{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,10]],"date-time":"2026-11-10T13:46:56Z","timestamp":1794318416338,"version":"4.9.0"},"reference-count":163,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,5,15]],"date-time":"2025-05-15T00:00:00Z","timestamp":1747267200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2025,5,15]],"date-time":"2025-05-15T00:00:00Z","timestamp":1747267200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Mater Sci: Mater Med"],"DOI":"10.1007\/s10856-025-06895-2","type":"journal-article","created":{"date-parts":[[2025,5,15]],"date-time":"2025-05-15T12:06:14Z","timestamp":1747310774000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["MXenes in the application of diabetic foot: mechanisms, therapeutic implications and future perspectives"],"prefix":"10.1007","volume":"36","author":[{"given":"Zhang","family":"Mengru","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wu","family":"Qinyi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yao","family":"Zimo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guo","family":"Bingqing","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xia","family":"Zhongyu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2523-6066","authenticated-orcid":false,"given":"Jianda","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,5,15]]},"reference":[{"key":"6895_CR1","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1001\/jama.2023.10578","volume":"330","author":"DG Armstrong","year":"2023","unstructured":"Armstrong DG, Tan TW, Boulton AJM, Bus SA. Diabetic foot ulcers: a review. JAMA. 2023;330:62\u201375.","journal-title":"JAMA"},{"key":"6895_CR2","doi-asserted-by":"crossref","first-page":"2367","DOI":"10.1056\/NEJMra1615439","volume":"376","author":"DG Armstrong","year":"2017","unstructured":"Armstrong DG, Boulton AJM, Bus SA. Diabetic foot ulcers and their recurrence. N Engl J Med. 2017;376:2367\u201375.","journal-title":"N Engl J Med"},{"key":"6895_CR3","doi-asserted-by":"crossref","first-page":"1480","DOI":"10.47391\/JPMA.6634","volume":"73","author":"ZU Rehman","year":"2023","unstructured":"Rehman ZU, Khan J, Noordin S. Diabetic foot ulcers: contemporary assessment and management. J Pak Med Assoc. 2023;73:1480\u20137.","journal-title":"J Pak Med Assoc"},{"key":"6895_CR4","doi-asserted-by":"crossref","DOI":"10.1098\/rsob.200223","volume":"10","author":"HN Wilkinson","year":"2020","unstructured":"Wilkinson HN, Hardman MJ. Wound healing: cellular mechanisms and pathological outcomes. Open Biol. 2020;10:200223.","journal-title":"Open Biol"},{"key":"6895_CR5","doi-asserted-by":"crossref","first-page":"373","DOI":"10.2217\/rme-2020-0066","volume":"16","author":"F Yang","year":"2021","unstructured":"Yang F, Bai XJ, Dai XJ, et al. The biological processes during wound healing. Regen Med. 2021;16:373\u201390.","journal-title":"Regen Med"},{"key":"6895_CR6","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1177\/1534734620924857","volume":"21","author":"M Abazari","year":"2022","unstructured":"Abazari M, Ghaffari A, Rashidzadeh H, Badeleh SM, Maleki Y, et al. A systematic review on classification, identification, and Healing process of burn Wound Healing. Int J Low Extrem Wounds. 2022;21:18\u201330.","journal-title":"Int J Low Extrem Wounds"},{"key":"6895_CR7","doi-asserted-by":"crossref","first-page":"2102","DOI":"10.3390\/polym13132102","volume":"13","author":"S Alven","year":"2021","unstructured":"Alven S, Aderibigbe BA. Hyaluronic acid-based scafolds as potential bioactive wound dressings. Polymers. 2021;13:2102.","journal-title":"Polymers"},{"key":"6895_CR8","doi-asserted-by":"crossref","first-page":"42","DOI":"10.3390\/pharmaceutics15010042","volume":"15","author":"N Ahmad","year":"2022","unstructured":"Ahmad N. In vitro and in vivo characterization methods for evaluation of modern wound dressings. Pharmaceutics. 2022;15:42.","journal-title":"Pharmaceutics"},{"key":"6895_CR9","doi-asserted-by":"crossref","first-page":"4925","DOI":"10.3390\/molecules27154925","volume":"27","author":"I Ali","year":"2022","unstructured":"Ali I, Faraz Ud Din M, Gu ZG. MXenes thin films: from fabrication to their applications. Molecules. 2022;27:4925.","journal-title":"Molecules"},{"key":"6895_CR10","doi-asserted-by":"crossref","first-page":"109634","DOI":"10.1016\/j.diamond.2022.109634","volume":"132","author":"D Ayodhya","year":"2023","unstructured":"Ayodhya D. A review of recent progress in 2D MXenes: synthesis, properties, and applications. Diam Relat Mater. 2023;132:109634.","journal-title":"Diam Relat Mater"},{"key":"6895_CR11","doi-asserted-by":"crossref","first-page":"8491","DOI":"10.1021\/acsnano.9b06394","volume":"13","author":"Y Gogotsi","year":"2019","unstructured":"Gogotsi Y, Anasori B. The rise of MXenes. ACS Nano. 2019;13:8491\u20134.","journal-title":"ACS Nano"},{"key":"6895_CR12","doi-asserted-by":"crossref","first-page":"1322","DOI":"10.1021\/nn204153h","volume":"6","author":"M Naguib","year":"2012","unstructured":"Naguib M, Mashtalir O, Carle J, Presser V, Lu J, Hultman L, et al. Two-dimensional transition metal carbides. ACS Nano. 2012;6:1322\u201331.","journal-title":"ACS Nano"},{"key":"6895_CR13","doi-asserted-by":"crossref","first-page":"992","DOI":"10.1002\/adma.201304138","volume":"26","author":"M Naguib","year":"2014","unstructured":"Naguib M, Mochalin VN, Barsoum MW, Gogotsi Y. 25th anniversary article: MXenes: a new family of two-dimensional materials. Adv Mater. 2014;26:992\u20131005.","journal-title":"Adv Mater"},{"key":"6895_CR14","doi-asserted-by":"crossref","DOI":"10.1002\/smll.202205249","volume":"19","author":"U Amara","year":"2023","unstructured":"Amara U, Hussain I, Ahmad M, Mahmood K, Zhang K. 2D MXene-based biosensing: a review. Small. 2023;19:e2205249.","journal-title":"Small"},{"key":"6895_CR15","volume":"17","author":"C Liang","year":"2023","unstructured":"Liang C, He J, Cao Y, Liu G, Zhang C, Qi Z, et al. Advances in the application of Mxene nanoparticles in wound healing. J Biol Eng. 2023;17:39.","journal-title":"J Biol Eng"},{"key":"6895_CR16","doi-asserted-by":"crossref","first-page":"5109","DOI":"10.1039\/C7CS00838D","volume":"47","author":"K Huang","year":"2018","unstructured":"Huang K, Li ZJ, Lin J, Han G, Huang P. Two-dimensional transition metal carbides and nitrides (MXenes) for biomedical applications. Chem Soc Rev. 2018;47:5109\u201324.","journal-title":"Chem Soc Rev"},{"key":"6895_CR17","volume":"33","author":"M Naguib","year":"2021","unstructured":"Naguib M, Barsoum MW, Gogotsi Y. Ten years of progress in the synthesis and development of MXenes. Adv Mater. 2021;33:e2103393.","journal-title":"Adv Mater"},{"key":"6895_CR18","doi-asserted-by":"crossref","first-page":"7703","DOI":"10.1021\/acsami.8b18931","volume":"11","author":"P Tang","year":"2019","unstructured":"Tang P, Han L, Li P, Jia Z, Wang K, Zhang H, et al. Mussel-inspired electroactive and antioxidative scaffolds with incorporation of polydopamine-reduced graphene oxide for enhancing skin wound healing. ACS Appl Mater Interfaces. 2019;11:7703\u201314.","journal-title":"ACS Appl Mater Interfaces"},{"key":"6895_CR19","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0070-2153(03)58001-2","volume":"58","author":"R Nuccitelli","year":"2003","unstructured":"Nuccitelli R. A role for endogenous electric fields in wound healing. Curr Top Dev Biol. 2003;58:1\u201326.","journal-title":"Curr Top Dev Biol"},{"key":"6895_CR20","doi-asserted-by":"crossref","DOI":"10.1016\/j.copbio.2022.102710","volume":"75","author":"M Verdes","year":"2022","unstructured":"Verdes M, Mace K, Margetts L, Cartmell S. Status and challenges of electrical stimulation use in chronic wound healing. Curr Opin Biotechnol. 