{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,16]],"date-time":"2026-03-16T12:45:02Z","timestamp":1773665102440,"version":"3.50.1"},"reference-count":59,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2014,2,13]],"date-time":"2014-02-13T00:00:00Z","timestamp":1392249600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Biol Phys"],"published-print":{"date-parts":[[2014,3]]},"DOI":"10.1007\/s10867-013-9339-3","type":"journal-article","created":{"date-parts":[[2014,2,12]],"date-time":"2014-02-12T08:14:30Z","timestamp":1392192870000},"page":"193-216","source":"Crossref","is-referenced-by-count":5,"title":["Molecular models of the Mojave rattlesnake (Crotalus scutulatus scutulatus) venom metalloproteinases reveal a structural basis for differences in hemorrhagic activities"],"prefix":"10.1007","volume":"40","author":[{"given":"Ruben K.","family":"Dagda","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sardar E.","family":"Gasanov","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Boris","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William","family":"Welch","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eppie D.","family":"Rael","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2014,2,13]]},"reference":[{"key":"9339_CR1","doi-asserted-by":"crossref","first-page":"119","DOI":"10.3109\/15569548309012695","volume":"2","author":"FS Markland","year":"1983","unstructured":"Markland, F.S.: Rattlesnake venom enzymes that interact with components of the hemostatic system. J. Toxicol. Tox. Rev. 2, 119\u2013160 (1983)","journal-title":"J. Toxicol. Tox. Rev."},{"issue":"3","key":"9339_CR2","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/0020-711X(90)90337-3","volume":"22","author":"O Molina","year":"1990","unstructured":"Molina, O., Seriel, R.K., Martinez, M., Sierra, M.L., Varela-Ramirez, A., Rael, E.D.: Isolation of two hemorrhagic toxins from Crotalus basiliscus basiliscus (Mexican west coast rattlesnake) venom and their effect on blood clotting and complement. Intern. J. Biochem. 22(3), 253\u2013261 (1990)","journal-title":"Intern. J. Biochem."},{"issue":"44","key":"9339_CR3","doi-asserted-by":"crossref","first-page":"31493","DOI":"10.1074\/jbc.274.44.31493","volume":"274","author":"O Pentikainen","year":"1999","unstructured":"Pentikainen, O., Hoffren, A.M., Ivaska, J., Kapyla, J., Nyronen, T., Heino, J., Johnson, M.S.: RKKH peptides from the snake venom metalloproteinase of Bothrops jararaca bind near the metal ion-dependent adhesion site of the human integrin alpha(2) I-domain. J. Biol. Chem. 274(44), 31493\u201331505 (1999)","journal-title":"J. Biol. Chem."},{"issue":"3","key":"9339_CR4","first-page":"595","volume":"106","author":"ED Rael","year":"1993","unstructured":"Rael, E.D., Lieb, C.S., Maddux, N., Varela-Ramirez, A., Perez, J.: Hemorrhagic and Mojave toxins in the venoms of the offspring of two Mojave rattlesnakes (Crotalus scutulatus scutulatus). Comp. Biochem. Physiol. 106(3), 595\u2013600 (1993)","journal-title":"Comp. Biochem. Physiol."},{"issue":"4","key":"9339_CR5","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1016\/S0041-0101(96)00139-0","volume":"35","author":"ED Rael","year":"1997","unstructured":"Rael, E.D., Rivas, J.Z., Chen, T., Maddux, N., Huizar, E., Lieb, C.S.: Differences in fibrinolysis and complement inactivation by venom from different northern blacktailed rattlesnakes (Crotalus molossus molossus). Toxicon 35(4), 505\u2013513 (1997)","journal-title":"Toxicon"},{"issue":"1","key":"9339_CR6","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1006\/abbi.1994.1026","volume":"308","author":"LA Hite","year":"1994","unstructured":"Hite, L.A., Jia, L.G., Bjarnason, J.B., Fox, J.W.: cDNA sequences for four snake venom metalloproteinases: structure, classification, and their relationship to mammalian reproductive proteins. Arch. Biochem. Biophys. 