{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T21:01:01Z","timestamp":1771016461489,"version":"3.50.1"},"reference-count":49,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2019,5,24]],"date-time":"2019-05-24T00:00:00Z","timestamp":1558656000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2019,5,24]],"date-time":"2019-05-24T00:00:00Z","timestamp":1558656000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Mater Sci: Mater Med"],"published-print":{"date-parts":[[2019,6]]},"DOI":"10.1007\/s10856-019-6261-7","type":"journal-article","created":{"date-parts":[[2019,5,24]],"date-time":"2019-05-24T11:14:00Z","timestamp":1558696440000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":35,"title":["Efficacy of novel nano-hydroxyapatite\/polyurethane composite scaffolds with silver phosphate particles in chronic osteomyelitis"],"prefix":"10.1007","volume":"30","author":[{"given":"Dongli","family":"Zhang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wen","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiang-Dong","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoqiang","family":"He","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiao","family":"Lin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Han","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jidong","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiaxing","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8894-0982","authenticated-orcid":false,"given":"Wei","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2019,5,24]]},"reference":[{"key":"6261_CR1","first-page":"257","volume":"109","author":"G Walter","year":"2012","unstructured":"Walter G, Kemmerer M, Kappler C, Hoffmann R. Treatment algorithms for chronic osteomyelitis. Dtsch Arztebl Int. 2012;109:257\u201364.","journal-title":"Dtsch Arztebl Int"},{"key":"6261_CR2","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1097\/QCO.0000000000000155","volume":"28","author":"BE Beck-Broichsitter","year":"2015","unstructured":"Beck-Broichsitter BE, Smeets R, Heiland M. Current concepts in pathogenesis of acute and chronic osteomyelitis. Curr Opin Infect Dis. 2015;28:240\u20135.","journal-title":"Curr Opin Infect Dis"},{"key":"6261_CR3","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1016\/S0140-6736(04)16727-5","volume":"364","author":"DP Lew","year":"2004","unstructured":"Lew DP, Waldvogel FA. Osteomyelitis. Lancet. 2004;364:369\u201379.","journal-title":"Lancet"},{"key":"6261_CR4","doi-asserted-by":"crossref","first-page":"918","DOI":"10.1302\/0301-620X.85B6.13509","volume":"85","author":"JK Ellington","year":"2003","unstructured":"Ellington JK, Harris M, Webb L, Smith B, Smith T, Tan K, et al. Intracellular Staphylococcus aureus: A mechanism for the indolence of osteomyelitis. J Bone Joint Surg Br. 2003;85:918\u201321.","journal-title":"J Bone Joint Surg Br"},{"key":"6261_CR5","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1093\/clinids\/10.1.103","volume":"10","author":"CW Norden","year":"1988","unstructured":"Norden CW. Lessons learned from animal models of osteomyelitis. Rev Infect Dis. 1988;10:103\u201310.","journal-title":"Rev Infect Dis"},{"key":"6261_CR6","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1097\/00003086-199310000-00013","volume":"295","author":"JT Mader","year":"1993","unstructured":"Mader JT, Landon GC, Calhoun J. Antimicrobial treatment of osteomyelitis. Clin Orthop Relat Res. 1993;295:87\u201395.","journal-title":"Clin Orthop Relat Res"},{"key":"6261_CR7","doi-asserted-by":"crossref","first-page":"e752","DOI":"10.1016\/j.ijid.2010.01.005","volume":"14","author":"R