{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T15:29:21Z","timestamp":1775057361227,"version":"3.50.1"},"reference-count":139,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2025,12,18]],"date-time":"2025-12-18T00:00:00Z","timestamp":1766016000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,12,18]],"date-time":"2025-12-18T00:00:00Z","timestamp":1766016000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82201836"],"award-info":[{"award-number":["82201836"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"He'nan Postdoctoral Science Foundation, He'nan Science and technology foundation","award":["252102311106"],"award-info":[{"award-number":["252102311106"]}]},{"name":"Innovation Central Plains of Henan Association for Science and Technology","award":["2025HYTP093"],"award-info":[{"award-number":["2025HYTP093"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Assist Reprod Genet"],"published-print":{"date-parts":[[2026,2]]},"DOI":"10.1007\/s10815-025-03765-2","type":"journal-article","created":{"date-parts":[[2025,12,18]],"date-time":"2025-12-18T14:51:46Z","timestamp":1766069506000},"page":"367-392","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["The roles of RNA-binding proteins in ovarian aging"],"prefix":"10.1007","volume":"43","author":[{"given":"Hanyue","family":"Zhang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Han","family":"Pan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tianying","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chen","family":"Dou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuan","family":"Geng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jing","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,12,18]]},"reference":[{"issue":"1","key":"3765_CR1","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1016\/j.mce.2008.11.004","volume":"299","author":"A Perheentupa","year":"2009","unstructured":"Perheentupa A, Huhtaniemi I. Aging of the human ovary and testis. Mol Cell Endocrinol. 2009;299(1):2\u201313. https:\/\/doi.org\/10.1016\/j.mce.2008.11.004.","journal-title":"Mol Cell Endocrinol"},{"issue":"1","key":"3765_CR2","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1186\/s13048-023-01151-z","volume":"16","author":"X Wang","year":"2023","unstructured":"Wang X, Wang L, Xiang W. Mechanisms of ovarian aging in women: a review. J Ovarian Res. 2023;16(1):67. https:\/\/doi.org\/10.1186\/s13048-023-01151-z.","journal-title":"J Ovarian Res"},{"issue":"3","key":"3765_CR3","doi-asserted-by":"publisher","first-page":"293","DOI":"10.1016\/j.gde.2006.04.005","volume":"16","author":"D Toniolo","year":"2006","unstructured":"Toniolo D. X-linked premature ovarian failure: a complex disease. Curr Opin Genet Dev. 2006;16(3):293\u2013300. https:\/\/doi.org\/10.1016\/j.gde.2006.04.005.","journal-title":"Curr Opin Genet Dev"},{"issue":"2","key":"3765_CR4","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1093\/humupd\/8.2.141","volume":"8","author":"ER te Velde","year":"2002","unstructured":"te Velde ER, Pearson PL. The variability of female reproductive ageing. Hum Reprod Update. 2002;8(2):141\u201354. https:\/\/doi.org\/10.1093\/humupd\/8.2.141.","journal-title":"Hum Reprod Update"},{"issue":"6","key":"3765_CR5","doi-asserted-by":"publisher","first-page":"725","DOI":"10.1093\/humupd\/dmw028","volume":"22","author":"P May-Panloup","year":"2016","unstructured":"May-Panloup P, Boucret L, de la Chao Barca JM, et al. Ovarian ageing: the role of mitochondria in oocytes and follicles. Hum Reprod Update. 2016;22(6):725\u201343. https:\/\/doi.org\/10.1093\/humupd\/dmw028.","journal-title":"Hum Reprod Update"},{"issue":"1","key":"3765_CR6","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1016\/j.fertnstert.2012.11.031","volume":"99","author":"Y Bentov","year":"2013","unstructured":"Bentov Y, Casper RF. The aging oocyte--can mitochondrial function be improved? Fertil Steril. 2013;99(1):18\u201322. https:\/\/doi.org\/10.1016\/j.fertnstert.2012.11.031.","journal-title":"Fertil Steril"},{"issue":"3","key":"3765_CR7","doi-asserted-by":"publisher","first-page":"911","DOI":"10.1210\/jcem.75.3.1517385","volume":"75","author":"JH Kim","year":"1992","unstructured":"Kim JH, Seibel MM, MacLaughlin DT, et al. The inhibitory effects of M\u00fcllerian-inhibiting substance on epidermal growth factor induced proliferation and progesterone production of human granulosa-luteal cells. J Clin Endocrinol Metab. 1992;75(3):911\u20137. https:\/\/doi.org\/10.1210\/jcem.75.3.1517385.","journal-title":"J Clin Endocrinol Metab"},{"issue":"1","key":"3765_CR8","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1093\/molehr\/gaw070","volume":"23","author":"C Yding Andersen","year":"2017","unstructured":"Yding Andersen C. Inhibin-B secretion and FSH isoform distribution may play an integral part of follicular selection in the natural menstrual cycle. Mol Hum Reprod. 2017;23(1):16\u201324. https:\/\/doi.org\/10.1093\/molehr\/gaw070.","journal-title":"Mol Hum Reprod"},{"issue":"11","key":"3765_CR9","doi-asserted-by":"publisher","first-page":"4025","DOI":"10.1210\/jcem.84.11.6158","volume":"84","author":"HG Burger","year":"1999","unstructured":"Burger HG, Dudley EC, Hopper JL, et al. Prospectively measured levels of serum follicle-stimulating hormone, estradiol, and the dimeric inhibins during the menopausal transition in a population-based cohort of women. J Clin Endocrinol Metab. 1999;84(11):4025\u201330. https:\/\/doi.org\/10.1210\/jcem.84.11.6158.","journal-title":"J Clin Endocrinol Metab"},{"issue":"2","key":"3765_CR10","doi-asserted-by":"publisher","first-page":"357","DOI":"10.1016\/s0015-0282(01)02993-4","volume":"77","author":"A de Vet","year":"2002","unstructured":"de Vet A, Laven JS, de Jong FH, Themmen AP, Fauser BC. Antim\u00fcllerian hormone serum levels: a putative marker for ovarian aging. Fertil Steril. 2002;77(2):357\u201362. https:\/\/doi.org\/10.1016\/s0015-0282(01)02993-4.","journal-title":"Fertil Steril"},{"issue":"9","key":"3765_CR11","doi-asserted-by":"publisher","first-page":"2264","DOI":"10.1093\/humrep\/dep210","volume":"24","author":"A La Marca","year":"2009","unstructured":"La Marca A, Broekmans FJ, Volpe A, Fauser BC, Macklon NS, Table ESIGfRE--AR. Anti-Mullerian hormone (AMH): what do we still need to know? Hum Reprod. 2009;24(9):2264\u201375. https:\/\/doi.org\/10.1093\/humrep\/dep210.","journal-title":"Hum Reprod"},{"issue":"2-3","key":"3765_CR12","doi-asserted-by":"publisher","first-page":"156","DOI":"10.1159\/000532072","volume":"17","author":"J Lopez","year":"2023","unstructured":"Lopez J, Hohensee G, Liang J, Sela M, Johnson J, Kallen AN. The aging ovary and the tales learned since fetal development. Sex Dev. 2023;17(2\u20133):156\u201368. https:\/\/doi.org\/10.1159\/000532072.","journal-title":"Sex Dev"},{"issue":"3","key":"3765_CR13","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1038\/nrc1011","volume":"3","author":"Y Shiloh","year":"2003","unstructured":"Shiloh Y. ATM and related protein kinases: safeguarding genome integrity. Nat Rev Cancer. 2003;3(3):155\u201368. https:\/\/doi.org\/10.1038\/nrc1011.","journal-title":"Nat Rev Cancer"},{"issue":"1","key":"3765_CR14","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1093\/humupd\/dmz043","volume":"26","author":"V Turan","year":"2020","unstructured":"Turan V, Oktay K. BRCA-related ATM-mediated DNA double-strand break repair and ovarian aging. Hum Reprod Update. 