{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T07:13:40Z","timestamp":1792653220630,"version":"4.5.0"},"reference-count":40,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2018,8,24]],"date-time":"2018-08-24T00:00:00Z","timestamp":1535068800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Bioenerg Biomembr"],"published-print":{"date-parts":[[2018,10]]},"DOI":"10.1007\/s10863-018-9768-6","type":"journal-article","created":{"date-parts":[[2018,8,24]],"date-time":"2018-08-24T07:05:54Z","timestamp":1535094354000},"page":"379-390","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Altered mitochondrial oxidative phosphorylation capacity in horses suffering from polysaccharide storage myopathy"],"prefix":"10.1007","volume":"50","author":[{"given":"Irene","family":"Tosi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tatiana","family":"Art","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dominique","family":"Cassart","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fr\u00e9d\u00e9ric","family":"Farnir","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Justine","family":"Ceusters","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Didier","family":"Serteyn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H\u00e9l\u00e8ne","family":"Lemieux","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dominique-Marie","family":"Votion","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2018,8,24]]},"reference":[{"key":"9768_CR1","doi-asserted-by":"publisher","first-page":"277","DOI":"10.1016\/j.nmd.2008.01.001","volume":"18","author":"M Aleman","year":"2008","unstructured":"Aleman M (2008) A review of equine muscle disorders. Neuromuscul Disord 18:277\u2013287","journal-title":"Neuromuscul Disord"},{"issue":"5","key":"9768_CR2","doi-asserted-by":"publisher","first-page":"839","DOI":"10.2460\/ajvr.2005.66.839","volume":"66","author":"EJ Annandale","year":"2005","unstructured":"Annandale EJ, Valberg SJ, Ess\u00e9n-Gustavsson B (2005) Effects of submaximal exercise on adenine nucleotide concentrations in skeletal muscle fibers of horses with polysaccharide storage myopathy. Am J Vet Res 66(5):839\u2013845","journal-title":"Am J Vet Res"},{"key":"9768_CR3","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1186\/1746-6148-5-29","volume":"5","author":"E Barrey","year":"2009","unstructured":"Barrey E, Mucher E, Jeansoule N, Larcher T, Guigand L, Herszberg B, Chaffaux S, Gu\u00e9rin G, Mata X, Benech P, Canale M, Alibert O, Maltere P, Gidrol X (2009) Gene expression profiling in equine polysaccharide storage myopathy revealed inflammation, glycogenesis inhibition, hypoxia and mitochondrial dysfunctions. BMC Vet Res 5:29","journal-title":"BMC Vet Res"},{"key":"9768_CR4","doi-asserted-by":"publisher","first-page":"427","DOI":"10.1007\/s10545-014-9784-6","volume":"38","author":"V Boczonadi","year":"2015","unstructured":"Boczonadi V, Bansagi B, Horvath R (2015) Reversible infantile mitochondrial diseases. J Inherit Metab Dis 38:427\u2013435","journal-title":"J Inherit Metab Dis"},{"issue":"3","key":"9768_CR5","doi-asserted-by":"publisher","first-page":"326","DOI":"10.2460\/ajvr.71.3.326","volume":"71","author":"L Borgia","year":"2010","unstructured":"Borgia L, Valberg SJ, McCue ME, Pagan JD, Roe CR (2010) Effect of dietary fats with odd or even numbers of carbon atoms on metabolic response and muscle damage with exercise in quarter horse\u2013type horses with type 1 polysaccharide storage myopathy. Am J Vet Res 71(3):326\u2013336","journal-title":"Am J Vet Res"},{"issue":"6","key":"9768_CR6","doi-asserted-by":"publisher","first-page":"798","DOI":"10.1111\/j.1439-0396.2010.01116.x","volume":"95","author":"L Borgia","year":"2011","unstructured":"Borgia L, Valberg SJ, McCue M, Watts K, Pagan J (2011) Glycaemic and insulinaemic responses to feeding hay with