{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T16:43:27Z","timestamp":1790181807506,"version":"4.1.0"},"reference-count":30,"publisher":"Springer Science and Business Media LLC","issue":"11","license":[{"start":{"date-parts":[[2024,9,17]],"date-time":"2024-09-17T00:00:00Z","timestamp":1726531200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2024,9,17]],"date-time":"2024-09-17T00:00:00Z","timestamp":1726531200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100004000","name":"Guangzhou Municipal Science and Technology Program key projects","doi-asserted-by":"publisher","award":["2024B03J1251"],"award-info":[{"award-number":["2024B03J1251"]}],"id":[{"id":"10.13039\/501100004000","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003453","name":"Natural Science Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["2024A1515012292"],"award-info":[{"award-number":["2024A1515012292"]}],"id":[{"id":"10.13039\/501100003453","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Assist Reprod Genet"],"published-print":{"date-parts":[[2024,11]]},"DOI":"10.1007\/s10815-024-03235-1","type":"journal-article","created":{"date-parts":[[2024,9,18]],"date-time":"2024-09-18T13:16:11Z","timestamp":1726665371000},"page":"3051-3059","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Differences in preimplantation blastocyst chromosomal aberrations between polycystic ovary syndrome women and controls: a multi-center retrospective cohort study"],"prefix":"10.1007","volume":"41","author":[{"given":"Lu","family":"Luo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenjun","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuanyuan","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Limei","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiayi","family":"Mai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9897-2120","authenticated-orcid":false,"given":"Qiong","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fei","family":"Gong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,9,17]]},"reference":[{"key":"3235_CR1","doi-asserted-by":"publisher","first-page":"523","DOI":"10.1056\/NEJMoa1513873","volume":"375","author":"ZJ Chen","year":"2016","unstructured":"Chen ZJ, Shi Y, Sun Y, Zhang B, Liang X, Cao Y, et al. Fresh versus frozen embryos for infertility in the polycystic ovary syndrome. N Engl J Med. 2016;375:523\u201333.","journal-title":"N Engl J Med"},{"issue":"4","key":"3235_CR2","doi-asserted-by":"publisher","first-page":"667","DOI":"10.1111\/1471-0528.16461","volume":"128","author":"L Luo","year":"2021","unstructured":"Luo L, Chen M, Wen Y, Zhang L, Zhou C, Wang Q. Pregnancy outcome and cost-effectiveness comparisons of artificial cycle-prepared frozen embryo transfer with or without GnRH agonist pretreatment for polycystic ovary syndrome: a randomised controlled trial. BJOG. 2021;128(4):667\u201374.","journal-title":"BJOG"},{"issue":"3","key":"3235_CR3","doi-asserted-by":"publisher","first-page":"565","DOI":"10.1016\/j.rbmo.2021.11.009","volume":"44","author":"S Mackens","year":"2022","unstructured":"Mackens S, Drakopoulos P, Moeykens MF, Mostinckx L, Boudry L, Segers I, et al. Cumulative live birth rate after ovarian stimulation with freeze-all in women with polycystic ovaries: does the polycystic ovary syndrome phenotype have an impact? Reprod Biomed Online. 2022;44(3):565\u201371.","journal-title":"Reprod Biomed Online"},{"issue":"7","key":"3235_CR4","doi-asserted-by":"publisher","first-page":"1160","DOI":"10.1111\/1471-0528.16590","volume":"128","author":"H Cai","year":"2021","unstructured":"Cai H, Mol BW, Gordts S, Wang H, Wang T, Li N, et al. Early and late pregnancy loss in women with polycystic ovary syndrome undergoing IVF\/ICSI treatment: a retrospective cohort analysis of 21820 pregnancies. BJOG. 2021;128(7):1160\u20139.","journal-title":"BJOG"},{"issue":"5","key":"3235_CR5","doi-asserted-by":"publisher","first-page":"575","DOI":"10.1093\/humupd\/dmv029","volume":"21","author":"S Palomba","year":"2015","unstructured":"Palomba S, de Wilde MA, Falbo A, Koster MP, La Sala GB, Fauser BC. Pregnancy complications in women with polycystic ovary syndrome. Hum Reprod Update. 