2020;26(1):43\u201357. https:\/\/doi.org\/10.1093\/humupd\/dmz043.","journal-title":"Hum Reprod Update"},{"issue":"10","key":"3765_CR15","doi-asserted-by":"publisher","first-page":"749","DOI":"10.1038\/nrc2723","volume":"9","author":"AJ Levine","year":"2009","unstructured":"Levine AJ, Oren M. The first 30 years of p53: growing ever more complex. Nat Rev Cancer. 2009;9(10):749\u201358. https:\/\/doi.org\/10.1038\/nrc2723.","journal-title":"Nat Rev Cancer"},{"issue":"4","key":"3765_CR16","doi-asserted-by":"publisher","first-page":"443","DOI":"10.1177\/1947601911410223","volume":"2","author":"Z Feng","year":"2011","unstructured":"Feng Z, Lin M, Wu R. The regulation of aging and longevity: a new and complex role of p53. Genes Cancer. 2011;2(4):443\u201352. https:\/\/doi.org\/10.1177\/1947601911410223.","journal-title":"Genes Cancer"},{"issue":"1","key":"3765_CR17","doi-asserted-by":"publisher","first-page":"888","DOI":"10.3892\/mmr.2016.5322","volume":"14","author":"L Liang","year":"2016","unstructured":"Liang L, Zhang XH, Ji B, et al. Yifuning postpones ovarian aging through antioxidant mechanisms and suppression of the Rb\/p53 signal transduction pathway. Mol Med Rep. 2016;14(1):888\u201396. https:\/\/doi.org\/10.3892\/mmr.2016.5322.","journal-title":"Mol Med Rep"},{"issue":"1","key":"3765_CR18","doi-asserted-by":"publisher","first-page":"68","DOI":"10.1038\/nrc3181","volume":"12","author":"R Roy","year":"2011","unstructured":"Roy R, Chun J, Powell SN. BRCA1 and BRCA2: different roles in a common pathway of genome protection. Nat Rev Cancer. 2011;12(1):68\u201378. https:\/\/doi.org\/10.1038\/nrc3181.","journal-title":"Nat Rev Cancer"},{"key":"3765_CR19","doi-asserted-by":"publisher","DOI":"10.1016\/j.exger.2020.110975","volume":"138","author":"EG Kosebent","year":"2020","unstructured":"Kosebent EG, Uysal F, Ozturk S. The altered expression of telomerase components and telomere-linked proteins may associate with ovarian aging in mouse. Exp Gerontol. 2020;138: 110975. https:\/\/doi.org\/10.1016\/j.exger.2020.110975.","journal-title":"Exp Gerontol"},{"issue":"6098","key":"3765_CR20","doi-asserted-by":"publisher","first-page":"1062","DOI":"10.1126\/science.1219855","volume":"337","author":"RJ Youle","year":"2012","unstructured":"Youle RJ, van der Bliek AM. Mitochondrial fission, fusion, and stress. Science. 2012;337(6098):1062\u20135. https:\/\/doi.org\/10.1126\/science.1219855.","journal-title":"Science"},{"key":"3765_CR21","doi-asserted-by":"publisher","first-page":"1424826","DOI":"10.3389\/fendo.2024.1424826","volume":"15","author":"S Mani","year":"2024","unstructured":"Mani S, Srivastava V, Shandilya C, Kaushik A, Singh KK. Mitochondria: the epigenetic regulators of ovarian aging and longevity. Front Endocrinol (Lausanne). 2024;15:1424826. https:\/\/doi.org\/10.3389\/fendo.2024.1424826.","journal-title":"Front Endocrinol (Lausanne)"},{"issue":"R2","key":"3765_CR22","doi-asserted-by":"publisher","first-page":"R169","DOI":"10.1093\/hmg\/ddp326","volume":"18","author":"H Chen","year":"2009","unstructured":"Chen H, Chan DC. Mitochondrial dynamics--fusion, fission, movement, and mitophagy--in neurodegenerative diseases. Hum Mol Genet. 2009;18(R2):R169\u201376. https:\/\/doi.org\/10.1093\/hmg\/ddp326.","journal-title":"Hum Mol Genet"},{"issue":"Pt 2","key":"3765_CR23","doi-asserted-by":"publisher","first-page":"511","DOI":"10.1016\/j.freeradbiomed.2022.10.324","volume":"193","author":"J Zhu","year":"2022","unstructured":"Zhu J, Yang Q, Li H, et al. Sirt3 deficiency accelerates ovarian senescence without affecting spermatogenesis in aging mice. Free Radic Biol Med. 2022;193(Pt 2):511\u201325. https:\/\/doi.org\/10.1016\/j.freeradbiomed.2022.10.324.","journal-title":"Free Radic Biol Med"},{"key":"3765_CR24","doi-asserted-by":"publisher","DOI":"10.1016\/j.arr.2020.101168","volume":"63","author":"JL Chiang","year":"2020","unstructured":"Chiang JL, Shukla P, Pagidas K, et al. Mitochondria in ovarian aging and reproductive longevity. Ageing Res Rev. 2020;63: 101168. https:\/\/doi.org\/10.1016\/j.arr.2020.101168.","journal-title":"Ageing Res Rev"},{"issue":"1","key":"3765_CR25","doi-asserted-by":"publisher","first-page":"44","DOI":"10.1016\/j.biocel.2006.07.001","volume":"39","author":"M Valko","year":"2007","unstructured":"Valko M, Leibfritz D, Moncol J, Cronin MT, Mazur M, Telser J. Free radicals and antioxidants in normal physiological functions and human disease. Int J Biochem Cell Biol. 2007;39(1):44\u201384. https:\/\/doi.org\/10.1016\/j.biocel.2006.07.001.","journal-title":"Int J Biochem Cell Biol"},{"issue":"9-10","key":"3765_CR26","doi-asserted-by":"publisher","first-page":"921","DOI":"10.1016\/j.bbagrm.2012.03.002","volume":"1819","author":"CT Campbell","year":"2012","unstructured":"Campbell CT, Kolesar JE, Kaufman BA. Mitochondrial transcription factor A regulates mitochondrial transcription initiation, DNA packaging, and genome copy number. Biochim Biophys Acta. 2012;1819(9\u201310):921\u20139. https:\/\/doi.org\/10.1016\/j.bbagrm.2012.03.002.","journal-title":"Biochim Biophys Acta"},{"issue":"12","key":"3765_CR27","doi-asserted-by":"publisher","first-page":"7966","DOI":"10.1002\/jcp.30468","volume":"236","author":"L Wang","year":"2021","unstructured":"Wang L, Tang J, Wang L, et al. Oxidative stress in oocyte aging and female reproduction. J Cell Physiol. 2021;236(12):7966\u201383. https:\/\/doi.org\/10.1002\/jcp.30468.","journal-title":"J Cell Physiol"},{"issue":"6","key":"3765_CR28","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0039034","volume":"7","author":"D Adhikari","year":"2012","unstructured":"Adhikari D, Gorre N, Risal S, et al. The safe use of a PTEN inhibitor for the activation of dormant mouse primordial follicles and generation of fertilizable eggs. PLoS ONE. 2012;7(6): e39034. https:\/\/doi.org\/10.1371\/journal.pone.0039034.","journal-title":"PLoS ONE"},{"issue":"2","key":"3765_CR29","doi-asserted-by":"publisher","first-page":"87","DOI":"10.14348\/molcells.2016.2318","volume":"39","author":"BL Tang","year":"2016","unstructured":"Tang BL. Sirt1 and the mitochondria. Mol Cells. 2016;39(2):87\u201395. https:\/\/doi.org\/10.14348\/molcells.2016.2318.","journal-title":"Mol Cells"},{"issue":"2","key":"3765_CR30","doi-asserted-by":"publisher","first-page":"611","DOI":"10.1152\/physrev.00025.2007","volume":"88","author":"RC Scarpulla","year":"2008","unstructured":"Scarpulla RC. Transcriptional paradigms in mammalian mitochondrial biogenesis and function. Physiol Rev. 2008;88(2):611\u201338. https:\/\/doi.org\/10.1152\/physrev.00025.2007.","journal-title":"Physiol Rev"},{"issue":"18","key":"3765_CR31","doi-asserted-by":"publisher","first-page":"1895","DOI":"10.1101\/gad.17420111","volume":"25","author":"DG Hardie","year":"2011","unstructured":"Hardie DG. AMP-activated protein kinase: an energy sensor that regulates all aspects of cell function. Genes Dev. 2011;25(18):1895\u2013908. https:\/\/doi.org\/10.1101\/gad.17420111.","journal-title":"Genes Dev"},{"issue":"5","key":"3765_CR32","doi-asserted-by":"publisher","DOI":"10.1016\/j.rbmo.2023.103697","volume":"48","author":"T Zhang","year":"2024","unstructured":"Zhang T, Zhang J, Yang G, et al. Long non-coding RNA PWRN1 affects ovarian follicular development by regulating the function of granulosa cells. Reprod Biomed Online. 2024;48(5): 103697. https:\/\/doi.org\/10.1016\/j.rbmo.2023.103697.","journal-title":"Reprod Biomed Online"},{"issue":"1","key":"3765_CR33","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1016\/j.fertnstert.2012.11.029","volume":"99","author":"C Tatone","year":"2013","unstructured":"Tatone C, Amicarelli F. The aging ovary--the poor granulosa cells. Fertil Steril. 