different non-structural carbohydrate content in control and polysaccharide storage myopathy-affected horses. J Anim Physiol Anim Nutr (Berl) 95(6):798\u2013807","journal-title":"J Anim Physiol Anim Nutr (Berl)"},{"issue":"6","key":"9768_CR7","doi-asserted-by":"publisher","first-page":"764","DOI":"10.1002\/(SICI)1097-4598(199606)19:6<764::AID-MUS12>3.0.CO;2-L","volume":"19","author":"N Stefano De","year":"1996","unstructured":"De Stefano N, Argov Z, Matthews PM, Karpati G, Arnold DL (1996) Impairment of muscle mitochondrial oxidative metabolism in McArdles's disease. Muscle Nerve 19(6):764\u2013769","journal-title":"Muscle Nerve"},{"issue":"1","key":"9768_CR8","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1186\/s13023-016-0488-x","volume":"11","author":"SM Gehrig","year":"2016","unstructured":"Gehrig SM, Mihaylova V, Frese S, Mueller SM, Ligon-Auer M, Spengler CM, Petersen JA, Lundby C, Jung HH (2016) Altered skeletal muscle (mitochondrial) properties in patients with mitochondrial DNA single deletion myopathy. Orphanet J Rare Dis 11(1):105","journal-title":"Orphanet J Rare Dis"},{"key":"9768_CR9","volume-title":"Mitochondrial pathways and respiratory control an introduction to OXPHOS analysis","author":"E Gnaiger","year":"2014","unstructured":"Gnaiger E (2014) Mitochondrial pathways and respiratory control an introduction to OXPHOS analysis, 4th edn. Steiger Druck GmbH, Austria","edition":"4"},{"key":"9768_CR10","doi-asserted-by":"crossref","unstructured":"Gnaiger E, Kuznetsov AV, Schneeberger S, Seiler R, Brandacher G, Steurer W, Raimund Margreiter (2000) Mitochondria in the cold. In: Heldmaier G, Klingenspor M (eds) Life in the cold. Springer, Heidelberg, p 431\u2013442","DOI":"10.1007\/978-3-662-04162-8_45"},{"key":"9768_CR11","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1016\/j.mito.2015.07.006","volume":"24","author":"R Houben","year":"2015","unstructured":"Houben R, Leleu C, Fraipont A, Serteyn D, Votion DM (2015) Determination of muscle mitochondrial respiratory capacity in Standardbred racehorses as an aid to predicting exertional rhabdomyolysis. Mitochondrion 24:99\u2013104","journal-title":"Mitochondrion"},{"issue":"7-8","key":"9768_CR12","doi-asserted-by":"publisher","first-page":"78","DOI":"10.15690\/vramn.v69i7-8.1112","volume":"69","author":"O.V. Kurbatova","year":"2014","unstructured":"Kurbatova OV, Izma\u012dlova TD, Surkov AN, Namazova-Baranova LS, Poliakova SI, Miroshkina LV, Semenova GF, Samokhina IV, Kapustina EIu, Dukhova ZN, Potapov AS, Petrichuk SV. [Mitochondrial dysfunction in children with hepatic forms of glycogen storage disease]. [Article in Russian]. Vestn Ross Akad Med Nauk (7\u20138): 78\u201384, 2014","journal-title":"Annals of the Russian academy of medical sciences"},{"key":"9768_CR13","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1016\/j.mito.2016.06.005","volume":"30","author":"H Lemieux","year":"2016","unstructured":"Lemieux H, Boemer F, van Galen G, Serteyn D, Amory H, Baise E, Cassart D, van Loon G, Marcillaud-Pitel C, Votion DM (2016) Mitochondrial function is altered in horse atypical myopathy. Mitochondrion 30:35\u201341","journal-title":"Mitochondrion"},{"issue":"1","key":"9768_CR14","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1203\/00006450-199207000-00004","volume":"32","author":"T Letellier","year":"1992","unstructured":"Letellier T, Malgat M, Coquet M, Moretto B, Parrot-Roulaud F, Mazat JP (1992) Mitochondrial myopathy studies on permeabilized muscle fibers. Pediatr Res 32(1):17\u201322","journal-title":"Pediatr Res"},{"key":"9768_CR15","doi-asserted-by":"publisher","first-page":"385","DOI":"10.1080\/15548627.2015.1009779","volume":"11","author":"JA Lim","year":"2015","unstructured":"Lim JA, Li L, Kakhlon O, Myerowitz R, Raben N (2015) Defects in calcium homeostasis and mitochondria can be reversed in