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Psychological interventions, particularly cognitive behavioral therapy, can support lifestyle changes. This study aimed to evaluate the efficacy of a cognitive behavioral therapy intervention for obesity management in patients with chronic kidney disease. Methods: Forty patients with chronic kidney disease (stages 2\u20134) were randomized to either an intervention group (nutritional and physical activity counseling and 16-week cognitive behavioral therapy) or a control group (nutritional and physical activity counseling only). Primary outcomes were body mass index (BMI) and proteinuria. Results: The intervention group lost an average of 5.42\u00a0kg (BMI decrease: 1.82\u00a0kg\/m\u00b2), compared to 1.53\u00a0kg (BMI decrease: 0.53\u00a0kg\/m\u00b2) in the control group. A significant group-by-time interaction was observed for BMI (F(1,36)\u2009=\u200932.24, <jats:italic>p<\/jats:italic>\u2009=\u20090.004, \u014b\u00b2=0.21), favoring the intervention group. Effects remained significant at three-month follow-up, with an average weight loss of 4.63\u00a0kg (BMI decrease: 1.59\u00a0kg\/m\u00b2) in the intervention group and 2.51\u00a0kg (BMI decrease: 0.87\u00a0kg\/m\u00b2) in control group (F(2,70)\u2009=\u20095.54, <jats:italic>p<\/jats:italic>\u2009=\u20090.026, \u014b\u00b2=0.12). Changes in proteinuria did not differ between groups. Conclusion: Cognitive behavioral therapy was effective and well-tolerated for promoting weight loss with most of the lost weight maintained at the three-month follow-up. This intervention may offer a valuable non-pharmacological treatment option for weight management in patients with chronic kidney disease.<\/jats:p>","DOI":"10.1007\/s10865-025-00583-w","type":"journal-article","created":{"date-parts":[[2025,6,19]],"date-time":"2025-06-19T14:05:55Z","timestamp":1750341955000},"page":"594-604","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Lost and not found: randomized controlled trial of cognitive behavioral therapy for weight-loss in patients with chronic kidney disease"],"prefix":"10.1007","volume":"48","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6312-4903","authenticated-orcid":false,"given":"Katja","family":"Kurnik Mesari\u010d","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4522-3788","authenticated-orcid":false,"given":"Jana","family":"Kodri\u010d","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1784-208X","authenticated-orcid":false,"given":"\u0160pela","family":"Bogataj","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4110-6894","authenticated-orcid":false,"given":"Andreja","family":"Marn Pernat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aljo\u0161a","family":"Kuzmanovski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernarda","family":"Logar Zakraj\u0161ek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3265-8053","authenticated-orcid":false,"given":"Jernej","family":"Pajek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,6,19]]},"reference":[{"issue":"1","key":"583_CR1","doi-asserted-by":"publisher","first-page":"38","DOI":"10.1001\/jama.2023.24945","volume":"331","author":"LJ Aronne","year":"2024","unstructured":"Aronne, L. 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