308(1), 182\u2013191 (1994)","journal-title":"Arch. Biochem. Biophys."},{"issue":"20","key":"9339_CR7","doi-asserted-by":"crossref","first-page":"13094","DOI":"10.1074\/jbc.272.20.13094","volume":"272","author":"LG Jia","year":"1997","unstructured":"Jia, L.G., Wang, X.M., Shannon, J.D., Bjarnason, J.B., Fox, J.W.: Function of disintegrin-like\/cysteine-rich domains of atrolysin A. Inhibition of platelet aggregation by recombinant protein and peptide antagonists. J. Biol. Chem. 272(20), 13094\u201313102 (1997)","journal-title":"J. Biol. Chem."},{"issue":"2","key":"9339_CR8","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1016\/j.semcdb.2008.07.009","volume":"20","author":"S Takeda","year":"2009","unstructured":"Takeda, S.: Three-dimensional domain architecture of the ADAM family proteinases. Semin. Cell. Dev. Biol. 20(2), 146\u2013152 (2009)","journal-title":"Semin. Cell. Dev. Biol."},{"issue":"3","key":"9339_CR9","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1101\/gr.3228405","volume":"15","author":"BG Fry","year":"2005","unstructured":"Fry, B.G.: From genome to venome: molecular origin and evolution of the snake venom proteome inferred from phylogenetic analysis of toxin sequences and related body proteins. Genome Res. 15(3), 403\u2013420 (2005)","journal-title":"Genome Res."},{"issue":"4","key":"9339_CR10","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1016\/j.toxicon.2012.02.006","volume":"60","author":"NR Casewell","year":"2012","unstructured":"Casewell, N.R.: On the ancestral recruitment of metalloproteinases into the venom of snakes. Toxicon 60(4), 449\u2013454 (2012)","journal-title":"Toxicon"},{"issue":"11","key":"9339_CR11","doi-asserted-by":"crossref","first-page":"2388","DOI":"10.1038\/sj.emboj.7601131","volume":"25","author":"S Takeda","year":"2006","unstructured":"Takeda, S., Igarashi, T., Mori, H., Araki, S.: Crystal structures of VAP1 reveal ADAMs\u2019 MDC domain architecture and its unique C-shaped scaffold. EMBO J. 25(11), 2388\u20132396 (2006)","journal-title":"EMBO J."},{"issue":"1","key":"9339_CR12","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1016\/j.bbapap.2011.04.009","volume":"1824","author":"S Takeda","year":"2012","unstructured":"Takeda, S., Takeya, H., Iwanaga, S.: Snake venom metalloproteinases: structure, function and relevance to the mammalian ADAM\/ADAMTS family proteins. Biochim. Biophys. Acta 1824(1), 164\u2013176 (2012)","journal-title":"Biochim. Biophys. Acta"},{"issue":"52","key":"9339_CR13","doi-asserted-by":"crossref","first-page":"39746","DOI":"10.1074\/jbc.M604855200","volume":"281","author":"SM Serrano","year":"2006","unstructured":"Serrano, S.M., Kim, J., Wang, D., Dragulev, B., Shannon, J.D., Mann, H.H., Veit, G., Wagener, R., Koch, M., Fox, J.W.: The cysteine-rich domain of snake venom metalloproteinases is a ligand for von Willebrand factor A domains: role in substrate targeting. J. Biol. Chem. 281(52), 39746\u201339756 (2006)","journal-title":"J. Biol. Chem."},{"issue":"13","key":"9339_CR14","doi-asserted-by":"crossref","first-page":"2416","DOI":"10.1016\/j.febslet.2007.04.057","volume":"581","author":"T Igarashi","year":"2007","unstructured":"Igarashi, T., Araki, S., Mori, H., Takeda, S.: Crystal structures of catrocollastatin\/VAP2B reveal a dynamic, modular architecture of ADAM\/adamalysin\/reprolysin family proteins. FEBS Lett. 581(13), 2416\u20132422 (2007)","journal-title":"FEBS Lett."