2013;99(1):12\u20137. https:\/\/doi.org\/10.1016\/j.fertnstert.2012.11.029.","journal-title":"Fertil Steril"},{"issue":"3","key":"3765_CR34","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2023.117201","volume":"319","author":"Y Wang","year":"2024","unstructured":"Wang Y, Liang G, Mu W, Sun S, Chen X, Xu X. Bushen Tianjing recipe inhibits human ovarian granulosa cell line KGN apoptosis induced by miR-23a through the regulation of the sirtuin family. J Ethnopharmacol. 2024;319(3): 117201. https:\/\/doi.org\/10.1016\/j.jep.2023.117201.","journal-title":"J Ethnopharmacol"},{"issue":"3","key":"3765_CR35","doi-asserted-by":"publisher","first-page":"215","DOI":"10.1002\/wdev.176","volume":"4","author":"DM Ornitz","year":"2015","unstructured":"Ornitz DM, Itoh N. The fibroblast growth factor signaling pathway. WIREs Dev Biol. 2015;4(3):215\u201366. https:\/\/doi.org\/10.1002\/wdev.176.","journal-title":"WIREs Dev Biol"},{"issue":"10","key":"3765_CR36","doi-asserted-by":"publisher","first-page":"616","DOI":"10.1038\/nrm3434","volume":"13","author":"J Massague","year":"2012","unstructured":"Massague J. TGFbeta signalling in context. Nat Rev Mol Cell Biol. 2012;13(10):616\u201330. https:\/\/doi.org\/10.1038\/nrm3434.","journal-title":"Nat Rev Mol Cell Biol"},{"issue":"1","key":"3765_CR37","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1111\/j.1439-0531.2011.01813.x","volume":"47","author":"J Lin","year":"2012","unstructured":"Lin J, Jia Y, Zeng W, Mi Y, Zhang C. Basic FGF promotes proliferation of ovarian granulosa cells in the laying chickens via FGFR1 and PKC pathway. Reprod Domest Anim. 2012;47(1):135\u201342. https:\/\/doi.org\/10.1111\/j.1439-0531.2011.01813.x.","journal-title":"Reprod Domest Anim"},{"key":"3765_CR38","doi-asserted-by":"publisher","first-page":"50","DOI":"10.1016\/j.theriogenology.2020.11.001","volume":"160","author":"Q Li","year":"2021","unstructured":"Li Q, Du X, Wang L, Shi K, Li Q. TGF-beta1 controls porcine granulosa cell states: a miRNA-mRNA network view. Theriogenology. 2021;160:50\u201360. https:\/\/doi.org\/10.1016\/j.theriogenology.2020.11.001.","journal-title":"Theriogenology"},{"issue":"1","key":"3765_CR39","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1093\/humupd\/dmac031","volume":"29","author":"G Fiorentino","year":"2023","unstructured":"Fiorentino G, Cimadomo D, Innocenti F, et al. Biomechanical forces and signals operating in the ovary during folliculogenesis and their dysregulation: implications for fertility. Hum Reprod Update. 2023;29(1):1\u201323. https:\/\/doi.org\/10.1093\/humupd\/dmac031.","journal-title":"Hum Reprod Update"},{"key":"3765_CR40","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2021.744257","volume":"11","author":"C Sun","year":"2021","unstructured":"Sun C, Yang X, Wang T, Cheng M, Han Y. Ovarian biomechanics: from health to disease. Front Oncol. 2021;11: 744257. https:\/\/doi.org\/10.3389\/fonc.2021.744257.","journal-title":"Front Oncol"},{"issue":"1","key":"3765_CR41","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1186\/s13048-024-01448-7","volume":"17","author":"M Gu","year":"2024","unstructured":"Gu M, Wang Y, Yu Y. Ovarian fibrosis: molecular mechanisms and potential therapeutic targets. J Ovarian Res. 2024;17(1):139. https:\/\/doi.org\/10.1186\/s13048-024-01448-7.","journal-title":"J Ovarian Res"},{"issue":"6","key":"3765_CR42","doi-asserted-by":"publisher","first-page":"913","DOI":"10.1111\/cen.12951","volume":"83","author":"M Liu","year":"2015","unstructured":"Liu M, Gao J, Zhang Y, et al. Serum levels of TSP-1, NF-kappaB and TGF-beta1 in polycystic ovarian syndrome (PCOS) patients in northern China suggest PCOS is associated with chronic inflammation. Clin Endocrinol (Oxf). 2015;83(6):913\u201322. https:\/\/doi.org\/10.1111\/cen.12951.","journal-title":"Clin Endocrinol (Oxf)"},{"issue":"4","key":"3765_CR43","doi-asserted-by":"publisher","first-page":"399","DOI":"10.1139\/y10-009","volume":"88","author":"GM Kidder","year":"2010","unstructured":"Kidder GM, Vanderhyden BC. Bidirectional communication between oocytes and follicle cells: ensuring oocyte developmental competence. Can J Physiol Pharmacol. 2010;88(4):399\u2013413. https:\/\/doi.org\/10.1139\/y10-009.","journal-title":"Can J Physiol Pharmacol"},{"issue":"3","key":"3765_CR44","doi-asserted-by":"publisher","DOI":"10.1002\/biof.70026","volume":"51","author":"S Nikanfar","year":"2025","unstructured":"Nikanfar S, Amorim CA. The potential role of matrix metalloproteinase in polycystic ovary syndrome: implications for extracellular matrix remodeling. BioFactors. 2025;51(3): e70026. https:\/\/doi.org\/10.1002\/biof.70026.","journal-title":"BioFactors"},{"issue":"3","key":"3765_CR45","doi-asserted-by":"publisher","first-page":"221","DOI":"10.1038\/nrm2125","volume":"8","author":"A Page-McCaw","year":"2007","unstructured":"Page-McCaw A, Ewald AJ, Werb Z. Matrix metalloproteinases and the regulation of tissue remodelling. Nat Rev Mol Cell Biol. 2007;8(3):221\u201333. https:\/\/doi.org\/10.1038\/nrm2125.","journal-title":"Nat Rev Mol Cell Biol"},{"issue":"2","key":"3765_CR46","doi-asserted-by":"publisher","first-page":"493","DOI":"10.1007\/s13577-022-00843-w","volume":"36","author":"DRA Sanya","year":"2023","unstructured":"Sanya DRA, Cava C, Onesime D. Roles of RNA-binding proteins in neurological disorders, COVID-19, and cancer. Hum Cell. 2023;36(2):493\u2013514. https:\/\/doi.org\/10.1007\/s13577-022-00843-w.","journal-title":"Hum Cell"},{"issue":"6","key":"3765_CR47","doi-asserted-by":"publisher","first-page":"1654","DOI":"10.1093\/plcell\/koac309","volume":"35","author":"S Marquardt","year":"2023","unstructured":"Marquardt S, Petrillo E, Manavella PA. Cotranscriptional RNA processing and modification in plants. Plant Cell. 2023;35(6):1654\u201370. https:\/\/doi.org\/10.1093\/plcell\/koac309.","journal-title":"Plant Cell"},{"key":"3765_CR48","doi-asserted-by":"publisher","unstructured":"Oksuz O, Henninger JE, Warneford-Thomson R, et al. Transcription factors interact with RNA to regulate genes. Mol Cell. 2023;83(14):2449\u201363.e13. https:\/\/doi.org\/10.1016\/j.molcel.2023.06.012.","DOI":"10.1016\/j.molcel.2023.06.012"},{"key":"3765_CR49","doi-asserted-by":"publisher","unstructured":"Kang D, Lee Y, Lee JS. RNA-binding proteins in cancer: functional and therapeutic perspectives. Cancers (Basel). 2020;12(9). https:\/\/doi.org\/10.3390\/cancers12092699.","DOI":"10.3390\/cancers12092699"},{"issue":"8","key":"3765_CR50","doi-asserted-by":"publisher","first-page":"416","DOI":"10.1016\/j.tig.2008.05.004","volume":"24","author":"KE Lukong","year":"2008","unstructured":"Lukong KE, Chang KW, Khandjian EW, Richard S. RNA-binding proteins in human genetic disease. Trends Genet. 2008;24(8):416\u201325. https:\/\/doi.org\/10.1016\/j.tig.2008.05.004.","journal-title":"Trends Genet"},{"issue":"2","key":"3765_CR51","doi-asserted-by":"publisher","first-page":"748","DOI":"10.1016\/j.semcancer.2022.03.018","volume":"86","author":"S Wang","year":"2022","unstructured":"Wang S, Sun Z, Lei Z, Zhang HT. RNA-binding proteins and cancer metastasis. Semin Cancer Biol. 2022;86(2):748\u201368. https:\/\/doi.org\/10.1016\/j.semcancer.2022.03.018.","journal-title":"Semin Cancer Biol"},{"issue":"3","key":"3765_CR52","doi-asserted-by":"publisher","first-page":"272","DOI":"10.1016\/j.tibs.2019.12.003","volume":"45","author":"X Sabate-Cadenas","year":"2020","unstructured":"Sabate-Cadenas X, Shkumatava A. In-cell discovery of RNA-protein interactions. Trends Biochem Sci. 2020;45(3):272\u20133. https:\/\/doi.org\/10.1016\/j.tibs.2019.12.003.","journal-title":"Trends Biochem Sci"},{"issue":"2","key":"3765_CR53","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1002\/cac2.12254","volume":"42","author":"ZT Yao","year":"2022","unstructured":"Yao ZT, Yang YM, Sun MM, et al. New insights into the interplay between long non-coding RNAs and RNA-binding proteins in cancer. Cancer Commun. 