Haidar","year":"2010","unstructured":"Haidar R, Der Boghossian A, Atiyeh B. Duration of post-surgical antibiotics in chronic osteomyelitis: empiric or evidence-based? Int J Infect Dis. 2010;14:e752\u20138.","journal-title":"Int J Infect Dis"},{"key":"6261_CR8","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/j.biomaterials.2015.12.012","volume":"81","author":"JA Inzana","year":"2016","unstructured":"Inzana JA, Schwarz EM, Kates SL, Awad HA. Biomaterials approaches to treating implant-associated osteomyelitis. Biomaterials. 2016;81:58\u201371.","journal-title":"Biomaterials"},{"key":"6261_CR9","doi-asserted-by":"crossref","first-page":"774","DOI":"10.1080\/17453670710014545","volume":"78","author":"N Dunne","year":"2007","unstructured":"Dunne N, Hill J, McAfee P, Todd K, Kirkpatrick R, Tunney M, et al. In vitro study of the efficacy of acrylic bone cement loaded with supplementary amounts of gentamicin: effect on mechanical properties, antibiotic release, and biofilm formation. Acta Orthop. 2007;78:774\u201385.","journal-title":"Acta Orthop"},{"key":"6261_CR10","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1080\/000164700317362280","volume":"71","author":"H Van De Belt","year":"2000","unstructured":"Van De Belt H, Neut D, Schenk W, van Horn JR, van der Mei HC, Busscher HJ. Gentamicin release from polymethylmethacrylate bone cements and Staphylococcus aureus biofilm formation. Acta Orthop Scand. 2000;71:625\u20139.","journal-title":"Acta Orthop Scand"},{"key":"6261_CR11","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1097\/01.blo.0000143571.18892.8d","volume":"427","author":"C Zalavras","year":"2004","unstructured":"Zalavras C, Patzakis M, Holtom P. Local antibiotic therapy in the treatment of open fractures and osteomyelitis. Clin Orthop Relat Res. 2004;427:86\u201393.","journal-title":"Clin Orthop Relat Res"},{"key":"6261_CR12","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1002\/jor.21531","volume":"30","author":"G Giavaresi","year":"2012","unstructured":"Giavaresi G, Bertazzoni Minelli E, Sartori M, Benini A, Della Bora T, Sambri V, et al. Microbiological and pharmacological tests on new antibiotic-loaded PMMA-based composites for the treatment of osteomyelitis. J Orthop Res. 2012;30:348\u201355.","journal-title":"J Orthop Res"},{"key":"6261_CR13","doi-asserted-by":"crossref","first-page":"3488","DOI":"10.1002\/jbm.a.35019","volume":"102","author":"H Cheng","year":"2014","unstructured":"Cheng H, Li Y, Huo K, Gao B, Xiong W. Long-lasting in vivo and in vitro antibacterial ability of nanostructured titania coating incorporated with silver nanoparticles. J Biomed Mater Res A. 2014;102:3488\u201399.","journal-title":"J Biomed Mater Res A"},{"key":"6261_CR14","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jhin.2004.11.014","volume":"60","author":"SL Percival","year":"2005","unstructured":"Percival SL, Bowler PG, Russell D. Bacterial resistance to silver in wound care. J Hosp Infect. 2005;60:1\u20137.","journal-title":"J Hosp Infect"},{"key":"6261_CR15","doi-asserted-by":"crossref","first-page":"871","DOI":"10.2106\/00004623-197860070-00001","volume":"60","author":"RO Becker","year":"1978","unstructured":"Becker RO, Spadaro JA. Treatment of orthopaedic infections with electrically generated silver ions. A preliminary report. J Bone Joint Surg Am. 1978;60:871\u201381.","journal-title":"J Bone Joint Surg Am"},{"key":"6261_CR16","first-page":"91","volume":"94","author":"S Nand","year":"1996","unstructured":"Nand S, Sengar GK, Nand S, Jain VK, Gupta TD. Dual use of silver for management of chronic bone infections and infected non-unions. J Indian Med Assoc. 