{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T05:46:06Z","timestamp":1777355166424,"version":"3.51.4"},"reference-count":34,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2010,12,1]],"date-time":"2010-12-01T00:00:00Z","timestamp":1291161600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2010,12,1]],"date-time":"2010-12-01T00:00:00Z","timestamp":1291161600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Clin Immunol"],"published-print":{"date-parts":[[2011,4]]},"DOI":"10.1007\/s10875-010-9479-1","type":"journal-article","created":{"date-parts":[[2010,11,30]],"date-time":"2010-11-30T09:20:51Z","timestamp":1291108851000},"page":"272-280","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Clinical Aspects and Genetic Analysis of Taiwanese Patients with the Phenotype of Hyper-Immunoglobulin E Recurrent Infection Syndromes (HIES)"],"prefix":"10.1007","volume":"31","author":[{"given":"Wen-I","family":"Lee","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jing-Long","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shy-Jae","family":"Lin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kuo-Wei","family":"Yeh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li-Chen","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meng-Ying","family":"Hsieh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yhu-Chering","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ho-Chang","family":"Kuo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kunder D.","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hong-Ren","family":"Yu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tang-Her","family":"Jaing","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chih-Hsun","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2010,12,1]]},"reference":[{"key":"9479_CR1","doi-asserted-by":"publisher","first-page":"692","DOI":"10.1056\/NEJM199903043400904","volume":"340","author":"B Grimbacher","year":"1999","unstructured":"Grimbacher B, Holland SM, Gallin JI, Greenberg F, Hill SC, Malech HL, et al. Hyper-IgE syndrome with recurrent infections\u2014an autosomal dominant multisystem disorder. N Engl J Med. 1999;340:692\u2013702.","journal-title":"N Engl J Med."},{"key":"9479_CR2","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1016\/S0022-3476(03)00449-9","volume":"144","author":"ED Renner","year":"2004","unstructured":"Renner ED, Puck JM, Holland SM, Schmitt M, Weiss M, Frosch M, et al. Autosomal recessive hyperimmunoglobulin E syndrome: a distinct disease entity. J Pediatr. 2004;144:93\u20139.","journal-title":"J Pediatr."},{"key":"9479_CR3","doi-asserted-by":"publisher","first-page":"745","DOI":"10.1016\/j.immuni.2006.09.009","volume":"25","author":"Y Minegishi","year":"2006","unstructured":"Minegishi Y, Saito M, Morio T, Watanabe K, Agematsu K, Tsuchiya S, et al. Human tyrosine kinase 2 deficiency reveals its requisite roles in multiple cytokine signals involved in innate and acquired immunity. Immunity. 2006;25:745\u201355.","journal-title":"Immunity"},{"key":"9479_CR4","doi-asserted-by":"publisher","first-page":"1013","DOI":"10.1016\/S0140-6736(66)90119-X","volume":"1","author":"SD Davis","year":"1966","unstructured":"Davis SD, Schaller J, Wedgwood RJ. Job\u2019s syndrome. Recurrent, \u201ccold\u201d, staphylococcal abscesses. Lancet. 1966;1:1013\u20135.","journal-title":"Lancet"},{"key":"9479_CR5","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1542\/peds.49.1.59","volume":"49","author":"RH Buckley","year":"1972","unstructured":"Buckley RH, Wray BB, Belmaker EZ. Extreme hyperimmunoglobulinemia E and undue susceptibility to infection. Pediatrics. 1972;49:59\u201370.","journal-title":"Pediatrics"},{"key":"9479_CR6","doi-asserted-by":"publisher","first-page":"1667","DOI":"10.1056\/NEJMc076367","volume":"357","author":"ED Renner","year":"2007","unstructured":"Renner ED, Torgerson TR, Rylaarsdam S, A\u00f1over-Sombke S, Golob K, LaFlam T, et al. STAT3 mutation in the original patient with Job\u2019s syndrome. N Engl J Med. 2007;357:1667\u20138.","journal-title":"N Engl J Med."