Pompe disease. Autophagy 11:385\u2013402","journal-title":"Autophagy"},{"issue":"3","key":"9768_CR16","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1186\/BF03547460","volume":"15","author":"A Lindholm","year":"1974","unstructured":"Lindholm A, Piehl K (1974) Fibre composition, enzyme activity and concentrations of metabolites and electrolytes in muscles of standardbred horses. Acta Vet Scand 15(3):287\u2013309","journal-title":"Acta Vet Scand"},{"key":"9768_CR17","doi-asserted-by":"publisher","first-page":"3388","DOI":"10.1016\/j.bbagen.2016.08.021","volume":"1861","author":"CA Maile","year":"2017","unstructured":"Maile CA, Hingst JR, Mahalingan KK, O\u2019Reilly AO, Cleasby ME, Mickelson JR McCue ME, Anderson SM, Hurley TD, Wojtaszewski JF, Piercy RJ (2017) A highly prevalent equine glycogen storage disease is explained by constitutive activation of a mutant glycogen synthase. Biochim Biophys Acta 1861:3388\u20133398","journal-title":"Biochim Biophys Acta"},{"issue":"4","key":"9768_CR18","doi-asserted-by":"publisher","first-page":"554","DOI":"10.2460\/javma.2000.216.554","volume":"216","author":"BB Martin Jr","year":"2000","unstructured":"Martin BB Jr, Reef VB, Parente EJ, Sage AD (2000) Causes of poor performance of horses during training, racing, or showing: 348 cases (1992-1996). J Am Vet Med Assoc 216(4):554\u2013558","journal-title":"J Am Vet Med Assoc"},{"key":"9768_CR19","doi-asserted-by":"publisher","first-page":"1281","DOI":"10.1354\/vp.08-VP-0177-M-FL","volume":"46","author":"ME McCue","year":"2009","unstructured":"McCue ME, Armi\u00e9n AG, Lucio M, Mickelson JR, Valberg SJ (2009) Comparative skeletal muscle histopathologic and ultrastructural features in two forms of polysaccharide storage myopathy in horses. Vet Pathol 46:1281\u20131291","journal-title":"Vet Pathol"},{"key":"9768_CR20","doi-asserted-by":"publisher","first-page":"340","DOI":"10.1111\/j.2042-3306.2006.tb05565.x","volume":"36","author":"ME McCue","year":"2006","unstructured":"McCue ME, Ribeiro WP, Valberg SJ (2006) Prevalence of polysaccharide storage myopathy in horses with neuromuscular disorders. Equine Vet J Suppl 36:340\u2013344","journal-title":"Equine Vet J Suppl"},{"key":"9768_CR21","doi-asserted-by":"publisher","first-page":"1228","DOI":"10.1111\/j.1939-1676.2008.0167.x","volume":"22","author":"ME McCue","year":"2008","unstructured":"McCue ME, Valberg SJ, Lucio M, Mickelson JR (2008a) Glycogen synthase 1 (GYS1) mutation in diverse breeds with polysaccharide storage myopathy. J Vet Intern Med 22:1228\u20131233","journal-title":"J Vet Intern Med"},{"issue":"5","key":"9768_CR22","doi-asserted-by":"publisher","first-page":"458","DOI":"10.1016\/j.ygeno.2008.01.011","volume":"91","author":"ME McCue","year":"2008","unstructured":"McCue ME, Valberg SJ, Miller MB, Wade C, DiMauro S, Akman HO, Mickelson JR (2008b) Glycogen synthase mutation causes a novel skeletal muscle glycogenosis. Genomics 91(5):458\u2013466","journal-title":"Genomics"},{"key":"9768_CR23","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1016\/j.bone.2016.02.012","volume":"86","author":"D Melis","year":"2016","unstructured":"Melis D, Rossi A, Pivonello R, Del Puente A, Pivonello C, Cangemi G, Negri M, Colao A, Andria G, Parenti G (2016) Reduced bone mineral density in glycogen storage disease type III: evidence for a possible connection between metabolic imbalance and bone homeostasis. Bone 86:79\u201385","journal-title":"Bone"},{"key":"9768_CR24","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1016\/j.biocel.2010.10.005","volume":"43","author":"K Nouette-Gaulaina","year":"2011","unstructured":"Nouette-Gaulaina K, Josea C, Capdevilac X, Rossignol R (2011) From analgesia to myopathy: when local anesthetics impair the mitochondrion. Int J Biochem Cell B 43:14\u201319","journal-title":"Int J Biochem Cell