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This study aimed to determine the effect of cerebral I\/R and 1-week 3',4'-Dihydroxyflavonol (DiOHF) treatment on the antioxidant\/antioxidant system and glutamate, GABA, and BDNF levels in cerebellum tissue in male rats. This study was performed on 28 Wistar-albino type male rats, which were formed as follows: 1-Control Group: No anesthesia or surgical procedure was applied to the animals in this group. 2-Sham Group: After general anesthesia was induced in the animals in this group, the carotid artery regions were opened and closed. After the application, solvent application was performed for 1\u00a0week (1\u00a0ml DiOHF vehicle). 3-Ischemia\u2013Reperfusion Group: After general anesthesia, the carotid arteries were isolated in rats and ligated for 30\u00a0min, ischemia was induced, and then reperfusion was performed. 4-Ischemia\u2013Reperfusion\u2009+\u2009DiOHF Group: After general anesthesia, the carotid arteries were ligated for 30\u00a0min and ischemia was performed in rats, then reperfusion was performed, and then DiOHF supplementation was performed for 1\u00a0week. After one week of treatment, the animals were sacrificed under general anaesthesia, and cerebellum tissues were taken. Malondialdehyde (MDA), glutathione peroxidase (GPx), catalase (CAT), superoxide dismutase (SOD), thioredoxin (TRx-2), glutamate, GABA, and brain-derived neurotrophic factor (BDNF) levels were evaluated in the relevant tissue. I\/R increased MDA, glutamate, and GABA levels, while GPx, catalase, SOD, thioredoxin and BDNF levels were decreased. However, 1\u00a0week of 3',4'-Dihydroxyflavonol treatment corrected the changes that occurred with I\/R. The study results show that 1\u00a0week of 3',4'-Dihydroxyflavonol treatment after I\/R has a positive effect on cerebellum changes that occur in global brain I\/R.<\/jats:p>","DOI":"10.1007\/s10863-026-10083-4","type":"journal-article","created":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T01:36:42Z","timestamp":1780018602000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["3',4'-Dihydroxyflavonol has a positive effect on the cerebellum oxidant\/antioxidant system and BDNF and transmitter levels in focal brain ischemia\u2013reperfusion"],"prefix":"10.1007","volume":"58","author":[{"given":"Nisanur","family":"Coskun","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gozde","family":"Acar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saltuk Bugra","family":"Baltaci","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ebru Kubra","family":"Uzdil","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tugce","family":"Aladag","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rasim","family":"Mogulkoc","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdulkerim Kas\u0131m","family":"Baltaci","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,5,1]]},"reference":[{"key":"10083_CR1","doi-asserted-by":"publisher","DOI":"10.1080\/1028415x.2025.2545513","author":"G Akkaya","year":"2025","unstructured":"Akkaya G, Acar G, Aladag T, Baltaci SB, Mogulkoc R, Baltaci AK (2025) The effect of 3\u2019,4\u2019-dihydroxyflavonol (DiOHF) on endoplasmic reticulum stress in the cerebellum during brain ischemia-reperfusion. 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