{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T13:43:25Z","timestamp":1780407805674,"version":"3.54.1"},"reference-count":50,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,3,24]],"date-time":"2026-03-24T00:00:00Z","timestamp":1774310400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,3,24]],"date-time":"2026-03-24T00:00:00Z","timestamp":1774310400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"name":"S&T program of Qinhuangdao","award":["grant number: 202501A194"],"award-info":[{"award-number":["grant number: 202501A194"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Bioenerg Biomembr"],"published-print":{"date-parts":[[2026,12]]},"DOI":"10.1007\/s10863-026-10104-2","type":"journal-article","created":{"date-parts":[[2026,3,24]],"date-time":"2026-03-24T07:06:03Z","timestamp":1774335963000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Ferulic acid relieves hypoxic damage by inhibiting endoplasmic reticulum stress, oxidative stress, and apoptosis through activating FOXA2-modulated Nrf2\/HO-1 pathway in spermatogonial cells"],"prefix":"10.1007","volume":"58","author":[{"given":"Weiwei","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiurong","family":"Yin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shihao","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chengmin","family":"Gu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,3,24]]},"reference":[{"key":"10104_CR1","doi-asserted-by":"publisher","first-page":"100257","DOI":"10.1016\/j.prmcm.2023.100257","volume":"7","author":"OE Adeyi","year":"2023","unstructured":"Adeyi OE, Somade OT, James AS, Adeyi AO, Ogbonna-Eze SN, Salako OQ et al (2023) Ferulic acid mitigates 2-methoxyethanol-induced testicular oxidative stress via combined downregulation of FoxO1, PTEN, and modulation of Nrf2-Hmox1-NQO1 signaling pathway in rats. Pharmacol Res Mod Chin Med 7:100257","journal-title":"Pharmacol Res Mod Chin Med"},{"key":"10104_CR2","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1186\/s13046-020-01824-3","volume":"40","author":"M Akman","year":"2021","unstructured":"Akman M, Belisario DC, Salaroglio IC, Kopecka J, Donadelli M, De Smaele E et al (2021) Hypoxia, endoplasmic reticulum stress and chemoresistance: dangerous liaisons. J Exp Clin Cancer Res 40:28","journal-title":"J Exp Clin Cancer Res"},{"key":"10104_CR3","doi-asserted-by":"publisher","first-page":"501","DOI":"10.1038\/s12276-024-01180-8","volume":"56","author":"T Bae","year":"2024","unstructured":"Bae T, Hallis SP, Kwak MK (2024) Hypoxia, oxidative stress, and the interplay of HIFs and NRF2 signaling in cancer. Exp Mol Med 56:501\u2013514","journal-title":"Exp Mol Med"},{"key":"10104_CR4","doi-asserted-by":"publisher","first-page":"103570","DOI":"10.1016\/j.ejmg.2018.11.004","volume":"62","author":"H Boda","year":"2019","unstructured":"Boda H, Miyata M, Inagaki H, Shinkai Y, Kato T, Yoshikawa T et al (2019) FOXA2 gene mutation in a patient with congenital complex pituitary hormone deficiency. Eur J Med Genet 62:103570","journal-title":"Eur J Med Genet"},{"key":"10104_CR5","doi-asserted-by":"publisher","first-page":"123076","DOI":"10.1016\/j.lfs.2024.123076","volume":"357","author":"J Chai","year":"2024","unstructured":"Chai J, Liu S, Tian X, Wang J, Wen J, Xu C (2024) Hypoxia impairs male reproductive functions via inducing rat Leydig cell ferroptosis under simulated environment at altitude of 5000 m. Life Sci 357:123076","journal-title":"Life Sci"},{"key":"10104_CR7","doi-asserted-by":"publisher","first-page":"173","DOI":"10.1080\/10715762.2022.2062339","volume":"56","author":"T Chen","year":"2022","unstructured":"Chen T, Niu L, Wang L, Zhou Q, Zhao X, Lai S et al (2022) Ferulic acid protects renal tubular epithelial cells against