B"},{"key":"9768_CR25","doi-asserted-by":"publisher","first-page":"1145","DOI":"10.1016\/j.cell.2012.02.035","volume":"148","author":"J Nunnari","year":"2012","unstructured":"Nunnari J, Suomalainen A (2012) Mitochondria: in sickness and in health. Cell 148:1145\u20131159","journal-title":"Cell"},{"key":"9768_CR26","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1007\/978-1-61779-382-0_3","volume":"810","author":"D Pesta","year":"2012","unstructured":"Pesta D, Gnaiger E (2012) High-resolution respirometry: OXPHOS protocols for human cells and permeabilized fibers from small biopsies of human muscle. Methods Mol Biol 810:25\u201358","journal-title":"Methods Mol Biol"},{"key":"9768_CR27","doi-asserted-by":"crossref","unstructured":"Rossi A, Ruoppolo M, Formisano P, Villani G, Albano L, Gallo G, Crisci D, Moccia A, Parenti G, Strisciuglio P, Melis D (2018) Insulin-resistance in glycogen storage disease type Ia: linking carbohydrates and mitochondria? J Inherit Metab Dis","DOI":"10.1007\/s10545-018-0149-4"},{"issue":"1","key":"9768_CR28","doi-asserted-by":"publisher","first-page":"54","DOI":"10.1016\/S0887-8994(00)00145-4","volume":"23","author":"MA Selak","year":"2000","unstructured":"Selak MA, de Chadarevian JP, Melvin JJ, Grover WD, Salganicoff L, Kaye EM (2000) Mitochondrial activity in pompe\u2019s disease. Pediatr Neurol 23(1):54\u201357","journal-title":"Pediatr Neurol"},{"issue":"1\u20132","key":"9768_CR29","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1023\/A:1006880529195","volume":"174","author":"W Sperl","year":"1997","unstructured":"Sperl W, Skladal D, Gnaiger E, Wyss M, Mayr U, Hager J, Gellerich FN (1997) High resolution respirometry of permeabilized skeletal muscle fibers in the diagnosis of neuromuscular disorders. Mol Cell Biochem 174(1\u20132):71\u201378","journal-title":"Mol Cell Biochem"},{"issue":"6","key":"9768_CR30","doi-asserted-by":"publisher","first-page":"597","DOI":"10.2746\/042516409X407611","volume":"41","author":"RL Stanley","year":"2009","unstructured":"Stanley RL, McCue ME, Valberg SJ, Mickelson JR, Mayhew IG, McGowan C, Hahn CN, Patterson-Kane JC, Piercy RJ (2009) A glycogen synthase 1 mutation associated with equine polysaccharide storage myopathy and exertional rhabdomyolysis occurs in a variety of UK breeds. Equine Vet J 41(6):597\u2013601","journal-title":"Equine Vet J"},{"issue":"5\u20136","key":"9768_CR31","doi-asserted-by":"publisher","first-page":"351","DOI":"10.1016\/S0960-8966(06)80006-4","volume":"2","author":"SJ Valberg","year":"1992","unstructured":"Valberg SJ, Cardinet GH 3rd, Carlson GP, Di Mauro S (1992) Polysaccharide storage myopathy associated with recurrent exertional rhabdomyolysis in horses. Neuromuscul Disord 2(5\u20136):351\u2013359","journal-title":"Neuromuscul Disord"},{"issue":"3","key":"9768_CR32","doi-asserted-by":"publisher","first-page":"305","DOI":"10.1002\/mus.880170308","volume":"17","author":"SJ Valberg","year":"1994","unstructured":"Valberg SJ, Carlson GP, Cardinet GH 3rd, Birks EK, Jones JH, Chomyn A, DiMauro S (1994) Skeletal muscle mitochondrial myopathy as a cause of exercise intolerance in a horse. Muscle Nerve 17(3):305\u2013312","journal-title":"Muscle Nerve"},{"key":"9768_CR33","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1111\/j.2042-3306.1995.tb04920.x","volume":"18","author":"SJ Valberg","year":"1995","unstructured":"Valberg SJ, Jones JH, Smith BL, Sommerville B (1995) Limitations to performance caused by skeletal muscle enzyme deficiencies. Equine Vet J Suppl 18:205\u2013208","journal-title":"Equine Vet J Suppl"},{"issue":"1","key":"9768_CR34","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1111\/j.2042-3306.1999.tb03789.x","volume":"31","author":"SJ Valberg","year":"1999","unstructured":"Valberg SJ, Macleay JM, Billstrom JA, Hower-Moritz MA, Mickelson JR (1999) Skeletal muscle metabolic response