1996;94:91\u20135.","journal-title":"J Indian Med Assoc"},{"key":"6261_CR17","doi-asserted-by":"crossref","first-page":"979","DOI":"10.1016\/j.msec.2012.11.033","volume":"33","author":"B Mahltig","year":"2013","unstructured":"Mahltig B, Soltmann U, Haase H. Modification of algae with zinc, copper and silver ions for usage as natural composite for antibacterial applications. Mater Sci Eng C Mater Biol Appl. 2013;33:979\u201383.","journal-title":"Mater Sci Eng C Mater Biol Appl"},{"key":"6261_CR18","doi-asserted-by":"crossref","first-page":"178123","DOI":"10.1155\/2014\/178123","volume":"2014","author":"J Kolmas","year":"2014","unstructured":"Kolmas J, Groszyk E, Kwiatkowska-R\u00f3\u017cycka D. Substituted hydroxyapatites with antibacterial properties. Biomed Res Int. 2014;2014:178123.","journal-title":"Biomed Res Int"},{"key":"6261_CR19","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1089\/sur.2011.097","volume":"14","author":"AD Politano","year":"2013","unstructured":"Politano AD, Campbell KT, Rosenberger LH, Sawyer RG. Use of silver in the prevention and treatment of infections: silver review. Surg Infect (Larchmt). 2013;14:8\u201320.","journal-title":"Surg Infect (Larchmt)"},{"key":"6261_CR20","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1089\/teb.2007.0133","volume":"14","author":"SA Guelcher","year":"2008","unstructured":"Guelcher SA. Biodegradable polyurethanes: synthesis and applications in regenerative medicine. Tissue Eng Part B Rev. 2008;14:3\u201317.","journal-title":"Tissue Eng Part B Rev"},{"key":"6261_CR21","first-page":"108","volume":"89","author":"SJ Heo","year":"2009","unstructured":"Heo SJ, Kim SE, Wei J, Hyun YT, Yun HS, Kim DH, et al. Fabrication and characterization of novel nano- and micro-HA\/PCL composite scaffolds using a modified rapid prototyping process. J Biomed Mater Res A. 2009;89:108\u201316.","journal-title":"J Biomed Mater Res A"},{"key":"6261_CR22","doi-asserted-by":"crossref","first-page":"1621","DOI":"10.1002\/jbm.b.33344","volume":"103","author":"JV Rau","year":"2015","unstructured":"Rau JV, Cacciotti I, Laureti S, Fosca M, Varvaro G, Latini A. Bioactive, nanostructured Si-substituted hydroxyapatite coatings on titanium prepared by pulsed laser deposition. J Biomed Mater Res B Appl Biomater. 2015;103:1621\u201331.","journal-title":"J Biomed Mater Res B Appl Biomater"},{"key":"6261_CR23","doi-asserted-by":"crossref","first-page":"2501","DOI":"10.1016\/j.actbio.2009.08.037","volume":"6","author":"M Bil","year":"2010","unstructured":"Bil M, Ryszkowska J, Wo\u017aniak P, Kurzyd\u0142owski KJ, Lewandowska-Szumie\u0142 M. Optimization of the structure of polyurethanes for bone tissue engineering applications. Acta Biomater. 2010;6:2501\u201310.","journal-title":"Acta Biomater"},{"key":"6261_CR24","doi-asserted-by":"crossref","first-page":"6034","DOI":"10.1016\/j.biomaterials.2011.04.048","volume":"32","author":"JE McBane","year":"2011","unstructured":"McBane JE, Sharifpoor S, Cai K, Labow RS, Santerre JP. Biodegradation and in vivo biocompatibility of a degradable, polar\/hydrophobic\/ionic polyurethane for tissue engineering applications. Biomaterials. 