{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,11]],"date-time":"2026-11-11T03:29:58Z","timestamp":1794367798790,"version":"4.9.0"},"reference-count":26,"publisher":"Springer Science and Business Media LLC","issue":"7","license":[{"start":{"date-parts":[[2024,5,16]],"date-time":"2024-05-16T00:00:00Z","timestamp":1715817600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2024,5,16]],"date-time":"2024-05-16T00:00:00Z","timestamp":1715817600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Assist Reprod Genet"],"published-print":{"date-parts":[[2024,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Purpose<\/jats:title>\n                <jats:p>Our objective is to predict the cumulative live birth rate (CLBR) and identify the specific subset within the population undergoing preimplantation genetic testing for monogenic disorders (PGT-M) and chromosomal structural rearrangements (PGT-SR) which is likely to exhibit a diminished expected CLBR based on various patient demographics.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>We performed a single-centre retrospective cohort study including 1522 women undergoing 3130 PGT cycles at a referral centre for PGT. A logistic regression analysis was performed to predict the CLBR per ovarian stimulation in women undergoing PGT-M by polymerase chain reaction (PCR) or single-nucleotide polymorphism (SNP) array, and in women undergoing PGT-SR by SNP array, array comparative genomic hybridization (CGH) or next-generation sequencing (NGS).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>The mean age of women was 32.6\u00a0years, with a mean AMH of 2.75\u00a0\u00b5g\/L. Female age and AMH significantly affected the expected CLBR irrespective of the inheritance mode or PGT technology. An expected CLBR\u2009&lt;\u200910% was reached above the age of 42\u00a0years and AMH\u2009\u2264\u20091.25\u00a0\u00b5g\/L. We found no significant difference in outcome per ovarian stimulation between the different PGT technologies, i.e. PCR, SNP array, array CGH and NGS. Whereas per embryo transfer, we noticed a significantly higher probability of live birth when SNP array, array CGH and NGS were used as compared to PCR.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>In a PGT-setting, couples with an unfavourable female age and AMH should be informed of the prognosis to allow other reproductive choices. The heatmap produced in this study can be used as a visual tool for PGT couples.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s10815-024-03141-6","type":"journal-article","created":{"date-parts":[[2024,5,16]],"date-time":"2024-05-16T12:01:56Z","timestamp":1715860916000},"page":"1907-1915","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["A heatmap for expected cumulative live birth rate in preimplantation genetic testing for monogenic disorders and chromosomal structural rearrangements"],"prefix":"10.1007","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9065-1960","authenticated-orcid":false,"given":"Annelore","family":"Van Der Kelen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathelijn","family":"Keymolen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wilfried","family":"Cools","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anick","family":"De Vos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"P\u00f6lsler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michel","family":"De Vos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christophe","family":"Blockeel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elia","family":"Fernandez-Gallardo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martine","family":"De Rycke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Veerle","family":"Berckmoes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pieter","family":"Verdyck","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frederik Jan","family":"Hes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Willem","family":"Verpoest","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,5,16]]},"reference":[{"key":"3141_CR1","doi-asserted-by":"publisher","first-page":"768","DOI":"10.1038\/344768a0","volume":"344","author":"AH Handyside","year":"1990","unstructured":"Handyside AH, Kontogianni EH, Hardy K, Winston RML. Pregnancies from biopsied human preimplantation embryos sexed by Y-specific DNA amplification. Nature. 