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Modulators of KATP channels are well-established treatments for metabolic as well as cardiovascular diseases. Experimental studies have also shown the potential of KATP modulation in neurodegenerative disorders. However, to date, data regarding the effects of KATP antagonists\/agonists in experiments related to neurodegeneration remain inconsistent. The main source of confusion in evaluating available data seems to be the choice of experimental models. The present study aims to provide a comprehensive understanding of the effects of both opening and blocking KATP channels in two forms of SH-SY5Y cells. Our results offer valuable insights into the significance of metabolic differences between differentiated and non-differentiated SH-SY5Y cells, particularly in the context of glibenclamide and diazoxide effects under normal conditions and during the initiation of pathological events simulating Parkinson\u2019s disease in vitro. We emphasize the analysis of mitochondrial functions and changes in mitochondrial network morphology. The heightened protein expression of KATP channels identified in non-differentiated SH-SY5Y cells seems to be a platform for a more significant impact of KATP modulators in this cell type. The efficiency of rotenone treatment in inducing morphological changes in the mitochondrial network depends on the differentiation status of SH-SY5Y cells.<\/jats:p>","DOI":"10.1007\/s10863-024-10018-x","type":"journal-article","created":{"date-parts":[[2024,5,1]],"date-time":"2024-05-01T00:02:54Z","timestamp":1714521774000},"page":"347-360","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["The impact of ATP-sensitive potassium channel modulation on mitochondria in a Parkinson\u2019s disease model using SH-SY5Y cells depends on their differentiation state"],"prefix":"10.1007","volume":"56","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5680-9616","authenticated-orcid":false,"given":"A","family":"Evinova","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1357-9368","authenticated-orcid":false,"given":"E","family":"Baranovicova","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0091-0744","authenticated-orcid":false,"given":"D","family":"Hajduchova","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6114-4524","authenticated-orcid":false,"given":"K","family":"Dibdiakova","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8273-2595","authenticated-orcid":false,"given":"I","family":"Baranova","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2166-1556","authenticated-orcid":false,"given":"P","family":"Racay","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7233-6537","authenticated-orcid":false,"given":"J","family":"Strnadel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4257-3213","authenticated-orcid":false,"given":"R","family":"Pecova","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2458-1391","authenticated-orcid":false,"given":"E","family":"Halasova","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6313-5100","authenticated-orcid":false,"given":"M","family":"Pokusa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2024,4,30]]},"reference":[{"key":"10018_CR1","doi-asserted-by":"publisher","unstructured":"Abdelkader NF, Farid HA, Youness ER, Abdel-Salam OME, Zaki HF (2020) The role of KATP channel blockade and activation in the protection against neurodegeneration in the rotenone model of Parkinson\u2019s disease. 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