{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,12]],"date-time":"2026-01-12T21:39:44Z","timestamp":1768253984093,"version":"3.49.0"},"reference-count":33,"publisher":"Springer Science and Business Media LLC","issue":"12","license":[{"start":{"date-parts":[[2024,11,16]],"date-time":"2024-11-16T00:00:00Z","timestamp":1731715200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2024,11,16]],"date-time":"2024-11-16T00:00:00Z","timestamp":1731715200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82171626"],"award-info":[{"award-number":["82171626"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"National Key Research and Development Program of Chin","award":["2023YFC2705504"],"award-info":[{"award-number":["2023YFC2705504"]}]},{"name":"Tibetan Plateau Scientific Expedition and Research Program","award":["2019QZKK0606"],"award-info":[{"award-number":["2019QZKK0606"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Assist Reprod Genet"],"published-print":{"date-parts":[[2024,12]]},"DOI":"10.1007\/s10815-024-03293-5","type":"journal-article","created":{"date-parts":[[2024,11,16]],"date-time":"2024-11-16T09:57:27Z","timestamp":1731751047000},"page":"3445-3453","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Dual trigger versus human chorionic gonadotropin trigger for blastocyst quality and cumulative live birth"],"prefix":"10.1007","volume":"41","author":[{"given":"Zining","family":"He","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yalong","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ning","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xintong","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lin","family":"Zeng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ying","family":"Lian","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rong","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6074-0663","authenticated-orcid":false,"given":"Hongbin","family":"Chi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2024,11,16]]},"reference":[{"key":"3293_CR1","doi-asserted-by":"publisher","first-page":"60","DOI":"10.1186\/s13048-015-0187-6","volume":"8","author":"R Orvieto","year":"2015","unstructured":"Orvieto R. Triggering final follicular maturation\u2013hCG, GnRH-agonist or both, when and to whom? J Ovarian Res. 2015;8:60. https:\/\/doi.org\/10.1186\/s13048-015-0187-6.","journal-title":"J Ovarian Res."},{"key":"3293_CR2","doi-asserted-by":"publisher","first-page":"80","DOI":"10.1186\/s12958-020-00639-3","volume":"18","author":"J Smitz","year":"2020","unstructured":"Smitz J, Platteau P. Influence of human chorionic gonadotrophin during ovarian stimulation: an overview. Reprod Biol Endocrinol. 2020;18:80. https:\/\/doi.org\/10.1186\/s12958-020-00639-3.","journal-title":"Reprod Biol Endocrinol."},{"key":"3293_CR3","doi-asserted-by":"publisher","unstructured":"Bosch E, Broer S, Griesinger G, Grynberg M, Humaidan P, Kolibianakis E, Kunicki M, La Marca A, Lainas G, Le Clef N, Massin N, Mastenbroek S, Polyzos N, Sunkara SK, Timeva T, T\u00f6yli M, Urbancsek J, Vermeulen N, Broekmans F. ESHRE guideline: ovarian stimulation for IVF\/ICSI\u2020. Hum Reprod Open 2020, hoaa009. https:\/\/doi.org\/10.1093\/hropen\/hoaa009.","DOI":"10.1093\/hropen\/hoaa009"},{"key":"3293_CR4","doi-asserted-by":"publisher","first-page":"145","DOI":"10.3109\/09513590.2014.978850","volume":"31","author":"E Zilberberg","year":"2015","unstructured":"Zilberberg E, Haas J, Dar S, Kedem A, Machtinger R, Orvieto R. Co-administration of GnRH-agonist and hCG, for final oocyte maturation (double trigger), in patients with low proportion of mature oocytes. Gynecol Endocrinol. 2015;31:145\u20137. https:\/\/doi.org\/10.3109\/09513590.2014.978850.","journal-title":"Gynecol Endocrinol."