{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,12]],"date-time":"2026-06-12T15:53:50Z","timestamp":1781279630944,"version":"3.54.1"},"reference-count":20,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2025,2,3]],"date-time":"2025-02-03T00:00:00Z","timestamp":1738540800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2025,2,3]],"date-time":"2025-02-03T00:00:00Z","timestamp":1738540800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100004375","name":"Tel Aviv University","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100004375","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Assist Reprod Genet"],"published-print":{"date-parts":[[2025,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n          <jats:sec>\n            <jats:title>Purpose<\/jats:title>\n            <jats:p>To assess the long-term outcomes of MR-guided focused ultrasound (MRgFUS) for treating uterine fibroids, focusing on re-intervention rates, pregnancy outcomes, and the onset of menopause over a 7-year follow-up period.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Materials and Methods<\/jats:title>\n            <jats:p>We conducted a historical cohort study of 99 women with symptomatic uterine fibroids who underwent MRgFUS between 2013 and 2020 at a single tertiary medical center. Data collection included patient demographics, treatment details, and follow-up interviews. Re-intervention rates were evaluated using Kaplan\u2013Meier curves and Cox regression analysis to identify predictors of further treatments, with a specific focus on age-related differences.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results<\/jats:title>\n            <jats:p>Over a median follow-up of 6.1\u00a0years, 33.1% of women required re-intervention for persistent fibroid symptoms. The median patient's age was 43\u00a0years old. Women aged\u2009\u2264\u200943\u00a0years had significantly higher re-intervention rates than those aged 44\u2009+\u2009years (47.5% vs. 16.7%, p\u2009=\u20090.005). Multivariable Cox regression identified age as the sole significant predictor of re-intervention (HR<jats:sub>44+vs. &lt;43<\/jats:sub> 0.303 95% CI 0.128\u20130.714, p\u2009=\u20090.006). Sixteen women conceived after MRgFUS, resulting in 21 pregnancies, with 72.2% live births and a spontaneous miscarriage rate of 22.2%. The mean age of menopause was 51.4\u00a0years, similar to global averages.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p>MRgFUS is a practical, noninvasive option for treating symptomatic uterine fibroids. Older women show lower re-intervention rates. Pregnancies post-MRgFUS are possible, and the procedure does not appear to affect the onset of menopause. Age remains a crucial predictor for further re-intervention.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1007\/s10815-025-03405-9","type":"journal-article","created":{"date-parts":[[2025,2,3]],"date-time":"2025-02-03T10:10:57Z","timestamp":1738577457000},"page":"1191-1196","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Long-term outcomes and re-intervention rates in women undergoing mri-guided focused ultrasound (mrgfus) for uterine fibroids: a 7-year follow-up study"],"prefix":"10.1007","volume":"42","author":[{"given":"Yael","family":"Inbar","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaron","family":"Rabinovici","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachael","family":"Sverdlove","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomer","family":"Ziv-Baran","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7758-9683","authenticated-orcid":false,"given":"Ronit","family":"Machtinger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,2,3]]},"reference":[{"issue":"10","key":"3405_CR1","first-page":"e47956","volume":"15","author":"U Lahoti","year":"2023","unstructured":"Lahoti U, et al. Exploring the landscape of social egg freezing: navigating medical advancements, ethical dilemmas, and societal impacts. Cureus. 2023;15(10):e47956.","journal-title":"Cureus"},{"issue":"1","key":"3405_CR2","doi-asserted-by":"publisher","first-page":"916","DOI":"10.1186\/s12889-023-15765-x","volume":"23","author":"Z Lou","year":"2023","unstructured":"Lou Z, et al. Global, regional, and national time trends in incidence, prevalence, years lived with disability for uterine fibroids, 1990\u20132019: an age-period-cohort analysis for the global burden of disease 2019 study. BMC Public Health. 2023;23(1):916.","journal-title":"BMC Public Health"},{"issue":"10","key":"3405_CR3","doi-asserted-by":"publisher","first-page":"1501","DOI":"10.1111\/1471-0528.14640","volume":"124","author":"EA Stewart","year":"2017","unstructured":"Stewart EA, et al. Epidemiology of uterine fibroids: a systematic review. 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