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M\u00f8llerske St\u00f8ttefond","doi-asserted-by":"publisher","award":["18-L-0173"],"award-info":[{"award-number":["18-L-0173"]}],"id":[{"id":"10.13039\/100020035","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009618","name":"Sundhed, Region Midtjylland","doi-asserted-by":"publisher","award":["421506"],"award-info":[{"award-number":["421506"]}],"id":[{"id":"10.13039\/501100009618","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007605","name":"Aarhus Universitet","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100007605","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Assist Reprod Genet"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>To investigate baseline parameters and vaginal intimate hygiene habits comparing IVF patients with and without vaginal dysbiosis, a cross-sectional study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Patients were grouped by the presence of vaginal dysbiosis status determined by a qPCR method (high quantities of\n                      <jats:italic>Gardnerella<\/jats:italic>\n                      spp. and\/or\n                      <jats:italic>Fannyhessea vaginae<\/jats:italic>\n                      ) and a 16S rRNA gene sequencing-based method (VALENCIA). Patients were asked to fill out a questionnaire alongside an interview with healthcare personnel. Prevalence ratios (PR) were computed in case of statistically significant findings between groups.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Among 1511 patients, the prevalence of vaginal dysbiosis by qPCR was 34%, and the prevalence of community state type IV was 32%. Prevalence of vaginal dysbiosis was higher with increasing BMI, BMI 25\u201330 (PR 1.23 (95% CI 1.05\u20131.44) and BMI\u2009&gt;\u200930 (PR 1.50 (1.24\u20131.82). Fishy odor was reported relatively rarely, but vaginal dysbiosis was significantly more prevalent in the presence of fishy odor, PR 1.72 (95% CI 1.39\u20132.11). Finally, vaginal douching was highly prevalent and correlated significantly to vaginal dysbiosis, PR 1.31 (95% CI 1.11\u20131.53). In a sub-study, we interviewed\n                      <jats:italic>N<\/jats:italic>\n                      \u2009=\u200910 women about vaginal douching, and all of them reported the use of douching with the intention to feel clean, thus contradicting general recommendations.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The high prevalence of vaginal dysbiosis in IVF patients is predominantly a subclinical condition which is linked to lifestyle and intimate hygiene habits.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s10815-025-03629-9","type":"journal-article","created":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T01:54:11Z","timestamp":1756691651000},"page":"3443-3452","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Vaginal microbiota correlations to gynecological symptoms, intimate hygiene practices, and background parameters of IVF patients: a cross-sectional study"],"prefix":"10.1007","volume":"42","author":[{"given":"Thor","family":"Haahr","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6904-1252","authenticated-orcid":false,"given":"Sophie","family":"Ovesen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nina","family":"la Cour Freiesleben","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mette Brix","family":"Jensen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helle Olesen","family":"Elbaek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Birgit","family":"Alsbjerg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rita","family":"Laursen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Malene","family":"Tanderup","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisbeth","family":"Pr\u00e6torius","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henriette Svarre","family":"Nielsen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anja","family":"Pinborg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vibeke","family":"Hartvig","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas Roland","family":"Pedersen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00f8rgen Skov","family":"Jensen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Humaidan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,9,1]]},"reference":[{"key":"3629_CR1","doi-asserted-by":"crossref","unstructured":"Maksimovic Celicanin M, Haahr T, Humaidan P, Skafte-Holm A. 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