},{"key":"3293_CR5","doi-asserted-by":"publisher","first-page":"1648","DOI":"10.1093\/humrep\/deaa107","volume":"35","author":"J Haas","year":"2020","unstructured":"Haas J, Bassil R, Samara N, Zilberberg E, Mehta C, Orvieto R, Casper RF. GnRH agonist and hCG (dual trigger) versus hCG trigger for final follicular maturation: a double-blinded, randomized controlled study. Hum Reprod. 2020;35:1648\u20134. https:\/\/doi.org\/10.1093\/humrep\/deaa107.","journal-title":"Hum Reprod."},{"key":"3293_CR6","doi-asserted-by":"publisher","unstructured":"Humaidan P, Kol S, Papanikolaou EG, Copenhagen GnRH Agonist Triggering Workshop Group. GnRH agonist for triggering of final oocyte maturation: time for a change of practice? Hum Reprod Update. 2011;17:510\u201324. https:\/\/doi.org\/10.1093\/humupd\/dmr008.","DOI":"10.1093\/humupd\/dmr008"},{"key":"3293_CR7","doi-asserted-by":"publisher","first-page":"395","DOI":"10.1002\/ijgo.13405","volume":"152","author":"AM Maged","year":"2021","unstructured":"Maged AM, Ragab MA, Shohayeb A, Saber W, Ekladious S, Hussein EA, El-Mazny A, Hany A. Comparative study between single versus dual trigger for poor responders in GnRH-antagonist ICSI cycles: a randomized controlled study. Int J Gynaecol Obstet. 2021;152:395\u2013400. https:\/\/doi.org\/10.1002\/ijgo.13405.","journal-title":"Int J Gynaecol Obstet."},{"key":"3293_CR8","doi-asserted-by":"publisher","DOI":"10.1016\/j.jogoh.2020.101728","volume":"49","author":"SS Ali","year":"2020","unstructured":"Ali SS, Elsenosy E, Sayed GH, Farghaly TA, Youssef AA, Badran E, Abbas AM, Abdelaleem AA. Dual trigger using recombinant HCG and gonadotropin-releasing hormone agonist improve oocyte maturity and embryo grading for normal responders in GnRH antagonist cycles: randomized controlled trial. J Gynecol Obstet Hum Reprod. 2020;49: 101728. https:\/\/doi.org\/10.1016\/j.jogoh.2020.101728.","journal-title":"J Gynecol Obstet Hum Reprod."},{"key":"3293_CR9","doi-asserted-by":"publisher","unstructured":"ESHRE PGT Consortium Steering Committee, Carvalho F, Coonen E, Goossens V, Kokkali G, Rubio C, Meijer-Hoogeveen M, Moutou C, Vermeulen N, De Rycke M. ESHRE PGT Consortium good practice recommendations for the organisation of PGT. Hum Reprod Open. 2020, hoaa021. https:\/\/doi.org\/10.1093\/hropen\/hoaa021.","DOI":"10.1093\/hropen\/hoaa021"},{"key":"3293_CR10","doi-asserted-by":"publisher","first-page":"986","DOI":"10.1093\/humrep\/deaa034","volume":"35","author":"R Theobald","year":"2020","unstructured":"Theobald R, SenGupta S, Harper J. The status of preimplantation genetic testing in the UK and USA. Hum Reprod. 2020;35:986\u201398. https:\/\/doi.org\/10.1093\/humrep\/deaa034.","journal-title":"Hum. Reprod."},{"key":"3293_CR11","doi-asserted-by":"publisher","first-page":"118","DOI":"10.1093\/humupd\/dmz037","volume":"26","author":"Y Mizrachi","year":"2020","unstructured":"Mizrachi Y, Horowitz E, Farhi J, Raziel A, Weissman A. Ovarian stimulation for freeze-all IVF cycles: a systematic review. Hum Reprod Update. 2020;26:118\u201335. https:\/\/doi.org\/10.1093\/humupd\/dmz037.","journal-title":"Hum Reprod Update."},{"key":"3293_CR12","doi-asserted-by":"publisher","first-page":"258","DOI":"10.1016\/j.fertnstert.2019.03.040","volume":"112","author":"J Thorne","year":"2019","unstructured":"Thorne J, Loza A, Kaye L, Nulsen J, Benadiva C, Grow D, Engmann L. Euploidy rates between cycles triggered with gonadotropin-releasing hormone agonist and human chorionic gonadotropin. Fertil Steril. 2019;112:258\u201365. https:\/\/doi.org\/10.1016\/j.fertnstert.2019.03.040.","journal-title":"Fertil Steril."