2011;32:6034\u201344.","journal-title":"Biomaterials"},{"key":"6261_CR25","doi-asserted-by":"crossref","first-page":"2251","DOI":"10.1002\/jbm.a.35365","volume":"103","author":"W Yang","year":"2015","unstructured":"Yang W, Both SK, Zuo Y, Birgani ZT, Habibovic P, Li Y, et al. Biological evaluation of porous aliphatic polyurethane\/hydroxyapatite composite scaffolds for bone tissue engineering. J Biomed Mater Res A. 2015;103:2251\u20139.","journal-title":"J Biomed Mater Res A"},{"key":"6261_CR26","doi-asserted-by":"crossref","unstructured":"Wang Q, Chen C, Liu W, He X, Zhou N, Zhang D, et al. Levofloxacin loaded mesoporous silica microspheres\/nano-hydroxyapatite\/polyurethane composite scaffold for the treatment of chronic osteomyelitis with bone defects. Sci Rep. 2017;7:41808.","DOI":"10.1038\/srep41808"},{"key":"6261_CR27","doi-asserted-by":"crossref","first-page":"1746","DOI":"10.4028\/www.scientific.net\/AMR.311-313.1746","volume":"311\u20133","author":"C Guo","year":"2011","unstructured":"Guo C, Li X, Dong Y. Preparation and characterization of silver\/hydroxyapatite nanoparticles. Advanced Materials Research. 2011;311\u20133:1746\u201350.","journal-title":"Advanced Materials Research"},{"key":"6261_CR28","doi-asserted-by":"crossref","first-page":"1195","DOI":"10.1002\/jor.22357","volume":"31","author":"T Akiyama","year":"2013","unstructured":"Akiyama T, Miyamoto H, Yonekura Y, Tsukamoto M, Ando Y, Noda I, et al. Silver oxide-containing hydroxyapatite coating has in vivo antibacterial activity in the rat tibia. J Orthop Res. 2013;31:1195\u2013200.","journal-title":"J Orthop Res"},{"key":"6261_CR29","first-page":"583","volume":"240\u20132","author":"KS Oh","year":"2003","unstructured":"Oh KS, Kim KJ, Jeong YK, Choa YH. Effect of fabrication processes on the antimicrobial properties of silver doped nano-sized HAp. Key Engineering Materials. 2003;240\u20132:583\u20136.","journal-title":"Key Engineering Materials"},{"key":"6261_CR30","doi-asserted-by":"crossref","first-page":"1584","DOI":"10.1080\/09205063.2016.1221699","volume":"27","author":"J Jiang","year":"2016","unstructured":"Jiang J, Li L, Li K, Li G, You F, Zuo Y, et al. Antibacterial nanohydroxyapatite\/polyurethane composite scaffolds with silver phosphate particles for bone regeneration. J Biomater Sci Polym Ed. 2016;27:1584\u201398.","journal-title":"J Biomater Sci Polym Ed"},{"key":"6261_CR31","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1007\/BF02699641","volume":"89","author":"VV Gite","year":"2006","unstructured":"Gite VV, Kulkarni RD, Hundiwale DG, Kapadi UR. Synthesis and characterisation of polyurethane coatings based on trimer of isophorone diisocyanate (IPDI) and monoglycerides of oils. Surf Coat Int. 2006;89:117\u201322.","journal-title":"Surf Coat Int"},{"key":"6261_CR32","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1093\/infdis\/122.5.410","volume":"122","author":"CW Norden","year":"1970","unstructured":"Norden CW. Experimental osteomyelitis. I. A description of the model. J Infect Dis. 1970;122:410\u20138.","journal-title":"J Infect Dis"},{"key":"6261_CR33","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1302\/0301-620X.97B5.33336","volume":"97","author":"SA Brennan","year":"2015","unstructured":"Brennan SA, N\u00ed Fhoghl\u00fa C, Devitt BM, O'Mahony FJ, Brabazon D, Walsh A. Silver nanoparticles and their orthopaedic applications. Bone Joint J. 2015;97:582\u20139.","journal-title":"Bone Joint J"},{"key":"6261_CR34","doi-asserted-by":"crossref","first-page":"5547","DOI":"10.1016\/j.biomaterials.2004.01.008","volume":"25","author":"G Gosheger","year":"2004","unstructured":"Gosheger G, Hardes J, Ahrens H, Streitburger A, Buerger H, Erren M, et al. Silver-coated megaendoprostheses in a rabbit model\u2014an analysis of the infection rate and toxicological side effects. Biomaterials. 