{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,19]],"date-time":"2026-01-19T01:59:12Z","timestamp":1768787952246,"version":"3.49.0"},"reference-count":22,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2015,4,12]],"date-time":"2015-04-12T00:00:00Z","timestamp":1428796800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2015,4,12]],"date-time":"2015-04-12T00:00:00Z","timestamp":1428796800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Interv Card Electrophysiol"],"published-print":{"date-parts":[[2015,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n          <jats:sec>\n            <jats:title>Purpose<\/jats:title>\n            <jats:p>Respiratory distress is the primary driver for heart failure (HF) hospitalization. Implantable pacemakers and defibrillators are capable of monitoring respiratory rate (RR) in ambulatory HF patients. We investigated changes in RR prior to HF hospitalizations and its near-term risk stratification power.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods<\/jats:title>\n            <jats:p>NOTICE-HF was an international multi-center study. Patients were implanted with an implantable cardioverter defibrillator or cardiac resynchronization therapy defibrillator, capable of trending daily maximum, median, and minimum RR (maxRR, medRR, minRR). RR from 120 patients with 9\u00a0months of follow-up was analyzed. One-tailed Student\u2019s <jats:italic>t<\/jats:italic> test was used to compare RR values prior to HF events to baseline defined as 4\u00a0weeks prior to the events. A Cox regression model was used to calculate the hazard ratios (HR) for the 30-day HF hospitalization risk based on RR values in the preceding month.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results<\/jats:title>\n            <jats:p>Daily maxRR, medRR, and minRR were significantly elevated prior to HF events compared to baseline (\u0394maxRR 1.8\u2009\u00b1\u20093.0; <jats:italic>p<\/jats:italic>\u2009=\u20090.02; \u0394medRR, 2.1\u2009\u00b1\u20092.8; <jats:italic>p<\/jats:italic>\u2009=\u20090.007; \u0394minRR, 1.5\u2009\u00b1\u20092.1, <jats:italic>p<\/jats:italic>\u2009=\u20090.008). Risk of experiencing HF events within 30-days was increased if the standard deviation of medRR over the preceding month was above 1.0\u00a0br\/min (HR\u2009=\u200912.3, 95\u00a0% confidence interval (CI) 2.57\u201359, <jats:italic>p<\/jats:italic>\u2009=\u20090.002). The risk remained high after adjusting for clinical variables that differed at enrollment.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusion<\/jats:title>\n            <jats:p>Ambulatory daily respiratory rate trends may be a valuable addition to standard management for HF patients.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1007\/s10840-015-9983-6","type":"journal-article","created":{"date-parts":[[2015,4,11]],"date-time":"2015-04-11T09:47:50Z","timestamp":1428745670000},"page":"21-29","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Ambulatory respiratory rate trends identify patients at higher risk of worsening heart failure in implantable cardioverter defibrillator and biventricular device recipients: a novel ambulatory parameter to optimize heart failure management"],"prefix":"10.1007","volume":"43","author":[{"given":"Stephan","family":"Goetze","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yi","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qi","family":"An","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Viktoria","family":"Averina","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pier","family":"Lambiase","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard","family":"Schilling","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hans-Joachim","family":"Trappe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Siegmund","family":"Winter","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicholas","family":"Wold","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ljubomir","family":"Manola","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dries","family":"Kestens","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2015,4,12]]},"reference":[{"key":"9983_CR1","first-page":"464","volume-title":"Heart Diseases","author":"E Braunwald","year":"1997","unstructured":"Braunwald, E., Colucci, W., & Grossman, W. (1997). Clinical aspects of heart failure: high-output heart failure; pulmonary edema. In E. Braunwald (Ed.), Heart Diseases (5th ed., pp. 464\u2013465). New York: WB Saunders.","edition":"5"},{"key":"9983_CR2","doi-asserted-by":"publisher","first-page":"347","DOI":"10.1016\/S0033-0620(05)80018-0","volume":"37","author":"DM Mancini","year":"1995","unstructured":"Mancini, D. M. (1995). Pulmonary factors limiting exercise capacity in patients with heart failure. Progress in Cardiovascular Diseases, 37, 347\u2013370.","journal-title":"Progress in Cardiovascular Diseases"},{"issue":"Suppl 7","key":"9983_CR3","first-page":"S21","volume":"4","author":"GC Fonarow","year":"2003","unstructured":"Fonarow, G. C., & ADHERE. Scientific Advisory Committee. (2003). The Acute Decompensated Heart Failure National Registry (ADHERE): opportunities to improve care of patients hospitalized with acute decompensated heart failure. 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