},{"key":"3293_CR13","doi-asserted-by":"publisher","first-page":"2265","DOI":"10.1007\/s43032-022-00954-7","volume":"29","author":"C Demirel","year":"2022","unstructured":"Demirel C, Celik HG, Tulek F, Uzun K, Bastu E. Dual trigger with hCG plus GnRHa for final oocyte maturation in PGT-A cycles results in similar euploidy rates when compared to hCG-only trigger. Reprod Sci. 2022;29:2265\u201371. https:\/\/doi.org\/10.1007\/s43032-022-00954-7.","journal-title":"Reprod Sci."},{"issue":"1","key":"3293_CR14","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1093\/humupd\/dmq034","volume":"17","author":"SL Broer","year":"2011","unstructured":"Broer SL, D\u00f3lleman M, Opmeer BC, Fauser BC, Mol BW, Broekmans FJ. AMH and AFC as predictors of excessive response in controlled ovarian hyperstimulation: a meta-analysis. Hum Reprod Update. 2011;17(1):46\u201354. https:\/\/doi.org\/10.1093\/humupd\/dmq034.","journal-title":"Hum Reprod Update."},{"issue":"1","key":"3293_CR15","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1016\/j.rbmo.2021.07.016","volume":"44","author":"Y Hao","year":"2022","unstructured":"Hao Y, Long X, Kong F, et al. Maternal and neonatal outcomes following blastocyst biopsy for PGT in single vitrified-warmed embryo transfer cycles. Reprod Biomed Online. 2022;44(1):151\u201362. https:\/\/doi.org\/10.1016\/j.rbmo.2021.07.016.","journal-title":"Reprod Biomed Online."},{"issue":"6","key":"3293_CR16","doi-asserted-by":"publisher","first-page":"1175","DOI":"10.1016\/s0015-0282(01)02888-6","volume":"76","author":"DK Gardner","year":"2001","unstructured":"Gardner DK, Lane M, Stevens J, Schoolcraft WB. Noninvasive assessment of human embryo nutrient consumption as a measure of developmental potential. Fertil Steril. 2001;76(6):1175\u201380. https:\/\/doi.org\/10.1016\/s0015-0282(01)02888-6.","journal-title":"Fertil Steril."},{"key":"3293_CR17","doi-asserted-by":"publisher","first-page":"1532","DOI":"10.1016\/j.fertnstert.2016.01.040","volume":"105","author":"J Huang","year":"2016","unstructured":"Huang J, Yan L, Lu S, Zhao N, Xie XS, Qiao J. Validation of a next-generation sequencing-based protocol for 24-chromosome aneuploidy screening of blastocysts. Fertil Steril. 2016;105:1532\u20136. https:\/\/doi.org\/10.1016\/j.fertnstert.2016.01.040.","journal-title":"Fertil Steril."},{"key":"3293_CR18","doi-asserted-by":"publisher","unstructured":"Yan L, Huang L, Xu L, Huang J, Ma F, Zhu X, Tang Y, Liu M, Lian Y, Liu P, Li R, Lu S, Tang F, Qiao J, Xie XS. Live births after simultaneous avoidance of monogenic diseases and chromosome abnormality by next-generation sequencing with linkage analyses. Proc Natl Acad Sci U. S. A. 2015;112:15964\u20139. https:\/\/doi.org\/10.1073\/pnas.1523297113.","DOI":"10.1073\/pnas.1523297113"},{"key":"3293_CR19","doi-asserted-by":"publisher","first-page":"1155","DOI":"10.1016\/s0015-0282(00)00518-5","volume":"73","author":"DK Gardner","year":"2000","unstructured":"Gardner DK, Lane M, Stevens J, Schlenker T, Schoolcraft WB. Blastocyst score affects implantation and pregnancy outcome: towards a single blastocyst transfer. Fertil Steril. 2000;73:1155\u20138. https:\/\/doi.org\/10.1016\/s0015-0282(00)00518-5.","journal-title":"Fertil Steril."},{"key":"3293_CR20","doi-asserted-by":"publisher","unstructured":"Poseidon Group (Patient-Oriented Strategies Encompassing IndividualizeD Oocyte Number), Alviggi C, Andersen CY, Buehler K, Conforti A, De Placido G, Esteves SC, Fischer R, Galliano D, Polyzos NP, Sunkara SK, Ubaldi FM, Humaidan P. A new more detailed stratification of low responders to ovarian stimulation: from a poor ovarian response to a low prognosis concept. Fertil Steril. 2016;105:1452\u20133. https:\/\/doi.org\/10.1016\/j.fertnstert.2016.02.005.","DOI":"10.1016\/j.fertnstert.2016.02.005"},{"key":"3293_CR21","doi-asserted-by":"publisher","unstructured":"Ben-Arie A, Weissman A, Shoham Z. Ovarian hyperstimulation: effects of GnRH analogues. Triggering the final stage of ovulation using gonadotrophin-releasing hormone analogues: effective dose, prevention of ovarian hyperstimulation syndrome and the luteal phase. Hum Reprod. 