anoxia\/reoxygenation injury mediated by AMPK\u03b11. Free Radic Res 56:173\u2013184","journal-title":"Free Radic Res"},{"key":"10104_CR8","doi-asserted-by":"publisher","first-page":"352","DOI":"10.1038\/s41392-023-01570-w","volume":"8","author":"X Chen","year":"2023","unstructured":"Chen X, Shi C, He M, Xiong S, Xia X (2023) Endoplasmic reticulum stress: molecular mechanism and therapeutic targets. Signal Transduct Target Ther 8:352","journal-title":"Signal Transduct Target Ther"},{"key":"10104_CR6","doi-asserted-by":"publisher","first-page":"109083","DOI":"10.1016\/j.reprotox.2025.109083","volume":"138","author":"K Chen","year":"2025","unstructured":"Chen K, Luo F, Huang X, Huang K, Liu X, Hu Q et al (2025) Irreversible male infertility from sleep restriction: A dual hit on testicular steroidogenesis and Keap1-Nrf2-mediated antioxidant defense. Reprod Toxicol 138:109083","journal-title":"Reprod Toxicol"},{"key":"10104_CR9","doi-asserted-by":"publisher","first-page":"433","DOI":"10.1089\/ars.2020.8148","volume":"35","author":"TL Duarte","year":"2021","unstructured":"Duarte TL, Talbot NP, Drakesmith H (2021) NRF2 and Hypoxia-Inducible Factors: Key Players in the Redox Control of Systemic Iron Homeostasis. Antioxid Redox Signal 35:433\u2013452","journal-title":"Antioxid Redox Signal"},{"key":"10104_CR10","doi-asserted-by":"publisher","first-page":"6218","DOI":"10.1007\/s11356-017-0873-6","volume":"25","author":"HO El-Mesallamy","year":"2018","unstructured":"El-Mesallamy HO, Gawish RA, Sallam AM, Fahmy HA, Nada AS (2018) Ferulic acid protects against radiation-induced testicular damage in male rats: impact on SIRT1 and PARP1. Environ Sci Pollut Res Int 25:6218\u20136227","journal-title":"Environ Sci Pollut Res Int"},{"key":"10104_CR11","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.tox.2018.11.012","volume":"413","author":"PR Guvvala","year":"2019","unstructured":"Guvvala PR, Ravindra JP, Selvaraju S, Arangasamy A, Venkata KM (2019) Ellagic and ferulic acids protect arsenic-induced male reproductive toxicity via regulating Nfe2l2, Ppargc1a and StAR expressions in testis. Toxicology 413:1\u201312","journal-title":"Toxicology"},{"key":"10104_CR12","doi-asserted-by":"crossref","unstructured":"Hasanein P, Fazeli F, Parviz M, Roghani M (2018) Ferulic acid prevents lead-induced testicular oxidative stress and suppressed spermatogenesis in rats. Andrologia 50:e12798","DOI":"10.1111\/and.12798"},{"key":"10104_CR13","doi-asserted-by":"publisher","first-page":"1171","DOI":"10.1093\/biolre\/ioab142","volume":"105","author":"T He","year":"2021","unstructured":"He T, Guo H, Shen X, Wu X, Xia L, Jiang X et al (2021) Hypoxia-induced alteration of RNA modifications in the mouse testis and sperm. Biol Reprod 105:1171\u20131178","journal-title":"Biol Reprod"},{"key":"10104_CR14","doi-asserted-by":"publisher","first-page":"2640","DOI":"10.1111\/febs.13598","volume":"283","author":"R Iurlaro","year":"2016","unstructured":"Iurlaro R, Munoz-Pinedo C (2016) Cell death induced by endoplasmic reticulum stress. FEBS J 283:2640\u20132652","journal-title":"FEBS J"},{"key":"10104_CR15","doi-asserted-by":"publisher","first-page":"2465","DOI":"10.1038\/s41467-025-57848-w","volume":"16","author":"Z Jia","year":"2025","unstructured":"Jia Z, Li B, Matsuo M, Dewar A, Mustafaraj A, Dey SK et al (2025) Foxa2-dependent uterine glandular cell differentiation is essential for successful implantation. Nat Commun 16:2465","journal-title":"Nat Commun"},{"key":"10104_CR16","doi-asserted-by":"publisher","first-page":"e13505","DOI":"10.1111\/jfbc.13505","volume":"44","author":"RB Kassab","year":"2020","unstructured":"Kassab RB, Lokman MS, Daabo HMA, Gaber DA, Habotta OA, Hafez MM et al (2020) Ferulic acid influences Nrf2 activation to restore testicular