{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,7]],"date-time":"2026-11-07T02:57:17Z","timestamp":1794020237170,"version":"4.8.0"},"reference-count":38,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2025,9,30]],"date-time":"2025-09-30T00:00:00Z","timestamp":1759190400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,9,30]],"date-time":"2025-09-30T00:00:00Z","timestamp":1759190400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Interv Card Electrophysiol"],"DOI":"10.1007\/s10840-025-02136-2","type":"journal-article","created":{"date-parts":[[2025,9,30]],"date-time":"2025-09-30T04:13:06Z","timestamp":1759205586000},"page":"285-295","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Efficacy and safety of left atrial appendage occlusion for atrial fibrillation in patients with a history of prior intracranial hemorrhage: a systematic review and meta-analysis of observational studies"],"prefix":"10.1007","volume":"69","author":[{"given":"Amer","family":"Hammad","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdullah","family":"Ahmad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noman","family":"Khalid","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hasan","family":"Munshi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Own","family":"Khraisat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-0034-2654","authenticated-orcid":false,"given":"Vicky","family":"Kumar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haris","family":"Muhammad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aparna","family":"Iyer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sacide","family":"Ozgur","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdel Rahman","family":"Dajani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adil","family":"Afzal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shivam","family":"Patel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satish","family":"Tiyyagura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fayez E.","family":"Shamoon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rahul","family":"Vasudev","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,9,30]]},"reference":[{"issue":"8","key":"2136_CR1","doi-asserted-by":"publisher","first-page":"983","DOI":"10.1161\/01.STR.22.8.983","volume":"22","author":"PA Wolf","year":"1981","unstructured":"Wolf PA, Abbott RD, Kannel WB. Atrial fibrillation as an independent risk factor for stroke: the Framingham study. Stroke. 1981;22(8):983\u20138.","journal-title":"Stroke"},{"issue":"2","key":"2136_CR2","doi-asserted-by":"publisher","first-page":"755","DOI":"10.1016\/0003-4975(95)00887-X","volume":"61","author":"JL Blackshear","year":"1996","unstructured":"Blackshear JL, Odell JA. Appendage obliteration to reduce stroke in cardiac surgical patients with atrial fibrillation. Ann Thorac Surg. 1996;61(2):755\u20139.","journal-title":"Ann Thorac Surg"},{"issue":"9689","key":"2136_CR3","doi-asserted-by":"publisher","first-page":"534","DOI":"10.1016\/S0140-6736(09)61343-X","volume":"374","author":"DR Holmes Jr","year":"2009","unstructured":"Holmes DR Jr, Reddy VY, Turi ZG, et al. Percutaneous closure of the left atrial appendage versus warfarin therapy for prevention of stroke in patients with atrial fibrillation: a randomized clinical trial. Lancet. 2009;374(9689):534\u201342.","journal-title":"Lancet"},{"issue":"1","key":"2136_CR4","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.jacc.2014.04.029","volume":"64","author":"DR Holmes Jr","year":"2014","unstructured":"Holmes DR Jr, Kar S, Price MJ, et al. Prospective randomized evaluation of the Watchman left atrial appendage closure device in patients with atrial fibrillation versus long-term warfarin therapy: the PREVAIL trial. J Am Coll Cardiol. 