2015;21(5):575\u201392.","journal-title":"Hum Reprod Update"},{"key":"3235_CR6","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1111\/1471-0528.12382","volume":"121","author":"RK Dhillon","year":"2014","unstructured":"Dhillon RK, Hillman SC, Morris RK, McMullan D, Williams D, Coomarasamy A, et al. Additional information from chromosomal microarray analysis (CMA) over conventional karyotyping when diagnosing chromosomal abnormalities in miscarriage: a systematic review and meta-analysis. BJOG. 2014;121:11\u201321.","journal-title":"BJOG"},{"key":"3235_CR7","doi-asserted-by":"publisher","first-page":"705","DOI":"10.1210\/jc.2006-2123","volume":"92","author":"JR Wood","year":"2007","unstructured":"Wood JR, Dumesic DA, Abbott DH, Strauss JF. Molecular abnormalities in oocytes from women with polycystic ovary syndrome revealed by microarray analysis. J Clin Endocrinol Metab. 2007;92:705\u201313.","journal-title":"J Clin Endocrinol Metab"},{"key":"3235_CR8","doi-asserted-by":"publisher","first-page":"1031","DOI":"10.1007\/s10815-015-0488-0","volume":"32","author":"L Sundvall","year":"2015","unstructured":"Sundvall L, Kirkegaard K, Ingerslev HJ, Knudsen UB. Unaltered timing of embryo development in women with polycystic ovarian syndrome (PCOS): a time-lapse study. J Assist Reprod Genet. 2015;32:1031\u201342.","journal-title":"J Assist Reprod Genet"},{"issue":"3","key":"3235_CR9","doi-asserted-by":"publisher","first-page":"474","DOI":"10.1093\/humrep\/12.3.474","volume":"12","author":"K Sengoku","year":"1997","unstructured":"Sengoku K, Tamate K, Takuma N, Yoshida T, Goishi K, Ishikawa M. The chromosomal normality of unfertilized oocytes from patients with polycystic ovarian syndrome. Hum Reprod. 1997;12(3):474\u20137.","journal-title":"Hum Reprod"},{"key":"3235_CR10","doi-asserted-by":"publisher","first-page":"900","DOI":"10.1016\/j.fertnstert.2006.12.018","volume":"88","author":"A Weghofer","year":"2007","unstructured":"Weghofer A, Munne S, Chen S, Barad D, Gleicher N. Lack of association between polycystic ovary syndrome and embryonic aneuploidy. Fertil Steril. 2007;88:900\u20135.","journal-title":"Fertil Steril"},{"issue":"6","key":"3235_CR11","doi-asserted-by":"publisher","first-page":"e249","DOI":"10.1210\/clinem\/dgac726","volume":"108","author":"J Wang","year":"2023","unstructured":"Wang J, Zhou W, Song Z, Ni T, Zhang Q, Chen ZJ, Yan J. Does the Risk of Embryo Abnormality Increase in PCOS Women? A Secondary Analysis of a Multicenter, Randomized Controlled Trial. J Clin Endocrinol Metab. 2023;108(6):e249-57.","journal-title":"J Clin Endocrinol Metab."},{"key":"3235_CR12","doi-asserted-by":"crossref","unstructured":"Rotterdam EA-SPcwg. Revised 2003 consensus on diagnostic criteria and long-term health risks related to polycystic ovary syndrome (PCOS). Hum Reprod. 2004;19:41\u20137.","DOI":"10.1093\/humrep\/deh098"},{"issue":"1","key":"3235_CR13","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1016\/j.rbmo.2016.04.006","volume":"33","author":"Q Wang","year":"2016","unstructured":"Wang Q, Luo L, Lei Q, Lin M, Huang X, Chen M, et al. Low aneuploidy rate in early pregnancy loss abortuses from patients with polycystic ovary syndrome. Reprod Biomed Online. 2016;33(1):85\u201392.","journal-title":"Reprod Biomed Online"},{"issue":"5","key":"3235_CR14","doi-asserted-by":"publisher","first-page":"936","DOI":"10.1016\/j.fertnstert.2019.01.026","volume":"111","author":"Y Li","year":"2019","unstructured":"Li Y, Wang L, Xu J, Niu W, Shi H, Hu L, et al. Higher chromosomal aberration rate in miscarried conceptus from polycystic ovary syndrome women undergoing assisted reproductive treatment. Fertil Steril. 