{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,27]],"date-time":"2026-03-27T02:46:08Z","timestamp":1774579568851,"version":"3.50.1"},"reference-count":19,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2025,1,3]],"date-time":"2025-01-03T00:00:00Z","timestamp":1735862400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,1,3]],"date-time":"2025-01-03T00:00:00Z","timestamp":1735862400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Assist Reprod Genet"],"published-print":{"date-parts":[[2025,2]]},"DOI":"10.1007\/s10815-024-03371-8","type":"journal-article","created":{"date-parts":[[2025,1,3]],"date-time":"2025-01-03T03:58:20Z","timestamp":1735876700000},"page":"541-544","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Treatment with 5-MTHF to support the one-carbon cycle can overcome the deleterious impact of a triple SNP mutation in the male partner\u2019s MTHFR gene for a couple with a history of repeated miscarriage"],"prefix":"10.1007","volume":"42","author":[{"given":"Geraldine","family":"Viot","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2425-3953","authenticated-orcid":false,"given":"Arthur","family":"Clement","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8449-1035","authenticated-orcid":false,"given":"Patrice","family":"Clement","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3510-8268","authenticated-orcid":false,"given":"Kay","family":"Elder","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6861-8905","authenticated-orcid":false,"given":"Yves Jean Remi","family":"Menezo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,1,3]]},"reference":[{"key":"3371_CR1","first-page":"193","volume":"16","author":"SS Tara","year":"2015","unstructured":"Tara SS, Ghaemimanesh F, Zarei S, Reihani-Sabet F, Pahlevanzadeh Z, et al. Methylenetetrahydrofolate reductase C677T and A1298C polymorphisms in male partners of recurrent miscarriages couples. J Reprod Infertil. 2015;16:193\u20138.","journal-title":"J Reprod Infertil"},{"key":"3371_CR2","doi-asserted-by":"publisher","first-page":"e13998","DOI":"10.1097\/MD.0000000000013998","volume":"98","author":"Y Yu","year":"2019","unstructured":"Yu Y, Jia C, Shi Q, Zhu Y, Liu Y. Hyperhomocysteinemia in men with a reproductive history of fetal neural tube defects: three case reports and literature review. Medicine. 2019;98:e13998.","journal-title":"Medicine"},{"key":"3371_CR3","doi-asserted-by":"publisher","first-page":"6301","DOI":"10.1093\/hmg\/ddv338","volume":"24","author":"M El Aarabi","year":"2015","unstructured":"El Aarabi M, San Gabriel MC, Chan D, Behan NA, et al. High-dose folic acid supplementation alters the human sperm methylome and is influenced by the MTHFR C677T polymorphism. Hum Mol Genet. 2015;24:6301\u201313.","journal-title":"Hum Mol Genet"},{"issue":"7","key":"3371_CR4","doi-asserted-by":"publisher","first-page":"461","DOI":"10.1093\/molehr\/gax029","volume":"23","author":"L Ly","year":"2017","unstructured":"Ly L, Chan D, Aarabi M, Landry M, Behan NA, MacFarlane AJ, Trasler J. Intergenerational impact of paternal lifetime exposures to both folic acid deficiency and supplementation on reproductive outcomes and imprinted gene methylation. Mol Hum Reprod. 2017;23(7):461\u201377.","journal-title":"Mol Hum Reprod"},{"key":"3371_CR5","doi-asserted-by":"publisher","first-page":"15424","DOI":"10.1073\/pnas.0902072106","volume":"10","author":"S Bailey","year":"2009","unstructured":"Bailey S, Aylin JE. The extremely slow and variable activity of dihydrofolate reductase in human liver and its implications for high folic acid intake. Proc Natl Acad Sci USA. 2009;10:15424\u20139.","journal-title":"Proc Natl Acad Sci USA"},{"key":"3371_CR6","doi-asserted-by":"publisher","first-page":"1184","DOI":"10.2174\/138920012802850137","volume":"13","author":"R Obeid","year":"2012","unstructured":"Obeid R, Herrmann W. The emerging role of unmetabolized folic acid in human diseases: myth or reality? Curr Drug Metab. 2012;13:1184\u201395.","journal-title":"Curr Drug Metab"},{"key":"3371_CR7","doi-asserted-by":"publisher","first-page":"e14400","DOI":"10.1111\/and.14400","volume":"54","author":"Y Menezo","year":"2022","unstructured":"Menezo Y, Clement P, Elder K. Are UMFA (un-metabolized folic acid) and endocrine disruptor chemicals (EDCs) co-responsible for sperm degradation? An epigenetic\/methylation perspective. Andrologia. 2022;54:e14400.","journal-title":"Andrologia"},{"key":"3371_CR8","doi-asserted-by":"crossref","unstructured":"Guo X, Zhang F, Hao G. Causal relationship between folic acid and prostate cancer risk: insights from Mendelian randomization analysis. Int J Urol. 2024;31:1356\u201364.","DOI":"10.1111\/iju.15565"},{"key":"3371_CR9","doi-asserted-by":"publisher","first-page":"197","DOI":"10.3390\/biom12020197","volume":"12","author":"Y Menezo","year":"2022","unstructured":"Menezo Y, Elder K, Clement A, Clement P. Folic acid, folinic acid, 5 methyl tetrahydrofolate supplementation for mutations that affect epigenesis through the folate and one-carbon cycles. Biomolecules. 