{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T18:03:32Z","timestamp":1780077812433,"version":"3.54.0"},"reference-count":25,"publisher":"Springer Science and Business Media LLC","issue":"9","license":[{"start":{"date-parts":[[2024,7,8]],"date-time":"2024-07-08T00:00:00Z","timestamp":1720396800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2024,7,8]],"date-time":"2024-07-08T00:00:00Z","timestamp":1720396800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Assist Reprod Genet"],"published-print":{"date-parts":[[2024,9]]},"DOI":"10.1007\/s10815-024-03166-x","type":"journal-article","created":{"date-parts":[[2024,7,8]],"date-time":"2024-07-08T14:02:21Z","timestamp":1720447341000},"page":"2311-2318","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Trophectoderm grade as a predictor of beta human-chorionic gonadotropin rise in early pregnancy"],"prefix":"10.1007","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6195-6781","authenticated-orcid":false,"given":"Stylianos","family":"Vagios","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Panagiotis","family":"Cherouveim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victoria W.","family":"Fitz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victoria S.","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hadi","family":"Ramadan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Evelyn","family":"Minis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaitlyn","family":"James","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irene","family":"Dimitriadis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles L.","family":"Bormann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irene","family":"Souter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,7,8]]},"reference":[{"key":"3166_CR1","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1007\/978-3-642-30406-4_9","volume":"55","author":"Y Marikawa","year":"2012","unstructured":"Marikawa Y, Alarcon VB. Creation of trophectoderm, the first epithelium, in mouse preimplantation development. Results Probl Cell Differ. 2012;55:165\u201384. https:\/\/doi.org\/10.1007\/978-3-642-30406-4_9.","journal-title":"Results Probl Cell Differ"},{"key":"3166_CR2","unstructured":"Betz D, Fane K. 2023 Human chorionic gonadotropin. StatPearls. Treasure Island (FL) ineligible companies. Disclosure: Kathleen Fane declares no relevant financial relationships with ineligible companies"},{"issue":"1","key":"3166_CR3","doi-asserted-by":"publisher","first-page":"50","DOI":"10.1097\/01.AOG.0000128174.48843.12","volume":"104","author":"KT Barnhart","year":"2004","unstructured":"Barnhart KT, Sammel MD, Rinaudo PF, Zhou L, Hummel AC, Guo W. Symptomatic patients with an early viable intrauterine pregnancy: HCG curves redefined. Obstet Gynecol. 2004;104(1):50\u20135. https:\/\/doi.org\/10.1097\/01.AOG.0000128174.48843.12.","journal-title":"Obstet Gynecol"},{"issue":"2","key":"3166_CR4","first-page":"162","volume":"58","author":"N Kadar","year":"1981","unstructured":"Kadar N, Caldwell BV, Romero R. A method of screening for ectopic pregnancy and its indications. Obstet Gynecol. 1981;58(2):162\u20136.","journal-title":"Obstet Gynecol"},{"issue":"1","key":"3166_CR5","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1016\/j.xfre.2020.11.006","volume":"2","author":"LK Rauchfuss","year":"2021","unstructured":"Rauchfuss LK, Ainsworth AJ, Shenoy CC. Abnormal rate of human chorionic gonadotropin rise: a case series of patients with viable intrauterine pregnancies after embryo transfer. F S Rep. 2021;2(1):129\u201332. https:\/\/doi.org\/10.1016\/j.xfre.2020.11.006.","journal-title":"F S Rep"},{"issue":"3","key":"3166_CR6","doi-asserted-by":"publisher","first-page":"504","DOI":"10.1097\/AOG.0000000000001568","volume":"128","author":"KT Barnhart","year":"2016","unstructured":"Barnhart KT, Guo W, Cary MS, Morse CB, Chung K, Takacs P, et al. Differences in serum human chorionic gonadotropin rise in early pregnancy by race and value at presentation. Obstet Gynecol. 