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Biodegradable magnesium (Mg) alloy as medical bone implant material has full advantages and huge potential development space. Wherein, Mg\u2013lithium (Li) based alloy, as an ultra-light alloy, has good properties for implants under certain conditions, and both Mg and Li have inhibitory effects on tumor cells. Therefore, Mg\u2013Li alloy is expected to be applied in bone implant materials for mechanical supporting and inhibiting tumor cells simultaneously. In this contribution, the Mg\u2013<jats:italic>x<\/jats:italic>Li\u2013Zinc (Zn) series alloys (<jats:italic>x<\/jats:italic>\u2009=\u20093 wt%, 6\u2009wt%, 9\u2009wt%) were prepared to study the influence of different elements and contents on the structure and properties of the alloy, and the biosafety of the alloy was also evaluated. Our data showed that the yield strength, tensile strength, and elongation of as-cast Mg\u2013<jats:italic>x<\/jats:italic>Li\u2013Zn alloy were higher than those of as-cast Mg\u2013Zn alloy; Mg\u2013<jats:italic>x<\/jats:italic>Li\u2013Zn alloy can kill osteosarcoma cells (MG-63) in a concentration-dependent manner, wherein Mg\u20133Li\u2013Zn alloy (x\u2009=\u20093\u2009wt%) and Mg\u20136Li\u2013Zn alloy (<jats:italic>x<\/jats:italic>\u2009=\u20096\u2009wt%) promoted the proliferation of osteoblasts (MC3T3) at a certain concentration of Li. In summary, our study demonstrated that the Mg\u20136Li\u2013Zn alloy could be potentially applied as a material of orthopedic implant for its excellent multi-functions.<\/jats:p>","DOI":"10.1007\/s10856-021-06516-8","type":"journal-article","created":{"date-parts":[[2021,4,6]],"date-time":"2021-04-06T19:03:00Z","timestamp":1617735780000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":33,"title":["Investigation of Mg\u2013xLi\u2013Zn alloys for potential application of biodegradable bone implant materials"],"prefix":"10.1007","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8311-1739","authenticated-orcid":false,"given":"Jingan","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Panyu","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liguo","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yachen","family":"Hou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xueqi","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shijie","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaokang","family":"Guan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,4,6]]},"reference":[{"key":"6516_CR1","doi-asserted-by":"publisher","first-page":"8534","DOI":"10.1016\/j.actbio.2013.07.001","volume":"9","author":"D Hong","year":"2013","unstructured":"Hong D, Saha P, Chou DT, Lee B, Collins BE, Tan Z, Dong Z, Kumta PN. 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