},{"issue":"30","key":"9339_CR15","doi-asserted-by":"crossref","first-page":"5859","DOI":"10.1016\/j.febslet.2007.11.062","volume":"581","author":"S Takeda","year":"2007","unstructured":"Takeda, S., Igarashi, T., Mori, H.: Crystal structure of RVV-X: an example of evolutionary gain of specificity by ADAM proteinases. FEBS Lett. 581(30), 5859\u20135864 (2007)","journal-title":"FEBS Lett."},{"issue":"1","key":"9339_CR16","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1110\/ps.073287008","volume":"17","author":"L Mosyak","year":"2008","unstructured":"Mosyak, L., Georgiadis, K., Shane, T., Svenson, K., Hebert, T., McDonagh, T., Mackie, S., Olland, S., Lin, L., Zhong, X., Kriz, R., Reifenberg, E.L., Collins-Racie, L.A., Corcoran, C., Freeman, B., Zollner, R., Marvell, T., Vera, M., Sum, P.E., Lavallie, E.R., Stahl, M., Somers, W.: Crystal structures of the two major aggrecan degrading enzymes, ADAMTS4 and ADAMTS5. Protein Sci. 17(1), 16\u201321 (2008)","journal-title":"Protein Sci."},{"issue":"12","key":"9339_CR17","doi-asserted-by":"crossref","first-page":"3016","DOI":"10.1111\/j.1742-4658.2008.06466.x","volume":"275","author":"JW Fox","year":"2008","unstructured":"Fox, J.W., Serrano, S.M.: Insights into and speculations about snake venom metalloproteinase (SVMP) synthesis, folding and disulfide bond formation and their contribution to venom complexity. FEBS J 275(12), 3016\u20133030 (2008)","journal-title":"FEBS J"},{"issue":"9\u201310","key":"9339_CR18","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1016\/S0300-9084(00)01163-9","volume":"82","author":"JM Gutierrez","year":"2000","unstructured":"Gutierrez, J.M., Rucavado, A.: Snake venom metalloproteinases: their role in the pathogenesis of local tissue damage. Biochimie 82(9\u201310), 841\u2013850 (2000)","journal-title":"Biochimie"},{"issue":"8","key":"9339_CR19","doi-asserted-by":"crossref","first-page":"969","DOI":"10.1016\/j.toxicon.2005.02.012","volume":"45","author":"JW Fox","year":"2005","unstructured":"Fox, J.W., Serrano, S.M.: Structural considerations of the snake venom metalloproteinases, key members of the M12 reprolysin family of metalloproteinases. Toxicon 45(8), 969\u2013985 (2005)","journal-title":"Toxicon"},{"issue":"1","key":"9339_CR20","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1006\/abbi.1999.1517","volume":"373","author":"LG Jia","year":"2000","unstructured":"Jia, L.G., Wang, X.M., Shannon, J.D., Bjarnason, J.B., Fox, J.W.: Inhibition of platelet aggregation by the recombinant cysteine-rich domain of the hemorrhagic snake venom metalloproteinase, atrolysin A. Arch. Biochem. Biophys. 373(1), 281\u2013286 (2000)","journal-title":"Arch. Biochem. Biophys."},{"issue":"3","key":"9339_CR21","doi-asserted-by":"crossref","first-page":"720","DOI":"10.1006\/bbrc.1996.0301","volume":"219","author":"Q Zhou","year":"1996","unstructured":"Zhou, Q., Dangelmaier, C., Smith, J.B.: The hemorrhagin catrocollastatin inhibits collagen-induced platelet aggregation by binding to collagen via its disintegrin-like domain. Biochem. Biophys. Res. Commun. 