1990;344:768\u201370.","journal-title":"Nature"},{"key":"3141_CR2","doi-asserted-by":"crossref","unstructured":"De Rycke M, Berckmoes V, De Vos A, Van De Voorde S, Verdyck P, Verpoest W, et al. Preimplantation genetic testing: clinical experience of preimplantation genetic testing. Reproduction [Internet]. 2020;160. Available from: https:\/\/rep.bioscientifica.com\/view\/journals\/rep\/160\/5\/REP-20-0082.xml.\u00a0[cited 2020 Nov 10].","DOI":"10.1530\/REP-20-0082"},{"key":"3141_CR3","doi-asserted-by":"publisher","first-page":"309","DOI":"10.1055\/s-0032-1313910","volume":"30","author":"I Tur-Kaspa","year":"2012","unstructured":"Tur-Kaspa I. Clinical management of in vitro fertilization with preimplantation genetic diagnosis. Semin Reprod Med. 2012;30:309\u201322.","journal-title":"Semin Reprod Med"},{"key":"3141_CR4","doi-asserted-by":"publisher","first-page":"572","DOI":"10.1093\/humrep\/dev336","volume":"31","author":"DJ McLernon","year":"2016","unstructured":"McLernon DJ, Maheshwari A, Lee AJ, Bhattacharya S. Cumulative live birth rates after one or more complete cycles of IVF: a population-based study of linked cycle data from 178,898 women. Human Reproduction (Oxford, England). 2016;31:572\u201381.","journal-title":"Human Reproduction (Oxford, England)"},{"key":"3141_CR5","doi-asserted-by":"publisher","first-page":"397","DOI":"10.1016\/j.fertnstert.2016.10.037","volume":"107","author":"DA Vaughan","year":"2017","unstructured":"Vaughan DA, Leung A, Resetkova N, Ruthazer R, Penzias AS, Sakkas D, et al. How many oocytes are optimal to achieve multiple live births with one stimulation cycle? The one-and-done approach. Fertil Steril. 2017;107:397-404.e3.","journal-title":"Fertil Steril"},{"key":"3141_CR6","doi-asserted-by":"crossref","unstructured":"Van Der Kelen A, Santos-Ribeiro S, De Vos A, Verdyck P, De Rycke M, Berckmoes V, et al. Parameters of poor prognosis in preimplantati on genetic testing for monogenic disorders. Hum Reprod. 2021;36:deab136.","DOI":"10.1093\/humrep\/deab136"},{"key":"3141_CR7","doi-asserted-by":"publisher","first-page":"2754","DOI":"10.1210\/clinem\/dgab168","volume":"106","author":"R Tal","year":"2021","unstructured":"Tal R, Seifer DB, Tal R, Granger E, Wantman E, Tal O. AMH highly correlates with cumulative live birth rate in women with diminished ovarian reserve independent of age. J Clin Endocrinol Metab. 2021;106:2754\u201366.","journal-title":"J Clin Endocrinol Metab"},{"key":"3141_CR8","doi-asserted-by":"crossref","unstructured":"De Rycke M, Berckmoes V. Preimplantation genetic testing for monogenic disorders. Genes (Basel) [Internet]. 2020;11. Available from: https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC7463885\/. [cited 2020 Oct 19].","DOI":"10.3390\/genes11080871"},{"key":"3141_CR9","doi-asserted-by":"publisher","first-page":"hoaa018","DOI":"10.1093\/hropen\/hoaa018","volume":"2020","author":"F Carvalho","year":"2020","unstructured":"Carvalho F, Moutou C, Dimitriadou E, Dreesen J, Gim\u00e9nez C, Goossens V, et al. ESHRE PGT Consortium good practice recommendations for the detection of monogenic disorders\u2020. Hum Reprod Open. 2020;2020:hoaa018.","journal-title":"Hum Reprod Open"},{"key":"3141_CR10","doi-asserted-by":"publisher","first-page":"1654","DOI":"10.1093\/humrep\/den105","volume":"23","author":"W Verpoest","year":"2008","unstructured":"Verpoest W, De Rademaeker M, Sermon K, De Rycke M, Seneca S, Papanikolaou E, et al. Real and expected delivery rates of patients with myotonic dystrophy undergoing intracytoplasmic sperm injection and preimplantation genetic diagnosis. Hum Reprod. 