2022;42(2):117\u201340. https:\/\/doi.org\/10.1002\/cac2.12254.","journal-title":"Cancer Commun"},{"key":"3765_CR54","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1146\/annurev-genet-120116-024704","volume":"51","author":"C Mayr","year":"2017","unstructured":"Mayr C. Regulation by 3\u2032-untranslated regions. Annu Rev Genet. 2017;51:171\u201394. https:\/\/doi.org\/10.1146\/annurev-genet-120116-024704.","journal-title":"Annu Rev Genet"},{"issue":"12","key":"3765_CR55","doi-asserted-by":"publisher","first-page":"779","DOI":"10.1038\/s41580-022-00507-5","volume":"23","author":"S Mitschka","year":"2022","unstructured":"Mitschka S, Mayr C. Context-specific regulation and function of mRNA alternative polyadenylation. Nat Rev Mol Cell Biol. 2022;23(12):779\u201396. https:\/\/doi.org\/10.1038\/s41580-022-00507-5.","journal-title":"Nat Rev Mol Cell Biol"},{"issue":"1","key":"3765_CR56","doi-asserted-by":"publisher","first-page":"90","DOI":"10.1186\/s13045-020-00927-w","volume":"13","author":"H Qin","year":"2020","unstructured":"Qin H, Ni H, Liu Y, et al. RNA-binding proteins in tumor progression. J Hematol Oncol. 2020;13(1):90. https:\/\/doi.org\/10.1186\/s13045-020-00927-w.","journal-title":"J Hematol Oncol"},{"issue":"1","key":"3765_CR57","doi-asserted-by":"publisher","first-page":"7","DOI":"10.3322\/caac.21654","volume":"71","author":"RL Siegel","year":"2021","unstructured":"Siegel RL, Miller KD, Fuchs HE, Jemal A. Cancer statistics, 2021. CA Cancer J Clin. 2021;71(1):7\u201333. https:\/\/doi.org\/10.3322\/caac.21654.","journal-title":"CA Cancer J Clin"},{"key":"3765_CR58","doi-asserted-by":"publisher","first-page":"84","DOI":"10.1016\/j.semcancer.2021.03.007","volume":"75","author":"L Li","year":"2021","unstructured":"Li L, Miao H, Chang Y, et al. Multidimensional crosstalk between RNA-binding proteins and noncoding RNAs in cancer biology. Semin Cancer Biol. 2021;75:84\u201396. https:\/\/doi.org\/10.1016\/j.semcancer.2021.03.007.","journal-title":"Semin Cancer Biol"},{"issue":"1","key":"3765_CR59","doi-asserted-by":"publisher","first-page":"36","DOI":"10.1038\/s41420-025-02316-z","volume":"11","author":"S Peng","year":"2025","unstructured":"Peng S, Li C, He Y, Xue L, Guo X. Regulatory roles of RNA binding proteins in the Hippo pathway. Cell Death Discov. 2025;11(1):36. https:\/\/doi.org\/10.1038\/s41420-025-02316-z.","journal-title":"Cell Death Discov"},{"issue":"5","key":"3765_CR60","doi-asserted-by":"publisher","DOI":"10.1002\/wrna.1647","volume":"12","author":"JJD Ho","year":"2021","unstructured":"Ho JJD, Man JHS, Schatz JH, Marsden PA. Translational remodeling by RNA-binding proteins and noncoding RNAs. WIREs RNA. 2021;12(5): e1647. https:\/\/doi.org\/10.1002\/wrna.1647.","journal-title":"WIREs RNA"},{"issue":"20","key":"3765_CR61","doi-asserted-by":"publisher","first-page":"9407","DOI":"10.7150\/thno.48520","volume":"10","author":"Y Wang","year":"2020","unstructured":"Wang Y, Wang Y, Luo W, et al. Roles of long non-coding RNAs and emerging RNA-binding proteins in innate antiviral responses. Theranostics. 2020;10(20):9407\u201324. https:\/\/doi.org\/10.7150\/thno.48520.","journal-title":"Theranostics"},{"key":"3765_CR62","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1016\/j.semcdb.2017.11.026","volume":"81","author":"AK Singh","year":"2018","unstructured":"Singh AK, Aryal B, Zhang X, et al. Posttranscriptional regulation of lipid metabolism by non-coding RNAs and RNA binding proteins. Semin Cell Dev Biol. 2018;81:129\u201340. https:\/\/doi.org\/10.1016\/j.semcdb.2017.11.026.","journal-title":"Semin Cell Dev Biol"},{"issue":"1","key":"3765_CR63","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-021-04374-4","volume":"13","author":"F E","year":"2021","unstructured":"E F, Zhang H, Yin W, et al. CPEB3 deficiency in mice affect ovarian follicle development and causes premature ovarian insufficiency. Cell Death Dis. 2021;13(1): 21. https:\/\/doi.org\/10.1038\/s41419-021-04374-4.","journal-title":"Cell Death Dis"},{"issue":"2","key":"3765_CR64","doi-asserted-by":"publisher","first-page":"275","DOI":"10.1038\/s43587-024-00762-5","volume":"5","author":"C Jin","year":"2025","unstructured":"Jin C, Wang X, Yang J, et al. Molecular and genetic insights into human ovarian aging from single-nuclei multi-omics analyses. Nat Aging. 2025;5(2):275\u201390. https:\/\/doi.org\/10.1038\/s43587-024-00762-5.","journal-title":"Nat Aging"},{"issue":"20","key":"3765_CR65","doi-asserted-by":"publisher","first-page":"2571","DOI":"10.1101\/gad.1593007","volume":"21","author":"JH Kim","year":"2007","unstructured":"Kim JH, Richter JD. RINGO\/cdk1 and CPEB mediate poly(A) tail stabilization and translational regulation by ePAB. Genes Dev. 2007;21(20):2571\u20139. https:\/\/doi.org\/10.1101\/gad.1593007.","journal-title":"Genes Dev"},{"key":"3765_CR66","doi-asserted-by":"publisher","DOI":"10.3390\/cells13100850","author":"L Lamacova","year":"2024","unstructured":"Lamacova L, Jansova D, Jiang Z, et al. CPEB3 maintains developmental competence of the oocyte. Cells. 2024. https:\/\/doi.org\/10.3390\/cells13100850.","journal-title":"Cells"},{"issue":"10","key":"3765_CR67","doi-asserted-by":"publisher","first-page":"1419","DOI":"10.1038\/cr.2012.86","volume":"22","author":"M Simonelig","year":"2012","unstructured":"Simonelig M. PABPN1 shuts down alternative poly(A) sites. Cell Res. 2012;22(10):1419\u201321. https:\/\/doi.org\/10.1038\/cr.2012.86.","journal-title":"Cell Res"},{"issue":"8","key":"3765_CR68","doi-asserted-by":"publisher","first-page":"1599","DOI":"10.1093\/humrep\/deae132","volume":"39","author":"Y Zeng","year":"2024","unstructured":"Zeng Y, Yang C, Shan X, Meng XQ, Zhang M. Unveiling the role of chronic inflammation in ovarian aging: insights into mechanisms and clinical implications. Hum Reprod. 2024;39(8):1599\u2013607. https:\/\/doi.org\/10.1093\/humrep\/deae132.","journal-title":"Hum Reprod"},{"issue":"7","key":"3765_CR69","doi-asserted-by":"publisher","first-page":"1582","DOI":"10.1016\/j.cell.2020.05.012","volume":"181","author":"S Zaccara","year":"2020","unstructured":"Zaccara S, Jaffrey SR. A unified model for the function of YTHDF proteins in regulating m(6)A-modified mRNA. Cell. 2020;181(7):1582-95 e18. https:\/\/doi.org\/10.1016\/j.cell.2020.05.012.","journal-title":"Cell"},{"issue":"6","key":"3765_CR70","doi-asserted-by":"publisher","first-page":"1059","DOI":"10.1016\/j.molcel.2017.08.003","volume":"67","author":"I Ivanova","year":"2017","unstructured":"Ivanova I, Much C, Di Giacomo M, et al. The RNA m6A reader YTHDF2 is essential for the post-transcriptional regulation of the maternal transcriptome and oocyte competence. Mol Cell. 2017;67(6):1059-67.e4. https:\/\/doi.org\/10.1016\/j.molcel.2017.08.003.","journal-title":"Mol Cell"},{"issue":"34","key":"3765_CR71","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.abq2945","volume":"8","author":"B Qian","year":"2022","unstructured":"Qian B, Li Y, Yan R, et al. RNA binding protein RBM46 regulates mitotic-to-meiotic transition in spermatogenesis. Sci Adv. 2022;8(34): eabq2945. https:\/\/doi.org\/10.1126\/sciadv.abq2945.","journal-title":"Sci Adv"},{"issue":"9","key":"3765_CR72","doi-asserted-by":"publisher","first-page":"3592","DOI":"10.7150\/ijbs.69771","volume":"18","author":"J Chen","year":"2022","unstructured":"Chen J, Fang Y, Xu Y, Sun H. Role of m6A modification in female infertility and reproductive system diseases. Int J Biol Sci. 2022;18(9):3592\u2013604. https:\/\/doi.org\/10.7150\/ijbs.69771.","journal-title":"Int J Biol Sci"},{"issue":"2","key":"3765_CR73","doi-asserted-by":"publisher","first-page":"494","DOI":"10.1016\/j.gendis.2020.08.005","volume":"9","author":"R Zhu","year":"2022","unstructured":"Zhu R, Ji X, Wu X, et al. Melatonin antagonizes ovarian aging via YTHDF2-MAPK-NF-kappaB pathway. Genes Dis. 2022;9(2):494\u2013509. https:\/\/doi.org\/10.1016\/j.gendis.2020.08.005.","journal-title":"Genes Dis"},{"key":"3765_CR74","doi-asserted-by":"publisher","unstructured":"McGlacken-Byrne SM, Del Valle I, Quesne Stabej PL.