2014;64(1):1\u201312.","journal-title":"J Am Coll Cardiol"},{"issue":"25","key":"2136_CR5","doi-asserted-by":"crossref","first-page":"3195","DOI":"10.1016\/j.jacc.2021.05.006","volume":"77","author":"D Lakkireddy","year":"2021","unstructured":"Lakkireddy D, Thaler D, Ellis CR, et al. Amplatzer Amulet left atrial appendage occluder vs Watchman device for stroke prophylaxis in atrial fibrillation: a randomized clinical trial. J Am Coll Cardiol. 2021;77(25):3195\u2013205.","journal-title":"J Am Coll Cardiol"},{"key":"2136_CR6","unstructured":"Wells GA et al. The Newcastle-Ottawa Scale (NOS) for assessing the quality of nonrandomised studies in meta-analyses. In: Proceedings of the Semantics Scholar API. 2014. Available from: https:\/\/api.semanticscholar.org\/CorpusID:79550924"},{"key":"2136_CR7","unstructured":"Cochrane Training. Review Manager (RevMan) [Computer program]. Version 5.4. The Cochrane Collaboration; 2020."},{"key":"2136_CR8","unstructured":"R Core Team. R: a language and environment for statistical computing. R Foundation for Statistical Computing; 2023. Available from: https:\/\/www.R-project.org\/"},{"key":"2136_CR9","unstructured":"Schwarzer G, Carpenter JR, R\u00fccker G et al. meta: meta-analysis with R (Version 5.4\u20130) [R package]. Available from: https:\/\/CRAN.R-project.org\/package=meta"},{"issue":"2","key":"2136_CR10","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1212\/WNL.0000000000000022","volume":"82","author":"S Horstmann","year":"2014","unstructured":"Horstmann S, Zugck C, Krumsdorf U, et al. Left atrial appendage occlusion in atrial fibrillation after intracranial hemorrhage. Neurology. 2014;82(2):135\u20138. https:\/\/doi.org\/10.1212\/WNL.0000000000000022.","journal-title":"Neurology"},{"issue":"3","key":"2136_CR11","doi-asserted-by":"publisher","first-page":"349","DOI":"10.1016\/j.cjca.2015.07.723","volume":"32","author":"P Fahmy","year":"2016","unstructured":"Fahmy P, Spencer R, Tsang M, Gooderham P, Saw J. Left atrial appendage closure for atrial fibrillation is safe and effective after intracranial or intraocular hemorrhage. Can J Cardiol. 2016;32(3):349\u201354. https:\/\/doi.org\/10.1016\/j.cjca.2015.07.723.","journal-title":"Can J Cardiol"},{"issue":"1","key":"2136_CR12","doi-asserted-by":"publisher","first-page":"58","DOI":"10.1016\/j.rec.2016.08.010","volume":"70","author":"I Cruz-Gonz\u00e1lez","year":"2017","unstructured":"Cruz-Gonz\u00e1lez I, Rama-Merchan JC, Mart\u00ednez-Peralta S, L\u00f3pez-Mesonero L, Rodr\u00edguez-Collado J, S\u00e1nchez PL. Safety and effectiveness of percutaneous closure of left atrial appendage in patients with intracranial hemorrhage. Rev Esp Cardiol (Engl Ed). 2017;70(1):58\u201360. https:\/\/doi.org\/10.1016\/j.rec.2016.08.010.","journal-title":"Rev Esp Cardiol (Engl Ed)"},{"key":"2136_CR13","doi-asserted-by":"publisher","first-page":"545","DOI":"10.1016\/j.jstrokecerebrovasdis.2016.10.011","volume":"26","author":"P Renou","year":"2017","unstructured":"Renou P, Thambo JB, Iriart X, et al. Left atrial appendage closure in patients with atrial fibrillation and previous intracerebral hemorrhage. J Stroke Cerebrovasc Dis. 2017;26:545\u201351. https:\/\/doi.org\/10.1016\/j.jstrokecerebrovasdis.2016.10.011.","journal-title":"J Stroke Cerebrovasc Dis"},{"issue":"3","key":"2136_CR14","doi-asserted-by":"publisher","first-page":"371","DOI":"10.4244\/EIJ-D-17-00201","volume":"13","author":"JE Nielsen-Kudsk","year":"2017","unstructured":"Nielsen-Kudsk JE, Johnsen SP, Wester P, et al. Left atrial appendage occlusion versus standard medical care in patients with atrial fibrillation and intracerebral haemorrhage: a propensity score-matched follow-up study. EuroIntervention. 