219(3), 720\u2013726 (1996)","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"1","key":"9339_CR22","first-page":"41","volume":"22","author":"ED Rael","year":"1992","unstructured":"Rael, E.D., Martinez, M., Molina, O.: Isolation of a fibrinolytic protease, M4, from venom of Crotalus molossus molossus (northern blacktail rattlesnake). Haemostasis 22(1), 41\u201349 (1992)","journal-title":"Haemostasis"},{"issue":"2","key":"9339_CR23","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1006\/abbi.1999.1682","volume":"375","author":"Q Zhou","year":"2000","unstructured":"Zhou, Q., Hu, P., Ritter, M.R., Swenson, S.D., Argounova, S., Epstein, A.L., Markland, F.S.: Molecular cloning and functional expression of contortrostatin, a homodimeric disintegrin from southern copperhead snake venom. Arch. Biochem. Biophys. 375(2), 278\u2013288 (2000)","journal-title":"Arch. Biochem. Biophys."},{"issue":"1","key":"9339_CR24","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1016\/j.bbapap.2011.04.009","volume":"1824","author":"S Takeda","year":"2012","unstructured":"Takeda, S., Takeya, H., Iwanaga, S.: Snake venom metalloproteinases: structure, function and relevance to the mammalian ADAM\/ADAMTS family proteins. Biochim. Biophys. Acta 1824(1), 164\u2013176 (2012)","journal-title":"Biochim. Biophys. Acta"},{"issue":"3","key":"9339_CR25","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1016\/0163-7258(94)90049-3","volume":"62","author":"JB Bjarnason","year":"1994","unstructured":"Bjarnason, J.B., Fox, J.W.: Hemorrhagic metalloproteinases from snake venoms. Pharmacol. Ther. 62(3), 325\u201372 (1994)","journal-title":"Pharmacol. Ther."},{"issue":"2","key":"9339_CR26","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1006\/abbi.1996.0509","volume":"335","author":"K Shimokawa","year":"1996","unstructured":"Shimokawa, K., Jia, L.G., Wang, X.M., Fox, J.W.: Expression, activation, and processing of the recombinant snake venom metalloproteinase, pro-atrolysin E. Arch. Biochem. Biophys. 335(2), 283\u2013294 (1996)","journal-title":"Arch. Biochem. Biophys."},{"issue":"5","key":"9339_CR27","doi-asserted-by":"crossref","first-page":"2302","DOI":"10.1021\/pr901042p","volume":"9","author":"D Georgieva","year":"2010","unstructured":"Georgieva, D., Ohler, M., Seifert, J., von Bergen, M., Arni, R.K., Genov, N., Betzel, C.: Snake venomic of Crotalus durissus terrificus\u2014correlation with pharmacological activities. J. Proteome Res. 9(5), 2302\u20132316 (2010)","journal-title":"J. Proteome Res."},{"key":"9339_CR28","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.toxicon.2013.05.006","volume":"71","author":"G Martinez-Romero","year":"2013","unstructured":"Martinez-Romero, G., Rucavado, A., Lazcano, D., Gutierrez, J.M., Borja, M., Lomonte, B., Garza-Garcia, Y., Zugasti-Cruz, A.: Comparison of venom composition and biological activities of the subspecies Crotalus lepidus lepidus, Crotalus lepidus klauberi and Crotalus lepidus morulus from Mexico. Toxicon 71, 84\u201395 (2013)","journal-title":"Toxicon"},{"key":"9339_CR29","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.jprot.2013.05.024","volume":"87","author":"EN Castro","year":"2013","unstructured":"Castro, E.N., Lomonte, B., del Carmen Gutierrez, M., Alagon, A., Gutierrez, J.M.: Intraspecies variation in the venom of the rattlesnake Crotalus simus from Mexico: different expression of crotoxin results in highly variable toxicity in the venoms of three subspecies. J. Proteomics 87, 103\u2013121 (2013)","journal-title":"J. Proteomics"},{"issue":"16","key":"9339_CR30","doi-asserted-by":"crossref","first-page":"3395","DOI":"10.1021\/bi00609a033","volume":"17","author":"JB Bjarnason","year":"1978","unstructured":"Bjarnason, J.B., Tu, A.T.: Hemorrhagic toxins from Western diamondback rattlesnake (Crotalus atrox) venom: isolation