1996;11:1146\u20138. https:\/\/doi.org\/10.1093\/oxfordjournals.humrep.a019341.","DOI":"10.1093\/oxfordjournals.humrep.a019341"},{"key":"3293_CR22","doi-asserted-by":"publisher","first-page":"593","DOI":"10.1210\/er.2017-00236","volume":"39","author":"A Abbara","year":"2018","unstructured":"Abbara A, Clarke SA, Dhillo WS. Novel concepts for inducing final oocyte maturation in in vitro fertilization treatment. Endocr Rev. 2018;39:593\u2013628. https:\/\/doi.org\/10.1210\/er.2017-00236.","journal-title":"Endocr Rev."},{"key":"3293_CR23","doi-asserted-by":"publisher","first-page":"653","DOI":"10.1016\/j.fertnstert.2016.06.002","volume":"106","author":"J Haas","year":"2016","unstructured":"Haas J, Ophir L, Barzilay E, Machtinger R, Yung Y, Orvieto R, Hourvitz A. Standard human chorionic gonadotropin versus double trigger for final oocyte maturation results in different granulosa cells gene expressions: a pilot study. Fertil Steril. 2016;106:653-9.e1. https:\/\/doi.org\/10.1016\/j.fertnstert.2016.06.002.","journal-title":"Fertil Steril."},{"key":"3293_CR24","doi-asserted-by":"publisher","first-page":"405","DOI":"10.1016\/j.fertnstert.2014.04.028","volume":"102","author":"D Griffin","year":"2014","unstructured":"Griffin D, Feinn R, Engmann L, Nulsen J, Budinetz T, Benadiva C. Dual trigger with gonadotropin-releasing hormone agonist and standard dose human chorionic gonadotropin to improve oocyte maturity rates. Fertil Steril. 2014;102:405\u20139. https:\/\/doi.org\/10.1016\/j.fertnstert.2014.04.028.","journal-title":"Fertil Steril."},{"key":"3293_CR25","doi-asserted-by":"publisher","first-page":"78","DOI":"10.1186\/s12958-021-00766-5","volume":"19","author":"KL Hu","year":"2021","unstructured":"Hu KL, Wang S, Ye X, Zhang D, Hunt S. GnRH agonist and hCG (dual trigger) versus hCG trigger for follicular maturation: a systematic review and meta-analysis of randomized trials. Reprod Biol Endocrinol. 2021;19:78. https:\/\/doi.org\/10.1186\/s12958-021-00766-5.","journal-title":"Reprod Biol Endocrinol."},{"key":"3293_CR26","doi-asserted-by":"publisher","unstructured":"Ferraretti AP, La Marca A, Fauser BC, Tarlatzis B, Nargund G, Gianaroli L, ESHRE working group on Poor Ovarian Response Definition. ESHRE consensus on the definition of \u2018poor response\u2019 to ovarian stimulation for in vitro fertilization: the Bologna criteria. Hum Reprod. 2011;26:1616\u201324. https:\/\/doi.org\/10.1093\/humrep\/der092.","DOI":"10.1093\/humrep\/der092"},{"key":"3293_CR27","doi-asserted-by":"publisher","first-page":"213","DOI":"10.1080\/09513590.2021.2000962","volume":"38","author":"A Sloth","year":"2022","unstructured":"Sloth A, Kj\u00f8lhede M, Sarmon KG, Knudsen UB. Effect of dual trigger on reproductive outcome in low responders: a systematic PRISMA review and meta-analysis. Gynecol Endocrinol. 2022;38:213\u201321. https:\/\/doi.org\/10.1080\/09513590.2021.2000962.","journal-title":"Gynecol Endocrinol."},{"key":"3293_CR28","doi-asserted-by":"publisher","first-page":"98","DOI":"10.4274\/jtgga.2017.0045","volume":"19","author":"A Eser","year":"2018","unstructured":"Eser A, Devrano\u011flu B, Bostanc\u0131 Ergen E, Yayla Abide \u00c7. Dual trigger with gonadotropin-releasing hormone and human chorionic gonadotropin for poor responders. J Turk Ger Gynecol Assoc. 2018;19:98\u2013103. https:\/\/doi.org\/10.4274\/jtgga.2017.0045.","journal-title":"J Turk Ger Gynecol Assoc."},{"key":"3293_CR29","doi-asserted-by":"publisher","first-page":"628","DOI":"10.1080\/09513590.2019.1576621","volume":"35","author":"J Haas","year":"2019","unstructured":"Haas J, Zilberberg E, Nahum R, Mor Sason A, Hourvitz A, Gat I, Orvieto R. Does double trigger (GnRH-agonist + hCG) improve outcome in poor responders undergoing IVF-ET cycle? A pilot study Gynecol Endocrinol. 