2017;13(3):371\u20138. https:\/\/doi.org\/10.4244\/EIJ-D-17-00201.","journal-title":"EuroIntervention"},{"issue":"1","key":"2136_CR15","doi-asserted-by":"publisher","first-page":"103","DOI":"10.4244\/EIJV12I1A18","volume":"12","author":"A Tzikas","year":"2016","unstructured":"Tzikas A, Holmes DR, Gafoor S, et al. Percutaneous left atrial appendage occlusion: the Munich consensus document. EuroIntervention. 2016;12(1):103\u201311.","journal-title":"EuroIntervention"},{"key":"2136_CR16","doi-asserted-by":"publisher","first-page":"663","DOI":"10.1016\/j.hrthm.2018.10.031","volume":"16","author":"E Hutt","year":"2019","unstructured":"Hutt E, Wazni OM, Saliba WI, et al. Left atrial appendage closure device implantation in patients with prior intracranial hemorrhage. Heart Rhythm. 2019;16:663\u20138. https:\/\/doi.org\/10.1016\/j.hrthm.2018.10.031.","journal-title":"Heart Rhythm"},{"issue":"31","key":"2136_CR17","doi-asserted-by":"publisher","first-page":"2465","DOI":"10.1093\/eurheartj\/ehv730","volume":"37","author":"LV Boersma","year":"2016","unstructured":"Boersma LV, Schmidt B, Betts TR, et al. Implant success and safety of left atrial appendage closure with the WATCHMAN device. Eur Heart J. 2016;37(31):2465\u201374.","journal-title":"Eur Heart J"},{"key":"2136_CR18","doi-asserted-by":"publisher","first-page":"415","DOI":"10.1007\/s10840-019-00678-w","volume":"59","author":"WJ Hucker","year":"2020","unstructured":"Hucker WJ, Cohen JA, Gurol ME, et al. Watchman implantation in patients with a history of atrial fibrillation and intracranial hemorrhage. J Interv Card Electrophysiol. 2020;59:415\u201321. https:\/\/doi.org\/10.1007\/s10840-019-00678-w.","journal-title":"J Interv Card Electrophysiol"},{"key":"2136_CR19","doi-asserted-by":"publisher","DOI":"10.1016\/j.jstrokecerebrovasdis.2020.104685","volume":"29","author":"M Ajmal","year":"2020","unstructured":"Ajmal M, Naik H, Kocheril A. Left atrial appendage closure in patients with intracranial hemorrhage and nonvalvular atrial fibrillation. J Stroke Cerebrovasc Dis. 2020;29:104685. https:\/\/doi.org\/10.1016\/j.jstrokecerebrovasdis.2020.104685.","journal-title":"J Stroke Cerebrovasc Dis"},{"issue":"8","key":"2136_CR20","doi-asserted-by":"publisher","first-page":"583","DOI":"10.2459\/JCM.0000000000000976","volume":"21","author":"F Barocelli","year":"2020","unstructured":"Barocelli F, Coli S, Crocamo A, et al. Left atrial appendage occlusion in patients with atrial fibrillation and large prevalence of prior intracranial bleeding. J Cardiovasc Med (Hagerstown). 2020;21(8):583\u201391. https:\/\/doi.org\/10.2459\/JCM.0000000000000976.","journal-title":"J Cardiovasc Med (Hagerstown)"},{"key":"2136_CR21","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1016\/j.ijcard.2020.11.045","volume":"328","author":"G Casu","year":"2021","unstructured":"Casu G, D\u2019Angelo G, Ugo F, et al. Left atrial appendage occlusion in atrial fibrillation patients with previous intracranial bleeding: a national multicenter study. Int J Cardiol. 2021;328:75\u201380. https:\/\/doi.org\/10.1016\/j.ijcard.2020.11.045.","journal-title":"Int J Cardiol"},{"issue":"1","key":"2136_CR22","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1016\/j.nrl.2017.05.013","volume":"35","author":"F Fayos-Vidal","year":"2020","unstructured":"Fayos-Vidal F, Arzamendi-Aizpurua D, Mill\u00e1n-\u00c1lvarez X, et al. Left atrial appendage closure in patients with intracranial haemorrhage and atrial fibrillation. Neurologia (Engl Ed). 2020;35(1):10\u20135. https:\/\/doi.org\/10.1016\/j.nrl.2017.05.013.","journal-title":"Neurologia (Engl Ed)"},{"issue":"6","key":"2136_CR23","doi-asserted-by":"publisher","first-page":"915","DOI":"10.1016\/j.hrthm.2020.01.028","volume":"17","author":"JP Pouru","year":"2020","unstructured":"Pouru JP, Lund J, Jaakkola S, et al. Percutaneous left atrial appendage closure in patients with prior intracranial bleeding and thromboembolism. Heart Rhythm. 