and characterization of five toxins and the role of zinc in hemorrhagic toxin e. Biochemistry 17(16), 3395\u20133404 (1978)","journal-title":"Biochemistry"},{"issue":"5","key":"9339_CR31","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1016\/j.toxicon.2011.01.008","volume":"57","author":"DR Rokyta","year":"2011","unstructured":"Rokyta, D.R., Wray, K.P., Lemmon, A.R., Lemmon, E.M., Caudle, S.B.: A high-throughput venom-gland transcriptome for the Eastern Diamondback Rattlesnake (Crotalus adamanteus) and evidence for pervasive positive selection across toxin classes. Toxicon 57(5), 657\u2013671 (2011)","journal-title":"Toxicon"},{"key":"9339_CR32","doi-asserted-by":"crossref","unstructured":"Dagda, R.K., Gasanov, S., De La OIII, Y., Rael, E.D., Lieb, C.: Genetic basis for variation of metalloproteinase-associated biochemical activity in venom of the Mojave rattlesnake (Crotalus scutulatus scutulatus). Int. Res. Biochem. 2013, 251474 (2013). doi: 10.1155\/2013\/251474","DOI":"10.1155\/2013\/251474"},{"issue":"9","key":"9339_CR33","doi-asserted-by":"crossref","first-page":"2576","DOI":"10.1016\/j.jprot.2012.02.035","volume":"75","author":"DJ Massey","year":"2012","unstructured":"Massey, D.J., Calvete, J.J., Sanchez, E.E., Sanz, L., Richards, K., Curtis, R., Boesen, K.: Venom variability and envenoming severity outcomes of the Crotalus scutulatus scutulatus (Mojave rattlesnake) from southern Arizona. J. Proteomics 75(9), 2576\u20132587 (2012)","journal-title":"J. Proteomics"},{"issue":"4","key":"9339_CR34","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1006\/jmbi.1994.1392","volume":"239","author":"FX Gomis-Ruth","year":"1994","unstructured":"Gomis-Ruth, F.X., Kress, L.F., Kellermann, J., Mayr, I., Lee, X., Huber, R., Bode, W.: Refined 2.0 An X-ray crystal structure of the snake venom zinc-endopeptidase adamalysin II. Primary and tertiary structure determination, refinement, molecular structure and comparison with astacin, collagenase and thermolysin. J. Mol. Biol. 239(4), 513\u2013544 (1994)","journal-title":"J. Mol. Biol."},{"issue":"18","key":"9339_CR35","doi-asserted-by":"crossref","first-page":"8447","DOI":"10.1073\/pnas.91.18.8447","volume":"91","author":"D Zhang","year":"1994","unstructured":"Zhang, D., Botos, I., Gomis-Ruth, F.X., Doll, R., Blood, C., Njoroge, F.G., Fox, J.W., Bode, W., Meyer, E.F.: Structural interaction of natural and synthetic inhibitors with the venom metalloproteinase, atrolysin C (form d). Proc. Natl. Acad. Sci. USA 91(18), 8447\u20138451 (1994)","journal-title":"Proc. Natl. Acad. Sci. USA"},{"issue":"1","key":"9339_CR36","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1042\/bst0240274","volume":"24","author":"MC Peitsch","year":"1996","unstructured":"Peitsch, M.C.: ProMod and Swiss-Model: Internet-based tools for automated comparative protein modelling. Biochem. Soc. Trans. 24(1), 274\u2013279 (1996)","journal-title":"Biochem. Soc. Trans."},{"issue":"2","key":"9339_CR37","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/S0968-0004(00)88963-X","volume":"20","author":"MC Peitsch","year":"1995","unstructured":"Peitsch, M.C., Wells, T.N., Stampf, D.R., Sussman, J.L.: The Swiss-3DImage collection and PDB-Browser on the World-Wide Web. Trends Biochem. Sci. 20(2), 82\u201384 (1995)","journal-title":"Trends Biochem. Sci."