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A total of 355 MII oocytes from 53 patients were described for intracytoplasmic and extracytoplasmic anomalies. Multiple clinical, laboratory, and demographic characteristics were analyzed. Statistically significant differences between independent groups in qualitative variables were identified using Pearson\u2019s \u03c7<jats:sup>2<\/jats:sup> and Fisher\u2019s exact tests. The diagnostic value of quantitative variables was assessed using the ROC curve analysis. Factors associated with the development of dysmorphism, taking patient age into account, were identified using the binary logistic regression analysis.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>Dysmorphisms were observed in 245 oocytes (69.0%), with a median number of dysmorphisms of 2. Oocyte dysmorphisms were found to be 2.211 times more likely to be detected in patients with ovarian cancer, while the presence of dark-colored cytoplasm was associated with gynecologic surgery in the anamnesis (<jats:italic>p<\/jats:italic>\u2009=\u20090.002; OR 16.652; 95% CI, 1.977\u2013140.237; Cramer\u2019s <jats:italic>V<\/jats:italic> 0.187). Small polar bodies developed 2.717 times more often (95% CI, 1.195\u20136.18) in patients older than 35. In the case of ovarian transportation on ice at 4 \u2103, the chances of development of cytoplasmic granularity increased 2.569 times (95% CI, 1.301\u20135.179). The use of biphasic CAPA IVM media contributed to a decrease in the probability of large polar body formation (<jats:italic>p<\/jats:italic>\u2009=\u20090.034) compared to the standard monophasic IVM media.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>Both patients\u2019 characteristics and laboratory parameters have an impact on the quality of IVM ovarian tissue oocytes.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s10815-024-03234-2","type":"journal-article","created":{"date-parts":[[2024,9,30]],"date-time":"2024-09-30T21:01:59Z","timestamp":1727730119000},"page":"3079-3088","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Quality of IVM ovarian tissue oocytes: impact of clinical, demographic, and laboratory factors"],"prefix":"10.1007","volume":"41","author":[{"given":"Maria","family":"Kashutina","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lilia","family":"Obosyan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ekaterina","family":"Bunyaeva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yury","family":"Zhernov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4014-4618","authenticated-orcid":false,"given":"Anastasia","family":"Kirillova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,9,30]]},"reference":[{"key":"3234_CR1","doi-asserted-by":"publisher","first-page":"276","DOI":"10.1093\/humrep\/det420","volume":"29","author":"EB Prasath","year":"2014","unstructured":"Prasath EB, Chan ML, Wong WH, Lim CJ, Tharmalingam MD, Hendricks M, et al. 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