{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,26]],"date-time":"2026-03-26T18:58:52Z","timestamp":1774551532139,"version":"3.50.1"},"reference-count":32,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2012,2,12]],"date-time":"2012-02-12T00:00:00Z","timestamp":1329004800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Clin Immunol"],"published-print":{"date-parts":[[2012,6]]},"DOI":"10.1007\/s10875-012-9655-6","type":"journal-article","created":{"date-parts":[[2012,2,11]],"date-time":"2012-02-11T14:06:54Z","timestamp":1328969214000},"page":"441-448","source":"Crossref","is-referenced-by-count":42,"title":["B-lymphocyte Subpopulations in Patients with Selective IgA Deficiency"],"prefix":"10.1007","volume":"32","author":[{"given":"Jana","family":"Nechvatalova","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zdenka","family":"Pikulova","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dagmar","family":"Stikarovska","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sava","family":"Pesak","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcela","family":"Vlkova","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiri","family":"Litzman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2012,2,12]]},"reference":[{"key":"9655_CR1","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1006\/clim.1999.4725","volume":"92","author":"C Cunningham-Rundles","year":"1999","unstructured":"Cunningham-Rundles C, Bodian C. Common variable immunodeficiency: clinical and immunological features of 248 patients. Clin Immunol. 1999;92:34\u201348.","journal-title":"Clin Immunol."},{"key":"9655_CR2","first-page":"103","volume":"3","author":"AD Webster","year":"2004","unstructured":"Webster AD. Clinical and immunological spectrum of common variable immunodeficiency (CVID). Iran J Allergy Asthma Immunol. 2004;3:103\u201313.","journal-title":"Iran J Allergy Asthma Immunol."},{"key":"9655_CR3","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1111\/j.1365-2141.2009.07669.x","volume":"145","author":"H Chapel","year":"2009","unstructured":"Chapel H, Cunningham-Rundles C. Update in understanding common variable immunodeficiency disorders (CVIDs) and the management of patients with these conditions. Br J Haematol. 2009;145:709\u201327.","journal-title":"Br J Haematol."},{"key":"9655_CR4","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1006\/clin.1995.1142","volume":"77","author":"I Vorechovsky","year":"1995","unstructured":"Vorechovsky I, Zetterquist H, Paganelli R, Koskinen S, Webster AD, Bj\u00f6rkander J, et al. Family and linkage study of selective IgA deficiency and common variable immunodeficiency. Clin Immunol Immunopathol. 1995;77:185\u201392.","journal-title":"Clin Immunol Immunopathol."},{"key":"9655_CR5","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1159\/000024438","volume":"123","author":"J Litzman","year":"2000","unstructured":"Litzman J, Sevc\u00edkov\u00e1 I, Stikarovska D, Pikulova Z, Pazdirkova A, Lokaj J. IgA deficiency in Czech healthy individuals and selected patient groups. Int Arch Allergy Immunol. 2000;123:177\u201380.","journal-title":"Int Arch Allergy Immunol."},{"key":"9655_CR6","doi-asserted-by":"crossref","first-page":"2046","DOI":"10.1182\/blood.V76.10.2046.2046","volume":"76","author":"JJ Wright","year":"1990","unstructured":"Wright JJ, Wagner DK, Blaese RM, Hagengruber C, Waldmann TA, Fleisher TA. Characterization of common variable immunodeficiency: identification of a subset of patients with distinctive immunophenotypic and clinical features. Blood. 1990;76:2046\u201351.","journal-title":"Blood."},{"key":"9655_CR7","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1111\/j.1365-2249.2005.02793.x","volume":"140","author":"BL Ferry","year":"2005","unstructured":"Ferry BL, Jones J, Bateman EA, Woodham N, Warnatz K, Schlesier M, et al. Measurement of peripheral B cell subpopulations in common variable immunodeficiency (CVID) using a whole blood method. Clin Exp Immunol. 2005;140:532\u20139.","journal-title":"Clin Exp Immunol."},{"key":"9655_CR8","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1111\/j.1365-2249.2006.02999.x","volume":"143","author":"M Vlkova","year":"2006","unstructured":"Vlkova M, Thon V, Sarfyova M, Blaha L, Svobodnik A, Lokaj J, et al. Age dependency and mutual relations in T and B lymphocyte abnormalities in common variable immunodeficiency patients. Clin Exp Immunol. 2006;143:373\u20139.","journal-title":"Clin Exp Immunol"},{"key":"9655_CR9","doi-asserted-by":"crossref","first-page":"1544","DOI":"10.1182\/blood.V99.5.1544","volume":"99","author":"K Warnatz","year":"2002","unstructured":"Warnatz K, Denz A, Dr\u00e4ger R, Braun M, Groth C, Wolff-Vorbeck G, et al. Severe deficiency of switched memory B cells (CD27(+)IgM(-)IgD(-)) in subgroups of patients with common variable immunodeficiency: a new approach to classify a heterogeneous disease. Blood. 