2019;111(5):936-943.e2.","journal-title":"Fertil Steril"},{"issue":"5","key":"3235_CR15","doi-asserted-by":"publisher","first-page":"576","DOI":"10.1016\/j.rbmo.2017.07.010","volume":"35","author":"L Luo","year":"2017","unstructured":"Luo L, Gu F, Jie H, Ding C, Zhao Q, Wang Q, et al. Early miscarriage rate in lean polycystic ovary syndrome women after euploid embryo transfer - a matched-pair study. Reprod Biomed Online. 2017;35(5):576\u201382.","journal-title":"Reprod Biomed Online"},{"issue":"2","key":"3235_CR16","doi-asserted-by":"publisher","first-page":"369","DOI":"10.1007\/s10815-022-02397-0","volume":"39","author":"J Tong","year":"2022","unstructured":"Tong J, Niu Y, Wan A, Zhang T. Comparison of day 5 blastocyst with day 6 blastocyst: evidence from NGS-based PGT-A results. J Assist Reprod Genet. 2022;39(2):369\u201377.","journal-title":"J Assist Reprod Genet"},{"issue":"12","key":"3235_CR17","doi-asserted-by":"publisher","first-page":"2515","DOI":"10.1007\/s10815-019-01595-7","volume":"36","author":"J Wang","year":"2019","unstructured":"Wang J, Lu BM, Li R, Guo J, Xu Y, Pan JF, et al. Karyomapping in preimplantation genetic testing for \u03b2-thalassemia combined with HLA matching: a systematic summary. J Assist Reprod Genet. 2019;36(12):2515\u201323.","journal-title":"J Assist Reprod Genet"},{"issue":"11","key":"3235_CR18","first-page":"2563","volume":"39","author":"D Leigh","year":"2022","unstructured":"Leigh D, Cram DS, Rechitsky S, Handyside A, Wells D, Munne S, et al. PGDIS position statement on the transfer of mosaic embryos 2021. Reprod Biomed Online. 2022;39(11):2563\u201370.","journal-title":"Reprod Biomed Online"},{"key":"3235_CR19","doi-asserted-by":"crossref","unstructured":"ESHRE Working Group on Chromosomal Mosaicism; De Rycke M, Capalbo A, Coonen E, Coticchio G, Fiorentino F, et al. ESHRE survey results and good practice recommendations on managing chromosomal mosaicism. Hum Reprod Open. 2022;2022(4):hoac044.","DOI":"10.1093\/hropen\/hoac044"},{"key":"3235_CR20","doi-asserted-by":"publisher","first-page":"250","DOI":"10.1016\/j.fertnstert.2014.04.004","volume":"102","author":"A Morciano","year":"2014","unstructured":"Morciano A, Romani F, Sagnella F, Scarinci E, Palla C, Moro F, et al. Assessment of insulin resistance in lean women with polycystic ovary syndrome. Fertil Steril. 2014;102:250-6.e3.","journal-title":"Fertil Steril"},{"issue":"3","key":"3235_CR21","doi-asserted-by":"publisher","first-page":"446","DOI":"10.1111\/j.1365-2265.2012.04395.x","volume":"77","author":"Z Zhou","year":"2012","unstructured":"Zhou Z, Ni R, Hong Y, Li Y, Wang Y, Zhao X, et al. Defining hyperandrogenaemia according to the free androgen index in Chinese women: a cross-sectional study. Clin Endocrinol (Oxf). 2012;77(3):446\u201352.","journal-title":"Clin Endocrinol (Oxf)"},{"issue":"3","key":"3235_CR22","doi-asserted-by":"publisher","first-page":"364","DOI":"10.1016\/j.fertnstert.2018.05.004","volume":"110","author":"HJ Teede","year":"2018","unstructured":"Teede HJ, Misso ML, Costello MF, Dokras A, Laven J, Moran L, et al. International PCOS Network. Recommendations from the international evidence-based guideline for the assessment and management of polycystic ovary syndrome. Fertil Steril. 2018;110(3):364\u201379.","journal-title":"Fertil Steril."},{"issue":"5","key":"3235_CR23","doi-asserted-by":"publisher","first-page":"1085","DOI":"10.1016\/j.fertnstert.2017.03.024","volume":"107","author":"S Munn\u00e9","year":"2017","unstructured":"Munn\u00e9 S, Wells D. Detection of mosaicism at blastocyst stage with the use of high-resolution next-generation sequencing. Fertil Steril. 2017;107(5):1085\u201391.","journal-title":"Fertil Steril"},{"key":"3235_CR24","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1007\/s10815-018-1347-6","volume":"36","author":"KL Palmerola","year":"2019","unstructured":"Palmerola KL, Vitez SF, Amrane S, Fischer CP, Forman EJ. Minimizing mosaicism: assessing the impact of fertilization method on rate of mosaicism after next-generation sequencing (NGS) preimplantation genetic testing for aneuploidy (PGT-A). J Assist Reprod Genet. 