2008;23:1654\u201360.","journal-title":"Hum Reprod"},{"key":"3141_CR11","doi-asserted-by":"publisher","first-page":"2988","DOI":"10.1093\/humrep\/dep251","volume":"24","author":"A De Vos","year":"2009","unstructured":"De Vos A, Staessen C, De Rycke M, Verpoest W, Haentjens P, Devroey P, et al. Impact of cleavage-stage embryo biopsy in view of PGD on human blastocyst implantation: a prospective cohort of single embryo transfers. Hum Reprod. 2009;24:2988\u201396.","journal-title":"Hum Reprod"},{"key":"3141_CR12","first-page":"370","volume":"31","author":"P Drakopoulos","year":"2016","unstructured":"Drakopoulos P, Blockeel C, Stoop D, Camus M, de Vos M, Tournaye H, et al. Conventional ovarian stimulation and single embryo transfer for IVF\/ICSI. How many oocytes do we need to maximize cumulative live birth rates after utilization of all fresh and frozen embryos? Hum Reprod. 2016;31:370\u20136.","journal-title":"Hum Reprod"},{"key":"3141_CR13","doi-asserted-by":"publisher","first-page":"2488","DOI":"10.1093\/humrep\/deaa236","volume":"35","author":"A De Vos","year":"2020","unstructured":"De Vos A, Van Landuyt L, De Rycke M, Verdyck P, Verheyen G, Buysse A, et al. Multiple vitrification-warming and biopsy procedures on human embryos: clinical outcome and neonatal follow-up of children. Hum Reprod. 2020;35:2488\u201396.","journal-title":"Hum Reprod"},{"key":"3141_CR14","doi-asserted-by":"publisher","first-page":"1155","DOI":"10.1016\/S0015-0282(00)00518-5","volume":"73","author":"DK Gardner","year":"2000","unstructured":"Gardner DK, Lane M, Stevens J, Schlenker T, Schoolcraft WB. Blastocyst score affects implantation and pregnancy outcome: towards a single blastocyst transfer. Fertil Steril. 2000;73:1155\u20138.","journal-title":"Fertil Steril"},{"key":"3141_CR15","doi-asserted-by":"publisher","first-page":"2509","DOI":"10.1093\/humrep\/dev218","volume":"30","author":"L Van Landuyt","year":"2015","unstructured":"Van Landuyt L, Polyzos NP, De Munck N, Blockeel C, Van de Velde H, Verheyen G. A prospective randomized controlled trial investigating the effect of artificial shrinkage (collapse) on the implantation potential of vitrified blastocysts. Hum Reprod. 2015;30:2509\u201318.","journal-title":"Hum Reprod"},{"key":"3141_CR16","doi-asserted-by":"publisher","first-page":"hoaa059","DOI":"10.1093\/hropen\/hoaa059","volume":"2020","author":"T Copp","year":"2020","unstructured":"Copp T, Kvesic D, Lieberman D, Bateson D, McCaffery KJ. \u2018Your hopes can run away with your realistic expectations\u2019: a qualitative study of women and men\u2019s decision-making when undergoing multiple cycles of IVF. Hum Reprod Open. 2020;2020:hoaa059.","journal-title":"Hum Reprod Open."},{"key":"3141_CR17","doi-asserted-by":"publisher","first-page":"997","DOI":"10.1093\/humrep\/deac038","volume":"37","author":"J Devroe","year":"2022","unstructured":"Devroe J, Peeraer K, D\u2019Hooghe TM, Boivin J, Laenen A, Vriens J, et al. Great expectations of IVF patients: the role of gender, dispositional optimism and shared IVF prognoses. Hum Reprod. 2022;37:997\u20131006.","journal-title":"Hum Reprod"},{"key":"3141_CR18","doi-asserted-by":"publisher","first-page":"656","DOI":"10.1016\/j.fertnstert.2013.11.004","volume":"101","author":"JM Franasiak","year":"2014","unstructured":"Franasiak JM, Forman EJ, Hong KH, Werner MD, Upham KM, Treff NR, et al. The nature of aneuploidy with increasing age of the female partner: a review of 15,169 consecutive trophectoderm biopsies evaluated with comprehensive chromosomal screening. Fertil Steril. 2014;101:656-663.e1.","journal-title":"Fertil Steril"},{"key":"3141_CR19","doi-asserted-by":"publisher","first-page":"891","DOI":"10.1016\/j.fertnstert.2015.06.030","volume":"104","author":"O Hamdine","year":"2015","unstructured":"Hamdine O, Eijkemans MJC, Lentjes EGW, Torrance HL, Macklon NS, Fauser BCJM, et al. Antim\u00fcllerian hormone: prediction of cumulative live birth in gonadotropin-releasing hormone antagonist treatment for in vitro fertilization. Fertil Steril. 