2002;99:1544\u201351.","journal-title":"Blood."},{"key":"9655_CR10","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1111\/j.1365-2249.2006.03274.x","volume":"147","author":"J Litzman","year":"2007","unstructured":"Litzman J, Vlkova M, Pikulova Z, Stikarovska D, Lokaj J. T and B lymphocyte subpopulations and activation\/differentiation markers in patients with selective IgA deficiency. Clin Exp Immunol. 2007;147:249\u201354.","journal-title":"Clin Exp Immunol."},{"key":"9655_CR11","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1159\/000323903","volume":"156","author":"A Aghamohammadi","year":"2011","unstructured":"Aghamohammadi A, Abolhassani H, Biglari M, Abolmaali S, Moazzami K, Tabatabaeiyan M, et al. Analysis of switched memory B cells in patients with IgA deficiency. Int Arch Allergy Immunol. 2011;156:462\u20138.","journal-title":"Int Arch Allergy Immunol."},{"key":"9655_CR12","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1006\/clim.1999.4799","volume":"93","author":"ME Conley","year":"1999","unstructured":"Conley ME, Notarangelo LD, Etzioni A. Diagnostic criteria for primary immunodeficiencies. Representing PAGID (Pan-American Group for Immunodeficiency) and ESID (European Society for Immunodeficiencies). Clin Immunol. 1999;93:190\u20137.","journal-title":"Clin Immunol."},{"key":"9655_CR13","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1002\/cyto.b.20432","volume":"74","author":"K Warnatz","year":"2008","unstructured":"Warnatz K, Schlesier M. Flowcytometric phenotyping of common variable immunodeficiency. Cytometry B Clin Cytom. 2008;74:261\u201371.","journal-title":"Cytometry B Clin Cytom."},{"key":"9655_CR14","doi-asserted-by":"crossref","first-page":"1570","DOI":"10.1182\/blood-2008-02-078071","volume":"112","author":"TW LeBien","year":"2008","unstructured":"LeBien TW, Tedder TF. B lymphocytes: how they develop and function. Blood. 2008;112:1570\u201380.","journal-title":"Blood."},{"key":"9655_CR15","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1016\/j.clim.2006.05.003","volume":"120","author":"H Alachkar","year":"2006","unstructured":"Alachkar H, Taubenheim N, Haeney MR, Durandy A, Arkwright PD. Memory switched B cell percentage and not serum immunoglobulin concentration is associated with clinical complications in children and adults with specific antibody deficiency and common variable immunodeficiency. Clinical Immunology. 2006;120:310\u20138.","journal-title":"Clinical Immunology."},{"key":"9655_CR16","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.clim.2005.03.019","volume":"116","author":"J Ko","year":"2005","unstructured":"Ko J, Radigan L, Cunningham-Rundles C. Immune competence and switched memory B cells in common variable immunodeficiency. Clin Immunol. 2005;116:37\u201341.","journal-title":"Clin Immunol."},{"key":"9655_CR17","doi-asserted-by":"crossref","first-page":"4142","DOI":"10.1016\/j.vaccine.2011.03.087","volume":"29","author":"Z Chovancova","year":"2011","unstructured":"Chovancova Z, Vlkova M, Litzman J, Lokaj J, Thon V. Antibody forming cells and plasmablasts in peripheral blood in CVID patients after vaccination. Vaccine. 2011;29:4142\u201350.","journal-title":"Vaccine."},{"key":"9655_CR18","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/j.clim.2006.07.003","volume":"121","author":"D Moratto","year":"2006","unstructured":"Moratto D, Gulino AV, Fontana S, Mori L, Pirovano S, Soresina A, et al. Combined decrease of defined B and T cell subsets in a group of common variable immunodeficiency patients. Clin Immunol. 2006;121:203\u201314.","journal-title":"Clin Immunol."},{"key":"9655_CR19","doi-asserted-by":"crossref","first-page":"2516","DOI":"10.1002\/1521-4141(200009)30:9<2516::AID-IMMU2516>3.0.CO;2-Z","volume":"30","author":"JC Brouet","year":"2000","unstructured":"Brouet JC, Chedeville A, Fermand JP, Royer B. Study of the B cell memory compartment in common variable immunodeficiency. Eur J Immunol. 2000;30:2516\u201320.","journal-title":"Eur J Immunol."},{"key":"9655_CR20","doi-asserted-by":"crossref","first-page":"4089","DOI":"10.1182\/blood-2009-02-207423","volume":"114","author":"S Borte","year":"2009","unstructured":"Borte S, Pan-Hammarstr\u00f6m Q, Liu C, Sack U, Borte M, Wagner U, et al. Interleukin-21 restores immunoglobulin production ex vivo in patients with common variable immunodeficiency and selective IgA deficiency. Blood. 2009;114:4089\u201398.","journal-title":"Blood."},{"key":"9655_CR21","doi-asserted-by":"crossref","first-page":"1767","DOI":"10.4049\/jimmunol.181.3.1767","volume":"181","author":"DT Avery","year":"2008","unstructured":"Avery DT, Bryant VL, Ma CS, de Waal Malefyt R, Tangye SG. IL-21-induced isotype switching to IgG and IgA by human naive B cells is differentially regulated by IL-4. J Immunol. 