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Two consecutive cohorts were enrolled, one treated with the Amplatzer Amulet (<jats:italic>n<\/jats:italic>\u2009=\u2009150) up till 2019, and a second cohort treated with the Watchman FLX (<jats:italic>n<\/jats:italic>\u2009=\u2009150) device from 2019. Cardiac CT was performed 2\u00a0months postprocedure. The primary outcome was complete LAA occlusion defined as no visible peri-device leak (PDL) and absence of contrast patency in the distal LAA. Secondary outcomes included PDL, contrast patency without visible PDL, PDL area, and periprocedural complications.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>Complete occlusion was achieved in 39 (30.5%) of the Amulet group, compared to 89 (71.8%) of the FLX group, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001. A PDL at the Amulet disc was present in 65 (50.8%), at the lobe in 16 (12.5%), and at both the disc and lobe in 13 (10.2%). For FLX, a PDL was present in 20 (16.1%). Contrast patency without visible PDL was observed in 24 (18.8%) and 15 (12.1%) of the Amulet and FLX group, respectively. The PDL area at the Amulet mid-lobe was 92 mm<jats:sup>2<\/jats:sup> (59\u2013158) and 32 mm<jats:sup>2<\/jats:sup> (IQR 28\u201396) for FLX, <jats:italic>p<\/jats:italic>\u2009=\u20090.019. Device-related thrombosis occurred in 1 (0.7%) and 2 (1.3%), respectively (<jats:italic>p<\/jats:italic>\u2009=\u20090.99), with periprocedural adverse events occurring in 6 (4%) and 8 (5.3%) of the Amulet and FLX group (<jats:italic>p<\/jats:italic>\u2009=\u20090.79).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>Complete LAA occlusion was achieved in a significantly higher proportion treated with the Watchman FLX compared to the Amulet device. PDL was smaller with the FLX than the Amulet. Conceptual device design differences make interpretation of results complex, and additional studies with clinical outcomes are needed.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s10840-022-01336-4","type":"journal-article","created":{"date-parts":[[2022,8,11]],"date-time":"2022-08-11T08:08:58Z","timestamp":1660205338000},"page":"391-401","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Left atrial appendage sealing performance of the Amplatzer Amulet and Watchman FLX device"],"prefix":"10.1007","volume":"66","author":[{"given":"Kasper","family":"Korsholm","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anders","family":"Kramer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Asger","family":"Andersen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacqueline","family":"Saw","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bjarne Linde","family":"N\u00f8rgaard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jesper M\u00f8ller","family":"Jensen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6473-2900","authenticated-orcid":false,"given":"Jens Erik","family":"Nielsen-Kudsk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,8,11]]},"reference":[{"issue":"5","key":"1336_CR1","doi-asserted-by":"publisher","first-page":"373","DOI":"10.1093\/eurheartj\/ehaa612","volume":"42","author":"G Hindricks","year":"2021","unstructured":"Hindricks G, Potpara T, Dagres N, Arbelo E, Bax JJ, Blomstrom-Lundqvist C, et al. 2020 ESC Guidelines for the diagnosis and management of atrial fibrillation developed in collaboration with the European Association for Cardio-Thoracic Surgery (EACTS): The Task Force for the diagnosis and management of atrial fibrillation of the European Society of Cardiology (ESC) Developed with the special contribution of the European Heart Rhythm Association (EHRA) of the ESC. 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All patients provided consent prior to intervention.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"Dr. Korsholm has received lecture fees from Boston Scientific and Abbott. Dr. Andersen has received consulting fees from Boston Scientific. Dr. Nielsen-Kudsk is proctor for Boston Scientific and Abbott. The remaining authors have nothing to disclosure in relation to the present work.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}