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However, this is a challenging problem due to the moist environment in surgical sites with bone surfaces covered with blood and biomolecules like lipids or proteins. A nanoparticle-loaded hydrogel that is based on a freeze-dried powder of silica-coated calcium phosphate\/carboxymethyl cellulose nanoparticles (CaP\/CMC\/SiO<jats:sub>2<\/jats:sub>) and an aqueous solution of sodium alginate (2\u2009wt%) was developed and optimized with respect to the gluing ability in air and in water. The final paste was crosslinked within about one minute by calcium ions released from the calcium phosphate nanoparticles and contained about 20\u2009wt% nanoparticles and 80\u2009wt% water. The mechanical properties of the hydrogel were determined by extensive rheological tests. The thixotropic pasty hydrogel can be applied with a syringe. The adhesion strength was about 84\u2009kPa between moist bone fragments in air. 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