2022;75:102710.","journal-title":"Curr Opin Biotechnol"},{"key":"6895_CR21","doi-asserted-by":"crossref","first-page":"19390","DOI":"10.1039\/C5NR06513E","volume":"7","author":"S Lai","year":"2015","unstructured":"Lai S, Jeon J, Jang SK, Xu J, Choi YJ, Park JH, et al. Surface group modification and carrier transport properties of layered transition metal carbides (Ti2CT(x), T: -OH, -F and -O). Nanoscale. 2015;7:19390\u20136.","journal-title":"Nanoscale"},{"key":"6895_CR22","volume":"10","author":"R Luo","year":"2021","unstructured":"Luo R, Dai J, Zhang J, Li Z. Accelerated skin wound healing by electrical stimulation. Adv Health Mater. 2021;10:e2100557.","journal-title":"Adv Health Mater"},{"key":"6895_CR23","doi-asserted-by":"crossref","first-page":"9672","DOI":"10.1007\/s12274-023-5527-z","volume":"16","author":"S Xu","year":"2023","unstructured":"Xu S, Du C, Zhang M, Wang R, Feng W, Wang C, et al. Electroactive and antibacterial wound dressings based on Ti3C2Tx MXene\/poly(epsilon-caprolactone)\/gelatin coaxial electrospun nanofibrous membranes. Nano Res. 2023;16:9672\u201387.","journal-title":"Nano Res"},{"key":"6895_CR24","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.actbio.2020.12.035","volume":"139","author":"R Guo","year":"2022","unstructured":"Guo R, Xiao M, Zhao W, Zhou S, Hu Y, Liao M, et al. 2D Ti3C2TxMXene couples electrical stimulation to promote proliferation and neural differentiation of neural stem cells. Acta Biomater. 2022;139:105\u201317.","journal-title":"Acta Biomater"},{"key":"6895_CR25","doi-asserted-by":"crossref","first-page":"130148","DOI":"10.1016\/j.cej.2021.130148","volume":"424","author":"H Zheng","year":"2021","unstructured":"Zheng H, Wang S, Cheng F, He X, Liu Z, Wang W, et al. Bioactive anti-inflammatory, antibacterial, conductive multifunctional scaffold based on MXene@ CeO2 nanocomposites for infection-impaired skin multimodal therapy. Chem Eng J 2021;424:130148.","journal-title":"Chem Eng J"},{"key":"6895_CR26","doi-asserted-by":"crossref","first-page":"3585","DOI":"10.1039\/D2BM00575A","volume":"10","author":"S Liu","year":"2022","unstructured":"Liu S, Li D, Wang Y, Zhou G, Ge K, Jiang L, et al. Flexible, high-strength and multifunctional polyvinyl alcohol\/MXene\/polyaniline hydrogel enhancing skin wound healing. Biomater Sci. 2022;10:3585\u201396.","journal-title":"Biomater Sci"},{"key":"6895_CR27","doi-asserted-by":"crossref","first-page":"3908","DOI":"10.3390\/polym14183908","volume":"14","author":"H Zhu","year":"2022","unstructured":"Zhu H, Dai W, Wang L, Yao C, Wang C, Gu B, et al. Electroactive oxidized alginate\/gelatin\/MXene (Ti3C2Tx) composite hydrogel with improved biocompatibility and self-healing property. Polymers. 2022;14:3908.","journal-title":"Polymers"},{"key":"6895_CR28","doi-asserted-by":"crossref","first-page":"12236","DOI":"10.1039\/D1TA01514A","volume":"9","author":"F Liao","year":"2021","unstructured":"Liao F, Xu Z, Fan Z, Meng Q, Lv B, Ye X, et al. Confined assembly of ultrathin dual-functionalized Z-MXene nanosheet intercalated GO nanofilms with controlled structure for size-selective permeation. J Mater Chem A. 2021;9:12236\u201343.","journal-title":"J Mater Chem A"},{"key":"6895_CR29","volume":"17","author":"B Lu","year":"2021","unstructured":"Lu B, Zhu Z, Ma B, Wang W, Zhu R, Zhang J. 2D MXene nanomaterials for versatile biomedical applications: current trends and future prospects. Small. 2021;17:e2100946.","journal-title":"Small"},{"key":"6895_CR30","doi-asserted-by":"crossref","first-page":"5437","DOI":"10.1039\/D1BM00526J","volume":"9","author":"X Lin","year":"2021","unstructured":"Lin X, Li Z, Qiu J, Wang Q, Wang J, Zhang H, et al. Fascinating MXene nanomaterials: emerging opportunities in the biomedical field. Biomater Sci. 2021;9:5437\u201371.","journal-title":"Biomater Sci"},{"key":"6895_CR31","doi-asserted-by":"crossref","first-page":"1325","DOI":"10.1039\/C9NR07616F","volume":"12","author":"H Huang","year":"2020","unstructured":"Huang H, Jiang R, Feng Y, Ouyang H, Zhou N, Zhang X, et al. Recent development and prospects of surface modification and biomedical applications of MXenes. Nanoscale. 2020;12:1325\u201338.","journal-title":"Nanoscale"},{"key":"6895_CR32","doi-asserted-by":"crossref","DOI":"10.1016\/j.wri.2023.100202","volume":"29","author":"FA Janjhi","year":"2023","unstructured":"Janjhi FA, Ihsanullah I, Bilal M, Castro-Mu\u00f1oz R, Boczkaj B, Gallucci F. MXene-based materials for removal of antibiotics and heavy metals from wastewater\u2013 a review. Water Resour Ind 2023;29:100202.","journal-title":"Water Resour Ind"},{"key":"6895_CR33","doi-asserted-by":"crossref","first-page":"1194","DOI":"10.1007\/s40145-021-0535-5","volume":"10","author":"A Zhou","year":"2021","unstructured":"Zhou A, Liu Y, Li S, Wang X, Ying G, Xia Q, et al. From structural ceramics to 2D materials with multi-applications: a review on the development from MAX phases to MXenes. J Adv Ceram. 2021;10:1194\u2013242.","journal-title":"J Adv Ceram"},{"key":"6895_CR34","doi-asserted-by":"crossref","DOI":"10.1002\/adma.202007973","volume":"33","author":"BC Wyatt","year":"2021","unstructured":"Wyatt BC, Rosenkranz A, Anasori B. 2D MXenes: tunable mechanical and tribological properties. Adv Mater. 2021;33:e2007973.","journal-title":"Adv Mater"},{"key":"6895_CR35","volume":"17","author":"B Fu","year":"2021","unstructured":"Fu B, Sun J, Wang C, Shang C, Xu L, Li J, et al. MXenes: synthesis, optical properties, and applications in ultrafast photonics. Small. 2021;17:e2006054.","journal-title":"Small"},{"key":"6895_CR36","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1021\/acs.nanolett.6b04339","volume":"17","author":"H Lin","year":"2017","unstructured":"Lin H, Wang X, Yu L, Chen Y, Shi J. Two-dimensional ultrathin mxene ceramic nanosheets for photothermal conversion. Nano Lett. 2017;17:384\u201391.","journal-title":"Nano Lett"},{"key":"6895_CR37","doi-asserted-by":"crossref","unstructured":"Lin H, Wang Y, Gao S, Chen Y, Shi J. Theranostic 2D Tantalum carbide (MXene). Adv Mater. 2018;30:1703284.","DOI":"10.1002\/adma.201703284"},{"key":"6895_CR38","doi-asserted-by":"crossref","first-page":"4990","DOI":"10.1039\/D0TB00251H","volume":"8","author":"A Sundaram","year":"2020","unstructured":"Sundaram A, Ponraj JS, Wang C, Peng WK, Manavalan RK, Dhanabalan SC, et al. Engineering of 2D transition metal carbides and nitrides MXenes for cancer therapeutics and diagnostics. J Mater Chem B. 2020;8:4990\u20135013.","journal-title":"J Mater Chem B"},{"key":"6895_CR39","volume":"12","author":"J Li","year":"2021","unstructured":"Li J, Li Z, Liu X, Li C, Zheng Y, Yeung KWK, et al. Interfacial engineering of Bi2S3\/Ti3C2Tx MXene based on work function for rapid photo-excited bacteria-killing. Nat Commun. 