2016;128(3):504\u201311. https:\/\/doi.org\/10.1097\/AOG.0000000000001568.","journal-title":"Obstet Gynecol"},{"issue":"3","key":"3166_CR7","doi-asserted-by":"publisher","first-page":"823","DOI":"10.1093\/humrep\/dei389","volume":"21","author":"K Chung","year":"2006","unstructured":"Chung K, Sammel MD, Coutifaris C, Chalian R, Lin K, Castelbaum AJ, et al. Defining the rise of serum HCG in viable pregnancies achieved through use of IVF. Hum Reprod. 2006;21(3):823\u20138. https:\/\/doi.org\/10.1093\/humrep\/dei389.","journal-title":"Hum Reprod"},{"issue":"5","key":"3166_CR8","doi-asserted-by":"publisher","first-page":"1208","DOI":"10.1016\/j.fertnstert.2015.12.141","volume":"105","author":"CB Morse","year":"2016","unstructured":"Morse CB, Barnhart KT, Senapati S, Sammel MD, Prochaska EC, Dokras A, et al. Association of the very early rise of human chorionic gonadotropin with adverse outcomes in singleton pregnancies after in vitro fertilization. Fertil Steril. 2016;105(5):1208\u201314. https:\/\/doi.org\/10.1016\/j.fertnstert.2015.12.141.","journal-title":"Fertil Steril"},{"issue":"5","key":"3166_CR9","doi-asserted-by":"publisher","first-page":"1760","DOI":"10.1016\/j.fertnstert.2008.02.171","volume":"91","author":"MI Shamonki","year":"2009","unstructured":"Shamonki MI, Frattarelli JL, Bergh PA, Scott RT. Logarithmic curves depicting initial level and rise of serum beta human chorionic gonadotropin and live delivery outcomes with in vitro fertilization: an analysis of 6021 pregnancies. Fertil Steril. 2009;91(5):1760\u20134. https:\/\/doi.org\/10.1016\/j.fertnstert.2008.02.171.","journal-title":"Fertil Steril"},{"issue":"10","key":"3166_CR10","doi-asserted-by":"publisher","first-page":"2355","DOI":"10.1007\/s10815-022-02606-w","volume":"39","author":"LM Hughes","year":"2022","unstructured":"Hughes LM, Schuler A, Sharmuk M, Schauer JM, Pavone ME, Bernardi LA. Early beta-hCG levels predict live birth after single embryo transfer. J Assist Reprod Genet. 2022;39(10):2355\u201364. https:\/\/doi.org\/10.1007\/s10815-022-02606-w.","journal-title":"J Assist Reprod Genet"},{"issue":"7","key":"3166_CR11","doi-asserted-by":"publisher","first-page":"1311","DOI":"10.1016\/j.fertnstert.2018.08.047","volume":"110","author":"RB Mejia","year":"2018","unstructured":"Mejia RB, Cox TW, Nguyen EB, Summers KM, Eyck PT, Sparks AE, et al. Effect of body weight on early hormone levels in singleton pregnancies resulting in delivery after in vitro fertilization. Fertil Steril. 2018;110(7):1311\u20137. https:\/\/doi.org\/10.1016\/j.fertnstert.2018.08.047.","journal-title":"Fertil Steril"},{"issue":"3","key":"3166_CR12","doi-asserted-by":"publisher","first-page":"261","DOI":"10.1080\/09513590.2018.1519789","volume":"35","author":"L Grin","year":"2019","unstructured":"Grin L, Indurski A, Leytes S, Rabinovich M, Friedler S. Trends in primeval beta-hCG level increment after fresh and frozen-thawed IVF embryo transfer cycles. Gynecol Endocrinol. 2019;35(3):261\u20136. https:\/\/doi.org\/10.1080\/09513590.2018.1519789.","journal-title":"Gynecol Endocrinol"},{"issue":"4","key":"3166_CR13","doi-asserted-by":"publisher","first-page":"801","DOI":"10.1016\/j.fertnstert.2020.05.015","volume":"114","author":"MM Lu","year":"2020","unstructured":"Lu MM, Wen YX, Liu YL, Ding CH, Zhou CQ, Xu YW. Trophectoderm biopsy reduces the level of serum beta-human chorionic gonadotropin in early pregnancy. Fertil Steril. 