2019;36:153\u20137.","journal-title":"J Assist Reprod Genet"},{"key":"3235_CR25","doi-asserted-by":"publisher","first-page":"571","DOI":"10.1093\/humupd\/dmu016","volume":"20","author":"TH Taylor","year":"2014","unstructured":"Taylor TH, Gitlin SA, Patrick JL, Crain JL, Wilson JM, Grifn DK. The origin, mechanisms, incidence and clinical consequences of chromosomal mosaicism in humans. Hum Reprod Update. 2014;20:571\u201381.","journal-title":"Hum Reprod Update"},{"issue":"6","key":"3235_CR26","doi-asserted-by":"publisher","first-page":"1695","DOI":"10.3390\/jcm9061695","volume":"9","author":"PY Lin","year":"2020","unstructured":"Lin PY, Lee CI, Cheng EH, Huang CC, Lee TH, Shih HH, et al. Clinical outcomes of single mosaic embryo transfer: high-level or low-level mosaic embryo, does it matter? J Clin Med. 2020;9(6):1695.","journal-title":"J Clin Med"},{"issue":"22","key":"3235_CR27","first-page":"00088","volume":"S1672\u20130229","author":"Y Gao","year":"2022","unstructured":"Gao Y, Zhang J, Liu Z, Qi S, Guo X, Wang H, et al. Single-cell sequencing reveals clearance of blastula chromosomal mosaicism in in vitro fertilization babies. Genomics Proteomics Bioinformatics. 2022;S1672\u20130229(22):00088\u201392.","journal-title":"Genomics Proteomics Bioinformatics"},{"issue":"6","key":"3235_CR28","doi-asserted-by":"publisher","first-page":"e174483","DOI":"10.1172\/JCI174483","volume":"134","author":"EA Chavli","year":"2024","unstructured":"Chavli EA, Klaasen JS, Opstal DV, Laven JS, Kops JG, Baart EB. Single-cell DNA sequencing reveals a high incidence of chromosomal abnormalities in human blastocysts. J Clin Invest. 2024;134(6):e174483.","journal-title":"J Clin Invest"},{"issue":"5","key":"3235_CR29","doi-asserted-by":"publisher","first-page":"982","DOI":"10.1093\/humrep\/dead049","volume":"38","author":"L Girardi","year":"2023","unstructured":"Girardi L, Figliuzzi M, Poli M, Serdarogullari M, Patassini C, Caroselli S, et al. The use of copy number loads to designate mosaicism in blastocyst stage PGT-A cycles: fewer is better. Hum Reprod. 2023;38(5):982\u201391.","journal-title":"Hum Reprod"},{"issue":"1","key":"3235_CR30","doi-asserted-by":"publisher","first-page":"54","DOI":"10.1016\/j.rbmo.2022.02.016","volume":"45","author":"X Ai","year":"2022","unstructured":"Ai X, Shi Y, Liu LW, Xu Y, Zhang H, Liu Y, et al. Risk factors related to chromosomal mosaicism in human blastocysts. Reprod Biomed Online. 2022;45(1):54\u201362.","journal-title":"Reprod Biomed Online"}],"container-title":["Journal of Assisted Reproduction and Genetics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10815-024-03235-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10815-024-03235-1\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10815-024-03235-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,12,5]],"date-time":"2024-12-05T12:06:13Z","timestamp":1733400373000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10815-024-03235-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,9,17]]},"references-count":30,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2024,11]]}},"alternative-id":["3235"],"URL":"https:\/\/doi.org\/10.1007\/s10815-024-03235-1","relation":{},"ISSN":["1058-0468","1573-7330"],"issn-type":[{"value":"1058-0468","type":"print"},{"value":"1573-7330","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,9,17]]},"assertion":[{"value":"16 April 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 August 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 September 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"This study was approved by the Ethics Committee of hospital on 12 September 2020 (approval No. 2020 [325]). It was performed in accordance with the ethical standards decided upon in the 1964 Declaration of Helsinki and its later amendments.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}},{"value":"The need for written informed consent was waived.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participate"}},{"value":"The hospital review board approved the publish of the study.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}