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The authors have no conflicts of interest to declare relevant to the content of this article. All authors certify that they have no affiliations with or involvement in any organization or entity with any financial interest or non-financial interest in the subject matter or materials discussed in 38 this manuscript. The authors have no financial or proprietary interests in any material discussed in this article.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"All study procedures were conducted in accordance with the ethical standards set forth in the 1964 Helsinki declaration and its later amendments and were approved by the University of Washington Institutional Review Board. 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