tissue from cadmium-induced oxidative challenge, inflammation, and apoptosis in rats. J Food Biochem 44:e13505","journal-title":"J Food Biochem"},{"key":"10104_CR17","doi-asserted-by":"publisher","first-page":"31675","DOI":"10.1007\/s11356-019-06099-6","volume":"26","author":"EG Kelainy","year":"2019","unstructured":"Kelainy EG, Ibrahim Laila IM, Ibrahim SR (2019) The effect of ferulic acid against lead-induced oxidative stress and DNA damage in kidney and testes of rats. Environ Sci Pollut Res Int 26:31675\u201331684","journal-title":"Environ Sci Pollut Res Int"},{"key":"10104_CR18","doi-asserted-by":"publisher","first-page":"e12595","DOI":"10.1002\/rmb2.12595","volume":"23","author":"S Kuribayashi","year":"2024","unstructured":"Kuribayashi S, Fukuhara S, Kitakaze H, Tsujimura G, Imanaka T, Okada K et al (2024) KEAP1-NRF2 system regulates age-related spermatogenesis dysfunction. Reprod Med Biol 23:e12595","journal-title":"Reprod Med Biol"},{"key":"10104_CR22","doi-asserted-by":"publisher","first-page":"146390","DOI":"10.1016\/j.gene.2022.146390","volume":"823","author":"S Li","year":"2022","unstructured":"Li S, Yang QE (2022) Hypobaric hypoxia exposure alters transcriptome in mouse testis and impairs spermatogenesis in offspring. Gene 823:146390","journal-title":"Gene"},{"key":"10104_CR19","doi-asserted-by":"publisher","first-page":"119921","DOI":"10.1016\/j.lfs.2021.119921","volume":"284","author":"D Li","year":"2021","unstructured":"Li D, Rui YX, Guo SD, Luan F, Liu R, Zeng N (2021a) Ferulic acid: A review of its pharmacology, pharmacokinetics and derivatives. Life Sci 284:119921","journal-title":"Life Sci"},{"key":"10104_CR26","doi-asserted-by":"publisher","first-page":"725933","DOI":"10.3389\/fcell.2021.725933","volume":"9","author":"Z Li","year":"2021","unstructured":"Li Z, Wang S, Gong C, Hu Y, Liu J, Wang W et al (2021b) Effects of Environmental and Pathological Hypoxia on Male Fertility. Front Cell Dev Biol 9:725933","journal-title":"Front Cell Dev Biol"},{"key":"10104_CR24","doi-asserted-by":"publisher","first-page":"2636","DOI":"10.1002\/ar.25203","volume":"306","author":"W Li","year":"2023","unstructured":"Li W, Liu D, Chen B, Chen X, Yu H (2023) Ferulic acid improves cognitive impairment by regulating jumonji C domain-containing protein 6 and synaptophysin in the hippocampus in neonatal and juvenile rats with intrauterine hypoxia during pregnancy. Anat Rec (Hoboken) 306:2636\u20132645","journal-title":"Anat Rec (Hoboken)"},{"key":"10104_CR23","doi-asserted-by":"publisher","first-page":"853","DOI":"10.1002\/jat.4580","volume":"44","author":"W Li","year":"2024","unstructured":"Li W, Han Z, Yin X, Zhou R, Liu H (2024) CDX2 alleviates hypoxia-induced apoptosis and oxidative stress in spermatogenic cells through suppression of reactive oxygen species-mediated Wnt\/beta-catenin pathway. J Appl Toxicol 44:853\u2013862","journal-title":"J Appl Toxicol"},{"key":"10104_CR21","doi-asserted-by":"publisher","first-page":"261","DOI":"10.1007\/s43032-024-01746-x","volume":"32","author":"S Li","year":"2025","unstructured":"Li S, Liu W, Chen X, Chen Z, Shi J, Hua J (2025a) From Hypoxia to Oxidative Stress: Antioxidants\u2019 Role to Reduce Male Reproductive Damage. Reprod Sci 32:261\u2013277","journal-title":"Reprod Sci"},{"key":"10104_CR25","doi-asserted-by":"publisher","first-page":"114388","DOI":"10.1016\/j.yexcr.2024.114388","volume":"444","author":"W Li","year":"2025","unstructured":"Li W, Yin X, Zhang L (2025b) FOXA2 regulates endoplasmic reticulum stress, oxidative stress, and apoptosis in spermatogonial cells by the Nrf2 pathway under hypoxic conditions. Exp Cell Res 444:114388","journal-title":"Exp Cell Res"},{"key":"10104_CR20","doi-asserted-by":"publisher","first-page":"121162","DOI":"10.1016\/j.jep.2026.121162","volume":"360","author":"S