2020;114(4):801\u20138. https:\/\/doi.org\/10.1016\/j.fertnstert.2020.05.015.","journal-title":"Fertil Steril"},{"issue":"6","key":"3166_CR14","doi-asserted-by":"publisher","first-page":"1155","DOI":"10.1016\/s0015-0282(00)00518-5","volume":"73","author":"DK Gardner","year":"2000","unstructured":"Gardner DK, Lane M, Stevens J, Schlenker T, Schoolcraft WB. Blastocyst score affects implantation and pregnancy outcome: towards a single blastocyst transfer. Fertil Steril. 2000;73(6):1155\u20138. https:\/\/doi.org\/10.1016\/s0015-0282(00)00518-5.","journal-title":"Fertil Steril"},{"issue":"9","key":"3166_CR15","doi-asserted-by":"publisher","first-page":"1379","DOI":"10.1007\/s10815-015-0532-0","volume":"32","author":"CJ Men","year":"2015","unstructured":"Men CJ, Bormann CL, Walsh BW, Racowsky C. Is the presence of an uncleaved embryo on day 3 a useful predictor of outcomes following day 5 transfer? J Assist Reprod Genet. 2015;32(9):1379\u201384. https:\/\/doi.org\/10.1007\/s10815-015-0532-0.","journal-title":"J Assist Reprod Genet"},{"issue":"1","key":"3166_CR16","doi-asserted-by":"publisher","first-page":"78","DOI":"10.1186\/s13048-021-00824-x","volume":"14","author":"Y Wu","year":"2021","unstructured":"Wu Y, Ying Y, Cao M, Liu J, Liu H. Trophectoderm biopsy of blastocysts for a preimplantation genetic test does not affect serum beta-hCG levels in early pregnancy: a study using propensity score matching. J Ovarian Res. 2021;14(1):78. https:\/\/doi.org\/10.1186\/s13048-021-00824-x.","journal-title":"J Ovarian Res"},{"key":"3166_CR17","doi-asserted-by":"publisher","first-page":"794720","DOI":"10.3389\/fendo.2022.794720","volume":"13","author":"Y Li","year":"2022","unstructured":"Li Y, Wen Q, Liao J, Ma S, Zhang S, Gu Y, et al. Trophectoderm biopsy differentially influences the level of serum beta-human chorionic gonadotropin with different embryonic trophectoderm scores in early pregnancy from 7847 single-blastocyst transfer cycles. Front Endocrinol (Lausanne). 2022;13:794720. https:\/\/doi.org\/10.3389\/fendo.2022.794720.","journal-title":"Front Endocrinol (Lausanne)"},{"issue":"6","key":"3166_CR18","doi-asserted-by":"publisher","first-page":"1359","DOI":"10.1016\/s0015-0282(03)02201-5","volume":"80","author":"X Zhang","year":"2003","unstructured":"Zhang X, Barnes R, Confino E, Milad M, Puscheck E, Kazer RR. Delay of embryo transfer to day 5 results in decreased initial serum beta-human chorionic gonadotropin levels. Fertil Steril. 2003;80(6):1359\u201363. https:\/\/doi.org\/10.1016\/s0015-0282(03)02201-5.","journal-title":"Fertil Steril"},{"issue":"2","key":"3166_CR19","doi-asserted-by":"publisher","first-page":"e65","DOI":"10.1097\/AOG.0000000000002464","volume":"131","author":"Committee on Practice B-G","year":"2018","unstructured":"Committee on Practice B-G. ACOG Practice Bulletin No 191: tubal ectopic pregnancy. Obstet Gynecol. 2018;131(2):e65\u201377. https:\/\/doi.org\/10.1097\/AOG.0000000000002464.","journal-title":"Obstet Gynecol"},{"issue":"18","key":"3166_CR20","doi-asserted-by":"publisher","first-page":"3479","DOI":"10.1007\/s00018-019-03104-6","volume":"76","author":"M Knofler","year":"2019","unstructured":"Knofler M, Haider S, Saleh L, Pollheimer J, Gamage T, James J. Human placenta and trophoblast development: key molecular mechanisms and model systems. Cell Mol Life Sci. 2019;76(18):3479\u201396. https:\/\/doi.org\/10.1007\/s00018-019-03104-6.","journal-title":"Cell Mol Life Sci"},{"issue":"11","key":"3166_CR21","doi-asserted-by":"publisher","first-page":"1475","DOI":"10.1007\/s10815-014-0317-x","volume":"31","author":"X Chen","year":"2014","unstructured":"Chen X, Zhang J, Wu X, Cao S, Zhou L, Wang Y, et al. Trophectoderm morphology predicts outcomes of pregnancy in vitrified-warmed single-blastocyst transfer cycle in a Chinese population. J Assist Reprod Genet. 