},{"issue":"8","key":"9339_CR38","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1016\/0968-0004(93)90038-O","volume":"18","author":"MC Peitsch","year":"1993","unstructured":"Peitsch, M.C., Borner, C., Tschopp, J.: Sequence similarity of phospholipase A2 activating protein and the G protein beta-subunits: a new concept of effector protein activation in signal transduction?Trends Biochem. Sci. 18(8), 292\u2013293 (1993)","journal-title":"Trends Biochem. Sci."},{"issue":"9","key":"9339_CR39","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1016\/S0968-0004(99)01427-9","volume":"24","author":"N Guex","year":"1999","unstructured":"Guex, N., Diemand, A., Peitsch, M.C.: Protein modelling for all. Trends Biochem. Sci. 24(9), 364\u2013367 (1999)","journal-title":"Trends Biochem. Sci."},{"issue":"6","key":"9339_CR40","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1002\/jcc.10061","volume":"23","author":"OV Tsodikov","year":"2002","unstructured":"Tsodikov, O.V., Record, M.T., Jr., Sergeev, Y.V.: Novel computer program for fast exact calculation of accessible and molecular surface areas and average surface curvature. J. Comput. Chem. 23(6), 600\u2013609 (2002)","journal-title":"J. Comput. Chem."},{"issue":"5","key":"9339_CR41","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1002\/pro.5560040502","volume":"4","author":"W Stocker","year":"1995","unstructured":"Stocker, W., Grams, F., Baumann, U., Reinemer, P., Gomis-Ruth, F.X., McKay, D.B., Bode, W.: The metzincins\u2013topological and sequential relations between the astacins, adamalysins, serralysins, and matrixins (collagenases) define a superfamily of zinc-peptidases. Protein Sci. 4(5), 823\u2013840 (1995)","journal-title":"Protein Sci."},{"issue":"2","key":"9339_CR42","first-page":"169","volume":"130","author":"BJ Wooldridge","year":"2001","unstructured":"Wooldridge, B.J., Pineda, G., Banuelas-Ornelas, J.J., Dagda, R.K., Gasanov, S.E., Rael, E.D., Lieb, C.S.: Mojave rattlesnakes (Crotalus scutulatus scutulatus) lacking the acidic subunit DNA sequence lack Mojave toxin in their venom. Mol. Biol. 130(2), 169\u2013179 (2001)","journal-title":"Mol. Biol."},{"issue":"7","key":"9339_CR43","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1016\/j.toxicon.2004.08.008","volume":"44","author":"WJ French","year":"2004","unstructured":"French, W.J., Hayes, W.K., Bush, S.P., Cardwell, M.D., Bader, J.O., Rael, E.D.: Mojave toxin in venom of Crotalus helleri (Southern Pacific Rattlesnake): molecular and geographic characterization. Toxicon 44(7), 781\u2013791 (2004)","journal-title":"Toxicon"},{"issue":"Pt 11","key":"9339_CR44","first-page":"1834","volume":"55","author":"X Zhu","year":"1999","unstructured":"Zhu, X., Teng, M., Niu, L.: Structure of acutolysin-C, a haemorrhagic toxin from the venom of Agkistrodon acutus, providing further evidence for the mechanism of the pH-dependent proteolytic reaction of zinc metalloproteinases. Acta Crystallogr. 55(Pt 11), 1834\u20131841 (1999)","journal-title":"Acta Crystallogr."},{"issue":"3","key":"9339_CR45","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1006\/jmbi.1998.2110","volume":"283","author":"W Gong","year":"1998","unstructured":"Gong, W., Zhu, X., Liu, S., Teng, M., Niu, L.: Crystal structures of acutolysin A, a three-disulfide hemorrhagic zinc metalloproteinase from the snake venom of Agkistrodon acutus. J. Mol. Biol. 283(3), 657\u2013668 (1998)","journal-title":"J. Mol. Biol."},{"issue":"2","key":"9339_CR46","doi-asserted-by":"crossref","first-page":"E16","DOI":"10.1208\/ps030216","volume":"3","author":"MB Bolger","year":"2001","unstructured":"Bolger, M.B., Swenson, S., Markland, F.S., Jr.: Three-dimensional structure of fibrolase, the fibrinolytic enzyme from southern copperhead venom, modeled from the X-ray structure of adamalysin II and atrolysin C. AAPS Pharm. Sci. 3(2), E16 (2001)","journal-title":"AAPS Pharm. Sci."