Li","year":"2026","unstructured":"Li S, Jing S, Zhou J, Li H, Yin P, Su L et al (2026) Mechanisms of Traditional Chinese Medicine in regulating Nrf2-related signaling pathways for the treatment of Oligoasthenozoospermia: A review. J Ethnopharmacol 360:121162","journal-title":"J Ethnopharmacol"},{"key":"10104_CR27","first-page":"478","volume":"18","author":"WC Lin","year":"2015","unstructured":"Lin WC, Peng YF, Hou CW (2015) Ferulic acid protects PC12 neurons against hypoxia by inhibiting the p-MAPKs and COX-2 pathways. Iran J Basic Med Sci 18:478\u2013484","journal-title":"Iran J Basic Med Sci"},{"key":"10104_CR28","doi-asserted-by":"publisher","first-page":"216927","DOI":"10.1016\/j.canlet.2024.216927","volume":"592","author":"Z Ling","year":"2024","unstructured":"Ling Z, Pan J, Zhang Z, Chen G, Geng J, Lin Q et al (2024) Small-molecule Molephantin induces apoptosis and mitophagy flux blockage through ROS production in glioblastoma. Cancer Lett 592:216927","journal-title":"Cancer Lett"},{"key":"10104_CR29","doi-asserted-by":"publisher","first-page":"172","DOI":"10.1038\/s41420-024-01936-1","volume":"10","author":"N Liu","year":"2024","unstructured":"Liu N, Wang A, Xue M, Zhu X, Liu Y, Chen M (2024) FOXA1 and FOXA2: the regulatory mechanisms and therapeutic implications in cancer. Cell Death Discov 10:172","journal-title":"Cell Death Discov"},{"key":"10104_CR30","doi-asserted-by":"publisher","first-page":"103","DOI":"10.3389\/fphar.2020.00103","volume":"11","author":"C Luo","year":"2020","unstructured":"Luo C, Zhang Y, Guo H, Han X, Ren J, Liu J (2020) Ferulic Acid Attenuates Hypoxia\/Reoxygenation Injury by Suppressing Mitophagy Through the PINK1\/Parkin Signaling Pathway in H9c2 Cells. Front Pharmacol 11:103","journal-title":"Front Pharmacol"},{"key":"10104_CR31","doi-asserted-by":"publisher","first-page":"e307","DOI":"10.1016\/j.fertnstert.2018.07.865","volume":"110","author":"D Prokai","year":"2018","unstructured":"Prokai D, Moehlman A, Chapman K, Chaudhary J, Pudasaini A, Hamra F (2018) Pioneering roles for FOXA transcription factors in rat stem and progenitor spermatogonia. Fertil Steril 110:e307","journal-title":"Fertil Steril"},{"key":"10104_CR32","doi-asserted-by":"publisher","first-page":"e70436","DOI":"10.1096\/fj.202403182R","volume":"39","author":"MS Rahman","year":"2025","unstructured":"Rahman MS, Kim TH, Barrier BF, Spencer TE, Kelleher AM, Jeong JW (2025) FOXA2 loss results in an increase of endometriosis development and LIF reveals a therapeutic effect for endometriosis. FASEB J 39:e70436","journal-title":"FASEB J"},{"key":"10104_CR33","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1080\/10520295.2022.2110615","volume":"98","author":"U Sa\u00e7\u0131k","year":"2023","unstructured":"Sa\u00e7\u0131k U, \u00c7avdar Z, Ural C, Ersoy N, \u00d6zo\u011ful C, Erbil G (2023) Effect of ferulic acid on testicular damage caused by torsion-detorsion in rats. Biotech Histochem 98:77\u201385","journal-title":"Biotech Histochem"},{"key":"10104_CR34","doi-asserted-by":"publisher","first-page":"2286","DOI":"10.1080\/13880209.2022.2147549","volume":"60","author":"X Tang","year":"2022","unstructured":"Tang X, Liu J, Yao S, Zheng J, Gong X, Xiao B (2022) Ferulic acid alleviates alveolar epithelial barrier dysfunction in sepsis-induced acute lung injury by activating the Nrf2\/HO-1 pathway and inhibiting ferroptosis. Pharm Biol 60:2286\u20132294","journal-title":"Pharm Biol"},{"key":"10104_CR35","first-page":"55","volume":"10","author":"GA Taqa","year":"2025","unstructured":"Taqa GA (2025) The ameliorative effects of ferulic acid against methotrexate induced testicular damage in rats. J Appl Veterinary Sci 10:55\u201364","journal-title":"J Appl