2022;12:197.","journal-title":"Biomolecules"},{"key":"3371_CR10","doi-asserted-by":"publisher","first-page":"4096","DOI":"10.1038\/s41598-018-22191-2","volume":"8","author":"SW Bailey","year":"2018","unstructured":"Bailey SW, Ayling JE. The pharmacokinetic advantage of 5-methyltetrahydrofolate for minimization of the risk for birth defects. Sci Rep. 2018;8:4096.","journal-title":"Sci Rep"},{"key":"3371_CR11","doi-asserted-by":"publisher","first-page":"4699","DOI":"10.3390\/nu15214699","volume":"15","author":"AM Fardous","year":"2023","unstructured":"Fardous AM, Heydari AR. Uncovering the hidden dangers and molecular mechanisms of excess folate: a narrative review. Nutrients. 2023;15:4699.","journal-title":"Nutrients"},{"key":"3371_CR12","doi-asserted-by":"publisher","first-page":"345","DOI":"10.26502\/acbr.50170349","volume":"7","author":"A Clement","year":"2023","unstructured":"Clement A, Alvarez S, Jacquesson-Fournols L, Amar E, Brami C, et al. Women are more protected than men against HHcy (hyperhomocysteinemia) during their reproductive life: gener-related differences in one-carbon and folates cycles metabolism. Arch Clin Biomed Res. 2023;7:345\u201352.","journal-title":"Arch Clin Biomed Res"},{"key":"3371_CR13","doi-asserted-by":"publisher","first-page":"1933","DOI":"10.1007\/s10815-023-02847-3","volume":"40","author":"T Kucuk","year":"2023","unstructured":"Kucuk T, Horozal PE, Karakulak A, Timucin E, Dattilo M. Follicular homocysteine as a marker of oocyte quality in PCOS and the role of micronutrients. J Assist Reprod Genet. 2023;40:1933\u201341.","journal-title":"J Assist Reprod Genet"},{"issue":"5","key":"3371_CR14","doi-asserted-by":"publisher","first-page":"1229997","DOI":"10.3389\/frph.2023.1229997","volume":"29","author":"A Clement","year":"2023","unstructured":"Clement A, Amar E, Clement P, Sedbon \u00c9, Brami C, et al. Hyperhomocysteinemia in hypofertile male patients can be alleviated by supplementation with 5MTHF associated with one carbon cycle support. Front Reprod Health. 2023;29(5):1229997.","journal-title":"Front Reprod Health"},{"key":"3371_CR15","doi-asserted-by":"publisher","first-page":"1431","DOI":"10.1007\/s10815-018-1225-2","volume":"35","author":"EJ Servy","year":"2018","unstructured":"Servy EJ, Jacquesson-Fournols L, Cohen M, Menezo YJR. MTHFR isoform carriers. 5-MTHF (5-methyl tetrahydrofolate) vs folic acid: a key to pregnancy outcome: a case series. Assist Reprod Genet. 2018;35:1431\u20135.","journal-title":"Assist Reprod Genet"},{"key":"3371_CR16","doi-asserted-by":"publisher","first-page":"1351","DOI":"10.1007\/s10815-019-01488-9","volume":"36","author":"L Jacquesson-Fournols","year":"2019","unstructured":"Jacquesson-Fournols L, Alvarez S, Cohen M, et al. A paternal effect of MTHFR SNPs on gametes and embryos should not be overlooked: case reports. J Assist Reprod Genet. 2019;36:1351\u20133.","journal-title":"J Assist Reprod Genet"},{"key":"3371_CR17","doi-asserted-by":"publisher","first-page":"e0216790","DOI":"10.1371\/journal.pone.0216790","volume":"14","author":"B Troesch","year":"2014","unstructured":"Troesch B, Demmelmair J, Gimpfl M, Hecht C, Lakovic G, MEFOLIN study group, et al. Suitability and safety of L-5- methyltetrahydrofolate as a folate source in infant formula: a randomized-controlled trial. PLoS ONE. 2014;14:e0216790.","journal-title":"PLoS ONE"},{"key":"3371_CR18","doi-asserted-by":"publisher","first-page":"20629","DOI":"10.1038\/s41598-022-25083-8","volume":"12","author":"A Golestanfar","year":"2022","unstructured":"Golestanfar A, Niasari-Naslaji A, Jafarpour F, Rouhollahi S, Rezaei N, Menezo Y, et al. Metabolic enhancement of the one carbon metabolism (OCM) in bovine oocytes IVM increases the blastocyst rate: evidences for a OCM checkpoint. Sci Rep. 2022;12:20629.","journal-title":"Sci Rep"},{"key":"3371_CR19","doi-asserted-by":"publisher","first-page":"848","DOI":"10.1002\/jimd.12504","volume":"45","author":"M Yverneau","year":"2022","unstructured":"Yverneau M, Leroux S, Imbard A, Gleich F, Arion A, et al. HOD consortium influence of early identification and therapy on long-term outcomes in early-onset MTHFR deficiency. J Inherit Metab Dis. 2022;45:848\u201361.","journal-title":"J Inherit Metab Dis"}],"container-title":["Journal of Assisted Reproduction and Genetics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10815-024-03371-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10815-024-03371-8\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10815-024-03371-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,28]],"date-time":"2025-02-28T13:42:33Z","timestamp":1740750153000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10815-024-03371-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1,3]]},"references-count":19,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2025,2]]}},"alternative-id":["3371"],"URL":"https:\/\/doi.org\/10.1007\/s10815-024-03371-8","relation":{},"ISSN":["1058-0468","1573-7330"],"issn-type":[{"value":"1058-0468","type":"print"},{"value":"1573-7330","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,1,3]]},"assertion":[{"value":"11 October 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 December 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 January 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}