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Samples from the endometrium were taken from the participants at the time of mock transfer; the bacterial profiles at genus level and percentage of lactobacilli in the endometrium of the patients were analyzed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Thirty-one cases (31.3%) had dysbiotic endometrium. The background profiles, pregnancy rates per transfer (52.9% vs 54.8%), and miscarriage rates (11.1% vs 5.9%) were comparable between patients with eubiotic or dysbiotic endometrium. Major bacterial genera other than\n                      <jats:italic>Lactobacillus<\/jats:italic>\n                      detected in the dysbiotic endometrium were\n                      <jats:italic>Atopobium<\/jats:italic>\n                      ,\n                      <jats:italic>Gardnerella<\/jats:italic>\n                      , and\n                      <jats:italic>Streptococcus<\/jats:italic>\n                      . Some patients achieved ongoing pregnancies with 0%\n                      <jats:italic>Lactobacillus<\/jats:italic>\n                      in the endometrium. The endometrial bacterial profiles of pregnant cases with dysbiotic endometrium were comparable with those of non-pregnant cases.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      Analyzing microbiota at the species-level resolution may be necessary for identifying the true pathogenic bacteria of the endometrium and avoiding over-intervention against non-\n                      <jats:italic>Lactobacillus<\/jats:italic>\n                      microbiota. Further studies are necessary for analyzing the mechanism of how the pathogenic bacteria affect embryo implantation.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s10815-019-01630-7","type":"journal-article","created":{"date-parts":[[2019,11,18]],"date-time":"2019-11-18T08:01:43Z","timestamp":1574064103000},"page":"2471-2479","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":102,"title":["Does dysbiotic endometrium affect blastocyst implantation in IVF patients?"],"prefix":"10.1007","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6178-7204","authenticated-orcid":false,"given":"Tomoko","family":"Hashimoto","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koichi","family":"Kyono","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2019,11,18]]},"reference":[{"issue":"1","key":"1630_CR1","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1007\/s10815-015-0614-z","volume":"33","author":"JM Franasiak","year":"2016","unstructured":"Franasiak JM, Werner MD, Juneau CR, Tao X, Landis J, Zhan Y, et al. 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