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Study population was 48,365 patients with ART pregnancy from January 2012 to September 2015, including non-obesity (<jats:italic>n<\/jats:italic>\u2009=\u200945,125, 93.3%), class I\u2013II obesity (<jats:italic>n<\/jats:italic>\u2009=\u20092445, 5.1%), and class III obesity (<jats:italic>n<\/jats:italic>\u2009=\u2009795, 1.6%). Severe maternal morbidity at delivery per the Centers for Disease and Control Prevention definition was assessed with multivariable binary logistic regression model.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>Patients in the class III obesity group were more likely to have a hypertensive disorder (adjusted-odds ratio (aOR) 3.03, 95% confidence interval (CI) 2.61\u20133.52), diabetes mellitus (aOR 3.08, 95%CI 2.64\u20133.60), large for gestational age neonate (aOR 3.57, 95%CI 2.77\u20134.60), and intrauterine fetal demise (aOR 2.03, 95%CI 1.05\u20133.94) compared to those in the non-obesity group. Increased risks of hypertensive disease (aOR 1.35, 95%CI 1.14\u20131.60) and diabetes mellitus (aOR 1.39, 95%CI 1.17\u20131.66) in the class III obesity group remained robust even compared to the class I\u2013II obesity group. After controlling for priori selected clinical, pregnancy, and delivery factors, patients with class III obesity were 70% more likely to have severe maternal morbidity at delivery compared to non-obese patients (8.2% vs 4.4%, aOR 1.70, 95%CI 1.30\u20132.22) whereas those with class I\u2013II obesity were not (4.1% vs 4.4%, aOR 0.87, 95%CI 0.70\u20131.08).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>The results of this national-level analysis in the United States suggested that morbidly obese pregnant patients conceived with ART have increased risks of adverse fetal and maternal outcomes.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s10815-024-03065-1","type":"journal-article","created":{"date-parts":[[2024,2,21]],"date-time":"2024-02-21T06:03:16Z","timestamp":1708495396000},"page":"903-914","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Pregnancy following assisted reproductive technology in morbidly obese patients: assessment of feto-maternal outcomes"],"prefix":"10.1007","volume":"41","author":[{"given":"Bonnie B.","family":"Song","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachel S.","family":"Mandelbaum","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zachary S.","family":"Anderson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aaron D.","family":"Masjedi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chelsey A.","family":"Harris","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caroline J.","family":"Violette","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph G.","family":"Ouzounian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6232-8701","authenticated-orcid":false,"given":"Koji","family":"Matsuo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard J.","family":"Paulson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,2,21]]},"reference":[{"issue":"25","key":"3065_CR1","doi-asserted-by":"publisher","first-page":"2440","DOI":"10.1056\/NEJMsa1909301","volume":"381","author":"ZJ Ward","year":"2019","unstructured":"Ward ZJ, Bleich SN, Cradock AL, et al. 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The National Inpatient Sample is developed for the Healthcare Cost and Utilization Project that is sponsored by the Agency for Healthcare Research and Quality, and the program is the source of the de-identified data used; race and ethnicity were grouped by the program; and the program has not verified and is not responsible for the statistical validity of the data analysis or the conclusions derived by the study team.","order":7,"name":"Ethics","group":{"name":"EthicsHeading","label":"Transparency"}},{"value":"Not applicable.","order":8,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declaration of generative AI and AI-assisted technologies in the writing process"}},{"value":"ASRM 2023 Scientific Congress & Expo New Orleans, LA, October 14\u201318, 2023.","order":9,"name":"Ethics","group":{"name":"EthicsHeading","label":"Abstract presentation"}}]}}