\u00a0Pathogenic variants in the human m6A reader YTHDC2 are associated with primary ovarian insufficiency. JCI Insight. 2022;7(5):e154671. https:\/\/doi.org\/10.1172\/jci.insight.154671.","DOI":"10.1172\/jci.insight.154671"},{"issue":"14","key":"3765_CR75","doi-asserted-by":"publisher","first-page":"dev202740","DOI":"10.1242\/dev.202740","volume":"151","author":"N Pfaltzgraff","year":"2024","unstructured":"Pfaltzgraff N, Liu B, de Rooij D, Page D, Mikedis M. Destabilization of mRNAs enhances competence to initiate meiosis in mouse spermatogenic cells. Development. 2024;151(14):dev202740. https:\/\/doi.org\/10.1242\/dev.202740.","journal-title":"Development"},{"issue":"43","key":"3765_CR76","doi-asserted-by":"publisher","first-page":"eabn9016","DOI":"10.1126\/sciadv.abn9016","volume":"8","author":"XX Dai","year":"2022","unstructured":"Dai XX, Pi S, Zhao LW, et al. PABPN1 functions as a hub in the assembly of nuclear poly(A) domains that are essential for mouse oocyte development. Sci Adv. 2022;8(43):eabn9016. https:\/\/doi.org\/10.1126\/sciadv.abn9016.","journal-title":"Sci Adv"},{"issue":"13","key":"3765_CR77","doi-asserted-by":"publisher","first-page":"2218","DOI":"10.1128\/MCB.00123-15","volume":"35","author":"L Muniz","year":"2015","unstructured":"Muniz L, Davidson L, West S. Poly(A) polymerase and the nuclear poly(A) binding protein, PABPN1, coordinate the splicing and degradation of a subset of human pre-mRNAs. Mol Cell Biol. 2015;35(13):2218\u201330. https:\/\/doi.org\/10.1128\/MCB.00123-15.","journal-title":"Mol Cell Biol"},{"issue":"4","key":"3765_CR78","doi-asserted-by":"publisher","first-page":"180","DOI":"10.2183\/pjab.94.013","volume":"94","author":"T Kishimoto","year":"2018","unstructured":"Kishimoto T. MPF-based meiotic cell cycle control: half a century of lessons from starfish oocytes. Proc Jpn Acad Ser B Phys Biol Sci. 2018;94(4):180\u2013203. https:\/\/doi.org\/10.2183\/pjab.94.013.","journal-title":"Proc Jpn Acad Ser B Phys Biol Sci"},{"issue":"4","key":"3765_CR79","doi-asserted-by":"publisher","first-page":"369","DOI":"10.1093\/jmcb\/mjw031","volume":"8","author":"D Wu","year":"2016","unstructured":"Wu D, Dean J. BTG4, a maternal mRNA cleaner. J Mol Cell Biol. 2016;8(4):369\u201370. https:\/\/doi.org\/10.1093\/jmcb\/mjw031.","journal-title":"J Mol Cell Biol"},{"issue":"23","key":"3765_CR80","doi-asserted-by":"publisher","first-page":"e2500048","DOI":"10.1002\/advs.202500048","volume":"12","author":"XX Dai","year":"2025","unstructured":"Dai XX, Wu YK, Pi SB, et al. PABPN1 couples the polyadenylation and translation of maternal transcripts to mouse oocyte meiotic maturation. Adv Sci. 2025;12(23):e2500048. https:\/\/doi.org\/10.1002\/advs.202500048.","journal-title":"Adv Sci"},{"issue":"8","key":"3765_CR81","doi-asserted-by":"publisher","first-page":"640","DOI":"10.1038\/s41422-023-00824-0","volume":"33","author":"Z Zhang","year":"2023","unstructured":"Zhang Z, Liu R, Zhou H, et al. YBX2-dependent stabilization of oocyte mRNA through a reversible sponge-like cortical partition. Cell Res. 2023;33(8):640\u20133. https:\/\/doi.org\/10.1038\/s41422-023-00824-0.","journal-title":"Cell Res"},{"issue":"1","key":"3765_CR82","doi-asserted-by":"publisher","DOI":"10.1016\/j.yexcr.2023.113586","volume":"427","author":"Y Cai","year":"2023","unstructured":"Cai Y, Li N, Li H. YBX2 modulates mRNA stability via interaction with YTHDF2 in endometrial cancer cells. Exp Cell Res. 2023;427(1): 113586. https:\/\/doi.org\/10.1016\/j.yexcr.2023.113586.","journal-title":"Exp Cell Res"},{"issue":"3","key":"3765_CR83","doi-asserted-by":"publisher","first-page":"575","DOI":"10.1095\/biolreprod.111.091710","volume":"85","author":"S Medvedev","year":"2011","unstructured":"Medvedev S, Pan H, Schultz RM. Absence of MSY2 in mouse oocytes perturbs oocyte growth and maturation, RNA stability, and the transcriptome. Biol Reprod. 2011;85(3):575\u201383. https:\/\/doi.org\/10.1095\/biolreprod.111.091710.","journal-title":"Biol Reprod"},{"issue":"9","key":"3765_CR84","doi-asserted-by":"publisher","first-page":"247","DOI":"10.1007\/s00018-023-04898-2","volume":"80","author":"LY Shan","year":"2023","unstructured":"Shan LY, Tian Y, Liu WX, et al. LSM14B controls oocyte mRNA storage and stability to ensure female fertility. Cell Mol Life Sci. 2023;80(9):247. https:\/\/doi.org\/10.1007\/s00018-023-04898-2.","journal-title":"Cell Mol Life Sci"},{"issue":"18","key":"3765_CR85","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202300043","volume":"10","author":"H Li","year":"2023","unstructured":"Li H, Zhao H, Yang C, et al. LSM14B is an oocyte-specific RNA-binding protein indispensable for maternal mRNA metabolism and oocyte development in mice. Adv Sci (Weinh). 2023;10(18): e2300043. https:\/\/doi.org\/10.1002\/advs.202300043.","journal-title":"Adv Sci (Weinh)"},{"issue":"4","key":"3765_CR86","doi-asserted-by":"publisher","first-page":"383","DOI":"10.1262\/jrd.2017-018","volume":"63","author":"T Zhang","year":"2017","unstructured":"Zhang T, Li Y, Li H, et al. RNA-associated protein LSM family member 14 controls oocyte meiotic maturation through regulating mRNA pools. J Reprod Dev. 2017;63(4):383\u20138. https:\/\/doi.org\/10.1262\/jrd.2017-018.","journal-title":"J Reprod Dev"},{"key":"3765_CR87","doi-asserted-by":"publisher","first-page":"RP9242","DOI":"10.7554\/eLife.92426","volume":"13","author":"R Weber","year":"2024","unstructured":"Weber R, Chang C. Human DDX6 regulates translation and decay of inefficiently translated mRNAs. Elife. 2024;13:RP9242. https:\/\/doi.org\/10.7554\/eLife.92426.","journal-title":"Elife"},{"issue":"1","key":"3765_CR88","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1093\/biolre\/ioad043","volume":"109","author":"Y Kato","year":"2023","unstructured":"Kato Y, Saga Y. Antagonism between DDX6 and PI3K-AKT signaling is an oocyte-intrinsic mechanism controlling primordial follicle growth\u2020. Biol Reprod. 2023;109(1):73\u201382. https:\/\/doi.org\/10.1093\/biolre\/ioad043.","journal-title":"Biol Reprod"},{"issue":"21","key":"3765_CR89","doi-asserted-by":"publisher","first-page":"11652","DOI":"10.1093\/nar\/gkad919","volume":"51","author":"Y Wan","year":"2023","unstructured":"Wan Y, Yang S, Li T, et al. LSM14B is essential for oocyte meiotic maturation by regulating maternal mRNA storage and clearance. Nucleic Acids Res. 2023;51(21):11652\u201367. https:\/\/doi.org\/10.1093\/nar\/gkad919.","journal-title":"Nucleic Acids Res"},{"issue":"5","key":"3765_CR90","doi-asserted-by":"publisher","first-page":"589","DOI":"10.1530\/rep.0.1260589","volume":"126","author":"P Saunders","year":"2003","unstructured":"Saunders P, Turner J, Ruggiu M, et al. Absence of mDazl produces a final block on germ cell development at meiosis. Reproduction. 