},{"key":"9479_CR7","doi-asserted-by":"publisher","first-page":"1058","DOI":"10.1038\/nature06096","volume":"448","author":"Y Minegishi","year":"2007","unstructured":"Minegishi Y, Saito M, Tsuchiya S, Tsuge I, Takada H, Hara T, et al. Dominant-negative mutations in the DNA-binding domain of STAT3 cause hyper-IgE syndrome. Nature. 2007;448:1058\u201362.","journal-title":"Nature"},{"key":"9479_CR8","doi-asserted-by":"publisher","first-page":"1608","DOI":"10.1056\/NEJMoa073687","volume":"357","author":"SM Holland","year":"2007","unstructured":"Holland SM, DeLeo FR, Elloumi HZ, Hsu AP, Uzel G, Brodsky N, et al. STAT3 mutations in the hyper-IgE syndrome. N Engl J Med. 2007;357:1608\u2013919.","journal-title":"N Engl J Med."},{"key":"9479_CR9","doi-asserted-by":"publisher","first-page":"487","DOI":"10.1016\/j.coi.2009.07.013","volume":"21","author":"Y Minegishi","year":"2009","unstructured":"Minegishi Y. Hyper-IgE syndrome. Curr Opin Immunol. 2009;21:487\u201392.","journal-title":"Curr Opin Immunol"},{"key":"9479_CR10","doi-asserted-by":"publisher","first-page":"2046","DOI":"10.1056\/NEJMoa0905506","volume":"361","author":"Q Zhang","year":"2009","unstructured":"Zhang Q, Davis JC, Lamborn IT, Freeman AF, Jing H, Favreau AJ, et al. Combined immunodeficiency associated with DOCK8 mutations. N Engl J Med. 2009;361:2046\u201355.","journal-title":"N Engl J Med."},{"key":"9479_CR11","doi-asserted-by":"publisher","first-page":"1289","DOI":"10.1016\/j.jaci.2009.10.038","volume":"124","author":"KR Engelhardt","year":"2009","unstructured":"Engelhardt KR, McGhee S, Winkler S, Sassi A, Woellner C, Lopez-Herrera G, et al. Large deletions and point mutations involving the dedicator of cytokinesis 8 (DOCK8) in the autosomal-recessive form of hyper-IgE syndrome. J Allergy Clin Immunol. 2009;124:1289\u2013302.","journal-title":"J Allergy Clin Immunol."},{"key":"9479_CR12","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1093\/intimm\/dxn134","volume":"21","author":"Y Minegishi","year":"2009","unstructured":"Minegishi Y, Karasuyama H. Defects in Jak-STAT-mediated cytokine signals cause hyper-IgE syndrome: lessons from a primary immunodeficiency. Int Immunol. 2009;21:105\u201312.","journal-title":"Int Immunol."},{"key":"9479_CR13","doi-asserted-by":"publisher","first-page":"735","DOI":"10.1086\/302547","volume":"65","author":"B Grimbacher","year":"1999","unstructured":"Grimbacher B, Sch\u00e4ffer AA, Holland SM, Davis J, Gallin JI, Malech HL, et al. Genetic linkage of hyper-IgE syndrome to chromosome 4. Am J Hum Genet. 1999;65:735\u201344.","journal-title":"Am J Hum Genet."},{"key":"9479_CR14","doi-asserted-by":"publisher","first-page":"244","DOI":"10.1111\/j.0105-2896.2005.00228.x","volume":"203","author":"B Grimbacher","year":"2005","unstructured":"Grimbacher B, Holland SM, Puck JM. Hyper-IgE syndromes. Immunol Rev. 2005;203:244\u201350.","journal-title":"Immunol Rev."},{"key":"9479_CR15","doi-asserted-by":"publisher","first-page":"424","DOI":"10.1016\/j.jaci.2009.10.059","volume":"125","author":"C Woellner","year":"2010","unstructured":"Woellner C, Gertz EM, Sch\u00e4ffer AA, Lagos M, Perro M, Glocker EO, et al. Mutations in STAT3 and diagnostic guidelines for hyper-IgE syndrome. J Allergy Clin Immunol. 2010;125:424\u201332. e8.","journal-title":"J Allergy Clin Immunol."},{"key":"9479_CR16","doi-asserted-by":"publisher","first-page":"162","DOI":"10.1007\/s10875-005-2822-2","volume":"25","author":"WI Lee","year":"2005","unstructured":"Lee WI, Kuo ML, Huang JL, Lin SJ, Wu CJ. Distribution and clinical aspects of primary immunodeficiencies in a Taiwan pediatric tertiary hospital during a 20-year period. J Clin Immunol. 2005;25:162\u201373.","journal-title":"J Clin Immunol."