{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T15:41:28Z","timestamp":1786981288392,"version":"build-2736575974"},"reference-count":25,"publisher":"Springer Science and Business Media LLC","issue":"7","license":[{"start":{"date-parts":[[2021,6,22]],"date-time":"2021-06-22T00:00:00Z","timestamp":1624320000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2021,6,22]],"date-time":"2021-06-22T00:00:00Z","timestamp":1624320000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Mater Sci: Mater Med"],"published-print":{"date-parts":[[2021,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Methicillin-resistant and Vancomycin-resistant\n                    <jats:italic>Staphylococcus aureus<\/jats:italic>\n                    bacteria (MRSA and VRSA, respectively) can seriously jeopardizes bone implants. This research aimed to examine the potential synergistic effects of Melittin and vancomycin in preventing MRSA and VRSA associated bone implant infections. Chitosan\/bioactive glass nanoparticles\/vancomycin composites were coated on hydrothermally etched titanium substrates by casting method. The composite coatings were coated by Melittin through drop casting technique. Melittin raised the proliferation of MC3T3 cells, making it an appropriate option as osteoinductive and antibacterial substance in coatings of orthopedic implants. Composite coatings having combined vancomycin and Melittin eliminated both planktonic and adherent MRSA and VRSA bacteria, whereas coatings containing one of them failed to kill the whole VRSA bacteria. Therefore, chitosan\/bioactive glass\/vancomycin\/Melittin coating can be used as a bone implant coating because of its anti-infective properties.\n                  <\/jats:p>","DOI":"10.1007\/s10856-021-06551-5","type":"journal-article","created":{"date-parts":[[2021,6,22]],"date-time":"2021-06-22T08:14:51Z","timestamp":1624349691000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["Prevention the formation of biofilm on orthopedic implants by melittin thin layer on chitosan\/bioactive glass\/vancomycin coatings"],"prefix":"10.1007","volume":"32","author":[{"given":"Vahid","family":"Zarghami","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1909-4671","authenticated-orcid":false,"given":"Mohammad","family":"Ghorbani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kamran Pooshang","family":"Bagheri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad Ali","family":"Shokrgozar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,6,22]]},"reference":[{"key":"6551_CR1","doi-asserted-by":"publisher","unstructured":"Raphel J, Holodniy M, Goodman SB, Heilshorn SC. Multifunctional coatings to simultaneously promote osseointegration and prevent infection of orthopaedic implants. Biomaterials. 2016. https:\/\/doi.org\/10.1016\/j.biomaterials.2016.01.016.","DOI":"10.1016\/j.biomaterials.2016.01.016"},{"key":"6551_CR2","doi-asserted-by":"publisher","unstructured":"Goodman SB, Yao Z, Keeney M, Yang F. The future of biologic coatings for orthopaedic implants. Biomaterials. 2013. https:\/\/doi.org\/10.1016\/j.biomaterials.2013.01.074.","DOI":"10.1016\/j.biomaterials.2013.01.074"},{"key":"6551_CR3","doi-asserted-by":"publisher","unstructured":"Kazemzadeh-Narbat M, Lai BF, Ding C, Kizhakkedathu JN, Hancock RE, Wang R. Multilayered coating on titanium for controlled release of antimicrobial peptides for the prevention of implant-associated infections. 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