"1041_CR17","doi-asserted-by":"crossref","first-page":"937","DOI":"10.1016\/j.placenta.2010.08.002","volume":"31","author":"A Markoff","year":"2010","unstructured":"Markoff A, Gerdes S, Feldner S, Bogdanova N, Gerke V, Grandone E. Reduced allele specific annexin A5 mRNA levels in placentas carrying the M2\/ANXA5 allele. Placenta. 2010;31:937\u201340.","journal-title":"Placenta"},{"key":"1041_CR18","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1016\/S0143-4004(05)80407-2","volume":"15","author":"G Krikun","year":"1994","unstructured":"Krikun G, Lockwood CJ, Wu XX, et al. The expression of the placental anticoagulant protein, annexin V, by villous trophoblasts: immunolocalization and in vitro regulation. Placenta. 1994;15:601\u201312.","journal-title":"Placenta"},{"key":"1041_CR19","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1056\/NEJM199707173370303","volume":"337","author":"JH Rand","year":"1997","unstructured":"Rand JH, Wu XX, Andree HA, et al. Pregnancy loss in the antiphospholipid-antibody syndrome\u2014a possible thrombogenic mechanism. N Engl J Med. 1997;337:154\u201360.","journal-title":"N Engl J Med"},{"key":"1041_CR20","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1016\/j.fertnstert.2012.04.026","volume":"98","author":"N Rogenhofer","year":"2012","unstructured":"Rogenhofer N, Engels L, Bogdanova N, T\u00fcttelmann F, Markoff A, Thaler CJ. Paternal and maternal carriage of the annexin A5 M2 haplotype are equal risk factors for recurrent pregnancy loss: a pilot study. Fertil Steril. 2012;98:383\u20138.","journal-title":"Fertil Steril"},{"key":"1041_CR21","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/S0029-7844(01)01747-1","volume":"99","author":"ACOG Committee","year":"2002","unstructured":"ACOG Committee. On practice bulletins-obstetrics. ACOG practice bulletin. Diagnosis and management of preeclampsia and eclampsia. Obstet Gynecol. 2002;99:159\u201367.","journal-title":"Obstet Gynecol"},{"key":"1041_CR22","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1016\/S1701-2163(15)30865-3","volume":"35","author":"A Lausman","year":"2013","unstructured":"Lausman A, Kingdom J, Maternal Fetal Medicine Committee, et al. Intrauterine growth restriction: screening, diagnosis, and management. J Obstet Gynaecol Can. 2013;35:741\u201357.","journal-title":"J Obstet Gynaecol Can"},{"key":"1041_CR23","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.ejogrb.2013.11.022","volume":"174","author":"J Unterscheider","year":"2014","unstructured":"Unterscheider J, Daly S, Geary MP, et al. Definition and management of fetal growth restriction: a survey of contemporary attitudes. Eur J Obstet Gynecol Reprod Biol. 2014;174:41\u20135.","journal-title":"Eur J Obstet Gynecol Reprod Biol"},{"key":"1041_CR24","doi-asserted-by":"crossref","first-page":"h6253","DOI":"10.1136\/bmj.h6253","volume":"351","author":"J Wise","year":"2015","unstructured":"Wise J. NICE guideline aims to cut premature birth rates. BMJ. 2015;351:h6253.","journal-title":"BMJ"},{"key":"1041_CR25","volume-title":"Preterm labour and birth","author":"National Collaborating Centre for Women\u2019s and Children\u2019s Health (UK)","year":"2015","unstructured":"National Collaborating Centre for Women\u2019s and Children\u2019s Health (UK). Preterm labour and birth. London: National Institute for Health and Care Excellence (UK); 2015."},{"key":"1041_CR26","first-page":"19","volume":"81","author":"Rotterdam ESHRE\u2044ASRM-Sponsored PCOS Consensus Workshop Group","year":"2004","unstructured":"Rotterdam ESHRE\u2044ASRM-Sponsored PCOS Consensus Workshop Group. Revised 2003 consensus on diagnostic criteria and long-term health risks related to polycystic ovary syndrome. Fertil Steril. 2004;81:19\u201325.","journal-title":"Fertil Steril"},{"key":"1041_CR27","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1111\/j.1538-7836.2006.01753.x","volume":"4","author":"S Miyakis","year":"2006","unstructured":"Miyakis S, Lockshin MD, Atsumi T, et al. International consensus statement on an update of the classification criteria for definite antiphospholipid syndrome (APS). J Thromb Haemost. 2006;4:295\u2013306.","journal-title":"J Thromb Haemost"},{"key":"1041_CR28","first-page":"55","volume":"9","author":"M Krawczak","year":"2006","unstructured":"Krawczak M, Nikolaus S, von Eberstein H, Croucher PJ, El Mokhtari NE, Schreiber S. PopGen: population-based recruitment of patients and controls for the analysis of complex genotype-phenotype relationships. Community Genet. 