Veterinary Sci"},{"key":"10104_CR36","doi-asserted-by":"publisher","first-page":"854","DOI":"10.2108\/zsj.25.854","volume":"25","author":"BM Thyagaraju","year":"2008","unstructured":"Thyagaraju BM, Muralidhara (2008) Ferulic acid supplements abrogate oxidative impairments in liver and testis in the streptozotocin-diabetic rat. Zoolog Sci 25:854\u2013860","journal-title":"Zoolog Sci"},{"key":"10104_CR37","doi-asserted-by":"publisher","first-page":"1757","DOI":"10.5665\/sleep.4166","volume":"37","author":"M Torres","year":"2014","unstructured":"Torres M, Laguna-Barraza R, Dalmases M, Calle A, Pericuesta E, Montserrat JM et al (2014) Male fertility is reduced by chronic intermittent hypoxia mimicking sleep apnea in mice. Sleep 37:1757\u20131765","journal-title":"Sleep"},{"key":"10104_CR38","doi-asserted-by":"publisher","first-page":"e21210300","DOI":"10.1590\/1678-4324-2021210300","volume":"64","author":"H Uzunbay\u0131r","year":"2021","unstructured":"Uzunbay\u0131r H, Apayd\u0131n FG (2021) Protective role of ferulic acid on testis-histoarchitecture and oxidative damages induced by dimethoate in rats. Brazilian Archives Biology Technol 64:e21210300","journal-title":"Brazilian Archives Biology Technol"},{"key":"10104_CR39","doi-asserted-by":"publisher","first-page":"e29752","DOI":"10.1016\/j.heliyon.2024.e29752","volume":"10","author":"J Valipour","year":"2024","unstructured":"Valipour J, Taghizadeh F, Esfahani R, Ramesh M, Rastegar T (2024) Role of nuclear factor erythroid 2-related factor 2 (Nrf2) in female and male fertility. Heliyon 10:e29752","journal-title":"Heliyon"},{"key":"10104_CR40","doi-asserted-by":"publisher","first-page":"172417","DOI":"10.1016\/j.ejphar.2019.172417","volume":"856","author":"F Wang","year":"2019","unstructured":"Wang F, Peng Q, Liu J, Alolga RN, Zhou W (2019) A novel ferulic acid derivative attenuates myocardial cell hypoxia reoxygenation injury through a succinate dehydrogenase dependent antioxidant mechanism. Eur J Pharmacol 856:172417","journal-title":"Eur J Pharmacol"},{"key":"10104_CR41","doi-asserted-by":"publisher","first-page":"850114","DOI":"10.3389\/fgene.2022.850114","volume":"13","author":"K Wang","year":"2022","unstructured":"Wang K, Gao Y, Wang C, Liang M, Liao Y, Hu K (2022) Role of Oxidative Stress in Varicocele. Front Genet 13:850114","journal-title":"Front Genet"},{"key":"10104_CR42","doi-asserted-by":"publisher","first-page":"154","DOI":"10.1002\/2211-5463.13523","volume":"13","author":"Z Wang","year":"2023","unstructured":"Wang Z, Zhu C, Song Y, Chen X, Zheng J, He L et al (2023) SIRT3 inhibition suppresses hypoxia-inducible factor 1alpha signaling and alleviates hypoxia-induced apoptosis of type B spermatogonia GC-2 cells. FEBS Open Bio 13:154\u2013163","journal-title":"FEBS Open Bio"},{"key":"10104_CR43","doi-asserted-by":"publisher","first-page":"880","DOI":"10.1002\/iub.2625","volume":"74","author":"J Wu","year":"2022","unstructured":"Wu J, Zhou F, Fan G, Liu J, Wang Y, Xue X et al (2022) Ferulic acid ameliorates acetaminophen-induced acute liver injury by promoting AMPK-mediated protective autophagy. IUBMB Life 74:880\u2013895","journal-title":"IUBMB Life"},{"key":"10104_CR44","doi-asserted-by":"publisher","first-page":"468","DOI":"10.1262\/jrd.2014-086","volume":"60","author":"K Yamagami","year":"2014","unstructured":"Yamagami K, Yamauchi N, Kubota K, Nishimura S, Chowdhury VS, Yamanaka K et al (2014) Expression and regulation of Foxa2 in the rat uterus during early pregnancy. J Reprod Dev 60:468\u2013475","journal-title":"J Reprod Dev"},{"key":"10104_CR45","doi-asserted-by":"publisher","first-page":"1169","DOI":"10.1152\/physrev.00023.2017","volume":"98","author":"M Yamamoto","year":"2018","unstructured":"Yamamoto M, Kensler TW, Motohashi H (2018) The