},{"issue":"11","key":"9339_CR47","doi-asserted-by":"crossref","first-page":"4151","DOI":"10.1002\/j.1460-2075.1993.tb06099.x","volume":"12","author":"FX Gomis-Ruth","year":"1993","unstructured":"Gomis-Ruth, F.X., Kress, L.F., Bode, W.: First structure of a snake venom metalloproteinase: A prototype for matrix metalloproteinases\/collagenases. EMBO J. 12(11), 4151\u20134157 (1993)","journal-title":"EMBO J."},{"issue":"4","key":"9339_CR48","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1111\/j.1742-7843.2011.00725.x","volume":"109","author":"K Sunitha","year":"2011","unstructured":"Sunitha, K., Hemshekhar, M., Gaonkar, S.L., Sebastin Santhosh, M., Suresh Kumar, M., Basappa Priya, B.S., Kemparaju, K., Rangappa, K.S., Nanjunda Swamy, S., Girish, K.S.: Neutralization of haemorrhagic activity of viper venoms by 1-(3-dimethylaminopropyl)-1-(4-fluorophenyl)-3-oxo-1,3-dihydroisobenzofuran-5-car bonitrile. Basic Clin. Pharmacol. Toxicol. 109(4), 292\u2013299 (2011)","journal-title":"Basic Clin. Pharmacol. Toxicol."},{"issue":"2","key":"9339_CR49","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1007\/s00239-008-9186-1","volume":"68","author":"HL Gibbs","year":"2009","unstructured":"Gibbs, H.L., Sanz, L., Calvete, J.J.: Snake population venomics: proteomics-based analyses of individual variation reveals significant gene regulation effects on venom protein expression in Sistrurus rattlesnakes. J. Mol. Evol. 68(2), 113\u2013125 (2009)","journal-title":"J. Mol. Evol."},{"issue":"3","key":"9339_CR50","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/j.toxicon.2009.04.008","volume":"54","author":"Y Jia","year":"2009","unstructured":"Jia, Y., Lucena, S., Cantu, E.Jr., Sanchez, E.E.: Perez, J.C.: cDNA cloning, expression and fibrin(ogen)olytic activity of two low-molecular weight snake venom metalloproteinases. Toxicon 54(3), 233\u2013243 (2009)","journal-title":"Toxicon"},{"issue":"1","key":"9339_CR51","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/0003-9861(89)90350-0","volume":"275","author":"EN Baramova","year":"1989","unstructured":"Baramova, E.N., Shannon, J.D., Bjarnason, J.B., Fox, J.W.: Degradation of extracellular matrix proteins by hemorrhagic metalloproteinases. Arch. Biochem. Biophys. 275(1), 63\u201371 (1989)","journal-title":"Arch. Biochem. Biophys."},{"issue":"30","key":"9339_CR52","doi-asserted-by":"crossref","first-page":"10330","DOI":"10.1021\/ja909908y","volume":"132","author":"HG Wallnoefer","year":"2010","unstructured":"Wallnoefer, H.G., Lingott, T., Gutierrez, J.M., Merfort, I., Liedl, K.R.: Backbone flexibility controls the activity and specificity of a protein\u2013protein interface: specificity in snake venom metalloproteases. J. Am. Chem. Soc. 132(30), 10330\u201310337 (2010)","journal-title":"J. Am. Chem. Soc."},{"issue":"10","key":"9339_CR53","doi-asserted-by":"crossref","first-page":"2273","DOI":"10.1110\/ps.03102403","volume":"12","author":"L Watanabe","year":"2003","unstructured":"Watanabe, L., Shannon, J.D., Valente, R.H., Rucavado, A., Alape-Giron, A., Kamiguti, A.S., Theakston, R.D., Fox, J.W., Gutierrez, J.M., Arni, R.K.: Amino acid sequence and crystal structure of BaP1, a metalloproteinase from Bothrops asper snake venom that exerts multiple tissue-damaging activities. Protein Sci. 12(10), 2273\u20132281 (2003)","journal-title":"Protein Sci."