2006;9:55\u201361.","journal-title":"Community Genet"},{"key":"1041_CR29","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1002\/bimj.200810425","volume":"50","author":"T Hothorn","year":"2008","unstructured":"Hothorn T, Bretz F, Westfall P. Simultaneous inference in general parametric models. Biom J. 2008;50:346\u201363.","journal-title":"Biom J"},{"key":"1041_CR30","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1016\/j.cll.2013.03.025","volume":"33","author":"N Hossain","year":"2013","unstructured":"Hossain N, Paidas MJ. Inherited thrombophilia: diagnosis and anticoagulation treatment in pregnancy. Clin Lab Med. 2013;33:377\u201390.","journal-title":"Clin Lab Med"},{"key":"1041_CR31","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1080\/19336918.2015.1120397","volume":"10","author":"JF Silva","year":"2016","unstructured":"Silva JF, Serakides R. Intrauterine trophoblast migration: a comparative view of humans and rodents. Cell Adhes Migr. 2016;10:88\u2013110.","journal-title":"Cell Adhes Migr"},{"key":"1041_CR32","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.cca.2010.09.030","volume":"412","author":"LM Dusse","year":"2011","unstructured":"Dusse LM, Rios DR, Pinheiro MB, Cooper AJ, Lwaleed BA. Pre-eclampsia: relationship between coagulation, fibrinolysis and inflammation. Clin Chim Acta. 2011;412:17\u201321.","journal-title":"Clin Chim Acta"},{"key":"1041_CR33","first-page":"1343","volume":"31","author":"RT Lie","year":"1998","unstructured":"Lie RT, Rasmussen S, Brunborg H, Gjessing HK, Lie-Nielsen E, Irgens LM. Fetal and maternal contributions to risk of pre-eclampsia: population based study. BMJ. 1998;31:1343\u20137.","journal-title":"BMJ"},{"key":"1041_CR34","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1097\/01.ede.0000112217.33111.23","volume":"15","author":"H Vefring","year":"2004","unstructured":"Vefring H, Lie RT, \u00d8Deg\u00e5rd R, Mansoor MA, Nilsen ST. Maternal and fetal variants of genetic thrombophilias and the risk of preeclampsia. Epidemiology. 2004;15:317\u201322.","journal-title":"Epidemiology"},{"key":"1041_CR35","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1136\/bmj.315.7099.32","volume":"315","author":"C Everett","year":"1997","unstructured":"Everett C. Incidence and outcome of bleeding before the 20th week of pregnancy: prospective study from general practice. BMJ. 1997;315:32\u20134.","journal-title":"BMJ"},{"key":"1041_CR36","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1097\/00006250-200701000-00054","volume":"109","author":"ACOG Committee","year":"2007","unstructured":"ACOG Committee. On practice bulletins. ACOG practice bulletin no. 77. Screening for fetal chromosomal abnormalities. Obstet Gynecol. 2007;109:217\u201327.","journal-title":"Obstet Gynecol"},{"key":"1041_CR37","doi-asserted-by":"crossref","first-page":"2217","DOI":"10.1093\/oxfordjournals.humrep.a019080","volume":"11","author":"DE Battaglia","year":"1996","unstructured":"Battaglia DE, Goodwin P, Klein NA, Soules MR. Influence of maternal age on meiotic spindle assembly in oocytes from naturally cycling women. Hum Reprod. 1996;11:2217\u201322.","journal-title":"Hum Reprod"},{"key":"1041_CR38","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1016\/j.ebiom.2016.06.024","volume":"10","author":"S Fishel","year":"2016","unstructured":"Fishel S, Baker D, Elson J, et al. Precision medicine in assisted conception: a multicenter observational treatment cohort study of the annexin A5 M2 haplotype as a biomarker for antithrombotic treatment to improve pregnancy outcome. EBioMedicine. 2016;10:298\u2013304.","journal-title":"EBioMedicine"}],"container-title":["Journal of Assisted Reproduction and Genetics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s10815-017-1041-0\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10815-017-1041-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10815-017-1041-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,10,3]],"date-time":"2019-10-03T07:39:06Z","timestamp":1570088346000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s10815-017-1041-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,9,13]]},"references-count":38,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2018,1]]}},"alternative-id":["1041"],"URL":"https:\/\/doi.org\/10.1007\/s10815-017-1041-0","relation":{},"ISSN":["1058-0468","1573-7330"],"issn-type":[{"type":"print","value":"1058-0468"},{"type":"electronic","value":"1573-7330"}],"subject":[],"published":{"date-parts":[[2017,9,13]]}}}