},{"key":"9479_CR17","doi-asserted-by":"publisher","first-page":"958","DOI":"10.1016\/S0091-6749(03)02021-9","volume":"112","author":"WI Lee","year":"2003","unstructured":"Lee WI, Zhu Q, Gambineri E, Jin Y, Welcher AA, Ochs HD. Inducible CO-stimulator molecule, a candidate gene for defective isotype switching, is normal in patients with hyper-IgM syndrome of unknown molecular diagnosis. J Allergy Clin Immunol. 2003;112:958\u201364.","journal-title":"J Allergy Clin Immunol."},{"key":"9479_CR18","doi-asserted-by":"publisher","first-page":"1881","DOI":"10.1182\/blood-2003-12-4420","volume":"105","author":"WI Lee","year":"2005","unstructured":"Lee WI, Torgerson TR, Schumacher MJ, Yel L, Zhu Q, Ochs HD. Molecular analysis of a large cohort of patients with the hyper immunoglobulin M (IgM) syndrome. Blood. 2005;105:1881\u201390.","journal-title":"Blood"},{"key":"9479_CR19","doi-asserted-by":"publisher","first-page":"274","DOI":"10.1007\/s10875-006-9013-7","volume":"26","author":"WI Lee","year":"2006","unstructured":"Lee WI, Jaing TH, Hsieh MY, Kuo ML, Lin SJ, Huang JL. Distribution, infections, treatments and molecular analysis in a large cohort of patients with primary immunodeficiency diseases (PIDs) in Taiwan. J Clin Immunol. 2006;26:274\u201383.","journal-title":"J Clin Immunol."},{"key":"9479_CR20","first-page":"3","volume":"49","author":"FC Liang","year":"2008","unstructured":"Liang FC, Wei YC, Jiang TH, Hsiehi MY, Wen YC, Chiou YS, et al. Current classification and status of primary immunodeficiency diseases in Taiwan. Acta Paediatr Taiwan. 2008;49:3\u20138.","journal-title":"Acta Paediatr Taiwan."},{"key":"9479_CR21","first-page":"89","volume":"58","author":"PH Schur","year":"1987","unstructured":"Schur PH. IgG subclasses\u2014a review. Ann Allergy. 1987;58:89\u201396.","journal-title":"Ann Allergy."},{"key":"9479_CR22","doi-asserted-by":"publisher","first-page":"310","DOI":"10.1111\/j.1525-1470.1996.tb01247.x","volume":"13","author":"M Dohil","year":"1996","unstructured":"Dohil M, Prendiville JS. Treatment of molluscum contagiosum with oral cimetidine: clinical experience in 13 patients. Pediatr Dermatol. 1996;13:310\u20132.","journal-title":"Pediatr Dermatol."},{"key":"9479_CR23","doi-asserted-by":"publisher","first-page":"e1253","DOI":"10.1542\/peds.2005-2706","volume":"117","author":"SS Kilic","year":"2006","unstructured":"Kilic SS, Kilicbay F. Interferon-alpha treatment of molluscum contagiosum in a patient with hyperimmunoglobulin E syndrome. Pediatrics. 2006;117:e1253\u20131255.","journal-title":"Pediatrics"},{"key":"9479_CR24","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1016\/S0140-6736(96)91603-7","volume":"347","author":"B Wolach","year":"1996","unstructured":"Wolach B, Eliakim A, Pomeranz A, Cohen AH, Nusbacher J, Metzker A. Cyclosporin treatment of hyperimmunoglobulin E syndrome. Lancet. 1996;347:67.","journal-title":"Lancet"},{"key":"9479_CR25","doi-asserted-by":"publisher","first-page":"413","DOI":"10.1016\/S1081-1206(10)63204-8","volume":"78","author":"A Etzioni","year":"1997","unstructured":"Etzioni A, Shehadeh N, Brecher A, Yorman S, Pollack S. Cyclosporin A in hyperimmunoglobulin E syndrome. Ann Allergy Asthma Immunol. 1997;78:413\u20134.","journal-title":"Ann Allergy Asthma Immunol."},{"key":"9479_CR26","doi-asserted-by":"publisher","first-page":"389","DOI":"10.1016\/S1081-1206(10)60887-3","volume":"98","author":"TY Young","year":"2007","unstructured":"Young TY, Jerome D, Gupta S. Hyperimmunoglobulinemia E syndrome associated with coronary artery aneurysms: deficiency of central memory CD4+ T cells and expansion of effector memory CD4+ T cells. Ann Allergy Asthma Immunol. 2007;98:389\u201392.","journal-title":"Ann Allergy Asthma Immunol."},{"key":"9479_CR27","doi-asserted-by":"publisher","first-page":"1234","DOI":"10.1016\/j.jaci.2006.12.666","volume":"119","author":"AF Freeman","year":"2007","unstructured":"Freeman AF, Kleiner DE, Nadiminti H, Davis J, Quezado M, Anderson V, et al. Causes of death in hyper-IgE syndrome. J Allergy Clin Immunol. 2007;119:1234\u201340.","journal-title":"J Allergy Clin Immunol."