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Although understanding of underlying processes is limited, heightened fear responding is a candidate. In 168 youth, we tested whether threat- and deprivation-related ELA were associated with fear responses across multiple levels of analysis and whether fear responses explained links of threat with accelerated biological aging (advanced pubertal stage and epigenetic age). Youth and caregivers reported on youths\u2019 lifetime ELA experiences to compute threat and deprivation composites. Youth reported their pubertal maturation and provided saliva samples for epigenetic age estimation. Fear responses (indexed by skin conductance response [SCR], self-reported fear, and amygdala activation) were collected during a fear conditioning and extinction task (SCR, self-reported fear) and emotional stimulus viewing task (amygdala activation). Multilevel models revealed that greater threat was associated with impaired discrimination between danger and safety cues during conditioning based on self-report and during early extinction based on SCR. Greater deprivation related to enhanced danger-safety discrimination during late conditioning based on SCR. Additionally, only threat was associated with greater left amygdala activation to negative (vs. neutral) stimuli. No evidence of indirect effects was found linking threat with accelerated biological aging. Results suggest that threat-related ELA may correspond to heightened neural sensitivity to danger and reduced danger-safety discrimination, whereas deprivation-related ELA may enhance learning of danger vs. safety cues. Findings indicate potential differential associations between threat- and deprivation-related ELA and fear-related processes.<\/jats:p>","DOI":"10.1007\/s10865-026-00708-9","type":"journal-article","created":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T11:29:58Z","timestamp":1788953398000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Dimensions of early life adversity and accelerated biological aging in adolescents: an examination of fear-related mechanisms"],"prefix":"10.1007","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1806-8962","authenticated-orcid":false,"given":"Leah","family":"Cha","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7048-8369","authenticated-orcid":false,"given":"Craig K.","family":"Enders","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2573-1737","authenticated-orcid":false,"given":"Shiloh","family":"Cleveland","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1362-2410","authenticated-orcid":false,"given":"Katie A.","family":"McLaughlin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0217-7171","authenticated-orcid":false,"given":"Jennifer A.","family":"Sumner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,9,9]]},"reference":[{"key":"708_CR1","unstructured":"Aiken, L. 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