KEAP1-NRF2 system: a thiol-based sensor-effector apparatus for maintaining redox homeostasis. Physiol Rev 98:1169\u20131203","journal-title":"Physiol Rev"},{"key":"10104_CR46","first-page":"4342","volume":"13","author":"F Yan","year":"2021","unstructured":"Yan F, Dou X, Zhu G, Xia M, Liu Y, Liu X et al (2021) Cistanoside of Cistanche Herba ameliorates hypoxia-induced male reproductive damage via suppression of oxidative stress. Am J Transl Res 13:4342\u20134359","journal-title":"Am J Transl Res"},{"key":"10104_CR47","doi-asserted-by":"publisher","first-page":"108603","DOI":"10.1016\/j.jnutbio.2021.108603","volume":"91","author":"C Yu","year":"2021","unstructured":"Yu C, Pan S, Zhang J, Li X, Niu Y (2021) Ferulic acid exerts Nrf2-dependent protection against prenatal lead exposure-induced cognitive impairment in offspring mice. J Nutr Biochem 91:108603","journal-title":"J Nutr Biochem"},{"key":"10104_CR48","doi-asserted-by":"publisher","first-page":"103593","DOI":"10.1016\/j.redox.2025.103593","volume":"82","author":"J Zhang","year":"2025","unstructured":"Zhang J, Zhang M, Tatar M, Gong R (2025) Keap1-independent Nrf2 regulation: A novel therapeutic target for treating kidney disease. Redox Biol 82:103593","journal-title":"Redox Biol"},{"key":"10104_CR49","doi-asserted-by":"publisher","first-page":"1124","DOI":"10.1002\/cbin.10971","volume":"42","author":"J Zhou","year":"2018","unstructured":"Zhou J, Qian CY, Tong RQ, Wang B, Chen XL, Zhuang YY et al (2018) Hypoxia induces apoptosis of mouse spermatocyte GC-2 cells through activation of autophagy. Cell Biol Int 42:1124\u20131131","journal-title":"Cell Biol Int"},{"key":"10104_CR50","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s44337-025-00503-6","volume":"2","author":"J Zhu","year":"2025","unstructured":"Zhu J, Cheng Y, Li H, Xie RK, Hu H, Gao L (2025) Impact of chronic hypoxia on spermatogenesis. Discover Med 2:1\u201318","journal-title":"Discover Med"}],"updated-by":[{"DOI":"10.1007\/s10863-026-10113-1","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T00:00:00Z","timestamp":1780012800000}}],"container-title":["Journal of Bioenergetics and Biomembranes"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10863-026-10104-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10863-026-10104-2","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10863-026-10104-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T03:55:56Z","timestamp":1780026956000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10863-026-10104-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3,24]]},"references-count":50,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,12]]}},"alternative-id":["10104"],"URL":"https:\/\/doi.org\/10.1007\/s10863-026-10104-2","relation":{},"ISSN":["0145-479X","1573-6881"],"issn-type":[{"value":"0145-479X","type":"print"},{"value":"1573-6881","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,3,24]]},"assertion":[{"value":"17 December 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 March 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"24 March 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"29 May 2026","order":5,"name":"change_date","label":"Change Date","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Correction","order":6,"name":"change_type","label":"Change Type","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"A Correction to this paper has been published:","order":7,"name":"change_details","label":"Change Details","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"https:\/\/doi.org\/10.1007\/s10863-026-10113-1","URL":"https:\/\/doi.org\/10.1007\/s10863-026-10113-1","order":8,"name":"change_details","label":"Change Details","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"4"}}