2014;31(11):1475\u201381. https:\/\/doi.org\/10.1007\/s10815-014-0317-x.","journal-title":"J Assist Reprod Genet"},{"issue":"12","key":"3166_CR22","doi-asserted-by":"publisher","first-page":"1577","DOI":"10.1007\/s10815-013-0100-4","volume":"30","author":"SM Thompson","year":"2013","unstructured":"Thompson SM, Onwubalili N, Brown K, Jindal SK, McGovern PG. Blastocyst expansion score and trophectoderm morphology strongly predict successful clinical pregnancy and live birth following elective single embryo blastocyst transfer (eSET): a national study. J Assist Reprod Genet. 2013;30(12):1577\u201381. https:\/\/doi.org\/10.1007\/s10815-013-0100-4.","journal-title":"J Assist Reprod Genet"},{"key":"3166_CR23","doi-asserted-by":"publisher","first-page":"621221","DOI":"10.3389\/fendo.2021.621221","volume":"12","author":"J Ai","year":"2021","unstructured":"Ai J, Jin L, Zheng Y, Yang P, Huang B, Dong X. The morphology of inner cell mass is the strongest predictor of live birth after a frozen-thawed single embryo transfer. Front Endocrinol (Lausanne). 2021;12:621221. https:\/\/doi.org\/10.3389\/fendo.2021.621221.","journal-title":"Front Endocrinol (Lausanne)"},{"key":"3166_CR24","doi-asserted-by":"publisher","first-page":"98","DOI":"10.1016\/j.ejogrb.2020.12.047","volume":"258","author":"N Steiner","year":"2021","unstructured":"Steiner N, Al Mamari N, Rotshenker-Olshinka K, Khayat S, Alzawawi N, Son WY, et al. Blastocyst morphology has no relationship with serum beta-hCG levels and live birth rates once pregnant. Eur J Obstet Gynecol Reprod Biol. 2021;258:98\u2013102. https:\/\/doi.org\/10.1016\/j.ejogrb.2020.12.047.","journal-title":"Eur J Obstet Gynecol Reprod Biol"},{"issue":"12","key":"3166_CR25","doi-asserted-by":"publisher","first-page":"2119","DOI":"10.1093\/oxfordjournals.humrep.a137993","volume":"8","author":"A Dokras","year":"1993","unstructured":"Dokras A, Sargent IL, Barlow DH. Human blastocyst grading: an indicator of developmental potential? Hum Reprod. 1993;8(12):2119\u201327. https:\/\/doi.org\/10.1093\/oxfordjournals.humrep.a137993.","journal-title":"Hum Reprod"}],"container-title":["Journal of Assisted Reproduction and Genetics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10815-024-03166-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10815-024-03166-x\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10815-024-03166-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,9,16]],"date-time":"2024-09-16T19:07:08Z","timestamp":1726513628000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10815-024-03166-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,7,8]]},"references-count":25,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2024,9]]}},"alternative-id":["3166"],"URL":"https:\/\/doi.org\/10.1007\/s10815-024-03166-x","relation":{},"ISSN":["1058-0468","1573-7330"],"issn-type":[{"value":"1058-0468","type":"print"},{"value":"1573-7330","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,7,8]]},"assertion":[{"value":"13 November 2023","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 June 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 July 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}