2004;25:5547\u201356.","journal-title":"Biomaterials"},{"key":"6261_CR35","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1002\/jbm.a.34322","volume":"101","author":"S Samani","year":"2013","unstructured":"Samani S, Hossainalipour SM, Tamizifar M, Rezaie HR. In vitro antibacterial evaluation of sol-gel-derived Zn-, Ag-, and (Zn+ Ag)-doped hydroxyapatite coatings against methicillin-resistant Staphylococcus aureus. J Biomed Mater Res A. 2013;101:222\u201330.","journal-title":"J Biomed Mater Res A"},{"key":"6261_CR36","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1002\/jbm.b.31526","volume":"92","author":"T Shimazaki","year":"2010","unstructured":"Shimazaki T, Miyamoto H, Ando Y, Noda I, Yonekura Y, Kawano S, et al. In vivo antibacterial and silver-releasing properties of novel thermal sprayed silver-containing hydroxyapatite coating. J Biomed Mater Res B Appl Biomater. 2010;92:386\u20139.","journal-title":"J Biomed Mater Res B Appl Biomater"},{"key":"6261_CR37","doi-asserted-by":"crossref","first-page":"644","DOI":"10.1302\/0301-620X.93B5.25518","volume":"93","author":"Y Yonekura","year":"2011","unstructured":"Yonekura Y, Miyamoto H, Shimazaki T, Ando Y, Noda I, Mawatari M, et al. Osteoconductivity of thermal-sprayed silver-containing hydroxyapatite coating in the rat tibia. J Bone Joint Surg Br. 2011;93:644\u20139.","journal-title":"J Bone Joint Surg Br"},{"key":"6261_CR38","doi-asserted-by":"crossref","first-page":"1391","DOI":"10.1002\/jor.22903","volume":"33","author":"S Eto","year":"2015","unstructured":"Eto S, Miyamoto H, Shobuike T, Noda I, Akiyama T, Tsukamoto M, et al. Silver oxide-containing hydroxyapatite coating supports osteoblast function and enhances implant anchorage strength in rat femur. J Orthop Res. 2015;33:1391\u20137.","journal-title":"J Orthop Res"},{"key":"6261_CR39","doi-asserted-by":"crossref","first-page":"3144","DOI":"10.1016\/j.actbio.2012.04.004","volume":"8","author":"GA Fielding","year":"2012","unstructured":"Fielding GA, Roy M, Bandyopadhyay A, Bose S. Antibacterial and biological characteristics of silver containing and strontium doped plasma sprayed hydroxyapatite coatings. Acta Biomater. 2012;8:3144\u201352.","journal-title":"Acta Biomater"},{"key":"6261_CR40","doi-asserted-by":"crossref","first-page":"1629","DOI":"10.1097\/BRS.0b013e3181d25803","volume":"35","author":"JA Rihn","year":"2010","unstructured":"Rihn JA, Kirkpatrick K, Albert TJ. Graft options in posterolateral and posterior interbody lumbar fusion. Spine (Phila Pa 1976). 2010;35:1629\u201339.","journal-title":"Spine (Phila Pa 1976)"},{"key":"6261_CR41","doi-asserted-by":"crossref","first-page":"045003.","DOI":"10.1088\/1748-6041\/4\/4\/045003","volume":"4","author":"K Mao","year":"2009","unstructured":"Mao K, Yang Y, Li J, Hao L, Tang P, Wang Z, et al. Investigation of the histology and interfacial bonding between carbonated hydroxyapatite cement and bone. Biomed Mater. 2009;4:045003.","journal-title":"Biomed Mater"},{"key":"6261_CR42","doi-asserted-by":"crossref","first-page":"2671","DOI":"10.1007\/s10856-012-4738-8","volume":"23","author":"SH Park","year":"2012","unstructured":"Park SH, Park DS, Shin JW, Kang YG, Kim HK, Yoon TR, et al. Scaffolds for bone tissue engineering fabricated from two different materials by the rapid prototyping technique: PCL versus PLGA. J Mater Sci Mater Med. 2012;23:2671\u20138.","journal-title":"J Mater Sci Mater Med"},{"key":"6261_CR43","doi-asserted-by":"crossref","first-page":"5186","DOI":"10.1016\/j.biomaterials.2006.05.051","volume":"27","author":"MC von Doernberg","year":"2006","unstructured":"von Doernberg MC, von Rechenberg B, Bohner M, Gr\u00fcnenfelder S, van Lenthe GH, M\u00fcller R, et al. In vivo behavior of calcium phosphate scaffolds with four different pore sizes. Biomaterials. 