2020;17(6):915\u201321. https:\/\/doi.org\/10.1016\/j.hrthm.2020.01.028.","journal-title":"Heart Rhythm"},{"issue":"2","key":"2136_CR24","doi-asserted-by":"publisher","first-page":"259","DOI":"10.1007\/s12975-020-00838-5","volume":"12","author":"M Schrag","year":"2021","unstructured":"Schrag M, Mac Grory B, Nackenoff A, et al. Left atrial appendage closure for patients with cerebral amyloid angiopathy and atrial fibrillation: the LAA-CAA cohort. Transl Stroke Res. 2021;12(2):259\u201365. https:\/\/doi.org\/10.1007\/s12975-020-00838-5.","journal-title":"Transl Stroke Res"},{"issue":"6","key":"2136_CR25","doi-asserted-by":"publisher","first-page":"404","DOI":"10.1016\/j.cjco.2023.03.004","volume":"5","author":"TS Gilhofer","year":"2023","unstructured":"Gilhofer TS, Nestelberger T, Kang M, et al. Stroke prevention with left atrial appendage closure in patients with atrial fibrillation and prior intracranial hemorrhage. CJC Open. 2023;5(6):404\u201311. https:\/\/doi.org\/10.1016\/j.cjco.2023.03.004.","journal-title":"CJC Open"},{"issue":"6","key":"2136_CR26","doi-asserted-by":"publisher","first-page":"1144","DOI":"10.1002\/ccd.30629","volume":"101","author":"F Gallo","year":"2023","unstructured":"Gallo F, Ronco F, D\u2019Amico G, et al. Clinical outcomes of left atrial appendage occlusion in patients with previous intracranial or gastrointestinal bleeding: insights from the LOGIC (left atrial appendage occlusion in patients with gastrointestinal or intracranial bleeding) international multicenter registry. Catheter Cardiovasc Interv. 2023;101(6):1144\u201353. https:\/\/doi.org\/10.1002\/ccd.30629.","journal-title":"Catheter Cardiovasc Interv"},{"issue":"2","key":"2136_CR27","doi-asserted-by":"publisher","DOI":"10.1016\/j.jstrokecerebrovasdis.2023.107481","volume":"33","author":"C Moliner-Ab\u00f3s","year":"2024","unstructured":"Moliner-Ab\u00f3s C, Albert\u00ed-Vall B, Millan-\u00c1lvarez X, et al. Left atrial appendage occlusion in patients with spontaneous intracerebral hemorrhage: an observational study. J Stroke Cerebrovasc Dis. 2024;33(2):107481. https:\/\/doi.org\/10.1016\/j.jstrokecerebrovasdis.2023.107481.","journal-title":"J Stroke Cerebrovasc Dis"},{"key":"2136_CR28","doi-asserted-by":"publisher","DOI":"10.1136\/svn-2024-003142","author":"A Abramovitz Fouks","year":"2024","unstructured":"Abramovitz Fouks A, Yaghi S, Gokcal E, et al. Left atrial appendage closure for patients with atrial fibrillation at high intracranial haemorrhagic risk. Stroke Vasc Neurol. 2024. https:\/\/doi.org\/10.1136\/svn-2024-003142.","journal-title":"Stroke Vasc Neurol"},{"issue":"19","key":"2136_CR29","doi-asserted-by":"publisher","first-page":"1988","DOI":"10.1001\/jama.2014.15192","volume":"312","author":"VY Reddy","year":"2014","unstructured":"Reddy VY, Sievert H, Halperin JL, et al. Percutaneous left atrial appendage closure vs warfarin for atrial fibrillation: a randomized clinical trial. JAMA. 2014;312(19):1988\u201398.","journal-title":"JAMA"},{"issue":"25","key":"2136_CR30","doi-asserted-by":"publisher","first-page":"3122","DOI":"10.1016\/j.jacc.2020.04.067","volume":"75","author":"P Osmancik","year":"2020","unstructured":"Osmancik P, Herman D, Neuzil P, et al. Left atrial appendage closure versus direct oral anticoagulants in high-risk patients with atrial fibrillation. J Am Coll Cardiol. 