{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T03:29:49Z","timestamp":1789788589052,"version":"4.0.1"},"reference-count":25,"publisher":"Springer Science and Business Media LLC","issue":"7","license":[{"start":{"date-parts":[[2024,6,5]],"date-time":"2024-06-05T00:00:00Z","timestamp":1717545600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2024,6,5]],"date-time":"2024-06-05T00:00:00Z","timestamp":1717545600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Assist Reprod Genet"],"published-print":{"date-parts":[[2024,7]]},"DOI":"10.1007\/s10815-024-03159-w","type":"journal-article","created":{"date-parts":[[2024,6,5]],"date-time":"2024-06-05T18:04:33Z","timestamp":1717610673000},"page":"1821-1824","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Too many embryos: a critical perspective on a global challenge"],"prefix":"10.1007","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5698-5513","authenticated-orcid":false,"given":"Alessandro","family":"Bartolacci","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carolina","family":"Dolci","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luca","family":"Pagliardini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enrico","family":"Papaleo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,6,5]]},"reference":[{"key":"3159_CR1","doi-asserted-by":"crossref","unstructured":"Zac\u00e0 C, Coticchio G, Calesini C, Vigiliano V, Tarozzi N, Lagalla C, Borini A. Towards a more sustainable balance between optimal live birth rate and supernumerary embryos in ART treatments. J Assist Reprod Genet. 2024;41(4):939\u201346.","DOI":"10.1007\/s10815-024-03043-7"},{"issue":"3","key":"3159_CR2","doi-asserted-by":"publisher","first-page":"766","DOI":"10.1016\/j.fertnstert.2021.04.006","volume":"116","author":"G Scaravelli","year":"2021","unstructured":"Scaravelli G, Zac\u00e0 C, Levi Setti PE, Livi C, Ubaldi FM, Villani MT, et al. Fertilization rate as a novel indicator for cumulative live birth rate: a multicenter retrospective cohort study of 9,394 complete in vitro fertilization cycles. Fertil Steril. 2021;116(3):766\u201373.","journal-title":"Fertil Steril"},{"issue":"5","key":"3159_CR3","doi-asserted-by":"publisher","first-page":"762","DOI":"10.1016\/j.fertnstert.2023.01.001","volume":"119","author":"M Fanton","year":"2023","unstructured":"Fanton M, Cho JH, Baker VL, Loewke K. A higher number of oocytes retrieved is associated with an increase in fertilized oocytes, blastocysts, and cumulative live birth rates. Fertil Steril. 2023;119(5):762\u20139.","journal-title":"Fertil Steril"},{"issue":"1","key":"3159_CR4","doi-asserted-by":"publisher","first-page":"e2249395","DOI":"10.1001\/jamanetworkopen.2022.49395","volume":"6","author":"KFB Correia","year":"2023","unstructured":"Correia KFB, Missmer SA, Weinerman R, Ginsburg ES, Rossi BV. Development of a model to estimate the optimal number of oocytes to attempt to fertilize during assisted reproductive technology treatment. JAMA Netw Open. 2023;6(1):e2249395.","journal-title":"JAMA Netw Open"},{"issue":"12","key":"3159_CR5","doi-asserted-by":"publisher","first-page":"1110","DOI":"10.1034\/j.1600-0412.2001.801206.x","volume":"80","author":"AS Svanberg","year":"2001","unstructured":"Svanberg AS, Boivin J, Hjelmstedt A, Bergh LA, Collins A, Bergh T. The impact of frozen embryos on emotional reactions during in vitro fertilization. Acta Obstet Gynecol Scand. 2001;80(12):1110\u20134.","journal-title":"Acta Obstet Gynecol Scand"},{"issue":"3","key":"3159_CR6","first-page":"587","volume":"21","author":"G Moutel","year":"2002","unstructured":"Moutel G, Gregg E, Meningaud JP, Herv\u00e9 C. Developments in the storage of embryos in France and the limitations of the laws of bioethics. Analysis of procedures in 17 storage centres and the destiny of stored embryos. Med Law. 2002;21(3):587\u2013604.","journal-title":"Med Law"},{"issue":"10","key":"3159_CR7","doi-asserted-by":"publisher","first-page":"2415","DOI":"10.1093\/humrep\/deh441","volume":"19","author":"S Bangsb\u00f8ll","year":"2004","unstructured":"Bangsb\u00f8ll S, Pinborg A, Yding Andersen C, Nyboe Andersen A. Patients\u2019 attitudes towards donation of surplus cryopreserved embryos for treatment or research. Hum Reprod. 