2021;12:1224.","journal-title":"Nat Commun"},{"key":"6895_CR40","doi-asserted-by":"crossref","first-page":"16235","DOI":"10.1021\/jacs.7b07818","volume":"139","author":"H Lin","year":"2017","unstructured":"Lin H, Gao S, Dai C, Chen Y, Shi J. A two-dimensional biodegradable niobium carbide (MXene) for photothermal tumor eradication in NIR-I and NIR-II biowindows. J Am Chem Soc. 2017;139:16235\u201347.","journal-title":"J Am Chem Soc"},{"key":"6895_CR41","doi-asserted-by":"crossref","first-page":"810","DOI":"10.1016\/j.carbon.2021.04.023","volume":"178","author":"DK Zhang","year":"2021","unstructured":"Zhang DK, Zheng W, Li X, Li A, Ye N, Zhang L, et al. Investigating the effect of Ti3C2 (MXene) nanosheet on human umbilical vein endothelial cells via a combined untargeted and targeted metabolomics approach. Carbon. 2021;178:810\u201321.","journal-title":"Carbon"},{"key":"6895_CR42","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jhazmat.2017.06.004","volume":"339","author":"AM Jastrz\u0119bska","year":"2017","unstructured":"Jastrz\u0119bska AM, Szuplewska A, Wojciechowski T, Chudy M, Ziemkowska W, Chlubny L, et al. In vitro studies on cytotoxicity of delaminated Ti3C2 MXene. J Hazard Mater. 2017;339:1\u20138.","journal-title":"J Hazard Mater"},{"key":"6895_CR43","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1186\/s12951-019-0545-4","volume":"17","author":"A Szuplewska","year":"2019","unstructured":"Szuplewska A, Rozmys\u0142owska-Wojciechowska A, Po\u017aniak S, Wojciechowski T, Birowska M, Popielski M, et al. Multilayered stable 2D nano-sheets of Ti(2)NT(x) MXene: synthesis, characterization, and anticancer activity. J Nanobiotechnol. 2019;17:114.","journal-title":"J Nanobiotechnol"},{"key":"6895_CR44","first-page":"22","volume":"84","author":"Y GogotsI","year":"2020","unstructured":"GogotsI Y. Many faces of MXene. Chem Ind. 2020;84:22\u201325.","journal-title":"Chem Ind"},{"key":"6895_CR45","doi-asserted-by":"crossref","first-page":"20699","DOI":"10.1021\/acsnano.3c08859","volume":"17","author":"H Wan","year":"2023","unstructured":"Wan H, Chen Y, Tao Y, Chen P, Wang S, Jiang X, et al. MXene-mediated cellulose conductive hydrogel with ultrastretchability and self-healing ability. ACS Nano. 2023;17:20699\u2013710.","journal-title":"ACS Nano"},{"key":"6895_CR46","doi-asserted-by":"crossref","unstructured":"L Li, Z Xing, T Liao, J Wang, Z Xu, Y Kuang, C Li. Ti3C2Tx MXene quantum dots coated hollow manganese dioxide nanoparticles for tumor combination therapy and magnetic resonance imaging. Mater Today Chem. 2024;39:102171.","DOI":"10.1016\/j.mtchem.2024.102171"},{"key":"6895_CR47","doi-asserted-by":"crossref","first-page":"7486","DOI":"10.1021\/acsnano.1c10575","volume":"16","author":"Y Li","year":"2022","unstructured":"Li Y, Fu R, Duan Z, Zhu C, Fan D. Artificial nonenzymatic antioxidant mxene nanosheet-anchored injectable hydrogel as a mild photothermal-controlled oxygen release platform for diabetic wound healing. ACS Nano. 2022;16:7486\u2013502.","journal-title":"ACS Nano"},{"key":"6895_CR48","volume":"6","author":"X Wang","year":"2022","unstructured":"Wang X, Tao Y, Pan S, Fang X, Lou C, Xu Y, et al. Biocompatible and breathable healthcare electronics with sensing performances and photothermal antibacterial effect for motion-detecting. npj Flex Electron. 2022;6:95.","journal-title":"npj Flex Electron"},{"key":"6895_CR49","volume":"12","author":"T Li","year":"2023","unstructured":"Li T, Ma J, Wang W, Lei B. Bioactive MXene promoting angiogenesis and skeletal muscle regeneration through regulating M2 polarization and oxidation stress. Adv Health Mater. 2023;12:e2201862.","journal-title":"Adv Health Mater"},{"key":"6895_CR50","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/j.blre.2014.10.003","volume":"29","author":"EM Golebiewska","year":"2015","unstructured":"Golebiewska EM, Poole AW. Platelet secretion: from haemostasis to wound healing and beyond. Blood Rev. 2015;29:153\u201362.","journal-title":"Blood Rev"},{"key":"6895_CR51","volume":"157","author":"G Wang","year":"2023","unstructured":"Wang G, Yang F, Zhou W, Xiao N, Luo M, Tang Z. The initiation of oxidative stress and therapeutic strategies in wound healing. Biomed Pharmacother. 2023;157:114004.","journal-title":"Biomed Pharmacother"},{"key":"6895_CR52","volume":"2021","author":"L Deng","year":"2021","unstructured":"Deng L, Du C, Song P, Chen T, Rui S, Armstrong DG, et al. The role of oxidative stress and antioxidants in diabetic wound healing. Oxid Med Cell Longev. 2021;2021:8852759.","journal-title":"Oxid Med Cell Longev"},{"key":"6895_CR53","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/j.phrs.2008.06.004","volume":"58","author":"M Sch\u00e4fer","year":"2008","unstructured":"Sch\u00e4fer M, Werner S. Oxidative stress in normal and impaired wound repair. Pharm Res. 2008;58:165\u201371.","journal-title":"Pharm Res"},{"key":"6895_CR54","doi-asserted-by":"crossref","first-page":"1200","DOI":"10.3390\/nano12071200","volume":"12","author":"S Iravani","year":"2022","unstructured":"Iravani S, Varma RS. Smart MXene quantum dot-based nanosystems for biomedical applications. Nanomaterials. 2022;12:1200.","journal-title":"Nanomaterials"},{"key":"6895_CR55","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1016\/j.actbio.2023.01.049","volume":"159","author":"T Liao","year":"2023","unstructured":"Liao T, Chen Z, Kuang Y, Ren Z, Yu W, Rao W, et al. Small-size Ti3C2Tx MXene nanosheets coated with metal-polyphenol nanodots for enhanced cancer photothermal therapy and anti-inflammation. Acta Biomater. 2023;159:312\u201323.","journal-title":"Acta Biomater"},{"key":"6895_CR56","doi-asserted-by":"crossref","first-page":"6438","DOI":"10.1021\/acsnano.8b09327","volume":"13","author":"XY Ren","year":"2019","unstructured":"Ren XY, Huo MF, Wang MM, et al. Highly catalytic niobium carbide (MXene) promotes hematopoietic recovery after radiation by free radical scavenging. ACS Nano. 2019;13:6438\u201354.","journal-title":"ACS Nano"},{"key":"6895_CR57","volume":"62","author":"H Yang","year":"2023","unstructured":"Yang H, Xia L, Ye X, Xu J, Liu T, Wang L, et al. Ultrathin niobium carbide MXenzyme for remedying hypertension by antioxidative and neuroprotective actions. Angew Chem Int Ed Engl. 2023;62:e202303539.","journal-title":"Angew Chem Int Ed Engl"},{"key":"6895_CR58","volume":"11","author":"Z Li","year":"2022","unstructured":"Li Z, Zhao Y, Huang H, Zhang C, Liu H, Wang Z, et al. A nanozyme-immobilized hydrogel with endogenous ROS-scavenging and oxygen generation abilities for significantly promoting oxidative diabetic wound healing. Adv Health Mater. 2022;11:e2201524.","journal-title":"Adv Health Mater"},{"key":"6895_CR59","volume":"11","author":"C Wei","year":"2022","unstructured":"Wei C, Tang P, Tang Y, Liu L, Lu X, Yang K, et al. Sponge-like macroporous hydrogel with antibacterial and ROS scavenging capabilities for diabetic wound regeneration. Adv Health Mater. 2022;11:e2200717.","journal-title":"Adv Health Mater"},{"key":"6895_CR60","volume":"11","author":"C Liang","year":"2023","unstructured":"Liang C, Wang H, Lin Z, Zhang C, Liu G, Hu Y. Augmented wound healing potential of photosensitive GelMA hydrogel incorporating antimicrobial peptides and MXene nanoparticles. Front Bioeng Biotechnol. 2023;11:1310349.","journal-title":"Front Bioeng Biotechnol"},{"key":"6895_CR61","volume":"308","author":"X Qiu","year":"2024","unstructured":"Qiu X, Nie L, Liu P, Xiong X, Chen F, Liu X, et al. From hemostasis to proliferation: accelerating the infected wound healing through a comprehensive repair strategy based on GA\/OKGM hydrogel loaded with MXene@TiO2 nanosheets. Biomaterials. 