},{"key":"9479_CR28","doi-asserted-by":"publisher","first-page":"162","DOI":"10.1016\/S0002-9343(98)00200-9","volume":"105","author":"TA Nester","year":"1998","unstructured":"Nester TA, Wagnon AH, Reilly WF, Spitzer G, Kjeldsberg CR, Hill HR. Effects of allogeneic peripheral stem cell transplantation in a patient with job syndrome of hyperimmunoglobulinemia E and recurrent infections. Am J Med. 1998;105:162\u20134.","journal-title":"Am J Med"},{"key":"9479_CR29","doi-asserted-by":"publisher","first-page":"1303","DOI":"10.1038\/sj.bmt.1702446","volume":"25","author":"AR Gennery","year":"2000","unstructured":"Gennery AR, Flood TJ, Abinun M, Cant AJ. Bone marrow transplantation does not correct the hyper IgE syndrome. Bone Marrow Transplant. 2000;25:1303\u20135.","journal-title":"Bone Marrow Transplant."},{"key":"9479_CR30","doi-asserted-by":"publisher","first-page":"392","DOI":"10.1016\/j.jaci.2010.05.005","volume":"126","author":"E Goussetis","year":"2010","unstructured":"Goussetis E, Peristeri I, Kitra V, Traeger-Synodinos J, Theodosaki M, Psarra K, et al. Successful long-term immunologic reconstitution by allogeneic hematopoietic stem cell transplantation cures patients with autosomal dominant hyper-IgE syndrome. J Allergy Clin Immunol. 2010;126:392\u20134.","journal-title":"J Allergy Clin Immunol."},{"key":"9479_CR31","doi-asserted-by":"crossref","unstructured":"Gatz SA, Benninghoff U, Sch\u00fctz C, Schulz A, H\u00f6nig M, Pannicke U, Holzmann KH, Schwarz K, Friedrich W. Curative treatment of autosomal-recessive hyper-IgE syndrome by hematopoietic cell transplantation. Bone Marrow Transplant (2010) (in press)","DOI":"10.1038\/bmt.2010.169"},{"key":"9479_CR32","doi-asserted-by":"publisher","first-page":"289873","DOI":"10.1155\/2010\/289873","volume":"2010","author":"L Xie","year":"2010","unstructured":"Xie L, Hu X, Li Y, Zhang W, Chen L. Hyper-IgE syndrome with STAT3 mutation: a case report in Mainland China. Clin Dev Immunol. 2010;2010:289873.","journal-title":"Clin Dev Immunol."},{"key":"9479_CR33","first-page":"286","volume-title":"Anthropometry of the head and face in medicine","author":"LG Farkas","year":"1994","unstructured":"Farkas LG. Anthropometry of the head and face in medicine. 2nd ed. New York: Raven Press; 1994. p. 286.","edition":"2"},{"key":"9479_CR34","doi-asserted-by":"publisher","first-page":"181","DOI":"10.1016\/j.jaci.2008.04.037","volume":"122","author":"ED Renner","year":"2008","unstructured":"Renner ED, Rylaarsdam S, Anover-Sombke S, Rack AL, Reichenbach J, Carey JC, et al. Novel signal transducer and activator of transcription 3 (STAT3) mutations, reduced T(H)17 cell numbers, and variably defective STAT3 phosphorylation in hyper-IgE syndrome. J Allergy Clin Immunol. 2008;122:181\u20137.","journal-title":"J Allergy Clin Immunol."}],"container-title":["Journal of Clinical Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10875-010-9479-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10875-010-9479-1\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10875-010-9479-1","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10875-010-9479-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,7,29]],"date-time":"2022-07-29T00:50:31Z","timestamp":1659055831000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10875-010-9479-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,12,1]]},"references-count":34,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2011,4]]}},"alternative-id":["9479"],"URL":"https:\/\/doi.org\/10.1007\/s10875-010-9479-1","relation":{},"ISSN":["0271-9142","1573-2592"],"issn-type":[{"value":"0271-9142","type":"print"},{"value":"1573-2592","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,12,1]]},"assertion":[{"value":"30 August 2010","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 October 2010","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 December 2010","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}]}}