{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,23]],"date-time":"2026-01-23T07:47:37Z","timestamp":1769154457518,"version":"3.49.0"},"reference-count":32,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2024,1,20]],"date-time":"2024-01-20T00:00:00Z","timestamp":1705708800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2024,1,20]],"date-time":"2024-01-20T00:00:00Z","timestamp":1705708800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/100000069","name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","doi-asserted-by":"publisher","award":["K12HD043451"],"award-info":[{"award-number":["K12HD043451"]}],"id":[{"id":"10.13039\/100000069","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Assist Reprod Genet"],"published-print":{"date-parts":[[2024,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Purpose<\/jats:title>\n                <jats:p>To examine the impact of medically assisted fertility treatments on the risk of developing perinatal and cardiometabolic complications during pregnancy and in-hospital deliveries.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>We conducted a retrospective cohort study using medical health records of deliveries occurring in 2016\u20132022 at a women\u2019s specialty hospital in a southern state of the Unites States (US). Pregnancies achieved using medically assisted reproductive (MAR) techniques were compared with unassisted pregnancies using propensity score matching (PSM), based on demographic, preexisting health, and reproductive factors. Study outcomes included cesarean delivery, gestational diabetes mellitus (GDM), hypertensive disorders of pregnancy (HDP), delivery complications, and postpartum readmission. We used Poisson regression with robust standard errors to generate risk ratios (RRs) and 95% confidence intervals (CIs) for all study outcomes.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>Among 57,354 deliveries, 586 (1.02%) pregnancies were achieved using MAR and 56,768 (98.98%) were unassisted (\u201cnon-MAR\u201d). Compared to the non-MAR group, MAR pregnancies had significantly higher prevalence of all study outcomes, including GDM (15.9% vs. 11.2%, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001), HDP (28.2% vs. 21.1%, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001), cesarean delivery (56.1% vs. 34.6%, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001), delivery complications (10.9% vs. 6.8%, <jats:italic>p<\/jats:italic>\u2009=\u20090.03), and postpartum readmission (4.3% vs. 2.7%, <jats:italic>p<\/jats:italic>\u2009=\u20090.02). In a PSM sample of 584 MAR and 1,727 unassisted pregnancies, MAR was associated with an increased risk of cesarean delivery (RR\u2009=\u20091.11, 95% CI\u2009=\u20091.01\u20131.22); whereas IVF was associated with an increased risk of cesarean delivery (RR\u2009=\u20091.15, 95% CI\u2009=\u20091.03\u20131.28) and delivery complications (RR\u2009=\u20091.44, 95% CI\u2009=\u20091.04\u20132.01).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>Women who conceived with MAR were at increased risk of cesarean deliveries, and those who conceived with IVF were additionally at risk of delivery complications.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s10815-024-03025-9","type":"journal-article","created":{"date-parts":[[2024,1,20]],"date-time":"2024-01-20T05:02:17Z","timestamp":1705726937000},"page":"613-621","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["The risk of perinatal and cardiometabolic complications in pregnancies conceived by medically assisted reproduction"],"prefix":"10.1007","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1763-3432","authenticated-orcid":false,"given":"Dovile","family":"Vilda","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elizabeth F.","family":"Sutton","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Venkata Sai Sahithi","family":"Kothamasu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul R.","family":"Clisham","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cecilia T.","family":"Gambala","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emily W.","family":"Harville","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2024,1,20]]},"reference":[{"issue":"3","key":"3025_CR1","doi-asserted-by":"publisher","first-page":"270","DOI":"10.1016\/j.ajog.2017.03.012","volume":"217","author":"B Luke","year":"2017","unstructured":"Luke B. Pregnancy and birth outcomes in couples with infertility with and without assisted reproductive technology: with an emphasis on US population-based studies. Am J Obstet Gynecol. 2017;217(3):270\u201381.","journal-title":"Am J Obstet Gynecol"},{"issue":"5","key":"3025_CR2","doi-asserted-by":"publisher","first-page":"e022658","DOI":"10.1161\/JAHA.121.022658","volume":"11","author":"P Wu","year":"2022","unstructured":"Wu P, et al. In-hospital complications in pregnancies conceived by assisted reproductive technology. J Am Heart Association. 2022;11(5):e022658.","journal-title":"J Am Heart Association"},{"key":"3025_CR3","first-page":"phox008","volume":"20172","author":"MI Cedars","year":"2017","unstructured":"Cedars MI, et al. The sixth vital sign: what reproduction tells us about overall health. Hum Reprod Open. 2017;20172:phox008. 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This study was determined not human subjects research after review by the Woman\u2019s Hospital Foundation Institutional Review Board.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}}]}}