{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,31]],"date-time":"2025-12-31T00:33:30Z","timestamp":1767141210651,"version":"build-2238731810"},"reference-count":31,"publisher":"Springer Science and Business Media LLC","issue":"11","license":[{"start":{"date-parts":[[2021,8,13]],"date-time":"2021-08-13T00:00:00Z","timestamp":1628812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2021,8,13]],"date-time":"2021-08-13T00:00:00Z","timestamp":1628812800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Assist Reprod Genet"],"published-print":{"date-parts":[[2021,11]]},"DOI":"10.1007\/s10815-021-02298-8","type":"journal-article","created":{"date-parts":[[2021,8,12]],"date-time":"2021-08-12T22:02:47Z","timestamp":1628805767000},"page":"2995-3002","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Hope for male fecundity: clinically insignificant changes in semen parameters over 10\u00a0years at a single clinic while assessing an infertility population"],"prefix":"10.1007","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9772-3613","authenticated-orcid":false,"given":"Ido","family":"Feferkorn","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guy","family":"Shrem","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liat","family":"Azani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Weon-Young","family":"Son","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tamar","family":"Nehushtan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mali","family":"Salmon-Divon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael Haim","family":"Dahan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2021,8,13]]},"reference":[{"key":"2298_CR1","doi-asserted-by":"crossref","unstructured":"MACOMBER D, SANDERS MB. The Spermatozoa Count. New England Journal of Medicine [Internet]. N Engl J Med (NEJM\/MMS); 1929 [cited 2021 Mar 14];200:981\u20134. Available from: http:\/\/www.nejm.org\/doi\/abs\/10.1056\/NEJM192905092001905..","DOI":"10.1056\/NEJM192905092001905"},{"key":"2298_CR2","unstructured":"WHO laboratory manual for the Examination and processing of human semen FIFTH EDITION. 2010."},{"key":"2298_CR3","doi-asserted-by":"crossref","unstructured":"Carlsen E, Giwercman A, Keiding N, Skakkebaek NE. Evidence for decreasing quality of semen during past 50 years. Br Med J [Internet]. British Medical Journal Publishing Group; 1992 [cited 2021 Mar 7];305:609\u201313. Available from: http:\/\/www.bmj.com\/.","DOI":"10.1136\/bmj.305.6854.609"},{"key":"2298_CR4","doi-asserted-by":"crossref","unstructured":"Merzenich H, Zeeb H, Blettner M. Decreasing sperm quality: a global problem? [Internet]. BMC Public Health. BMC Public Health; 2010 [cited 2021 Mar 7]. Available from: https:\/\/pubmed-ncbi-nlm-nih-gov.proxy3.library.mcgill.ca\/20085639\/.","DOI":"10.1186\/1471-2458-10-24"},{"key":"2298_CR5","doi-asserted-by":"crossref","unstructured":"Fisch H, Braun SR. Trends in global semen parameter values [Internet]. Asian J Androl. Wolters Kluwer -- Medknow Publications; 2013 [cited 2021 Mar 7]. p. 169\u201373. Available from: \/pmc\/articles\/PMC3739153\/.","DOI":"10.1038\/aja.2012.143"},{"key":"2298_CR6","doi-asserted-by":"crossref","unstructured":"Ravanos K, Petousis S, Margioula-Siarkou C, Papatheodorou A, Panagiotidis Y, Prapas N, et al. Declining sperm counts. or rather not? A mini review [Internet]. Obstet Gynecol Surv. Lippincott Williams and Wilkins; 2018 [cited 2021 Mar 7]. p. 595\u2013605. Available from: https:\/\/pubmed-ncbi-nlm-nih-gov.proxy3.library.mcgill.ca\/30379321\/.","DOI":"10.1097\/OGX.0000000000000599"},{"key":"2298_CR7","doi-asserted-by":"crossref","unstructured":"Levine H, J\u00f8rgensen N, Martino-Andrade A, Mendiola J, Weksler-Derri D, Mindlis I, et al. Temporal trends in sperm count: a systematic review and meta-regression analysis. Hum Reprod Update [Internet]. Oxford University Press; 2017 [cited 2021 Mar 7];23:646\u201359. Available from: \/pmc\/articles\/PMC6455044\/.","DOI":"10.1093\/humupd\/dmx022"},{"key":"2298_CR8","doi-asserted-by":"crossref","unstructured":"J\u00f8rgensen