{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T07:18:57Z","timestamp":1740122337363,"version":"3.37.3"},"reference-count":13,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2020,4,30]],"date-time":"2020-04-30T00:00:00Z","timestamp":1588204800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2020,4,30]],"date-time":"2020-04-30T00:00:00Z","timestamp":1588204800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100001835","name":"Maastricht University","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100001835","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Interv Card Electrophysiol"],"published-print":{"date-parts":[[2021,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Background<\/jats:title>\n                <jats:p>Adenosine can be used to reveal dormant pulmonary vein (PV) conduction after PV isolation (PVI). This study presents a subanalysis of real-world 1-year follow-up data from the ESC-EHRA EORP Atrial Fibrillation (AF) Ablation Long-Term registry to analyze the usage of adenosine during PVI treatment in terms of rhythm outcome and safety.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>The registry consists of 104 participating centers in 27 countries within the European Society of Cardiology. The registry data was split into an adenosine group (AG) and no-adenosine group (NAG). Procedure characteristics and patient outcome were compared.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>Adenosine was administered in 10.8% of the 3591 PVI patients included in the registry. Spain, the Netherlands, and Italy included the majority of adenosine cases (48.8%). Adenosine was applied more often in combination with open irrigation radiofrequency (RF) energy (74.7%) and less often in combination with nonirrigated RF energy (1.6%). After 1\u00a0year, a higher percentage of the AG was free from AF compared with the NAG (68.9% vs 59.1%, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). Adenosine was associated with better rhythm outcome in RF ablation procedures, but not in cryo-ablation procedures (freedom from AF: RF: AG: 70.9%, NAG: 58.1%, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001, cryo: AG: 63.9%, NAG: 63.8%, <jats:italic>p<\/jats:italic>\u2009=\u20090.991).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>The use of adenosine was associated with a better rhythm outcome after 1\u00a0year follow-up and seems more useful in patients treated with RF energy compared with patients treated with cryo energy. Given the improved rhythm outcome at 1-year follow-up, it seems reasonable to encourage the use of adenosine during RF AF ablation.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s10840-020-00744-8","type":"journal-article","created":{"date-parts":[[2020,4,30]],"date-time":"2020-04-30T08:03:30Z","timestamp":1588233810000},"page":"395-406","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Adenosine usage during AF ablation in Europe and selected long-term findings from the ESC-EHRA EORP Atrial Fibrillation Ablation Long-Term registry"],"prefix":"10.1007","volume":"60","author":[{"name":"on behalf of the ESC-EHRA Atrial Fibrillation Ablation Long-Term Registry investigators","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Frank","family":"van Rosmalen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tammo","family":"Delhaas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nikolaos","family":"Dagres","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elena","family":"Arbelo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carina","family":"Blomstr\u00f6m-Lundqvist","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Harry J. 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Mechanisms by which adenosine restores conduction in dormant canine pulmonary veins. Circulation. 2010;121:963\u201372.","journal-title":"Circulation"},{"key":"744_CR2","doi-asserted-by":"publisher","first-page":"e1","DOI":"10.1093\/europace\/eux274","volume":"20","author":"H Calkins","year":"2018","unstructured":"Calkins H, Hindricks G, Cappato R, Kim Y-H, Saad EB, Aguinaga L, et al. Document Reviewers: 2017 HRS\/EHRA\/ECAS\/APHRS\/SOLAECE expert consensus statement on catheter and surgical ablation of atrial fibrillation. Europace. 2018;20:e1\u2013e160.","journal-title":"Europace"},{"key":"744_CR3","unstructured":"Wang N, Phan S, Kanagaratnam A, Kumar N, Phan K. Adenosine testing after atrial fibrillation ablation: systematic review and meta-analysis. 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Eur Heart J. 2017;38:1303\u201316.","journal-title":"Eur Heart J"},{"key":"744_CR6","doi-asserted-by":"publisher","first-page":"e003337","DOI":"10.1161\/CIRCEP.115.003337","volume":"9","author":"K-H Kuck","year":"2016","unstructured":"Kuck K-H, Hoffmann BA, Ernst S, Wegscheider K, Treszl A, Metzner A, et al. Impact of complete versus incomplete circumferential lines around the pulmonary veins during catheter ablation of paroxysmal atrial fibrillation: results from the Gap-Atrial Fibrillation-German Atrial Fibrillation Competence Network 1 Trial. Circ Arrhythm Electrophysiol. 2016;9:e003337.","journal-title":"Circ Arrhythm Electrophysiol"},{"key":"744_CR7","first-page":"3276","volume":"36","author":"A Kobori","year":"2015","unstructured":"Kobori A, Shizuta S, Inoue K, Kaitani K, Morimoto T, Nakazawa Y, et al. Adenosine triphosphate-guided pulmonary vein isolation for atrial fibrillation: the UNmasking dormant electrical reconduction by adenosine triphosphate (UNDER-ATP) trial. 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