2024;308:122548.","journal-title":"Biomaterials"},{"key":"6895_CR62","volume":"18","author":"J Chen","year":"2022","unstructured":"Chen J, Liu Y, Cheng G, Guo J, Du S, Qiu J, et al. Tailored hydrogel delivering niobium carbide boosts ROS-scavenging and antimicrobial activities for diabetic wound healing. Small. 2022;18:e2201300.","journal-title":"Small"},{"key":"6895_CR63","volume":"18","author":"X Yang","year":"2022","unstructured":"Yang X, Zhang C, Deng D, Gu Y, Wang H, Zhong Q. Multiple stimuli-responsive MXene-based hydrogel as intelligent drug delivery carriers for deep chronic wound healing. Small. 2022;18:e2104368.","journal-title":"Small"},{"key":"6895_CR64","volume":"11","author":"M Liu","year":"2023","unstructured":"Liu M, Zheng L, Zha K, Yang Y, Hu Y, Chen K, et al. Cu(II)@MXene based photothermal hydrogel with antioxidative and antibacterial properties for the infected wounds. Front Bioeng Biotechnol. 2023;11:1308184.","journal-title":"Front Bioeng Biotechnol"},{"key":"6895_CR65","doi-asserted-by":"crossref","first-page":"11128","DOI":"10.1039\/D2RA01225A","volume":"12","author":"H Geng","year":"2022","unstructured":"Geng H, Ren Y, Qin G, Wen T, Liu Q, Xu H, et al. Ti3C2 nanosheets with broad-spectrum antioxidant activity for cytoprotection against oxidative stress. RSC Adv. 2022;12:11128\u201338.","journal-title":"RSC Adv"},{"key":"6895_CR66","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1016\/j.matt.2021.12.021","volume":"5","author":"PA Rasheed","year":"2022","unstructured":"Rasheed PA, Pandey RP, Banat F, Hasan SW. Recent advances in niobium MXenes: synthesis, properties, and emerging applications. Matter. 2022;5:546\u201372.","journal-title":"Matter"},{"key":"6895_CR67","volume":"364","author":"LSJ Roope","year":"2019","unstructured":"Roope LSJ, Smith RD, Pouwels KB, Buchanan J, Abel L, Eibich P, et al. The challenge of antimicrobial resistance: What economics can contribute. Science. 2019;364:eaau4679.","journal-title":"Science"},{"key":"6895_CR68","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1159\/000454919","volume":"58","author":"H Sorg","year":"2017","unstructured":"Sorg H, Tilkorn DJ, Hager S, Hauser J, Mirastschijski U. Skin wound healing: an update on the current knowledge and concepts. Eur Surg Res. 2017;58:81\u201394.","journal-title":"Eur Surg Res"},{"key":"6895_CR69","doi-asserted-by":"crossref","first-page":"3674","DOI":"10.1021\/acsnano.6b00181","volume":"10","author":"K Rasool","year":"2016","unstructured":"Rasool K, Helal M, Ali A, Ren CE, Gogotsi Y, Mahmoud KA. Antibacterial activity of Ti3C2Tx MXene. ACS Nano. 2016;10:3674\u201384.","journal-title":"ACS Nano"},{"key":"6895_CR70","doi-asserted-by":"crossref","first-page":"20306","DOI":"10.1016\/j.ceramint.2020.05.118","volume":"46","author":"GP Lim","year":"2020","unstructured":"Lim GP, Soon CF, Morsin M, Ahmad MK, Nayan N, Tee KS. Synthesis, characterization and antifungal property of Ti3C2Tx MXene nanosheets. Ceram Int. 2020;46:20306\u201312.","journal-title":"Ceram Int"},{"key":"6895_CR71","doi-asserted-by":"crossref","DOI":"10.1002\/smll.202206716","volume":"19","author":"F Seidi","year":"2023","unstructured":"Seidi F, Arabi Shamsabadi A, Dadashi Firouzjaei M, Elliott M, Saeb MR, Huang Y, et al. MXenes antibacterial properties and applications: a review and perspective. Small. 2023;19:e2206716.","journal-title":"Small"},{"key":"6895_CR72","doi-asserted-by":"crossref","first-page":"16586","DOI":"10.1021\/acssuschemeng.8b03823","volume":"6","author":"AA Shamsabadi","year":"2018","unstructured":"Shamsabadi AA, Gh MS, Anasori B, Soroush M. Antimicrobial mode-of-action of colloidal Ti3C2Tx MXene nanosheets. ACS Sustain Chem Eng. 2018;6:16586\u201396.","journal-title":"ACS Sustain Chem Eng"},{"key":"6895_CR73","doi-asserted-by":"crossref","first-page":"035040","DOI":"10.1088\/2053-1583\/ab23ce","volume":"6","author":"K Rajavel","year":"2019","unstructured":"Rajavel K, Shen SY, Ke T, et al. Achieving high bactericidal and antibiofouling activities of 2D titanium carbide (Ti3C2Tx) by delamination and intercalation. 2D Mater. 2019;6:035040.","journal-title":"2D Mater"},{"key":"6895_CR74","volume":"17","author":"Z Yang","year":"2021","unstructured":"Yang Z, Fu X, Ma D, Wang Y, Peng L, Shi J, et al. Growth factor-decorated Ti3C2 MXene\/MoS2 2D bio-heterojunctions with quad-channel photonic disinfection for effective regeneration of bacteria-invaded cutaneous tissue. Small. 2021;17:e2103993.","journal-title":"Small"},{"key":"6895_CR75","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.mimet.2016.02.009","volume":"123","author":"B Kramer","year":"2016","unstructured":"Kramer B, Thielmann J. Monitoring the live to dead transition of bacteria during thermal stress by a multimethod approach. J Microbiol Meth. 2016;123:24.","journal-title":"J Microbiol Meth"},{"key":"6895_CR76","doi-asserted-by":"crossref","first-page":"2233","DOI":"10.1515\/nanoph-2019-0571","volume":"9","author":"Z Huang","year":"2020","unstructured":"Huang Z, Cui X, Li S, Ei J, Li P, Wang Y, et al. Two-dimensional MXene-based materials for photothermal therapy. Nanophotonics. 2020;9:2233\u201349.","journal-title":"Nanophotonics"},{"key":"6895_CR77","doi-asserted-by":"crossref","unstructured":"J Jin, S Wu, X Fang, H Li, J Wang, S Xuan, et al. MXene@Fe3O4\/PDA nanosheets with photothermal-magnetically coupled antibacterial properties. Mater Chem Phys. 2024;322:129562.","DOI":"10.1016\/j.matchemphys.2024.129562"},{"key":"6895_CR78","volume":"261","author":"H Li","year":"2024","unstructured":"Li H, Yang Y, Mu M, Feng C, Chuan D, Ren Y, et al. MXene-based polysaccharide aerogel with multifunctional enduring antimicrobial effects for infected wound healing. Int J Biol Macromol. 2024;261:129238.","journal-title":"Int J Biol Macromol"},{"key":"6895_CR79","doi-asserted-by":"publisher","DOI":"10.3389\/fchem.2023.1280040","volume":"11","author":"J Feng","year":"2023","unstructured":"Feng J, Liu R, Yuan X, Cao C, Xie J, Sun Z, et al. MXene-enhanced ePatch with antibacterial activity for wound healing. Front Chem. 2023;11:1280040. https:\/\/doi.org\/10.3389\/fchem.2023.1280040.","journal-title":"Front Chem"},{"key":"6895_CR80","volume":"2","author":"C Guo","year":"2022","unstructured":"Guo C, Cheng F, Liang G, Zhang S, Duan S, Fu Y, et al. Multimodal antibacterial platform constructed by the Schottky junction of curcumin-based bio metal-organic frameworks and Ti3C2Tx MXene nanosheets for efficient wound healing. Adv NanoBiomed Res. 2022;2:2200064.","journal-title":"Adv NanoBiomed Res"},{"key":"6895_CR81","volume":"11","author":"S Li","year":"2022","unstructured":"Li S, Gu B, Li X, Tang S, Zheng L, Ruiz-Hitzky E, et al. MXene-enhanced chitin composite sponges with antibacterial and hemostatic activity for wound healing. Adv Health Mater. 2022;11:e2102367.","journal-title":"Adv Health Mater"},{"key":"6895_CR82","volume":"207","author":"X Xu","year":"2021","unstructured":"Xu X, Wang S, Wu H, Liu Y, Xu F, Zhao J. A multimodal antimicrobial platform based on MXene for treatment of wound infection. Colloids Surf B Biointerfaces. 