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Endpoints included pregnancy loss, total pregnancy, clinical pregnancy rate (CPR), ongoing pregnancy rate\/live birth rate (OPR), and the incidence of chronic endometritis (CE).<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results<\/jats:title>\n            <jats:p>Women in case and control groups had similar characteristics, such as age, body mass index, and parity. Overall total pregnancy rate was 82.43% following single euploid embryo transfer in cases compared to 85.7% in controls (<jats:italic>p<\/jats:italic>\u2009=\u20090.57; OR\u2009=\u20091.27; 95% CI\u2009=\u20090.565 to 2.78). CPR was 73.3% and 76.2% (<jats:italic>p<\/jats:italic>\u2009=\u20090.62; OR\u2009=\u20091.18; 95% CI\u2009=\u20090.594 to 2.29), and OPR between groups was 64.8% and 72.3% (<jats:italic>p<\/jats:italic>\u2009=\u20090.28; OR\u2009=\u20091.42; 95% CI\u2009=\u20090.74 to 2.7). First trimester loss rate was similar at 16.9%% and 15.5%%, respectively (<jats:italic>p<\/jats:italic>\u2009=\u20090.82). Subjects who underwent scratching closer to their frozen embryo transfer (\u2264\u20093\u00a0months) had a similar overall pregnancy rate to those with a longer delay between retrieval and frozen embryo transfer (&gt;\u20093\u00a0months 81.4% vs.87.5%; <jats:italic>p<\/jats:italic>\u2009=\u20090.56). CE incidence was 10.8% (8 out of 74; 95% CI\u2009=\u20095.5% to 19.9%). The odds of having a second trimester loss were significantly higher in the scratch group compared to controls (<jats:italic>p<\/jats:italic>\u2009=\u20090.03; OR\u2009=\u2009infinity; 95% CI\u2009=\u20091.3 to infinity).<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p>Endometrial scratching before frozen euploid embryo transfer did not influence pregnancy outcome but increased the chances of second trimester loss. CE was a frequent finding in those undergoing endometrial scratching at the time of retrieval.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1007\/s10815-024-03360-x","type":"journal-article","created":{"date-parts":[[2025,1,17]],"date-time":"2025-01-17T13:17:24Z","timestamp":1737119844000},"page":"781-789","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Endometrial scratching before euploid embryo transfer: a case\u2013control study"],"prefix":"10.1007","volume":"42","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2074-6913","authenticated-orcid":false,"given":"Sophia M. 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