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This study evaluates whether switching sperm donors impacts the number of IUI cycles required to achieve pregnancy.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods<\/jats:title>\n            <jats:p>This retrospective cohort study analyzed 312 women undergoing donor sperm IUI at Lis Maternity Hospital, Tel Aviv Sourasky Medical Center, from 1992 to 2020. Participants were divided into two groups: Group A (conceived using only\u00a0one donor) and Group B (switched donors after initial unsuccessful attempts). The primary outcome was the number of IUI cycles until pregnancy. Statistical analyses included <jats:italic>t<\/jats:italic>-tests, ANOVA, and multivariate analysis of covariance (MANCOVA).<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results<\/jats:title>\n            <jats:p>Women in Group A required fewer cycles (mean 3.78\u2009\u00b1\u20091.90) to achieve pregnancy compared to Group B (mean 6.07\u2009\u00b1\u20092.95, <jats:italic>P<\/jats:italic>\u2009&lt;\u2009.001). However, after switching donors, the mean number of cycles needed in Group B (2.23\u2009\u00b1\u20091.61) was significantly lower than the total cycles required by Group A (<jats:italic>P<\/jats:italic>\u2009&lt;\u2009.001). Cumulative live birth rates were higher in Group A (50.5% after three cycles; 81.5% after six cycles) compared to Group B (26.0% after three cycles; 61.9% after six cycles).<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusion<\/jats:title>\n            <jats:p>Switching sperm donors after repeated unsuccessful IUI attempts significantly reduces the additional number of cycles needed to achieve pregnancy. These findings suggest that sperm-oocyte compatibility may influence IUI success. Clinicians should consider donor replacement after multiple failures. Prospective studies are required to confirm these results and investigate underlying biological mechanisms.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1007\/s10815-025-03464-y","type":"journal-article","created":{"date-parts":[[2025,4,2]],"date-time":"2025-04-02T21:43:52Z","timestamp":1743630232000},"page":"1257-1263","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Changing sperm donors\u2014a shortcut to pregnancy or just a myth?"],"prefix":"10.1007","volume":"42","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6553-0350","authenticated-orcid":false,"given":"Shimi","family":"Barda","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yael","family":"Eliner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Noga Fuchs","family":"Weizman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hadar","family":"Amir","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sandra E.","family":"Kleiman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Foad","family":"Azem","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ron","family":"Hauser","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,3,31]]},"reference":[{"issue":"2","key":"3464_CR1","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1093\/humrep\/13.suppl_2.55","volume":"13","author":"JK Critser","year":"1998","unstructured":"Critser JK. 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