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Despite its therapeutic potential, clinical translation remains constrained by pharmacokinetic limitations such as rapid metabolism, poor aqueous solubility, and low bioavailability. Recent advancements in biomaterial-based co-delivery systems have emerged as a transformative strategy to circumvent these challenges while amplifying tumor-specific cytotoxicity. By integrating resveratrol with chemotherapeutics, photothermal agents, metal complexes, or covalent organic frameworks (COFs), these systems synergistically enhance therapeutic efficacy through improved drug stability, targeted delivery, and stimuli-responsive release. Furthermore, multifunctional platforms combining photothermal ablation, ROS modulation, and immunotherapy exhibit promise in overcoming multidrug resistance and reprogramming immunosuppressive microenvironments. However, critical gaps persist in understanding structure-activity relationships, long-term biosafety profiles, and clinical scalability. This review comprehensively summarizes the current progress in resveratrol co-delivery systems, emphasizing their mechanisms, preclinical outcomes, and technological innovations. Future directions should prioritize interdisciplinary approaches, including AI-driven nanomaterial design, pharmacogenomic stratification, and biomarker-driven clinical trials, to bridge the gap between preclinical promise and therapeutic reality. By harmonizing resveratrol\u2019s phytochemical efficacy with advanced biomaterial engineering, these co-delivery systems hold transformative potential for precision oncology.<\/jats:p>","DOI":"10.1007\/s10856-025-06968-2","type":"journal-article","created":{"date-parts":[[2025,11,25]],"date-time":"2025-11-25T17:46:06Z","timestamp":1764092766000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["A review: advances of resveratrol co-delivery biomaterials-based system in anti-tumor therapy"],"prefix":"10.1007","volume":"36","author":[{"given":"Huifang","family":"Yang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiran","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yilin","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kexin","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-8423-7097","authenticated-orcid":false,"given":"Tong","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,11,25]]},"reference":[{"key":"6968_CR1","first-page":"209","volume":"71","author":"H Sung","year":"2021","unstructured":"Sung H, Ferlay J, Siegel RL, Laversanne M, Soerjomataram I, Jemal A, et al. 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