{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T18:14:04Z","timestamp":1792001644026,"version":"4.4.0"},"reference-count":23,"publisher":"Springer Science and Business Media LLC","issue":"7","license":[{"start":{"date-parts":[[2022,5,21]],"date-time":"2022-05-21T00:00:00Z","timestamp":1653091200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2022,5,21]],"date-time":"2022-05-21T00:00:00Z","timestamp":1653091200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Assist Reprod Genet"],"published-print":{"date-parts":[[2022,7]]},"DOI":"10.1007\/s10815-022-02501-4","type":"journal-article","created":{"date-parts":[[2022,5,21]],"date-time":"2022-05-21T19:02:30Z","timestamp":1653159750000},"page":"1625-1631","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Down syndrome live births following assisted reproductive technology in Japan: a nationwide survey between 2007 and 2016"],"prefix":"10.1007","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8815-5714","authenticated-orcid":false,"given":"Seung Chik","family":"Jwa","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akira","family":"Namba","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shunsuke","family":"Tamaru","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akira","family":"Kuwahara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haruhiko","family":"Sago","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Osamu","family":"Ishihara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshimasa","family":"Kamei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,5,21]]},"reference":[{"key":"2501_CR1","unstructured":"OECD. OECD family database 2019, available at (http:\/\/www.oecd.org\/els\/family\/database.htm). Accessed 08 Feb\u00a02021"},{"key":"2501_CR2","unstructured":"Cabinet Office. Declining Birthrate White Paper (In Japanese), available at (https:\/\/www8.cao.go.jp\/shoushi\/shoushika\/whitepaper\/measures\/w-2020\/r02pdfhonpen\/r02honpen.html). Accessed 20 May\u00a02022"},{"key":"2501_CR3","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1002\/rmb2.12358","volume":"20","author":"O Ishihara","year":"2021","unstructured":"Ishihara O, Jwa SC, Kuwahara A, Katagiri Y, Kuwabara Y, Hamatani T, et al. Assisted reproductive technology in Japan: a summary report for 2018 by the Ethics Committee of the Japan Society of Obstetrics and Gynecology. Reprod Med Biol. 2021;20:3\u201312.","journal-title":"Reprod Med Biol"},{"key":"2501_CR4","unstructured":"Adamson GD, de Mouzon J, Chambers GM, Zegers-Hochschild F, Mansour R, Ishihara O, et al. International Committee for Monitoring Assisted Reproductive Technology: world report on assisted reproductive technology, 2016. [Internet]. accessed on 13\/Sep\/2020. Available from: https:\/\/secureservercdn.net\/198.71.233.47\/3nz.654.myftpupload.com\/wp-content\/uploads\/ICMART-ESHRE-WR2016-FINAL-20200901.pdf"},{"key":"2501_CR5","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1016\/S0301-2115(97)00190-5","volume":"75","author":"G Breart","year":"1997","unstructured":"Breart G. Delayed childbearing. Eur J Obstet Gynecol Reprod Biol. 1997;75:71\u20133.","journal-title":"Eur J Obstet Gynecol Reprod Biol"},{"key":"2501_CR6","doi-asserted-by":"publisher","first-page":"1972","DOI":"10.1111\/jog.14381","volume":"46","author":"M Shibata","year":"2020","unstructured":"Shibata M, Akaishi R, Sasaki A, Ogawa K, Nishiyama M, Wada S, et al. Pregnant women\u2019s preferences for prenatal genetic testing: a single-center study in Japan. J Obstet Gynaecol Res. 2020;46:1972\u20136.","journal-title":"J Obstet Gynaecol Res"},{"key":"2501_CR7","doi-asserted-by":"publisher","first-page":"1049","DOI":"10.1002\/pd.3953","volume":"32","author":"L Hunt","year":"2012","unstructured":"Hunt L, Peterson M, Sinnott S, Sutton B, Cincotta R, Duncombe G, et al. Uptake of invasive prenatal tests in pregnancies conceived via assisted reproductive technologies: the experience in Queensland, Australia. Prenat Diagn. 