2021;207:111979.","journal-title":"Colloids Surf B Biointerfaces"},{"key":"6895_CR83","volume":"459","author":"Y Ding","year":"2023","unstructured":"Ding Y, Xu L, Chen S, Zhu Y, Sun Y, Ding L, et al. Mxene composite fibers with advanced thermal management for inhibiting tumor recurrence and accelerating wound healing. Chem Eng J. 2023;459:141529.","journal-title":"Chem Eng J"},{"key":"6895_CR84","doi-asserted-by":"publisher","unstructured":"Wang Y, Xu Y, Zhang R, Li J, Cong Y, Li R, et al. Tuning molecular assembly behavior to amplify the sonodynamic activity of porphyrins for efficient antibacterial therapy. Biomater Sci. 2024. https:\/\/doi.org\/10.1039\/d4bm00706a.","DOI":"10.1039\/d4bm00706a"},{"key":"6895_CR85","doi-asserted-by":"crossref","first-page":"112857","DOI":"10.1016\/j.matdes.2024.112857","volume":"240","author":"W Song","year":"2024","unstructured":"Song W, Wang D, Xiao S, He X, Xiong W, Shen J. NIR-II-amplify high-entropy MXene-based sonosensitizer as sonodynamic therapy promotes methicillin-resistant Staphylococcus aureus-Infected wound healing. Mater Des. 2024;240:112857.","journal-title":"Mater Des"},{"key":"6895_CR86","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1039\/D3BM01676E","volume":"12","author":"Y Zhong","year":"2024","unstructured":"Zhong Y, Lai Y, Feng Z, Huang S, Fu Y, Huang L, et al. Multifunctional MXene-doped photothermal microneedles for drug-resistant bacteria-infected wound healing. Biomater Sci. 2024;12:660\u201373.","journal-title":"Biomater Sci"},{"key":"6895_CR87","doi-asserted-by":"crossref","first-page":"6425","DOI":"10.1002\/jcp.26429","volume":"233","author":"A Shapouri-Moghaddam","year":"2018","unstructured":"Shapouri-Moghaddam A, Mohammadian S, Vazini H, Taghadosi M, Esmaeili SA, Mardani F, et al. Macrophage plasticity, polarization, and function in health and disease. J Cell Physiol. 2018;233:6425\u201340.","journal-title":"J Cell Physiol"},{"key":"6895_CR88","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/j.trsl.2021.05.006","volume":"236","author":"AE Louiselle","year":"2021","unstructured":"Louiselle AE, Niemiec SM, Zgheib C, Liechty KW. Macrophage polarization and diabetic wound healing. Transl Res. 2021;236:109\u201316.","journal-title":"Transl Res"},{"key":"6895_CR89","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejphar.2020.173090","volume":"877","author":"C Yunna","year":"2020","unstructured":"Yunna C, Mengru H, Lei W, Weidong C. Macrophage M1\/M2 polarization. Eur J Pharm. 2020;877:173090.","journal-title":"Eur J Pharm"},{"key":"6895_CR90","doi-asserted-by":"crossref","first-page":"2953","DOI":"10.3390\/cells11192953","volume":"11","author":"A Hassanshahi","year":"2022","unstructured":"Hassanshahi A, Moradzad M, Ghalamkari S, Fadaei M, Cowin AJ, Hassanshahi M. Macrophage-mediated inflammation in skin wound healing. Cells. 2022;11:2953.","journal-title":"Cells"},{"key":"6895_CR91","doi-asserted-by":"crossref","first-page":"617","DOI":"10.3390\/ijms21020617","volume":"21","author":"D Jiang","year":"2020","unstructured":"Jiang D, Rinkevich Y. Scars or regeneration?-Dermal fibroblasts as drivers of diverse skin wound responses. Int J Mol Sci 2020;21:617.","journal-title":"Int J Mol Sci"},{"key":"6895_CR92","doi-asserted-by":"crossref","first-page":"2351","DOI":"10.3390\/antiox11122351","volume":"11","author":"CS Wang","year":"2022","unstructured":"Wang CS, Luo SD, Jia S, Wu W, Chang SF, Feng SW, et al. Balance of macrophage activation by a complex coacervate-based adhesive drug carrier facilitates diabetic wound healing. Antioxidants. 2022;11:2351.","journal-title":"Antioxidants"},{"key":"6895_CR93","doi-asserted-by":"crossref","first-page":"21415","DOI":"10.1021\/acsami.3c18158","volume":"16","author":"M Asadi Tokmedash","year":"2024","unstructured":"Asadi Tokmedash M, Min J. Designer micro-\/nanocrumpled MXene multilayer coatings accelerate osteogenesis and regulate macrophage polarization. ACS Appl Mater Interfaces. 2024;16:21415\u201326.","journal-title":"ACS Appl Mater Interfaces"},{"key":"6895_CR94","volume":"27","author":"S Xia","year":"2024","unstructured":"Xia S, Liu D, Jiang K, Cao M, Lou Z, Cheng R, et al. Photothermal driven BMSCs osteogenesis and M2 macrophage polarization on polydopamine-coated Ti3C2 nanosheets\/poly(vinylidene fluoride trifluoroethylene) nanocomposite coatings. Mater Today Bio. 2024;27:101156.","journal-title":"Mater Today Bio"},{"key":"6895_CR95","volume":"19","author":"SM Chin","year":"2023","unstructured":"Chin SM, Reina G, Chau NDQ, Chabrol T, Wion D, Bouamrani A, et al. Functional graphene for peritumoral brain microenvironment modulation therapy in glioblastoma. Small. 2023;19:e2208227.","journal-title":"Small"},{"key":"6895_CR96","doi-asserted-by":"crossref","first-page":"4269","DOI":"10.1021\/acsnano.3c09721","volume":"18","author":"X Jiang","year":"2024","unstructured":"Jiang X, Ma J, Xue K, Chen J, Zhang Y, Zhang G, et al. Highly bioactive MXene-M2-exosome nanocomposites promote angiogenic diabetic wound repair through reconstructing high glucose-derived immune inhibition. ACS Nano. 2024;18:4269\u201386.","journal-title":"ACS Nano"},{"key":"6895_CR97","doi-asserted-by":"crossref","first-page":"2100","DOI":"10.3390\/polym13132100","volume":"13","author":"X Zhang","year":"2021","unstructured":"Zhang X, Tan B, Wu Y, Zhang M, Liao J. A review on hydrogels with photothermal effect in wound healing and bone tissue engineering. Polym (Basel). 2021;13:2100.","journal-title":"Polym (Basel)"},{"key":"6895_CR98","doi-asserted-by":"crossref","first-page":"18684","DOI":"10.1039\/D4NR02843K","volume":"16","author":"V Ferrara","year":"2024","unstructured":"Ferrara V, Perfili C, Artemi G, Iacolino B, Sciandra F, Perini G, et al. Advanced approaches in skin wound healing - a review on the multifunctional properties of MXenes in therapy and sensing. Nanoscale. 2024;16:18684\u2013714.","journal-title":"Nanoscale"},{"key":"6895_CR99","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1021\/acsami.8b18146","volume":"11","author":"L Zhang","year":"2019","unstructured":"Zhang L, Wang Y, Wang J, Wang Y, Chen A, Wang C, et al. Photon-responsive antibacterial nanoplatform for synergistic photothermal-\/pharmaco-therapy of skin infection. ACS Appl Mater Interfaces. 2019;11:300\u201310.","journal-title":"ACS Appl Mater Interfaces"},{"key":"6895_CR100","doi-asserted-by":"crossref","first-page":"19129","DOI":"10.1039\/D0NR04925E","volume":"12","author":"X Zhu","year":"2020","unstructured":"Zhu X, Zhu Y, Jia K, Abraha BS, Li Y, Peng W, et al. A near-infrared light-mediated antimicrobial based on Ag\/Ti3C2Tx for effective synergetic antibacterial applications. Nanoscale. 2020;12:19129\u201341.","journal-title":"Nanoscale"},{"key":"6895_CR101","first-page":"178","volume":"14","author":"S Hao","year":"2022","unstructured":"Hao S, Han H, Yang Z, Chen M, Jiang Y, Lu G, et al. Recent advancements on photothermal conversion and antibacterial applications over MXenes-based materials. Nanomicro Lett. 2022;14:178.","journal-title":"Nanomicro Lett"},{"key":"6895_CR102","doi-asserted-by":"crossref","first-page":"56525","DOI":"10.1021\/acsami.2c16277","volume":"14","author":"Y Shao","year":"2022","unstructured":"Shao Y, Dong K, Lu X, Gao B, He B. Bioinspired 3D-printed MXene and spidroin-based near-infrared light-responsive microneedle scaffolds for efficient wound management. ACS Appl Mater Interfaces. 2022;14:56525\u201334.","journal-title":"ACS Appl Mater Interfaces"},{"key":"6895_CR103","volume":"7","author":"X Han","year":"2018","unstructured":"Han X, Huang J, Lin H, Wang Z, Li P, Chen Y. 2D ultrathin MXene-based drug-delivery nanoplatform for synergistic photothermal ablation and chemotherapy of cancer. Adv Health Mater. 