N, Joensen UN, Jensen TK, Jensen MB, Almstrup K, Olesen IA, et al. Human semen quality in the new millennium: a prospective cross-sectional population-based study of 4867 men. BMJ Open [Internet]. British Medical Journal Publishing Group; 2012 [cited 2021 Mar 7];2:e000990. Available from: http:\/\/bmjopen.bmj.comhttp:\/\/bmjopen.bmj.com\/.","DOI":"10.1136\/bmjopen-2012-000990"},{"key":"2298_CR9","doi-asserted-by":"crossref","unstructured":"Chen Z, Isaacson KB, Toth TL, Godfrey-Bailey L, Schiff I, Hauser R. Temporal trends in human semen parameters in New England in the United States, 1989\u20132000 [Internet]. Arch Androl. Taylor and Francis Inc.; 2003 [cited 2021 May 7]. p. 369\u201374. Available from: https:\/\/pubmed-ncbi-nlm-nih-gov.proxy3.library.mcgill.ca\/12893515\/.","DOI":"10.1080\/0145010390219700"},{"key":"2298_CR10","doi-asserted-by":"crossref","unstructured":"Ravanos K, Petousis S, Margioula-Siarkou C, Papatheodorou A, Panagiotidis Y, Prapas N, et al. Declining sperm counts. or rather not? A mini review. Obstet Gynecol Surv. Lippincott Williams and Wilkins; 2018. p. 595\u2013605.","DOI":"10.1097\/OGX.0000000000000599"},{"key":"#cr-split#-2298_CR11.1","unstructured":"Mascarenhas MN, Flaxman SR, Boerma T, Vanderpoel S, Stevens GA. National, regional, and global trends in infertility prevalence since 1990: A systematic analysis of 277 health surveys. PLoS Med [Internet]. Public Library of Science"},{"key":"#cr-split#-2298_CR11.2","unstructured":"2012 [cited 2021 May 5];9. Available from: \/pmc\/articles\/PMC3525527\/."},{"key":"2298_CR12","doi-asserted-by":"crossref","unstructured":"Priskorn L, Nordkap L, Bang AK, Krause M, Holmboe SA, Egeberg Palme DL, et al. Average sperm count remains unchanged despite reduction in maternal smoking: results from a large cross-sectional study with annual investigations over 21 years. Hum Reprod [Internet]. Oxford University Press; 2018 [cited 2021 Mar 7];33:998\u20131008. Available from: https:\/\/pubmed-ncbi-nlm-nih-gov.proxy3.library.mcgill.ca\/29659832\/.","DOI":"10.1093\/humrep\/dey090"},{"key":"2298_CR13","doi-asserted-by":"crossref","unstructured":"Virtanen HE, J\u00f8rgensen N, Toppari J. Semen quality in the 21 st century [Internet]. Nature Reviews Urology. Nature Publishing Group; 2017 [cited 2021 Mar 14]. p. 120\u201330. Available from: https:\/\/www.nature.com\/articles\/nrurol.2016.261.","DOI":"10.1038\/nrurol.2016.261"},{"key":"2298_CR14","doi-asserted-by":"crossref","unstructured":"Tiegs AW, Landis J, Garrido N, Scott RT, Hotaling JM. Total motile sperm count trend over time: evaluation of semen analyses from 119,972 men from subfertile couples. Urology [Internet]. Elsevier Inc.; 2019 [cited 2021 Mar 7];132:109\u201316. Available from: https:\/\/pubmed.ncbi.nlm.nih.gov\/31326545\/.","DOI":"10.1016\/j.urology.2019.06.038"},{"key":"2298_CR15","doi-asserted-by":"crossref","unstructured":"Younglai EV, Collins JA, Foster WG. Canadian semen quality: an analysis of sperm density among eleven academic fertility centers. Fertil Steril. Elsevier; 1998;70:76\u201380.","DOI":"10.1016\/S0015-0282(98)00118-6"},{"key":"2298_CR16","doi-asserted-by":"crossref","unstructured":"Nogueira C, Yoshida IH, Vilarino FL, de Carvalho WP, Cordts EB, Barbosa CP. Seminal profile of 23,504 patients over the years: 7 years of experience. Jornal Brasileiro de Reproducao Assistida [Internet]. Sociedade Brasileira de Reproducao Assistida; 2018 [cited 2021 May 5];22:286\u20138. Available from: https:\/\/pubmed-ncbi-nlm-nih-gov.proxy3.library.mcgill.ca\/30118194\/.","DOI":"10.5935\/1518-0557.20180055"},{"key":"2298_CR17","doi-asserted-by":"crossref","unstructured":"M\u00ednguez-Alarc\u00f3n L, Williams PL, Chiu YH, Gaskins AJ, Nassan FL, Dadd R, et al. Secular trends in semen parameters among men attending a fertility center between 2000 and 2017: identifying potential predictors. Environ Int [Internet]. Elsevier Ltd; 2018 [cited 2021 May 5];121:1297\u2013303. Available from: \/pmc\/articles\/PMC6279498\/.","DOI":"10.1016\/j.envint.2018.10.052"},{"key":"2298_CR18","doi-asserted-by":"crossref","unstructured":"Sharma R, Harlev A, Agarwal A, Esteves SC. cigarette smoking and semen quality: a new meta-analysis examining the effect of the 2010 World Health Organization Laboratory Methods for the examination of human semen [Internet]. European Urology. Elsevier B.V.; 2016 [cited 2021 May 5]. p. 635\u201345. Available from: https:\/\/pubmed-ncbi-nlm-nih-gov.proxy3.library.mcgill.ca\/27113031\/.","DOI":"10.1016\/j.eururo.2016.04.010"},{"key":"2298_CR19","doi-asserted-by":"crossref","unstructured":"Mostafa RM, Nasrallah YS, Hassan MM, Farrag AF, Majzoub A, Agarwal A. The effect of cigarette smoking on human seminal parameters, sperm chromatin structure and condensation. Andrologia [Internet]. Blackwell Publishing Ltd; 2018 [cited 2021 May 5];50. Available from: https:\/\/pubmed-ncbi-nlm-nih-gov.proxy3.library.mcgill.ca\/29124782\/.","DOI":"10.1111\/and.12910"},{"key":"2298_CR20","doi-asserted-by":"crossref","unstructured":"Ricci E, al Beitawi S, Cipriani S, Candiani M, Chiaffarino F, Vigan\u00f2 P, et al. Semen quality and alcohol intake: a systematic review and meta-analysis [Internet]. Reprod BioMed Online. Elsevier Ltd; 2017 [cited 2021 May 5]. p. 38\u201347. Available from: https:\/\/pubmed-ncbi-nlm-nih-gov.proxy3.library.mcgill.ca\/28029592\/.","DOI":"10.1016\/j.rbmo.2016.09.012"},{"key":"2298_CR21","doi-asserted-by":"crossref","unstructured":"Ramaraju GA, Teppala S, Prathigudupu K, Kalagara M, Thota S, Kota M, et al. Association between obesity and sperm quality. Andrologia [Internet]. Blackwell Publishing Ltd; 2018 [cited 2021 May 5];50. Available from: https:\/\/pubmed-ncbi-nlm-nih-gov.proxy3.library.mcgill.ca\/28929508\/.","DOI":"10.1111\/and.12888"},{"key":"2298_CR22","doi-asserted-by":"crossref","unstructured":"Liu Y, Ding Z. Obesity, a serious etiologic factor for male subfertility in modern society [Internet]. Reproduction. BioScientifica Ltd.; 2017 [cited 2021 May 5]. p. R123\u201331. Available from: https:\/\/pubmed-ncbi-nlm-nih-gov.proxy3.library.mcgill.ca\/28747541\/.","DOI":"10.1530\/REP-17-0161"},{"key":"2298_CR23","doi-asserted-by":"crossref","unstructured":"Thurston SW, Mendiola J, Bellamy AR, Levine H, Wang C, Sparks A, et al. Phthalate exposure and semen quality in fertile US men. Andrology [Internet]. Blackwell Publishing Ltd; 2016 [cited 2021 May 5];4:632\u20138. Available from: https:\/\/pubmed-ncbi-nlm-nih-gov.proxy3.library.mcgill.ca\/26601918\/.","DOI":"10.1111\/andr.12124"},{"key":"2298_CR24","doi-asserted-by":"crossref","unstructured":"Zamkowska D, Karwacka A, Jurewicz J, Radwan M. Environmental exposure to non-persistent endocrine disrupting chemicals and semen quality: an overview of the current epidemiological evidence [Internet]. Int J Occup Med Environ Health. Nofer Institute of Occupational Medicine; 2018 [cited 2021 May 5]. p. 377\u2013414. Available from: https:\/\/pubmed-ncbi-nlm-nih-gov.proxy3.library.mcgill.ca\/30160090\/.","DOI":"10.13075\/ijomeh.1896.01195"},{"key":"2298_CR25","doi-asserted-by":"crossref","unstructured":"Bonde JP, Flachs EM, Rimborg S, Glazer CH, Giwercman A, Ramlau-Hansen CH, et al. The epidemiologic evidence linking prenatal and postnatal exposure to endocrine disrupting chemicals with male reproductive disorders: a systematic review and meta-analysis. Hum Reprod Update [Internet]. Oxford University Press; 2016 [cited 2021 May 5];23:104\u201325. Available from: https:\/\/pubmed-ncbi-nlm-nih-gov.proxy3.library.mcgill.ca\/27655588\/.","DOI":"10.1093\/humupd\/dmw036"},{"key":"2298_CR26","doi-asserted-by":"crossref","unstructured":"Agarwal A, Deepinder F, Sharma RK, Ranga G, Li J. Effect of cell phone usage on semen analysis in men attending infertility clinic: an observational study [Internet]. Fertil Steril; 2008 [cited 2021 May 5];89:124\u20138. Available from: https:\/\/pubmed-ncbi-nlm-nih-gov.proxy3.library.mcgill.ca\/17482179\/.","DOI":"10.1016\/j.fertnstert.2007.01.166"},{"key":"2298_CR27","doi-asserted-by":"crossref","unstructured":"Liu