2003;126(5):589\u201397. https:\/\/doi.org\/10.1530\/rep.0.1260589.","journal-title":"Reproduction"},{"issue":"2","key":"3765_CR91","doi-asserted-by":"publisher","DOI":"10.1093\/lifemedi\/lnae007","volume":"3","author":"Q Liu","year":"2024","unstructured":"Liu Q, Guo T, Yan A, Kee K. Truncated DAZL mutation reduces NANOS3 expression in primordial germ cells and leads to premature ovarian insufficiency. Life medicine. 2024;3(2): lnae007. https:\/\/doi.org\/10.1093\/lifemedi\/lnae007.","journal-title":"Life medicine"},{"issue":"7","key":"3765_CR92","doi-asserted-by":"publisher","first-page":"974","DOI":"10.1261\/rna.465507","volume":"13","author":"N Reynolds","year":"2007","unstructured":"Reynolds N, Collier B, Bingham V, Gray NK, Cooke HJ. Translation of the synaptonemal complex component Sycp3 is enhanced in vivo by the germ cell specific regulator Dazl. RNA. 2007;13(7):974\u201381. https:\/\/doi.org\/10.1261\/rna.465507.","journal-title":"RNA"},{"issue":"1","key":"3765_CR93","doi-asserted-by":"publisher","first-page":"1399","DOI":"10.1038\/s41467-020-15209-9","volume":"11","author":"CR Yang","year":"2020","unstructured":"Yang CR, Rajkovic G, Daldello EM, Luong XG, Chen J, Conti M. The RNA-binding protein DAZL functions as repressor and activator of mRNA translation during oocyte maturation. Nat Commun. 2020;11(1):1399. https:\/\/doi.org\/10.1038\/s41467-020-15209-9.","journal-title":"Nat Commun"},{"issue":"12","key":"3765_CR94","doi-asserted-by":"publisher","first-page":"971","DOI":"10.18632\/aging.100105","volume":"1","author":"Y Niikura","year":"2009","unstructured":"Niikura Y, Niikura T, Tilly J. Aged mouse ovaries possess rare premeiotic germ cells that can generate oocytes following transplantation into a young host environment. Aging. 2009;1(12):971\u20138. https:\/\/doi.org\/10.18632\/aging.100105.","journal-title":"Aging"},{"issue":"3","key":"3765_CR95","doi-asserted-by":"publisher","first-page":"584","DOI":"10.1095\/biolreprod.110.086264","volume":"85","author":"JR McNeilly","year":"2011","unstructured":"McNeilly JR, Watson EA, White YA, Murray AA, Spears N, McNeilly AS. Decreased oocyte DAZL expression in mice results in increased litter size by modulating follicle-stimulating hormone-induced follicular growth. Biol Reprod. 2011;85(3):584\u201393. https:\/\/doi.org\/10.1095\/biolreprod.110.086264.","journal-title":"Biol Reprod"},{"issue":"12","key":"3765_CR96","doi-asserted-by":"publisher","first-page":"972","DOI":"10.1016\/j.tig.2018.09.006","volume":"34","author":"AC Goldstrohm","year":"2018","unstructured":"Goldstrohm AC, Hall TMT, McKenney KM. Post-transcriptional regulatory functions of mammalian pumilio proteins. Trends Genet. 2018;34(12):972\u201390. https:\/\/doi.org\/10.1016\/j.tig.2018.09.006.","journal-title":"Trends Genet"},{"key":"3765_CR97","doi-asserted-by":"publisher","DOI":"10.3390\/genes15010124","author":"A Caponnetto","year":"2024","unstructured":"Caponnetto A, Ferrara C, Fazzio A, et al. A circular RNA derived from the Pumilio 1 gene could regulate PTEN in human cumulus cells. Genes. 2024. https:\/\/doi.org\/10.3390\/genes15010124.","journal-title":"Genes"},{"issue":"1","key":"3765_CR98","doi-asserted-by":"publisher","first-page":"2","DOI":"10.2174\/0929866530666221124122507","volume":"30","author":"J Liu","year":"2023","unstructured":"Liu J, Wei Q, Jin Y, Jin Y, Jiang Y. Cold-induced RNA-binding protein and RNA-binding motif protein 3: two RNA molecular chaperones closely related to reproductive development and reproductive system diseases. Protein Pept Lett. 2023;30(1):2\u201312. https:\/\/doi.org\/10.2174\/0929866530666221124122507.","journal-title":"Protein Pept Lett"},{"key":"3765_CR99","doi-asserted-by":"publisher","first-page":"614","DOI":"10.1016\/j.omtn.2020.12.008","volume":"23","author":"J Huang","year":"2021","unstructured":"Huang J, Zhao J, Geng X, et al. Long non-coding RNA lnc-CCNL1-3:1 promotes granulosa cell apoptosis and suppresses glucose uptake in women with polycystic ovary syndrome. Mol Ther Nucleic Acids. 2021;23:614\u201328. https:\/\/doi.org\/10.1016\/j.omtn.2020.12.008.","journal-title":"Mol Ther Nucleic Acids"},{"issue":"2","key":"3765_CR100","doi-asserted-by":"publisher","first-page":"501","DOI":"10.1007\/s00404-022-06461-z","volume":"306","author":"Y Li","year":"2022","unstructured":"Li Y, Wu X, Miao S, Cao Q. MiR-383-5p promotes apoptosis of ovarian granulosa cells by targeting CIRP through the PI3K\/AKT signaling pathway. Arch Gynecol Obstet. 2022;306(2):501\u201312. https:\/\/doi.org\/10.1007\/s00404-022-06461-z.","journal-title":"Arch Gynecol Obstet"},{"key":"3765_CR101","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1016\/j.theriogenology.2022.03.010","volume":"185","author":"J Gardela","year":"2022","unstructured":"Gardela J, Ruiz-Conca M, Garcia-Sanmartin J, et al. Mild hypothermia and vitrification increase the mRNA expression of cold-inducible proteins in bovine oocytes and cumulus cells. Theriogenology. 2022;185:16\u201323. https:\/\/doi.org\/10.1016\/j.theriogenology.2022.03.010.","journal-title":"Theriogenology"},{"issue":"1","key":"3765_CR102","doi-asserted-by":"publisher","first-page":"10652","DOI":"10.1038\/s41598-017-10907-9","volume":"7","author":"N Wang","year":"2017","unstructured":"Wang N, Hao HS, Li CY, et al. Calcium ion regulation by BAPTA-AM and ruthenium red improved the fertilisation capacity and developmental ability of vitrified bovine oocytes. Sci Rep. 2017;7(1):10652. https:\/\/doi.org\/10.1038\/s41598-017-10907-9.","journal-title":"Sci Rep"},{"key":"3765_CR103","doi-asserted-by":"publisher","DOI":"10.1016\/j.jsbmb.2023.106449","volume":"238","author":"R Zhang","year":"2024","unstructured":"Zhang R, Pan Y, Wang M, et al. CIRBP increases the synthesis and secretion of steroid hormones by in yak granulaso cells. J Steroid Biochem Mol Biol. 2024;238: 106449. https:\/\/doi.org\/10.1016\/j.jsbmb.2023.106449.","journal-title":"J Steroid Biochem Mol Biol"},{"issue":"11","key":"3765_CR104","doi-asserted-by":"publisher","first-page":"e22612","DOI":"10.1096\/fj.202200468RR","volume":"36","author":"R Rosario","year":"2022","unstructured":"Rosario R, Stewart HL, Choudhury NR, Michlewski G, Charlet-Berguerand N, Anderson RA. Evidence for a fragile X messenger ribonucleoprotein 1 (FMR1) mRNA gain-of-function toxicity mechanism contributing to the pathogenesis of fragile X-associated premature ovarian insufficiency. FASEB J. 2022;36(11):e22612. https:\/\/doi.org\/10.1096\/fj.202200468RR.","journal-title":"FASEB J"},{"issue":"5","key":"3765_CR105","doi-asserted-by":"publisher","first-page":"485","DOI":"10.1016\/j.rbmo.2017.07.016","volume":"35","author":"J Rehnitz","year":"2017","unstructured":"Rehnitz J, Alcoba DD, Brum IS, et al. FMR1 and AKT\/mTOR signalling pathways: potential functional interactions controlling folliculogenesis in human granulosa cells. Reprod Biomed Online. 2017;35(5):485\u201393. https:\/\/doi.org\/10.1016\/j.rbmo.2017.07.016.","journal-title":"Reprod Biomed Online"},{"key":"3765_CR106","doi-asserted-by":"publisher","first-page":"1129534","DOI":"10.3389\/fendo.2023.1129534","volume":"14","author":"PA Villa","year":"2023","unstructured":"Villa PA, Lainez NM, Jonak CR, Berlin SC, Ethell IM, Coss D. Altered GnRH neuron and ovarian innervation characterize reproductive dysfunction linked to the Fragile X messenger ribonucleoprotein (Fmr1) gene mutation. Front Endocrinol (Lausanne). 