2018;7:e1701394.","journal-title":"Adv Health Mater"},{"key":"6895_CR104","volume":"285","author":"L Wang","year":"2022","unstructured":"Wang L, Du L, Wang M, Wang X, Tian S, Chen Y, et al. Chitosan for constructing stable polymer-inorganic suspensions and multifunctional membranes for wound healing. Carbohydr Polym. 2022;285:119209.","journal-title":"Carbohydr Polym"},{"key":"6895_CR105","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1016\/j.jcis.2021.04.109","volume":"599","author":"S Zhang","year":"2021","unstructured":"Zhang S, Ye J, Liu X, Wang Y, Li C, Fang J, et al. Titanium carbide\/zeolite imidazole framework-8\/polylactic acid electrospun membrane for near-infrared regulated photothermal\/photodynamic therapy of drug-resistant bacterial infections. J Colloid Interface Sci. 2021;599:390\u2013403.","journal-title":"J Colloid Interface Sci"},{"key":"6895_CR106","doi-asserted-by":"crossref","first-page":"3596","DOI":"10.1021\/acsbiomaterials.2c00410","volume":"8","author":"B Bhattacharjee","year":"2022","unstructured":"Bhattacharjee B, Mukherjee R, Haldar J. Biocompatible hemostatic sponge exhibiting broad-spectrum antibacterial activity. ACS Biomater Sci Eng. 2022;8:3596\u2013607.","journal-title":"ACS Biomater Sci Eng"},{"key":"6895_CR107","doi-asserted-by":"crossref","first-page":"3748","DOI":"10.3390\/polym13213748","volume":"13","author":"Y Wu","year":"2021","unstructured":"Wu Y, Zheng W, Xiao Y, Du B, Zhang X, Wen M, et al. Multifunctional, robust, and porous PHBV-GO\/MXene composite membranes with good hydrophilicity, antibacterial activity, and platelet adsorption performance. Polymers. 2021;13:3748.","journal-title":"Polymers"},{"key":"6895_CR108","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijbiomac.2024.129489","volume":"260","author":"Y Huang","year":"2024","unstructured":"Huang Y, Wang X, Luo B, Jin P, Zheng Y, Xu C, et al. MXene-NH2\/chitosan hemostatic sponges for rapid wound healing. Int J Biol Macromol. 2024;260:129489.","journal-title":"Int J Biol Macromol"},{"key":"6895_CR109","doi-asserted-by":"crossref","first-page":"3792","DOI":"10.3390\/nano12213792","volume":"12","author":"Y Yang","year":"2022","unstructured":"Yang Y, Li K, Wang Y, Wu Z, Russell TP, Shi S. MXene-based porous monoliths. Nanomaterials. 2022;12:3792.","journal-title":"Nanomaterials"},{"key":"6895_CR110","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.biomaterials.2018.06.037","volume":"179","author":"C Liu","year":"2018","unstructured":"Liu C, Yao W, Tian M, Wei J, Song Q, Qiao W. Mussel-inspired degradable antibacterial polydopamine\/silica nanoparticle for rapid hemostasis. Biomaterials. 2018;179:83\u201395.","journal-title":"Biomaterials"},{"key":"6895_CR111","doi-asserted-by":"crossref","first-page":"2232","DOI":"10.3390\/sym14112232","volume":"14","author":"M Tang","year":"2022","unstructured":"Tang M, Li J, Wang Y, Han W, Xu S, Lu M, et al. Surface terminations of MXene: synthesis, characterization, and properties. Symmetry Symmetry. 2022;14:2232.","journal-title":"Symmetry Symmetry"},{"key":"6895_CR112","volume":"140","author":"H Li","year":"2022","unstructured":"Li H, Dai J, Yi X, Cheng F. Generation of cost-effective MXene@polydopamine-decorated chitosan nanofibrous wound dressing for promoting wound healing. Biomater Adv. 2022;140:213055.","journal-title":"Biomater Adv"},{"key":"6895_CR113","doi-asserted-by":"crossref","first-page":"2468","DOI":"10.1021\/acsnano.0c06287","volume":"15","author":"L Zhou","year":"2021","unstructured":"Zhou L, Zheng H, Liu Z, Wang S, Liu Z, Chen F, et al. Conductive antibacterial hemostatic multifunctional scaffolds based on Ti3C2Tx MXene nanosheets for promoting multidrug-resistant bacteria-infected wound healing. ACS Nano. 2021;15:2468\u201380.","journal-title":"ACS Nano"},{"key":"6895_CR114","volume":"18","author":"Y Yang","year":"2022","unstructured":"Yang Y, Zhou X, Chan YK, Wang Z, Li L, Li J, et al. Photo-activated nanofibrous membrane with self-rechargeable antibacterial function for stubborn infected cutaneous regeneration. Small. 2022;18:e2105988.","journal-title":"Small"},{"key":"6895_CR115","doi-asserted-by":"crossref","first-page":"5782","DOI":"10.2174\/0929867324666170920161246","volume":"25","author":"A Francesko","year":"2018","unstructured":"Francesko A, Petkova P, Tzanov T. Hydrogel dressings for advanced wound management. Curr Med Chem. 2018;25:5782\u201397.","journal-title":"Curr Med Chem"},{"key":"6895_CR116","doi-asserted-by":"crossref","first-page":"1414","DOI":"10.1016\/j.ijbiomac.2020.07.311","volume":"162","author":"M Zhang","year":"2020","unstructured":"Zhang M, Zhao X. Alginate hydrogel dressings for advanced wound management. Int J Biol Macromol. 2020;162:1414\u201328.","journal-title":"Int J Biol Macromol"},{"key":"6895_CR117","doi-asserted-by":"crossref","first-page":"35386","DOI":"10.1039\/C8RA06274A","volume":"8","author":"EA Mayerberger","year":"2018","unstructured":"Mayerberger EA, Street RM, McDaniel RM, Barsoum MW, Schauer CL. Antibacterial properties of electrospun Ti3C2T z (MXene)\/chitosan nanofibers. RSC Adv. 2018;8:35386\u201394.","journal-title":"RSC Adv"},{"key":"6895_CR118","first-page":"21094","volume":"32","author":"X Zhou","year":"2022","unstructured":"Zhou X, Wang ZY, Chan YK, Yang Y, Jiao Z, Li L, et al. Infection micromilieu-activated nanocatalytic membrane for orchestrating rapid sterilization and stalled chronic wound regeneration. Adv Funct Mater. 2022;32:21094.","journal-title":"Adv Funct Mater"},{"key":"6895_CR119","volume":"334","author":"Z Wu","year":"2024","unstructured":"Wu Z, Li S, Qin X, Zheng L, Fang J, Wei L, et al. Facile preparation of fatigue-resistant Mxene-reinforced chitosan cryogel for accelerated hemostasis and wound healing. Carbohydr Polym. 2024;334:121934.","journal-title":"Carbohydr Polym"},{"key":"6895_CR120","doi-asserted-by":"crossref","first-page":"1068","DOI":"10.1039\/D1BM01604K","volume":"10","author":"Y Li","year":"2022","unstructured":"Li Y, Han M, Cai Y, Jiang B, Zhang Y, Yuan B, et al. Muscle-inspired MXene\/PVA hydrogel with high toughness and photothermal therapy for promoting bacteria-infected wound healing. Biomater Sci. 2022;10:1068\u201382.","journal-title":"Biomater Sci"},{"key":"6895_CR121","doi-asserted-by":"crossref","first-page":"4136","DOI":"10.1039\/D4SM00157E","volume":"20","author":"J Hu","year":"2024","unstructured":"Hu J, Xie J, Peng T, Shi Q, Pan C, Tan H, et al. Fabrication of a MXene-based shape-memory hydrogel and its application in the wound repair of skin. Soft Matter. 2024;20:4136\u201342.","journal-title":"Soft Matter"},{"key":"6895_CR122","volume":"9","author":"L Mao","year":"2020","unstructured":"Mao L, Hu S, Gao Y, Wang L, Zhao W, Fu L, et al. Biodegradable and electroactive regenerated bacterial cellulose\/MXene (Ti3C2Tx) composite hydrogel as wound dressing for accelerating skin wound healing under electrical stimulation. Adv Health Mater. 2020;9:e2000872.","journal-title":"Adv Health Mater"},{"key":"6895_CR123","doi-asserted-by":"crossref","first-page":"68","DOI":"10.3390\/pharmaceutics15010068","volume":"15","author":"X Zhang","year":"2022","unstructured":"Zhang X, Wei P, Yang Z, Liu Y, Yang K, Cheng Y, et al. Current progress and outlook of nano-based hydrogel dressings for wound healing. Pharmaceutics. 2022;15:68.","journal-title":"Pharmaceutics"},{"key":"6895_CR124","first-page":"162","volume":"16","author":"L Jin","year":"2022","unstructured":"Jin L, Guo X, Gao D, Liu Y, Ni J, Zhang Z, et al. An NIR photothermal responsive hybrid hydrogel for enhanced wound healing. Bioact Mater. 