2012;32:1049\u201352.","journal-title":"Prenat Diagn"},{"key":"2501_CR8","doi-asserted-by":"publisher","first-page":"1007","DOI":"10.1002\/pd.2816","volume":"31","author":"A Sasaki","year":"2011","unstructured":"Sasaki A, Sawai H, Masuzaki H, Hirahara F, Sago H. Low prevalence of genetic prenatal diagnosis in Japan. Prenat Diagn. 2011;31:1007\u20139.","journal-title":"Prenat Diagn"},{"key":"2501_CR9","first-page":"101","volume":"54","author":"A Sasaki","year":"2018","unstructured":"Sasaki A, Sago H, Yoshihashi H, Yamada S, Miyake H, Suzumori N, et al. Current status of prenatal diagnosis in Japan 1998\u20132016. Nihon Shusanki-Shinseiji Gakkai Zasshi (in Japanese). 2018;54:101\u20137.","journal-title":"Nihon Shusanki-Shinseiji Gakkai Zasshi (in Japanese)"},{"key":"2501_CR10","doi-asserted-by":"publisher","first-page":"437","DOI":"10.1186\/1472-6963-14-437","volume":"14","author":"NM Crombag","year":"2014","unstructured":"Crombag NM, Vellinga YE, Kluijfhout SA, Bryant LD, Ward PA, Iedema-Kuiper R, et al. Explaining variation in Down\u2019s syndrome screening uptake: comparing the Netherlands with England and Denmark using documentary analysis and expert stakeholder interviews. BMC Health Serv Res. 2014;14:437.","journal-title":"BMC Health Serv Res"},{"key":"2501_CR11","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1016\/j.socscimed.2014.01.046","volume":"106","author":"C Vassy","year":"2014","unstructured":"Vassy C, Rosman S, Rousseau B. From policy making to service use. Down\u2019s syndrome antenatal screening in England, France and the Netherlands. Soc Sci Med. 2014;106:67\u201374.","journal-title":"Soc Sci Med"},{"key":"2501_CR12","doi-asserted-by":"publisher","first-page":"195","DOI":"10.1111\/aogs.13273","volume":"97","author":"S Lou","year":"2018","unstructured":"Lou S, Petersen OB, Jorgensen FS, Lund ICB, Kjaergaard S, Danish Cytogenetic Central Registry Study G, et al. National screening guidelines and developments in prenatal diagnoses and live births of Down syndrome in 1973\u20132016 in Denmark. Acta Obstet Gynecol Scand. 2018;97:195\u2013203.","journal-title":"Acta Obstet Gynecol Scand"},{"key":"2501_CR13","doi-asserted-by":"publisher","first-page":"331","DOI":"10.1002\/pd.4539","volume":"35","author":"H Sago","year":"2015","unstructured":"Sago H, Sekizawa A, Japan Nc. Nationwide demonstration project of next-generation sequencing of cell-free DNA in maternal plasma in Japan: 1-year experience. Prenat Diagn. 2015;35:331\u20136.","journal-title":"Prenat Diagn"},{"key":"2501_CR14","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1002\/rmb2.12258","volume":"18","author":"O Ishihara","year":"2019","unstructured":"Ishihara O, Jwa SC, Kuwahara A, Ishikawa T, Kugu K, Sawa R, et al. Assisted reproductive technology in Japan: a summary report for 2016 by the Ethics Committee of the Japan Society of Obstetrics and Gynecology. Reprod Med Biol. 2019;18:7\u201316.","journal-title":"Reprod Med Biol"},{"key":"2501_CR15","doi-asserted-by":"publisher","first-page":"1900","DOI":"10.1093\/humrep\/deaa090","volume":"35","author":"J de Mouzon","year":"2020","unstructured":"de Mouzon J, Chambers GM, Zegers-Hochschild F, Mansour R, Ishihara O, Banker M, et al. International Committee for Monitoring Assisted Reproductive Technologies world report: assisted reproductive technology 2012dagger. Hum Reprod. 2020;35:1900\u201313.","journal-title":"Hum Reprod"},{"key":"2501_CR16","doi-asserted-by":"publisher","first-page":"356","DOI":"10.1159\/000264259","volume":"10","author":"RJ Snijders","year":"1995","unstructured":"Snijders RJ, Sebire NJ, Nicolaides KH. Maternal age and gestational age-specific risk for chromosomal defects. Fetal Diagn Ther. 1995;10:356\u201367.","journal-title":"Fetal Diagn Ther"},{"key":"2501_CR17","doi-asserted-by":"publisher","first-page":"461","DOI":"10.1111\/jir.12371","volume":"61","author":"G de Graaf","year":"2017","unstructured":"de Graaf G, Engelen JJM, Gijsbers ACJ, Hochstenbach