to exercise in horses with \u2018tying-up\u2019 due to polysaccharide storage myopathy. Equine Vet J 31(1):43\u201347","journal-title":"Equine Vet J"},{"issue":"6","key":"9768_CR35","doi-asserted-by":"crossref","first-page":"782","DOI":"10.2460\/ajvr.1998.59.06.782","volume":"59","author":"SJ Valberg","year":"1998","unstructured":"Valberg SJ, Townsend D, Mickelson JR (1998) Skeletal muscle glycolytic capacity and phosphofructokinase regulation in horses with polysaccharide storage myopathy. Am J Vet Res 59(6):782\u2013785","journal-title":"Am J Vet Res"},{"issue":"5","key":"9768_CR36","doi-asserted-by":"publisher","first-page":"254","DOI":"10.1111\/j.2042-3292.2003.tb00537.x","volume":"15","author":"BA Valentine","year":"2003","unstructured":"Valentine BA (2003) Equine polysaccharide storage myopathy. Equine Vet Educ 15(5):254\u2013262","journal-title":"Equine Vet Educ"},{"key":"9768_CR37","doi-asserted-by":"crossref","unstructured":"Van den Hoven R, Wensing T, Breukink HJ, Meijer AE, Kruip TA (1985) Variation of fiber types in the triceps brachii, longissimus dorsi, gluteus medius. and biceps femori of horses Am J Vet Res 46:939\u2013941","DOI":"10.2460\/ajvr.1985.46.04.939"},{"issue":"2","key":"9768_CR38","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1016\/0005-2728(87)90174-5","volume":"892","author":"VI Veksler","year":"1987","unstructured":"Veksler VI, Kuznetsov AV, Sharov VG, Kapelko VI, Saks VA (1987) Mitochondrial respiratory parameters in cardiac tissue: a novel method of assessment by using saponin-skinned fibers. Biochim Biophys Acta 892(2):191\u2013196","journal-title":"Biochim Biophys Acta"},{"issue":"Suppl. 38","key":"9768_CR39","doi-asserted-by":"publisher","first-page":"268","DOI":"10.1111\/j.2042-3306.2010.00271.x","volume":"42","author":"DM Votion","year":"2010","unstructured":"Votion DM, Fraipont A, Goachet AG, Robert C, Van Erck E, Amory H, Ceusters J, de la Rebi\u00e8re de Pouyade G, Franck T, Mouithys-Mickalad A, Niesten A, Serteyn D (2010) Alterations in mitochondrial respiratory function in response to endurance training and endurance racing. Equine Vet J 42(Suppl. 38):268\u2013274","journal-title":"Equine Vet J"},{"issue":"4","key":"9768_CR40","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0034890","volume":"7","author":"DM Votion","year":"2012","unstructured":"Votion DM, Gnaiger E, Lemieux H, Mouithys-Mickalad A, Serteyn D (2012) Physical fitness and mitochondrial respiratory capacity in horse skeletal muscle. PLoS One 7(4):e34890","journal-title":"PLoS One"}],"container-title":["Journal of Bioenergetics and Biomembranes"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s10863-018-9768-6\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10863-018-9768-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10863-018-9768-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,7,6]],"date-time":"2025-07-06T14:36:48Z","timestamp":1751812608000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s10863-018-9768-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,8,24]]},"references-count":40,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2018,10]]}},"alternative-id":["9768"],"URL":"https:\/\/doi.org\/10.1007\/s10863-018-9768-6","relation":{},"ISSN":["0145-479X","1573-6881"],"issn-type":[{"value":"0145-479X","type":"print"},{"value":"1573-6881","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,8,24]]},"assertion":[{"value":"8 March 2018","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 August 2018","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"24 August 2018","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflicts of interest"}},{"value":"All applicable international, national, and\/or institutional guidelines for the care and use of animals were followed.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}}]}}