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The scaffolds were exposed to ultrasonic waves while immersed in an ethanol\/acetone solvent mixture that possessed both polar and nonpolar properties. A factorial experiment was conducted in which the scaffolds were treated to three levels of sonication power (<jats:italic>p<\/jats:italic><jats:sub>W<\/jats:sub>): 0, 20% (22\u2009W) and 40% (44\u2009W), and soaking duration (<jats:italic>t<\/jats:italic>): 5, 15, and 30\u2009min. The treated scaffolds were characterized by FT-IR, optical microscopy, and mechanical (compressive) testing. FT-IR revealed that the amount of PVA decreased with increasing <jats:italic>p<\/jats:italic><jats:sub>W<\/jats:sub> and <jats:italic>t<\/jats:italic>. Two-way ANOVA revealed that increasing <jats:italic>p<\/jats:italic><jats:sub>W<\/jats:sub> and <jats:italic>t<\/jats:italic>, respectively, resulted in increasing scaffold surface area to volume (SVR). Sonication and solvent caused structural damage (i.e., unevenness) on the scaffold surface, but the damage was minimal at 20% <jats:italic>p<\/jats:italic><jats:sub>W<\/jats:sub> and 30\u2009min. The optimal values of p<jats:sub>W<\/jats:sub> and t resulting in enhanced fracture strength, strain and toughness were 20% and 30\u2009min, respectively, which corroborated the findings of minimal structural damage. However, sonication had no significant effects on the scaffold stiffness. Mechanistic analysis of the effects of sonication predicted that the ultrasonic energy absorbed by the scaffold was sufficient to disrupt the van Der Waals bonds between the PVA and PLGA but not high enough to disrupt the covalent bonds within the PLGA. This technique is promising as it can partially remove the PVA from the scaffold, and mitigate problematic issues down the line, such as thermal degradation during sterilization, and undue delay\/variability in biodegradation.<\/jats:p>","DOI":"10.1007\/s10856-021-06561-3","type":"journal-article","created":{"date-parts":[[2021,7,31]],"date-time":"2021-07-31T12:02:32Z","timestamp":1627732952000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Post-process optimization of 3D printed poly(lactic-co-glycolic acid) dental implant scaffold for enhanced structure and mechanical properties: effects of sonication duration and power"],"prefix":"10.1007","volume":"32","author":[{"given":"R. N. V. 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