R, Hoffer MJV, Kooper AJA, et al. Estimates of live birth prevalence of children with Down syndrome in the period 1991\u20132015 in the Netherlands. J Intellect Disabil Res. 2017;61:461\u201370.","journal-title":"J Intellect Disabil Res"},{"key":"2501_CR18","doi-asserted-by":"publisher","first-page":"1245","DOI":"10.1111\/jog.13373","volume":"43","author":"O Samura","year":"2017","unstructured":"Samura O, Sekizawa A, Suzumori N, Sasaki A, Wada S, Hamanoue H, et al. Current status of non-invasive prenatal testing in Japan. J Obstet Gynaecol Res. 2017;43:1245\u201355.","journal-title":"J Obstet Gynaecol Res"},{"key":"2501_CR19","doi-asserted-by":"crossref","first-page":"1815","DOI":"10.1002\/ajmg.a.61298","volume":"179","author":"A Sasaki","year":"2019","unstructured":"Sasaki A, Sago H. Equipoise of recent estimated Down syndrome live births in Japan. Am J Med Genet A. 2019;179:1815\u20139.","journal-title":"Am J Med Genet A"},{"key":"2501_CR20","doi-asserted-by":"publisher","first-page":"756","DOI":"10.1002\/ajmg.a.37001","volume":"167A","author":"G de Graaf","year":"2015","unstructured":"de Graaf G, Buckley F, Skotko BG. Estimates of the live births, natural losses, and elective terminations with Down syndrome in the United States. Am J Med Genet A. 2015;167A:756\u201367.","journal-title":"Am J Med Genet A"},{"key":"2501_CR21","doi-asserted-by":"publisher","first-page":"1016","DOI":"10.1038\/ejhg.2012.294","volume":"21","author":"J Wu","year":"2013","unstructured":"Wu J, Morris JK. The population prevalence of Down\u2019s syndrome in England and Wales in 2011. Eur J Hum Genet. 2013;21:1016\u20139.","journal-title":"Eur J Hum Genet"},{"key":"2501_CR22","doi-asserted-by":"crossref","unstructured":"de Groot-van der Mooren M, de Graaf G, Weijerman ME, Hoffer MJV, Knijnenburg J, van der Kevie-Kersemaekers AMF, et al. Does non-invasive prenatal testing affect the livebirth prevalence of Down syndrome in the Netherlands? A population-based register study. Prenat Diagn. 2021","DOI":"10.1002\/pd.6003"},{"key":"2501_CR23","doi-asserted-by":"publisher","first-page":"1121","DOI":"10.1002\/pd.4947","volume":"36","author":"M Nishiyama","year":"2016","unstructured":"Nishiyama M, Sekizawa A, Ogawa K, Sawai H, Nakamura H, Samura O, et al. Factors affecting parental decisions to terminate pregnancy in the presence of chromosome abnormalities: a Japanese multicenter study. Prenat Diagn. 2016;36:1121\u20136.","journal-title":"Prenat Diagn"}],"container-title":["Journal of Assisted Reproduction and Genetics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10815-022-02501-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10815-022-02501-4\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10815-022-02501-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,22]],"date-time":"2023-11-22T00:47:48Z","timestamp":1700614068000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10815-022-02501-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,5,21]]},"references-count":23,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2022,7]]}},"alternative-id":["2501"],"URL":"https:\/\/doi.org\/10.1007\/s10815-022-02501-4","relation":{},"ISSN":["1058-0468","1573-7330"],"issn-type":[{"value":"1058-0468","type":"print"},{"value":"1573-7330","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,5,21]]},"assertion":[{"value":"2 December 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 April 2022","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 May 2022","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and\/or national research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards. The study was approved by the institutional review board at the Saitama Medical University (Approval number 875; February 2018) and the ethics committee of the JSOG (Approval number 78; September 2018).","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}},{"value":"The authors declare no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}