2023;14:1129534. https:\/\/doi.org\/10.3389\/fendo.2023.1129534.","journal-title":"Front Endocrinol (Lausanne)"},{"issue":"4","key":"3765_CR107","doi-asserted-by":"publisher","first-page":"775","DOI":"10.1016\/j.molcel.2018.11.034","volume":"73","author":"D D\u2019Amico","year":"2019","unstructured":"D\u2019Amico D, Mottis A, Potenza F, et al. The RNA-binding protein PUM2 impairs mitochondrial dynamics and mitophagy during aging. Mol Cell. 2019;73(4):775-87.e10. https:\/\/doi.org\/10.1016\/j.molcel.2018.11.034.","journal-title":"Mol Cell"},{"issue":"4","key":"3765_CR108","doi-asserted-by":"publisher","first-page":"643","DOI":"10.1016\/j.molcel.2019.02.006","volume":"73","author":"R Bar-Ziv","year":"2019","unstructured":"Bar-Ziv R, Nguyen NT, Dillin A. Vive ut numquam moriturus: tweaking translational control to regulate longevity. Mol Cell. 2019;73(4):643\u20134. https:\/\/doi.org\/10.1016\/j.molcel.2019.02.006.","journal-title":"Mol Cell"},{"issue":"9","key":"3765_CR109","doi-asserted-by":"publisher","first-page":"499","DOI":"10.1023\/a:1016601110424","volume":"18","author":"G Barroso","year":"2001","unstructured":"Barroso G, Oehninger S, Monz\u00f3 A, Kolm P, Gibbons W, Muasher S. High FSH:LH ratio and low LH levels in basal cycle day 3: impact on follicular development and IVF outcome. J Assist Reprod Genet. 2001;18(9):499\u2013505. https:\/\/doi.org\/10.1023\/a:1016601110424.","journal-title":"J Assist Reprod Genet"},{"issue":"6","key":"3765_CR110","doi-asserted-by":"publisher","first-page":"1469","DOI":"10.1093\/humrep\/deab065","volume":"36","author":"E Bosch","year":"2021","unstructured":"Bosch E, Alviggi C, Lispi M, et al. Reduced FSH and LH action: implications for medically assisted reproduction. Hum Reprod. 2021;36(6):1469\u201380. https:\/\/doi.org\/10.1093\/humrep\/deab065.","journal-title":"Hum Reprod"},{"key":"3765_CR111","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1016\/bs.vh.2018.01.010","volume":"107","author":"KMJ Menon","year":"2018","unstructured":"Menon KMJ, Menon B, Gulappa T. Regulation of luteinizing hormone receptor mRNA expression in the ovary: the role of miR-122. Vitam Horm. 2018;107:67\u201387. https:\/\/doi.org\/10.1016\/bs.vh.2018.01.010.","journal-title":"Vitam Horm"},{"issue":"5","key":"3765_CR112","doi-asserted-by":"publisher","first-page":"1173","DOI":"10.1016\/j.bbamcr.2013.01.024","volume":"1833","author":"B Menon","year":"2013","unstructured":"Menon B, Sinden J, Menon K. Association of luteinizing hormone receptor (LHR) mRNA with its binding protein leads to decapping and degradation of the mRNA in the p bodies. Biochim Biophys Acta. 2013;1833(5):1173\u20139. https:\/\/doi.org\/10.1016\/j.bbamcr.2013.01.024.","journal-title":"Biochim Biophys Acta"},{"issue":"5","key":"3765_CR113","doi-asserted-by":"publisher","first-page":"591","DOI":"10.1016\/j.bbamcr.2010.02.003","volume":"1803","author":"L Wang","year":"2010","unstructured":"Wang L, Gulappa T, Menon KM. Identification and characterization of proteins that selectively interact with the LHR mRNA binding protein (LRBP) in rat ovaries. Biochim Biophys Acta. 2010;1803(5):591\u20137. https:\/\/doi.org\/10.1016\/j.bbamcr.2010.02.003.","journal-title":"Biochim Biophys Acta"},{"issue":"11","key":"3765_CR114","doi-asserted-by":"publisher","first-page":"2189","DOI":"10.1210\/me.2003-0205","volume":"17","author":"T Hirakawa","year":"2003","unstructured":"Hirakawa T, Ascoli M. The lutropin\/choriogonadotropin receptor-induced phosphorylation of the extracellular signal-regulated kinases in Leydig cells is mediated by a protein kinase a-dependent activation of ras. Mol Endocrinol. 2003;17(11):2189\u2013200. https:\/\/doi.org\/10.1210\/me.2003-0205.","journal-title":"Mol Endocrinol"},{"issue":"10","key":"3765_CR115","doi-asserted-by":"publisher","first-page":"9686","DOI":"10.18632\/aging.103237","volume":"12","author":"JNZL Mara","year":"2020","unstructured":"Mara JNZL, Larmore M, et al. Ovulation and ovarian wound healing are impaired with advanced reproductive age. Aging (Albany NY). 2020;12(10):9686\u2013713. https:\/\/doi.org\/10.18632\/aging.103237.","journal-title":"Aging (Albany NY)"},{"issue":"6","key":"3765_CR116","doi-asserted-by":"publisher","first-page":"1097","DOI":"10.1016\/s0015-0282(01)02863-1","volume":"76","author":"R Cv","year":"2001","unstructured":"Cv R. Multiple novel roles of luteinizing hormone. Fertil Steril. 2001;76(6):1097\u2013100. https:\/\/doi.org\/10.1016\/s0015-0282(01)02863-1.","journal-title":"Fertil Steril"},{"issue":"1","key":"3765_CR117","doi-asserted-by":"publisher","first-page":"100","DOI":"10.1186\/s13048-022-01032-x","volume":"15","author":"F Yan","year":"2022","unstructured":"Yan F, Zhao Q, Li Y, et al. The role of oxidative stress in ovarian aging: a review. J Ovarian Res. 2022;15(1):100. https:\/\/doi.org\/10.1186\/s13048-022-01032-x.","journal-title":"J Ovarian Res"},{"issue":"3","key":"3765_CR118","doi-asserted-by":"publisher","first-page":"400","DOI":"10.1093\/jnci\/djab213","volume":"114","author":"M Lambertini","year":"2022","unstructured":"Lambertini M, Boni L, Michelotti A, et al. Long-term outcomes with pharmacological ovarian suppression during chemotherapy in premenopausal early breast cancer patients. J Natl Cancer Inst. 2022;114(3):400\u20138. https:\/\/doi.org\/10.1093\/jnci\/djab213.","journal-title":"J Natl Cancer Inst"},{"issue":"8","key":"3765_CR119","doi-asserted-by":"publisher","first-page":"e2410305","DOI":"10.1002\/advs.202410305","volume":"12","author":"Y Rong","year":"2025","unstructured":"Rong Y, Wu YK, Chen Y, et al. ZAR1\/2-regulated epigenetic modifications are essential for age-associated oocyte quality maintenance and zygotic activation. Adv Sci. 2025;12(8):e2410305. https:\/\/doi.org\/10.1002\/advs.202410305.","journal-title":"Adv Sci"},{"key":"3765_CR120","doi-asserted-by":"publisher","DOI":"10.1007\/s43032-025-01857-z","author":"X Zhao","year":"2025","unstructured":"Zhao X, Mao B, Wang J, et al. The regulation of ZAR1 on apoptosis and mitophagy in ovarian granular cells and primary ovarian insufficiency (POI) mice. Reprod Sci. 2025. https:\/\/doi.org\/10.1007\/s43032-025-01857-z.","journal-title":"Reprod Sci"},{"key":"3765_CR121","doi-asserted-by":"publisher","DOI":"10.1016\/j.biocel.2023.106431","volume":"160","author":"P Melchinger","year":"2023","unstructured":"Melchinger P, Garcia BM. Mitochondria are midfield players in steroid synthesis. Int J Biochem Cell Biol. 2023;160: 106431. https:\/\/doi.org\/10.1016\/j.biocel.2023.106431.","journal-title":"Int J Biochem Cell Biol"},{"issue":"21","key":"3765_CR122","doi-asserted-by":"publisher","first-page":"11387","DOI":"10.1093\/nar\/gkz863","volume":"47","author":"Y Rong","year":"2019","unstructured":"Rong Y, Ji SY, Zhu YZ, Wu YW, Shen L, Fan HY. ZAR1 and ZAR2 are required for oocyte meiotic maturation by regulating the maternal transcriptome and mRNA translational activation. Nucleic Acids Res. 2019;47(21):11387\u2013402. https:\/\/doi.org\/10.1093\/nar\/gkz863.","journal-title":"Nucleic Acids Res"},{"issue":"6617","key":"3765_CR123","doi-asserted-by":"publisher","DOI":"10.1126\/science.abq4835","volume":"378","author":"S Cheng","year":"2022","unstructured":"Cheng S, Altmeppen G, So C, et al. Mammalian oocytes store mRNAs in a mitochondria-associated membraneless compartment. Science. 