2019;35:628\u201330. https:\/\/doi.org\/10.1080\/09513590.2019.1576621.","journal-title":"A pilot study. Gynecol Endocrinol."},{"key":"3293_CR30","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1186\/s12958-018-0451-x","volume":"17","author":"MH Lin","year":"2019","unstructured":"Lin MH, Wu FS, Hwu YM, Lee RK, Li RS, Li SH. Dual trigger with gonadotropin releasing hormone agonist and human chorionic gonadotropin significantly improves live birth rate for women with diminished ovarian reserve. Reprod Biol Endocrinol. 2019;17:7. https:\/\/doi.org\/10.1186\/s12958-018-0451-x.","journal-title":"Reprod Biol Endocrinol."},{"key":"3293_CR31","doi-asserted-by":"publisher","first-page":"1795","DOI":"10.1093\/humrep\/deac114","volume":"37","author":"C Zhou","year":"2022","unstructured":"Zhou C, Yang X, Wang Y, Xi J, Pan H, Wang M, Zhou Y, Xiao Y. Ovulation triggering with hCG alone, GnRH agonist alone or in combination? A randomized controlled trial in advanced-age women undergoing IVF\/ICSI cycles. Hum Reprod. 2022;37:1795\u2013805. https:\/\/doi.org\/10.1093\/humrep\/deac114.","journal-title":"Hum Reprod."},{"key":"3293_CR32","first-page":"63","volume":"59","author":"CH Kim","year":"2014","unstructured":"Kim CH, Ahn JW, You RM, Kim SH, Chae HD, Kang BM. Combined administration of gonadotropin-releasing hormone agonist with human chorionic gonadotropin for final oocyte maturation in GnRH antagonist cycles for in vitro fertilization. J Reprod Med. 2014;59:63\u20138.","journal-title":"J Reprod Med."},{"key":"3293_CR33","doi-asserted-by":"publisher","first-page":"1087","DOI":"10.1016\/j.fertnstert.2007.07.1316","volume":"90","author":"M Schachter","year":"2008","unstructured":"Schachter M, Friedler S, Ron-El R, Zimmerman AL, Strassburger D, Bern O, Raziel A. Can pregnancy rate be improved in gonadotropin-releasing hormone (GnRH) antagonist cycles by administering GnRH agonist before oocyte retrieval? A prospective, randomized study. Fertil Steril. 2008;90:1087\u201393. https:\/\/doi.org\/10.1016\/j.fertnstert.2007.07.1316.","journal-title":"Fertil Steril."}],"container-title":["Journal of Assisted Reproduction and Genetics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10815-024-03293-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10815-024-03293-5\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10815-024-03293-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,8]],"date-time":"2025-01-08T01:05:35Z","timestamp":1736298335000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10815-024-03293-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,11,16]]},"references-count":33,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2024,12]]}},"alternative-id":["3293"],"URL":"https:\/\/doi.org\/10.1007\/s10815-024-03293-5","relation":{},"ISSN":["1058-0468","1573-7330"],"issn-type":[{"value":"1058-0468","type":"print"},{"value":"1573-7330","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,11,16]]},"assertion":[{"value":"20 March 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 October 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 November 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The study was approved by the Peking University Third Hospital Medical Science Research Ethics Committee (approval no. IRB00006761-M2022305).","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}},{"value":"Approval for a waiver for written consent was obtained from the Peking University Third Hospital Medical Science Research Ethics Committee due to the retrospective design of this study.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participate"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}