2015;104:891-898.e2.","journal-title":"Fertil Steril"},{"key":"3141_CR20","doi-asserted-by":"publisher","first-page":"1466","DOI":"10.1126\/science.aav7321","volume":"365","author":"JR Gruhn","year":"2019","unstructured":"Gruhn JR, Zielinska AP, Shukla V, Blanshard R, Capalbo A, Cimadomo D, et al. Chromosome errors in human eggs shape natural fertility over reproductive life span. Science. 2019;365:1466\u20139.","journal-title":"Science"},{"key":"3141_CR21","doi-asserted-by":"publisher","first-page":"595","DOI":"10.1007\/s10815-020-01739-0","volume":"37","author":"A Reig","year":"2020","unstructured":"Reig A, Franasiak J, Scott RT, Seli E. The impact of age beyond ploidy: outcome data from 8175 euploid single embryo transfers. J Assist Reprod Genet. 2020;37:595\u2013602.","journal-title":"J Assist Reprod Genet"},{"key":"3141_CR22","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1186\/s12978-018-0481-z","volume":"15","author":"PR Supramaniam","year":"2018","unstructured":"Supramaniam PR, Mittal M, McVeigh E, Lim LN. The correlation between raised body mass index and assisted reproductive treatment outcomes: a systematic review and meta-analysis of the evidence. Reprod Health. 2018;15:34.","journal-title":"Reprod Health"},{"key":"3141_CR23","doi-asserted-by":"publisher","first-page":"149","DOI":"10.3389\/fendo.2020.00149","volume":"11","author":"X Xue","year":"2020","unstructured":"Xue X, Shi W, Zhou H, Tian L, Zhao Z, Zhou D, et al. Cumulative live birth rates according to maternal body mass index after first ovarian stimulation for in vitro fertilization: a single center analysis of 14,782 patients. Front Endocrinol (Lausanne). 2020;11:149.","journal-title":"Front Endocrinol (Lausanne)"},{"key":"3141_CR24","doi-asserted-by":"publisher","first-page":"770","DOI":"10.1016\/j.fertnstert.2017.08.024","volume":"108","author":"IG Insogna","year":"2017","unstructured":"Insogna IG, Lee MS, Reimers RM, Toth TL. Neutral effect of body mass index on implantation rate after frozen-thawed blastocyst transfer. Fertil Steril. 2017;108:770-776.e1.","journal-title":"Fertil Steril"},{"key":"3141_CR25","doi-asserted-by":"publisher","first-page":"1295","DOI":"10.1007\/s10815-018-1186-5","volume":"35","author":"A Ben-Haroush","year":"2018","unstructured":"Ben-Haroush A, Sirota I, Salman L, Son W-Y, Tulandi T, Holzer H, et al. The influence of body mass index on pregnancy outcome following single-embryo transfer. J Assist Reprod Genet. 2018;35:1295\u2013300.","journal-title":"J Assist Reprod Genet"},{"key":"3141_CR26","doi-asserted-by":"publisher","first-page":"624","DOI":"10.1016\/j.fertnstert.2013.04.039","volume":"100","author":"RT Scott","year":"2013","unstructured":"Scott RT, Upham KM, Forman EJ, Zhao T, Treff NR. Cleavage-stage biopsy significantly impairs human embryonic implantation potential while blastocyst biopsy does not: a randomized and paired clinical trial. Fertil Steril. 2013;100:624\u201330.","journal-title":"Fertil Steril"}],"container-title":["Journal of Assisted Reproduction and Genetics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10815-024-03141-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10815-024-03141-6\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10815-024-03141-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,7,22]],"date-time":"2024-07-22T11:17:07Z","timestamp":1721647027000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10815-024-03141-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,5,16]]},"references-count":26,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2024,7]]}},"alternative-id":["3141"],"URL":"https:\/\/doi.org\/10.1007\/s10815-024-03141-6","relation":{},"ISSN":["1058-0468","1573-7330"],"issn-type":[{"value":"1058-0468","type":"print"},{"value":"1573-7330","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,5,16]]},"assertion":[{"value":"21 February 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 May 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 May 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}