2022;16:162\u201372.","journal-title":"Bioact Mater"},{"key":"6895_CR125","volume":"13","author":"L Jin","year":"2021","unstructured":"Jin L, Guo X, Gao D, Wu C, Hu B, Tan G, et al. NIR-responsive MXene nanobelts for wound healing. NPG Asia Mater. 2021;13:24.","journal-title":"NPG Asia Mater"},{"key":"6895_CR126","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/j.addr.2018.12.014","volume":"146","author":"HS Kim","year":"2019","unstructured":"Kim HS, Sun X, Lee JH, Kim HW, Fu X, Leong KW. Advanced drug delivery systems and artificial skin grafts for skin wound healing. Adv Drug Deliv Rev. 2019;146:209\u201339.","journal-title":"Adv Drug Deliv Rev"},{"key":"6895_CR127","doi-asserted-by":"crossref","first-page":"6912","DOI":"10.1021\/acsabm.1c00607","volume":"4","author":"S Song","year":"2021","unstructured":"Song S, Jiang X, Shen H, Wu W, Shi Q, Wan M, et al. MXene (Ti3C2) based pesticide delivery system for sustained release and enhanced pest control. ACS Appl Bio Mater. 2021;4:6912\u201323.","journal-title":"ACS Appl Bio Mater"},{"key":"6895_CR128","doi-asserted-by":"crossref","first-page":"4392","DOI":"10.3390\/nano12244392","volume":"12","author":"WJ Zhang","year":"2022","unstructured":"Zhang WJ, Li S, Vijayan V, Lee JS, Park SS, Cui X, et al. ROS- and pH-responsive polydopamine functionalized Ti3C2Tx MXene-based nanoparticles as drug delivery nanocarriers with high antibacterial activity. Nanomaterials. 2022;12:4392.","journal-title":"Nanomaterials"},{"key":"6895_CR129","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1016\/j.ijbiomac.2021.09.037","volume":"190","author":"Y Dong","year":"2021","unstructured":"Dong Y, Li S, Li X, Wang X. Smart MXene\/agarose hydrogel with photothermal property for controlled drug release. Int J Biol Macromol. 2021;190:693\u20139.","journal-title":"Int J Biol Macromol"},{"key":"6895_CR130","doi-asserted-by":"crossref","first-page":"7229","DOI":"10.1039\/D0CS00022A","volume":"49","author":"YZ Zhang","year":"2020","unstructured":"Zhang YZ, El-Demellawi JK, Jiang Q, Ge G, Liang H, Lee K, et al. MXene hydrogels: fundamentals and applications. Chem Soc Rev. 2020;49:7229\u201351.","journal-title":"Chem Soc Rev"},{"key":"6895_CR131","doi-asserted-by":"crossref","unstructured":"X Luo, Y Liu, R Qin, F Ao, X Wang, H Zhang, et al. Tissue-nanoengineered hyperbranched polymer based multifunctional hydrogels as flexible \u201cwound treatment-health monitoring\u201d bioelectronic implant. App Mater Today. 2022;29:101576.","DOI":"10.1016\/j.apmt.2022.101576"},{"key":"6895_CR132","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/j.actbio.2023.01.035","volume":"159","author":"H Lu","year":"2023","unstructured":"Lu H, Shao W, Gao B, Zheng S, He B. Intestine-inspired wrinkled MXene microneedle dressings for smart wound management. Acta Biomater. 2023;159:201\u201310.","journal-title":"Acta Biomater"},{"key":"6895_CR133","doi-asserted-by":"crossref","unstructured":"Y Gan, B Liang, Y Gong, L Wu, P Li, C Gong, et al. Mxene-based mild hyperthemia microneedle patch for diabetic wound healing. Chem Eng J. 2024;481:148592.","DOI":"10.1016\/j.cej.2024.148592"},{"key":"6895_CR134","volume":"2021","author":"L Sun","year":"2021","unstructured":"Sun L, Fan L, Bian F, Chen G, Wang Y, Zhao Y. MXene-integrated microneedle patches with innate molecule encapsulation for wound healing. Research. 2021;2021:9838490.","journal-title":"Research"},{"key":"6895_CR135","doi-asserted-by":"crossref","first-page":"15316","DOI":"10.1021\/acsnano.1c06279","volume":"15","author":"MZ Guo","year":"2021","unstructured":"Guo MZ, Wang YQ, Gao BB, He BF. Shark tooth -inspired microneedle dressing for intelligent wound management. ACS Nano. 2021;15:15316\u201327.","journal-title":"ACS Nano"},{"key":"6895_CR136","doi-asserted-by":"crossref","first-page":"46938","DOI":"10.1021\/acsami.1c15312","volume":"13","author":"F Hao","year":"2021","unstructured":"Hao F, Wang L, Chen B, Qiu L, Nie J, Ma G. Bifunctional smart hydrogel dressing with strain sensitivity and NIR-responsive performance. ACS Appl Mater Interfaces. 2021;13:46938\u201350.","journal-title":"ACS Appl Mater Interfaces"},{"key":"6895_CR137","doi-asserted-by":"crossref","first-page":"7445","DOI":"10.1039\/D1MA01199E","volume":"3","author":"V Hada","year":"2022","unstructured":"Hada V, Malvi D, Mili M, Khan MM, Chaturvedi G, Hashmi S, et al. MXenes: promising 2D materials for wound dressing applications-a perspective review. Mater Adv. 2022;3:7445\u201362.","journal-title":"Mater Adv"},{"key":"6895_CR138","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.cej.2021.130148","volume":"424","author":"H Zheng","year":"2021","unstructured":"Zheng H, Wang SQ, Cheng F, He XW, Liu ZX, Wang WY, et al. Bioactive anti-inflammatory, antibacterial, conductive multifunctional scaffold based on MXene@CeO2 nanocomposites for infection-impaired skin multimodal therapy. Chem Eng J. 2021;424:12.","journal-title":"Chem Eng J"},{"key":"6895_CR139","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41528-023-00287-8","volume":"8","author":"Y Hu","year":"2024","unstructured":"Hu Y, Wang F, Ye H, Jiang J, Li S, Dai B, et al. MXene-based flexible electronic materials for wound infection detection and treatment. npj Flex Electron. 2024;8:1\u201315.","journal-title":"npj Flex Electron"},{"key":"6895_CR140","doi-asserted-by":"crossref","first-page":"3513","DOI":"10.1039\/D4NA00239C","volume":"6","author":"A Zarepour","year":"2024","unstructured":"Zarepour A, Rafati N, Khosravi A, Rabiee N, Iravani S, Zarrabi A. MXene-based composites in smart wound healing and dressings. Nanoscale Adv. 2024;6:3513\u201332.","journal-title":"Nanoscale Adv"},{"key":"6895_CR141","doi-asserted-by":"crossref","unstructured":"R Song, H Xie, G Liu. Advances of MXene-based hydrogels for chronic wound healing. Chin Chem Lett. 2024:110442.","DOI":"10.1016\/j.cclet.2024.110442"},{"key":"6895_CR142","volume":"20","author":"P Wang","year":"2022","unstructured":"Wang P, Wang Y, Yi Y, Gong Y, Ji H, Gan Y, et al. MXenes-integrated microneedle combined with asiaticoside to penetrate the cuticle for treatment of diabetic foot ulcer. J Nanobiotechnol. 2022;20:259.","journal-title":"J Nanobiotechnol"},{"key":"6895_CR143","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/j.jechem.2023.11.031","volume":"90","author":"S Kumar","year":"2024","unstructured":"Kumar S, Kumari N, Seo Y. MXenes: versatile 2D materials with tailored surface chemistry and diverse applications. J Energy Chem. 2024;90:253\u201393.","journal-title":"J Energy Chem"},{"key":"6895_CR144","doi-asserted-by":"crossref","first-page":"139078","DOI":"10.1016\/j.cej.2022.139078","volume":"452","author":"D Zhang","year":"2023","unstructured":"Zhang D, Huang L, Sun D-W, Pu H, Wei Q. Bio-interface engineering of MXene nanosheets with immobilized lysozyme for light-enhanced enzymatic inactivation of methicillin-resistant Staphylococcus aureus. Chem Eng J 2023;452:139078.","journal-title":"Chem Eng J"},{"key":"6895_CR145","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1007\/s00604-019-4000-x","volume":"187","author":"YE Shi","year":"2019","unstructured":"Shi YE, Han F, Xie L, Zhang C, Li T, Wang H, et al. A MXene of type Ti3C2Tx functionalized with copper nanoclusters for the fluorometric determination of glutathione. Mikrochim Acta. 2019;187:38.","journal-title":"Mikrochim Acta"},{"key":"6895_CR146","volume":"259","author":"M Yan","year":"2024","unstructured":"Yan M, Wu Z, Li Z, Li Z, Wang J, Hu Z. Self-powered biosensing sutures for real-time wound monitoring. Biosens Bioelectron. 