2006;27:5186\u201398.","journal-title":"Biomaterials"},{"key":"6261_CR44","doi-asserted-by":"crossref","first-page":"1829","DOI":"10.1016\/S0142-9612(02)00614-2","volume":"24","author":"D Neut","year":"2003","unstructured":"Neut D, van de Belt H, van Horn JR, van der Mei HC, Busscher HJ. Residual gentamicin-release from antibiotic-loaded polymethylmethacrylate beads after 5 years of implantation. Biomaterials. 2003;24:1829\u201331.","journal-title":"Biomaterials"},{"key":"6261_CR45","first-page":"27","volume":"493-4","author":"ES Thian","year":"2012","unstructured":"Thian ES, Lim PN, Shi Z, Tay BY, Neoh KG. Silver-doped apatite as a bioactive and an antimicrobial bone material. Key Engineering Materials. 2012;493-4:27\u201330.","journal-title":"Key Engineering Materials"},{"key":"6261_CR46","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.msea.2004.05.068","volume":"254\u20136","author":"JW Choi","year":"2004","unstructured":"Choi JW, Cho HM, Kwak EK, Kwon TG, Ryoo HM, Jeong YK, et al. Effect of Ag-doped hydroxyapatite as a bone filler for inflamed bone defects. Key Engineering Materials. 2004;254\u20136:47\u201350.","journal-title":"Key Engineering Materials"},{"key":"6261_CR47","doi-asserted-by":"crossref","first-page":"1341","DOI":"10.1021\/am201610q","volume":"4","author":"M Roy","year":"2012","unstructured":"Roy M, Fielding GA, Beyenal H, Bandyopadhyay A, Bose S. Mechanical, in vitro antimicrobial, and biological properties of plasma-sprayed silver-doped hydroxyapatite coating. ACS Appl Mater Interfaces. 2012;4:1341\u20139.","journal-title":"ACS Appl Mater Interfaces"},{"key":"6261_CR48","first-page":"108","volume":"5","author":"E Pepla","year":"2014","unstructured":"Pepla E, Besharat LK, Palaia G, Tenore G, Migliau G. Nano-hydroxyapatite and its applications in preventive, restorative and regenerative dentistry: a review of literature. Ann Stomatol (Roma). 2014;5:108\u201314.","journal-title":"Ann Stomatol (Roma)"},{"key":"6261_CR49","doi-asserted-by":"crossref","first-page":"3124","DOI":"10.1166\/jbn.2014.1893","volume":"10","author":"J Venkatesan","year":"2014","unstructured":"Venkatesan J, Kim SK. Nano-hydroxyapatite composite biomaterials for bone tissue engineering\u2013a review. J Biomed Nanotechnol. 2014;10:3124\u201340.","journal-title":"J Biomed Nanotechnol"}],"container-title":["Journal of Materials Science: Materials in Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10856-019-6261-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s10856-019-6261-7\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10856-019-6261-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,7,18]],"date-time":"2024-07-18T16:00:25Z","timestamp":1721318425000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s10856-019-6261-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,5,24]]},"references-count":49,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2019,6]]}},"alternative-id":["6261"],"URL":"https:\/\/doi.org\/10.1007\/s10856-019-6261-7","relation":{},"ISSN":["0957-4530","1573-4838"],"issn-type":[{"value":"0957-4530","type":"print"},{"value":"1573-4838","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,5,24]]},"assertion":[{"value":"13 March 2018","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 May 2019","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"24 May 2019","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"The study was approved by the animal experiment ethic committee of The First Affiliated Hospital of Chongqing Medical University.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics statement"}}],"article-number":"59"}}