2022;378(6617): eabq4835. https:\/\/doi.org\/10.1126\/science.abq4835.","journal-title":"Science"},{"issue":"2","key":"3765_CR124","doi-asserted-by":"publisher","first-page":"92","DOI":"10.1007\/s00018-022-04141-4","volume":"79","author":"YK Wu","year":"2022","unstructured":"Wu YK, Fan HY. Revisiting ZAR proteins: the understudied regulator of female fertility and beyond. Cell Mol Life Sci. 2022;79(2):92. https:\/\/doi.org\/10.1007\/s00018-022-04141-4.","journal-title":"Cell Mol Life Sci"},{"issue":"12","key":"3765_CR125","doi-asserted-by":"publisher","first-page":"5265","DOI":"10.1038\/s44319-024-00315-2","volume":"25","author":"M Solyga","year":"2024","unstructured":"Solyga M, Majumdar A, Besse F. Regulating translation in aging: from global to gene-specific mechanisms. EMBO Rep. 2024;25(12):5265\u201376. https:\/\/doi.org\/10.1038\/s44319-024-00315-2.","journal-title":"EMBO Rep"},{"key":"3765_CR126","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2023.102824","volume":"65","author":"F Niu","year":"2023","unstructured":"Niu F, Li Z, Ren Y, et al. Aberrant hyper-expression of the RNA binding protein GIGYF2 in endothelial cells modulates vascular aging and function. Redox Biol. 2023;65: 102824. https:\/\/doi.org\/10.1016\/j.redox.2023.102824.","journal-title":"Redox Biol"},{"issue":"3","key":"3765_CR127","doi-asserted-by":"publisher","first-page":"240","DOI":"10.1093\/humupd\/dmaf002","volume":"31","author":"F Zhang","year":"2025","unstructured":"Zhang F, Zhu M, Chen Y, et al. Harnessing omics data for drug discovery and development in ovarian aging. Hum Reprod Update. 2025;31(3):240\u201368. https:\/\/doi.org\/10.1093\/humupd\/dmaf002.","journal-title":"Hum Reprod Update"},{"issue":"2","key":"3765_CR128","doi-asserted-by":"publisher","first-page":"e152","DOI":"10.1016\/S2666-7568(23)00258-1","volume":"5","author":"DJW Lee","year":"2024","unstructured":"Lee DJW, Hodzic Kuerec A, Maier AB. Targeting ageing with rapamycin and its derivatives in humans: a systematic review. Lancet Healthy Longev. 2024;5(2):e152\u201362. https:\/\/doi.org\/10.1016\/S2666-7568(23)00258-1.","journal-title":"Lancet Healthy Longev"},{"key":"3765_CR129","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aan4296","author":"C Hine","year":"2017","unstructured":"Hine C. Rapamycin keeps the reproductive clock ticking. Sci Transl Med. 2017. https:\/\/doi.org\/10.1126\/scitranslmed.aan4296.","journal-title":"Sci Transl Med"},{"issue":"4","key":"3765_CR130","doi-asserted-by":"publisher","first-page":"522","DOI":"10.1093\/biolre\/ioac222","volume":"108","author":"M Trujillo","year":"2023","unstructured":"Trujillo M, Odle AK, Aykin-Burns N, Allen AR. Chemotherapy induced oxidative stress in the ovary: drug-dependent mechanisms and potential interventions\u2020. Biol Reprod. 2023;108(4):522\u201337. https:\/\/doi.org\/10.1093\/biolre\/ioac222.","journal-title":"Biol Reprod"},{"issue":"1","key":"3765_CR131","doi-asserted-by":"publisher","first-page":"110","DOI":"10.1038\/s43587-023-00532-9","volume":"4","author":"Q Yang","year":"2024","unstructured":"Yang Q, Chen W, Cong L, et al. NADase CD38 is a key determinant of ovarian aging. Nat Aging. 2024;4(1):110\u201328. https:\/\/doi.org\/10.1038\/s43587-023-00532-9.","journal-title":"Nat Aging"},{"issue":"2","key":"3765_CR132","doi-asserted-by":"publisher","first-page":"R19","DOI":"10.1530\/REP-21-0022","volume":"162","author":"S Park","year":"2021","unstructured":"Park S, Walsh L, Berkowitz K. Mechanisms of ovarian aging. Reproduction. 2021;162(2):R19\u201333. https:\/\/doi.org\/10.1530\/REP-21-0022.","journal-title":"Reproduction"},{"issue":"21","key":"3765_CR133","doi-asserted-by":"publisher","first-page":"2895","DOI":"10.1080\/15384101.2016.1208873","volume":"15","author":"S Yuan","year":"2016","unstructured":"Yuan S, Wen J, Cheng J, et al. Age-associated up-regulation of EGR1 promotes granulosa cell apoptosis during follicle atresia in mice through the NF-\u03baB pathway. Cell Cycle. 2016;15(21):2895\u2013905. https:\/\/doi.org\/10.1080\/15384101.2016.1208873.","journal-title":"Cell Cycle"},{"issue":"5","key":"3765_CR134","doi-asserted-by":"publisher","first-page":"975","DOI":"10.1093\/biolre\/ioz135","volume":"101","author":"C Zhang","year":"2019","unstructured":"Zhang C, Shen J, Kong S, et al. MicroRNA-181a promotes follicular granulosa cell apoptosis via sphingosine-1-phosphate receptor 1 expression downregulation\u2020. Biol Reprod. 2019;101(5):975\u201385. https:\/\/doi.org\/10.1093\/biolre\/ioz135.","journal-title":"Biol Reprod"},{"issue":"2","key":"3765_CR135","doi-asserted-by":"publisher","first-page":"87","DOI":"10.14348\/molcells.2016.2318","volume":"39","author":"B Tang","year":"2016","unstructured":"Tang B. Sirt1 and the mitochondria. Molecules Cells. 2016;39(2):87\u201395. https:\/\/doi.org\/10.14348\/molcells.2016.2318.","journal-title":"Molecules Cells"},{"issue":"5","key":"3765_CR136","doi-asserted-by":"publisher","first-page":"418","DOI":"10.1016\/j.tem.2025.01.005","volume":"36","author":"C Wu","year":"2025","unstructured":"Wu C, Chen D, Stout MB, Wu M, Wang S. Hallmarks of ovarian aging. Trends Endocrinol Metab. 2025;36(5):418\u201339. https:\/\/doi.org\/10.1016\/j.tem.2025.01.005.","journal-title":"Trends Endocrinol Metab"},{"issue":"5","key":"3765_CR137","doi-asserted-by":"publisher","first-page":"364","DOI":"10.1093\/procel\/pwad063","volume":"15","author":"H Lu","year":"2024","unstructured":"Lu H, Jing Y, Zhang C, et al. Aging hallmarks of the primate ovary revealed by spatiotemporal transcriptomics. Protein Cell. 2024;15(5):364\u201384. https:\/\/doi.org\/10.1093\/procel\/pwad063.","journal-title":"Protein Cell"},{"key":"3765_CR138","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2018345118","author":"G Xi","year":"2021","unstructured":"Xi G, An L, Wang W, et al. The mRNA-destabilizing protein tristetraprolin targets \u201cmeiosis arrester\u201d Nppc mRNA in mammalian preovulatory follicles. Proc Natl Acad Sci U S A. 2021. https:\/\/doi.org\/10.1073\/pnas.2018345118.","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"76","key":"3765_CR139","doi-asserted-by":"publisher","DOI":"10.1126\/sciimmunol.abo0981","volume":"7","author":"ME Cook","year":"2022","unstructured":"Cook ME, Bradstreet TR, Webber AM, et al. The ZFP36 family of RNA binding proteins regulates homeostatic and autoreactive T cell responses. Sci Immunol. 2022;7(76): eabo0981. https:\/\/doi.org\/10.1126\/sciimmunol.abo0981.","journal-title":"Sci Immunol"}],"container-title":["Journal of Assisted Reproduction and Genetics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10815-025-03765-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10815-025-03765-2","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10815-025-03765-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,12]],"date-time":"2026-02-12T08:49:45Z","timestamp":1770886185000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10815-025-03765-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12,18]]},"references-count":139,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026,2]]}},"alternative-id":["3765"],"URL":"https:\/\/doi.org\/10.1007\/s10815-025-03765-2","relation":{},"ISSN":["1058-0468","1573-7330"],"issn-type":[{"value":"1058-0468","type":"print"},{"value":"1573-7330","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,12,18]]},"assertion":[{"value":"14 August 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 November 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 December 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}