2024;259:116365.","journal-title":"Biosens Bioelectron"},{"key":"6895_CR147","doi-asserted-by":"crossref","DOI":"10.3389\/fbioe.2022.952198","volume":"10","author":"WD Short","year":"2022","unstructured":"Short WD, Olutoye OO 2nd, Padon BW, Parikh UM, Colchado D, et al. Advances in non-invasive biosensing measures to monitor wound healing progression. Front Bioeng Biotechnol. 2022;10:952198.","journal-title":"Front Bioeng Biotechnol"},{"key":"6895_CR148","volume":"18","author":"WD Li","year":"2022","unstructured":"Li WD, Ke K, Jia J, Pu JH, Zhao X, Bao RY, et al. Recent advances in multiresponsive flexible sensors towards E-skin: a delicate design for versatile sensing. Small. 2022;18:e2103734.","journal-title":"Small"},{"key":"6895_CR149","volume":"482","author":"M Mao","year":"2024","unstructured":"Mao M, Kong J, Ge X, Sun Y, Yu H, Liu J, et al. Mxene-based wearable self-powered and photothermal triboelectric nanogenerator patches for wound healing acceleration and tactile sensing. Chem Eng J. 2024;482:148949.","journal-title":"Chem Eng J"},{"key":"6895_CR150","volume":"237","author":"L Xu","year":"2023","unstructured":"Xu L, Ding L, Sun Y, Zhang T, Zhu Y, Yan B, et al. Stretchable, flexible and breathable polylactic acid\/polyvinyl pyrrolidone bandage based on Kirigami for wounds monitoring and treatment. Int J Biol Macromol. 2023;237:124204.","journal-title":"Int J Biol Macromol"},{"key":"6895_CR151","doi-asserted-by":"crossref","unstructured":"D Liu, S Bi, H Wang, J Gu, S Wang. Polydopamine interface-modulated MXene-based conductive antibacterial hydrogels for on-skin health monitoring and diabetic wound healing. Compos Part A Appl Sci Manuf. 2024;180:108065.","DOI":"10.1016\/j.compositesa.2024.108065"},{"key":"6895_CR152","first-page":"14033","volume":"15","author":"K Diedkova","year":"2023","unstructured":"Diedkova K, Pogrebnjak AD, Kyrylenko S, Smyrnova K, Buranich VV, Horodek P, et al. Polycaprolactone-MXene nanofibrous scaffolds for tissue engineering. ACS Appl Mater Interfaces. 2023;15:14033\u201347.","journal-title":"ACS Appl Mater Interfaces"},{"key":"6895_CR153","doi-asserted-by":"crossref","first-page":"9672","DOI":"10.1007\/s12274-023-5527-z","volume":"16","author":"S Xu","year":"2023","unstructured":"Xu S, Du C, Zhang M, Wang R, Feng W, Wang C, et al. Electroactive and antibacterial wound dressings based on Ti3C2Tx MXene\/poly(\u03b5-caprolactone)\/gelatin coaxial electrospun nanofibrous membranes. Nano Res. 2023;16:9672\u201387.","journal-title":"Nano Res"},{"key":"6895_CR154","doi-asserted-by":"crossref","first-page":"7319","DOI":"10.1021\/acs.analchem.2c00684","volume":"94","author":"L Chen","year":"2022","unstructured":"Chen L, Chen F, Liu G, Lin H, Bao Y, Han D, et al. Superhydrophobic functionalized Ti3C2Tx MXene-based skin-attachable and wearable electrochemical pH sensor for real-time sweat detection. Anal Chem. 2022;94:7319\u201328.","journal-title":"Anal Chem"},{"key":"6895_CR155","doi-asserted-by":"crossref","DOI":"10.1016\/j.flatc.2023.100576","volume":"42","author":"H Goel","year":"2023","unstructured":"Goel H, Gupta P, Jha K, et al. Mxene-based nanocomposites for biosensing: Recent developments and future prospects. FlatChem. 2023;42:100576.","journal-title":"FlatChem"},{"key":"6895_CR156","doi-asserted-by":"crossref","first-page":"2232","DOI":"10.1021\/acsbiomaterials.1c01516","volume":"8","author":"S Saxena","year":"2022","unstructured":"Saxena S, Punjabi K, Ahamad N, Singh S, Bendale P, Banerjee R. Nanotechnology approaches for rapid detection and theranostics of antimicrobial resistant bacterial infections. ACS Biomater Sci Eng. 2022;8:2232\u201357.","journal-title":"ACS Biomater Sci Eng"},{"key":"6895_CR157","volume":"380","author":"K Li","year":"2023","unstructured":"Li K, Yang Y, Xu C, Ye Y, Huang L, Sun L, et al. Vertical gold nanowires-based surface-enhanced Raman scattering for direct detection of ocular bacteria. Sens Actuators B Chem. 2023;380:133381.","journal-title":"Sens Actuators B Chem"},{"key":"6895_CR158","volume":"390","author":"K Wang","year":"2023","unstructured":"Wang K, Zheng X, Qi M, Zhang W, Du J, Han Q, et al. Flexible screen-printed electrochemical platform to detect hydrogen peroxide for the indication of periodontal disease. Sens Actuators B: Chem. 2023;390:133955.","journal-title":"Sens Actuators B: Chem"},{"key":"6895_CR159","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1007\/s12274-020-3130-0","volume":"14","author":"S Zhao","year":"2021","unstructured":"Zhao S, Hu F, Shi Z, Fu J, Chen Y, Dai F, et al. 2-D\/2-D heterostructured biomimetic enzyme by interfacial assembling Mn3(PO4)2 and MXene as a flexible platform for realtime sensitive sensing cell superoxide. Nano Res. 2021;14:879\u201386.","journal-title":"Nano Res"},{"key":"6895_CR160","volume":"383","author":"Z Shi","year":"2023","unstructured":"Shi Z, Dai C, Deng P, Li X, Wu Y, Lv J, et al. Wearable battery-free smart bandage with peptide functionalized biosensors based on MXene for bacterial wound infection detection. Sens Actuators B Chem. 2023;383:133598.","journal-title":"Sens Actuators B Chem"},{"key":"6895_CR161","volume":"32","author":"M Li","year":"2022","unstructured":"Li M, Zhang Y, Lian L, Liu K, Lu M, Chen Y, et al. Flexible accelerated-wound-healing antibacterial MXene-based epidermic sensor for intelligent wearable human-machine interaction. Adv Funct Mater. 2022;32:2208141.","journal-title":"Adv Funct Mater"},{"key":"6895_CR162","doi-asserted-by":"crossref","DOI":"10.1016\/j.bios.2020.112637","volume":"169","author":"M Sharifuzzaman","year":"2020","unstructured":"Sharifuzzaman M, Chhetry A, Zahed MA, Yoon SH, Park CI, Zhang S, et al. Smart bandage with integrated multifunctional sensors based on MXene-functionalized porous graphene scaffold for chronic wound care management. Biosens Bioelectron. 2020;169:112637.","journal-title":"Biosens Bioelectron"},{"key":"6895_CR163","doi-asserted-by":"crossref","DOI":"10.1186\/s12938-021-00873-9","volume":"20","author":"A Zamhuri","year":"2021","unstructured":"Zamhuri A, Lim GP, Ma NL, Tee KS, Soon CF. MXene in the lens of biomedical engineering: synthesis, applications and future outlook. Biomed Eng Online. 2021;20:33.","journal-title":"Biomed Eng Online"}],"container-title":["Journal of Materials Science: Materials in Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10856-025-06895-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10856-025-06895-2","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10856-025-06895-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,5]],"date-time":"2026-01-05T12:10:00Z","timestamp":1767615000000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10856-025-06895-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5,15]]},"references-count":163,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["6895"],"URL":"https:\/\/doi.org\/10.1007\/s10856-025-06895-2","relation":{},"ISSN":["1573-4838"],"issn-type":[{"value":"1573-4838","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,5,15]]},"assertion":[{"value":"20 January 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 April 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 May 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}],"article-number":"42"}}