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Catheter ablation (CA) is the most effective rhythm-control strategy, while percutaneous LAA closure (LAAC) provides mechanical stroke prophylaxis. Combining both in a single one-stop procedure is increasingly performed, yet data on its rhythmic and periprocedural consequences remain scarce.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      We performed a systematic review and meta-analysis to compare the efficacy and safety of combined CA\u2009+\u2009LAAC versus CA-only in patients with AF.\u00a0PubMed, Scopus and Web of Science were searched through June 12th 2026. The primary efficacy and safety outcomes were arrhythmia recurrence and periprocedural pericardial effusion requiring drainage, respectively. Binary endpoints were pooled as odds ratios (OR), continuous endpoints as mean differences (MD), using a random-effects model with heterogeneity reported as I\n                      <jats:sup>2<\/jats:sup>\n                      .\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Fourteen studies comprising 3,274 patients (1,505 CA\u2009+\u2009LAAC; 1,769 CA-only) were included. Arrhythmia recurrence was significantly more frequent after combined CA\u2009+\u2009LAAC (OR\u2009=\u20091.56, 95% CI\u2009=\u20091.11\u20132.19, I\n                      <jats:sup>2<\/jats:sup>\n                      \u2009=\u200947%). Systemic thromboembolism was numerically lower but did not differ significantly (OR\u2009=\u20090.66, 95% CI\u2009=\u20090.37\u20131.21, I\n                      <jats:sup>2<\/jats:sup>\n                      \u2009=\u20090%). Total procedure time was significantly longer for the combined procedure (MD\u2009= +\u20099.34\u00a0min, 95% CI\u2009=\u20090.63\u201318.05, I\n                      <jats:sup>2<\/jats:sup>\n                      \u2009=\u200990%). Periprocedural pericardial effusion requiring drainage did not differ between groups (OR\u2009=\u20091.19, 95% CI\u2009=\u20090.59\u20132.44, I\n                      <jats:sup>2<\/jats:sup>\n                      \u2009=\u20090%).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Combined CA\u2009+\u2009LAAC was associated with significantly higher arrhythmia recurrence than CA-only, potentially attributable to limited substrate modification in the one-stop setting. The primary safety outcome, pericardial effusion requiring drainage, did not differ between groups. Randomised controlled trials are warranted to confirm these findings.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s10840-026-02418-3","type":"journal-article","created":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T03:22:28Z","timestamp":1786936948000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Efficacy and safety of concomitant catheter ablation and left atrial appendage closure compared to catheter ablation only \u2013 a meta-analysis"],"prefix":"10.1007","author":[{"given":"Isabel","family":"Rattka","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8492-2982","authenticated-orcid":false,"given":"Christine","family":"Poch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tabea","family":"Deichsel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eimo","family":"Martens","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karl-Ludwig","family":"Laugwitz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander","family":"Steger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3269-3871","authenticated-orcid":false,"given":"Manuel","family":"Rattka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,8,17]]},"reference":[{"key":"2418_CR1","doi-asserted-by":"publisher","first-page":"3314","DOI":"10.1093\/eurheartj\/ehae176","volume":"45","author":"IC Van Gelder","year":"2024","unstructured":"Van Gelder IC, Rienstra M, Bunting KV, Casado-Arroyo R, Caso V, Crijns HJGM, et al. 2024 ESC guidelines for the management of atrial fibrillation developed in collaboration with the European Association for Cardio-Thoracic Surgery (EACTS). 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As all analyses were based on previously published studies, neither patient consent nor ethical committee approval was required.","order":1,"name":"Ethics","label":"Ethics approval","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":2,"name":"Ethics","label":"Consent to participate","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors have nothing to declare.","order":3,"name":"Ethics","label":"Competing interests","group":{"name":"EthicsHeading","label":"Declarations"}}]}}