2004;19(10):2415\u20139.","journal-title":"Hum Reprod"},{"issue":"2","key":"3159_CR8","first-page":"71","volume":"1","author":"MS Christianson","year":"2020","unstructured":"Christianson MS, Stern JE, Sun F, Zhang H, Styer AK, Vitek W, et al. Embryo cryopreservation and utilization in the United States from 2004\u20132013. F S Rep. 2020;1(2):71\u20137.","journal-title":"F S Rep"},{"issue":"12","key":"3159_CR9","doi-asserted-by":"publisher","first-page":"2447","DOI":"10.1007\/s10815-019-01592-w","volume":"36","author":"M Simopoulou","year":"2019","unstructured":"Simopoulou M, Sfakianoudis K, Giannelou P, Rapani A, Maziotis E, Tsioulou P, et al. Discarding IVF embryos: reporting on global practices. J Assist Reprod Genet. 2019;36(12):2447\u201357.","journal-title":"J Assist Reprod Genet"},{"key":"3159_CR10","first-page":"57","volume":"22","author":"S Canestrari","year":"2005","unstructured":"Canestrari S. The law of February 19th 2004, 40: procreation and punishment. Rev Derecho Genoma Hum. 2005;(22):57\u201373.","journal-title":"Rev Derecho Genoma Hum"},{"issue":"12","key":"3159_CR11","doi-asserted-by":"publisher","first-page":"2321","DOI":"10.1093\/humrep\/dead197","volume":"38","author":"J Smeenk","year":"2023","unstructured":"European IVF Monitoring Consortium (EIM) for the European Society of Human Reproduction and Embryology (ESHRE), Smeenk J, Wyns C, De Geyter C, Kupka M, Bergh C, et al. ART in Europe, 2019: results generated from European registries by ESHRE\u2020. Hum Reprod. 2023;38(12):2321\u201338.","journal-title":"Hum Reprod"},{"issue":"9","key":"3159_CR12","doi-asserted-by":"publisher","first-page":"1153","DOI":"10.1007\/s10815-017-0959-6","volume":"34","author":"Y-H Chen","year":"2017","unstructured":"Chen Y-H, Wang Q, Zhang Y-N, Han X, Li D-H, Zhang C-L. Cumulative live birth and surplus embryo incidence after frozen-thaw cycles in PCOS: how many oocytes do we need? J Assist Reprod Genet. 2017;34(9):1153\u20139.","journal-title":"J Assist Reprod Genet"},{"issue":"1","key":"3159_CR13","doi-asserted-by":"publisher","first-page":"140","DOI":"10.1016\/j.fertnstert.2007.08.004","volume":"91","author":"CA McMahon","year":"2009","unstructured":"McMahon CA, Saunders DM. Attitudes of couples with stored frozen embryos toward conditional embryo donation. Fertil Steril. 2009;91(1):140\u20137.","journal-title":"Fertil Steril"},{"issue":"1","key":"3159_CR14","doi-asserted-by":"publisher","first-page":"86","DOI":"10.1016\/j.fertnstert.2005.11.071","volume":"86","author":"K Hammarberg","year":"2006","unstructured":"Hammarberg K, Tinney L. Deciding the fate of supernumerary frozen embryos: a survey of couples\u2019 decisions and the factors influencing their choice. Fertil Steril. 2006;86(1):86\u201391.","journal-title":"Fertil Steril"},{"issue":"1","key":"3159_CR15","doi-asserted-by":"publisher","first-page":"52","DOI":"10.1007\/s40592-016-0060-4","volume":"34","author":"R Tonkens","year":"2016","unstructured":"Tonkens R. The moral unacceptability of abandoning human embryos. Monash Bioeth Rev. 2016;34(1):52\u201369.","journal-title":"Monash Bioeth Rev"},{"key":"3159_CR16","unstructured":"Law 19 February. 2004 No. 40.\u00a0https:\/\/www.gazzettaufficiale.it\/eli\/id\/2004\/02\/24\/004G0062\/sg."},{"key":"3159_CR17","first-page":"161","volume":"25","author":"J Vidal Mart\u00ednez","year":"2006","unstructured":"Vidal Mart\u00ednez J. Biomedical research with human embryos: changes in the legislation on assisted reproduction in Spain. Rev Derecho Genoma Hum. 2006 Jul-Dec;(25):161\u201382.","journal-title":"Rev Derecho Genoma Hum"},{"issue":"5","key":"3159_CR18","doi-asserted-by":"publisher","first-page":"752","DOI":"10.1016\/j.fertnstert.2024.03.013","volume":"121","author":"EC Feinberg","year":"2024","unstructured":"Feinberg EC, Santoro N, Cedars MI, Amato P. An egg is not a chicken and an embryo is not a child. Fertil Steril. 2024;121(5):752\u20133. https:\/\/doi.org\/10.1016\/j.fertnstert.2024.03.013. Epub 2024 Mar 18.","journal-title":"Fertil Steril"},{"key":"3159_CR19","unstructured":"Correia KFB, Vaughan D, Sakkas D, Rossi BV. Estimating the number of oocytes to expose to sperm in assisted reproductive technology treatment. Fertil Steril. 