K, Li Y, Zhang G, Liu J, Cao J, Ao L, et al. Association between mobile phone use and semen quality: a systemic review and meta-analysis [Internet]. Andrology. Blackwell Publishing Ltd; 2014 [cited 2021 May 5]. p. 491\u2013501. Available from: https:\/\/pubmed-ncbi-nlm-nih-gov.proxy3.library.mcgill.ca\/24700791\/.","DOI":"10.1111\/j.2047-2927.2014.00205.x"},{"key":"2298_CR28","doi-asserted-by":"crossref","unstructured":"Hamilton JAM, Cissen M, Brandes M, Smeenk JMJ, de Bruin JP, Kremer JAM, et al. Total motile sperm count: a better indicator for the severity of male factor infertility than the WHO sperm classification system. Hum Reprod [Internet]. Oxford University Press; 2015 [cited 2021 May 20];30:1110\u201321. Available from: https:\/\/academic.oup.com\/humrep\/article\/30\/5\/1110\/591132.","DOI":"10.1093\/humrep\/dev058"},{"key":"2298_CR29","doi-asserted-by":"crossref","unstructured":"Borges E, Setti AS, Braga DPAF, Figueira RCS, Iaconelli A. Total motile sperm count has a superior predictive value over the WHO 2010 cut-off values for the outcomes of intracytoplasmic sperm injection cycles. Andrology [Internet]. Blackwell Publishing Ltd; 2016 [cited 2021 May 20];4:880\u20136. Available from: https:\/\/onlinelibrary-wiley-com.proxy3.library.mcgill.ca\/doi\/full\/10.1111\/andr.12199.","DOI":"10.1111\/andr.12199"},{"key":"2298_CR30","doi-asserted-by":"crossref","unstructured":"Salmon-Divon M, Shrem G, Balayla J, Nehushtan T, Volodarsky-Perel A, Steiner N, et al. An age-based sperm nomogram: the McGill reference guide. Hum Reprod [Internet]. Oxford University Press; 2020 [cited 2021 Mar 7];35:2213\u201325. Available from: https:\/\/pubmed-ncbi-nlm-nih-gov.proxy3.library.mcgill.ca\/32914183\/.","DOI":"10.1093\/humrep\/deaa196"}],"updated-by":[{"DOI":"10.1007\/s10815-021-02317-8","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[2021,9,13]],"date-time":"2021-09-13T00:00:00Z","timestamp":1631491200000}}],"container-title":["Journal of Assisted Reproduction and Genetics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10815-021-02298-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10815-021-02298-8\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10815-021-02298-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,11,22]],"date-time":"2021-11-22T21:04:12Z","timestamp":1637615052000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10815-021-02298-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,8,13]]},"references-count":31,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2021,11]]}},"alternative-id":["2298"],"URL":"https:\/\/doi.org\/10.1007\/s10815-021-02298-8","relation":{},"ISSN":["1058-0468","1573-7330"],"issn-type":[{"value":"1058-0468","type":"print"},{"value":"1573-7330","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,8,13]]},"assertion":[{"value":"13 June 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 August 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 August 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 September 2021","order":4,"name":"change_date","label":"Change Date","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Correction","order":5,"name":"change_type","label":"Change Type","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"A Correction to this paper has been published:","order":6,"name":"change_details","label":"Change Details","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"https:\/\/doi.org\/10.1007\/s10815-021-02317-8","URL":"https:\/\/doi.org\/10.1007\/s10815-021-02317-8","order":7,"name":"change_details","label":"Change Details","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Ethical approval was obtained through the Institutional Review Board (IRB) and the Institutional Ethics Committee of the MUHC, number 2020\u20135643.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}},{"value":"NA","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participate"}},{"value":"NA","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}