2020;75(25):3122\u201335.","journal-title":"J Am Coll Cardiol"},{"issue":"5","key":"2136_CR31","doi-asserted-by":"publisher","first-page":"373","DOI":"10.1093\/eurheartj\/ehaa612","volume":"42","author":"G Hindricks","year":"2021","unstructured":"Hindricks G, Potpara T, Dagres N, et al. 2020 ESC Guidelines for the diagnosis and management of atrial fibrillation. Eur Heart J. 2021;42(5):373\u2013498.","journal-title":"Eur Heart J"},{"issue":"6","key":"2136_CR32","doi-asserted-by":"publisher","first-page":"517","DOI":"10.1161\/CIRCULATIONAHA.115.015735","volume":"132","author":"PB Nielsen","year":"2015","unstructured":"Nielsen PB, Larsen TB, Skj\u00f8th F, et al. Restarting anticoagulation after intracranial hemorrhage in atrial fibrillation patients. Circulation. 2015;132(6):517\u201325.","journal-title":"Circulation"},{"issue":"9","key":"2136_CR33","doi-asserted-by":"publisher","first-page":"874","DOI":"10.1161\/CIRCULATIONAHA.118.035090","volume":"138","author":"SR Dukkipati","year":"2018","unstructured":"Dukkipati SR, Kar S, Holmes DR, et al. Device-related thrombus after left atrial appendage closure. Circulation. 2018;138(9):874\u201385.","journal-title":"Circulation"},{"issue":"6","key":"2136_CR34","first-page":"637","volume":"67","author":"X Freixa","year":"2016","unstructured":"Freixa X, Tzikas A, Sobrino A, et al. Percutaneous left atrial appendage closure: initial experience with the AMPLATZER Amulet. J Am Coll Cardiol. 2016;67(6):637\u201344.","journal-title":"J Am Coll Cardiol"},{"key":"2136_CR35","doi-asserted-by":"publisher","first-page":"68","DOI":"10.1016\/j.ahj.2017.03.007","volume":"189","author":"DR Holmes Jr","year":"2017","unstructured":"Holmes DR Jr, Reddy VY, Buchbinder M, et al. The assessment of the Watchman device in patients unsuitable for oral anticoagulation. Am Heart J. 2017;189:68\u201374.","journal-title":"Am Heart J"},{"issue":"15","key":"2136_CR36","doi-asserted-by":"publisher","first-page":"1925","DOI":"10.1016\/j.jcin.2015.08.035","volume":"8","author":"MJ Price","year":"2015","unstructured":"Price MJ, Reddy VY, Valderr\u00e1bano M, et al. Bleeding outcomes after left atrial appendage closure compared with long-term warfarin. JACC Cardiovasc Interv. 2015;8(15):1925\u201332.","journal-title":"JACC Cardiovasc Interv"},{"issue":"10","key":"2136_CR37","first-page":"549","volume":"15","author":"GY Lip","year":"2018","unstructured":"Lip GY, Banerjee A, Boriani G, et al. Antithrombotic therapy for atrial fibrillation. Nat Rev Cardiol. 2018;15(10):549\u201364.","journal-title":"Nat Rev Cardiol"},{"issue":"7","key":"2136_CR38","first-page":"578","volume":"16","author":"A Charidimou","year":"2017","unstructured":"Charidimou A, Imaizumi T, Moulin S, et al. Brain hemorrhage recurrence, small vessel disease type, and cerebral microbleeds. Lancet Neurol. 2017;16(7):578\u201387.","journal-title":"Lancet Neurol"}],"container-title":["Journal of Interventional Cardiac Electrophysiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10840-025-02136-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10840-025-02136-2","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10840-025-02136-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,5]],"date-time":"2026-02-05T04:33:52Z","timestamp":1770266032000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10840-025-02136-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9,30]]},"references-count":38,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2026,3]]}},"alternative-id":["2136"],"URL":"https:\/\/doi.org\/10.1007\/s10840-025-02136-2","relation":{},"ISSN":["1572-8595"],"issn-type":[{"value":"1572-8595","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,9,30]]},"assertion":[{"value":"26 June 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"25 August 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"30 September 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"The authors declare no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}