2024;23:S0015-0282(24)00127-4."},{"issue":"7","key":"3159_CR20","doi-asserted-by":"publisher","first-page":"1235","DOI":"10.1093\/humrep\/dead082","volume":"38","author":"E Somigliana","year":"2023","unstructured":"Somigliana E, Parazzini F, Goisis A, Esposito G, Li Piani L, Filippi F, et al. ART and the forgotten siblings: a call for research. Hum Reprod. 2023;38(7):1235\u20138.","journal-title":"Hum Reprod"},{"issue":"2","key":"3159_CR21","doi-asserted-by":"publisher","first-page":"361","DOI":"10.1007\/s10815-022-02682-y","volume":"40","author":"R Villanacci","year":"2023","unstructured":"Villanacci R, Buzzaccarini G, Marzanati D, Vanni VS, De Santis L, Alteri A, Candiani M, Pagliardini L, Papaleo E. Delayed blastocyst development is influenced by the level of progesterone on the day of trigger. J Assist Reprod Genet. 2023;40(2):361\u201370.","journal-title":"J Assist Reprod Genet"},{"issue":"5","key":"3159_CR22","doi-asserted-by":"publisher","first-page":"e0176482","DOI":"10.1371\/journal.pone.0176482","volume":"12","author":"VS Vanni","year":"2017","unstructured":"Vanni VS, Somigliana E, Reschini M, Pagliardini L, Marotta E, Faulisi S, Paffoni A, Vigano\u2019 P, Vegetti W, Candiani M, Papaleo E. Top quality blastocyst formation rates in relation to progesterone levels on the day of oocyte maturation in GnRH antagonist IVF\/ICSI cycles. PLoS ONE. 2017;12(5):e0176482.","journal-title":"PLoS ONE"},{"issue":"1","key":"3159_CR23","first-page":"169","volume":"290","author":"E Papaleo","year":"2014","unstructured":"Papaleo E, Corti L, Vanni VS, Pagliardini L, Ottolina J, De Michele F. al3 basal progesterone level as the main determinant of progesterone elevation on the day of hCG triggering in controlled ovarian stimulation cycles. Arch Gynecol Obstet. 2014;290(1):169\u201376.","journal-title":"Arch Gynecol Obstet"},{"issue":"10","key":"3159_CR24","doi-asserted-by":"publisher","first-page":"1897","DOI":"10.1007\/s10815-018-1256-8","volume":"35","author":"A Bartolacci","year":"2018","unstructured":"Bartolacci A, Pagliardini L, Makieva S, Salonia A, Papaleo E, Vigan\u00f2 P. Abnormal sperm concentration and motility as well as advanced paternal age compromise early embryonic development but not pregnancy outcomes: a retrospective study of 1266 ICSI cycles. J Assist Reprod Genet. 2018;35(10):1897\u2013903.","journal-title":"J Assist Reprod Genet"},{"issue":"6","key":"3159_CR25","doi-asserted-by":"publisher","first-page":"961","DOI":"10.1016\/j.fertnstert.2017.08.033","volume":"108","author":"R Mazzilli","year":"2017","unstructured":"Mazzilli R, Cimadomo D, Vaiarelli A, Capalbo A, Dovere L, Alviggi E, et al. Effect of the male factor on the clinical outcome of intracytoplasmic sperm injection combined with preimplantation aneuploidy testing: observational longitudinal cohort study of 1,219 consecutive cycles. Fertil Steril. 2017;108(6):961\u2013e9723.","journal-title":"Fertil Steril"}],"container-title":["Journal of Assisted Reproduction and Genetics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10815-024-03159-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10815-024-03159-w\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10815-024-03159-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,7,22]],"date-time":"2024-07-22T11:18:29Z","timestamp":1721647109000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10815-024-03159-w"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,6,5]]},"references-count":25,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2024,7]]}},"alternative-id":["3159"],"URL":"https:\/\/doi.org\/10.1007\/s10815-024-03159-w","relation":{},"ISSN":["1058-0468","1573-7330"],"issn-type":[{"value":"1058-0468","type":"print"},{"value":"1573-7330","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,6,5]]},"assertion":[{"value":"7 March 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"24 May 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"5 June 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"E.P. reported grants and personal fees from MSD; grants from Ferring, IBSA, TEVA, and Gedeon Richter; and grants and personal fees from Merck. The other authors declare no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}