},{"key":"9339_CR54","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1186\/1471-2164-14-234","volume":"14","author":"J Durban","year":"2013","unstructured":"Durban, J., Perez, A., Sanz, L., Gomez, A., Bonilla, F., Rodriguez, S., Chacon, D., Sasa, M., Angulo, Y., Gutierrez, J.M., Calvete, J.J.: Integrated omics profiling indicates that miRNAs are modulators of the ontogenetic venom composition shift in the Central American rattlesnake, Crolatus simus simus. BMC Genomics 14, 234 (2013)","journal-title":"BMC Genomics"},{"issue":"27","key":"9339_CR55","doi-asserted-by":"crossref","first-page":"6203","DOI":"10.1021\/bi00142a005","volume":"31","author":"LA Hite","year":"1992","unstructured":"Hite, L.A., Shannon, J.D., Bjarnason, J.B., Fox, J.W.: Sequence of a cDNA clone encoding the zinc metalloproteinase hemorrhagic toxin e from Crotalus atrox: evidence for signal, zymogen, and disintegrin-like structures. Biochemistry 31(27), 6203\u20136211 (1992)","journal-title":"Biochemistry"},{"issue":"7","key":"9339_CR56","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1515\/bchm3.1992.373.2.381","volume":"373","author":"LA Hite","year":"1992","unstructured":"Hite, L.A., Fox, J.W., Bjarnason, J.B.: A new family of proteinases is defined by several snake venom metalloproteinases. Biol. Chem. Hoppe Seyler 373(7), 381\u2013385 (1992)","journal-title":"Biol. Chem. Hoppe Seyler"},{"issue":"3","key":"9339_CR57","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1016\/0163-7258(94)90049-3","volume":"62","author":"JB Bjarnason","year":"1994","unstructured":"Bjarnason, J.B., Fox, J.W.: Hemorrhagic metalloproteinases from snake venoms. Pharmacol. Ther. 62(3), 325\u2013372 (1994)","journal-title":"Pharmacol. Ther."},{"issue":"6","key":"9339_CR58","first-page":"1041","volume":"31","author":"KF Huang","year":"1993","unstructured":"Huang, K.F., Hung, C.C., Chiou, S.H.: Characterization of three fibrinogenolytic proteases isolated from the venom of Taiwan habu (Trimeresurus mucrosquamatus). Biochem. Mol. Biol. Int. 31(6), 1041\u20131050 (1993)","journal-title":"Biochem. Mol. Biol. Int."},{"issue":"5","key":"9339_CR59","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1016\/j.toxicon.2004.07.005","volume":"44","author":"OH Ramos","year":"2004","unstructured":"Ramos, O.H., Selistre-de-Araujo, H.S.: Comparative analysis of the catalytic domain of hemorrhagic and non-hemorrhagic snake venom metallopeptidases using bioinformatic tools. Toxicon 44(5), 529\u2013538 (2004)","journal-title":"Toxicon"}],"updated-by":[{"DOI":"10.1007\/s10867-014-9347-y","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[2014,4,1]],"date-time":"2014-04-01T00:00:00Z","timestamp":1396310400000}}],"container-title":["Journal of Biological Physics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10867-013-9339-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s10867-013-9339-3\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10867-013-9339-3","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,8,7]],"date-time":"2019-08-07T15:03:06Z","timestamp":1565190186000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s10867-013-9339-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,2,13]]},"references-count":59,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2014,3]]}},"alternative-id":["9339"],"URL":"https:\/\/doi.org\/10.1007\/s10867-013-9339-3","relation":{"correction":[{"id-type":"doi","id":"10.1007\/s10867-014-9347-y","asserted-by":"object"}]},"ISSN":["0092-0606","1573-0689"],"issn-type":[{"value":"0092-0606","type":"print"},{"value":"1573-0689","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,2,13]]}}}