2008;181:1767\u201379.","journal-title":"J Immunol."},{"key":"9655_CR22","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1038\/nri2322","volume":"8","author":"A Cerutti","year":"2008","unstructured":"Cerutti A. The regulation of IgA class switching. Nat Rev Immunol. 2008;8:421\u201334.","journal-title":"Nat Rev Immunol"},{"key":"9655_CR23","doi-asserted-by":"crossref","first-page":"3156","DOI":"10.4049\/jimmunol.154.7.3156","volume":"154","author":"TM McIntyre","year":"1995","unstructured":"McIntyre TM, Kehry MR, Snapper CM. Novel in vitro model for high-rate IgA class switching. J Immunol. 1995;154:3156\u201361.","journal-title":"J Immunol."},{"key":"9655_CR24","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1111\/j.1365-2249.2006.03096.x","volume":"144","author":"L Hummelshoj","year":"2006","unstructured":"Hummelshoj L, Ryder LP, Nielsen LK, Nielsen CH, Poulsen LK. Class switch recombination in selective IgA-deficient subjects. Clin Exp Immunol. 2006;144:458\u201366.","journal-title":"Clin Exp Immunol."},{"key":"9655_CR25","doi-asserted-by":"crossref","first-page":"13451","DOI":"10.1073\/pnas.0901984106","volume":"106","author":"M Rakhmanov","year":"2009","unstructured":"Rakhmanov M, Keller B, Gutenberger S, Foerster C, Hoenig M, Driessen G, et al. Circulating CD21low B cells in common variable immunodeficiency resemble tissue homing, innate-like B cells. Proc Natl Acad Sci USA. 2009;106:13451\u20136.","journal-title":"Proc Natl Acad Sci USA."},{"key":"9655_CR26","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1182\/blood-2007-06-091744","volume":"111","author":"C Wehr","year":"2008","unstructured":"Wehr C, Kivioja T, Schmitt C, Ferry B, Witte T, Eren E, et al. The EUROclass trial: defining subgroups in common variable immunodeficiency. Blood. 2008;111:77\u201385.","journal-title":"Blood."},{"key":"9655_CR27","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/j.clim.2004.05.010","volume":"113","author":"C Wehr","year":"2004","unstructured":"Wehr C, Eibel H, Masilamani M, Illges H, Schlesier M, Peter HH, et al. A new CD21low B cell population in the peripheral blood of patients with SLE. Clin Immunol. 2004;113:161\u201371.","journal-title":"Clin Immunol."},{"key":"9655_CR28","doi-asserted-by":"crossref","first-page":"5026","DOI":"10.1182\/blood-2009-09-243071","volume":"115","author":"I Isnardi","year":"2010","unstructured":"Isnardi I, Ng YS, Menard L, Meyers G, Saadoun D, Srdanovic I, et al. Complement receptor 2\/CD21- human naive B cells contain mostly autoreactive unresponsive clones. Blood. 2010;115:5026\u201336.","journal-title":"Blood."},{"key":"9655_CR29","first-page":"833","volume":"7","author":"AJ Ammann","year":"1970","unstructured":"Ammann AJ, Hong R. Selective IgA deficiency and autoimmunity. Clin Exp Immunol. 1970;7:833\u20138.","journal-title":"Clin Exp Immunol."},{"key":"9655_CR30","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1006\/clin.1996.0132","volume":"80","author":"T Espa\u00f1ol","year":"1996","unstructured":"Espa\u00f1ol T, Catala M, Hernandez M, Caragol I, Bertran JM. Development of a common variable immunodeficiency in IgA-deficient patients. Clin Immunol Immunopathol. 1996;80:333\u20135.","journal-title":"Clin Immunol Immunopathol."},{"key":"9655_CR31","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1159\/000301584","volume":"153","author":"J Litzman","year":"2010","unstructured":"Litzman J, Stikarovska D, Pikulova Z, Pavlik T, Pesak S, Thon V, et al. Change in referral diagnoses and diagnostic delay in hypogammaglobulinaemic patients during 28 years in a single referral centre. Int Arch Allergy Immunol. 2010;153:95\u2013101.","journal-title":"Int Arch Allergy Immunol."},{"key":"9655_CR32","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1159\/000135694","volume":"147","author":"A Aghamohammadi","year":"2008","unstructured":"Aghamohammadi A, Mohammadi J, Parvaneh N, Rezaei N, Moin M, Espanol T, et al. Progression of selective IgA deficiency to common variable immunodeficiency. Int Arch Allergy Immunol. 2008;147:87\u201392.","journal-title":"Int Arch Allergy Immunol."}],"container-title":["Journal of Clinical Immunology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10875-012-9655-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s10875-012-9655-6\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10875-012-9655-6","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,6,14]],"date-time":"2023-06-14T16:10:17Z","timestamp":1686759017000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s10875-012-9655-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,2,12]]},"references-count":32,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2012,6]]}},"alternative-id":["9655"],"URL":"https:\/\/doi.org\/10.1007\/s10875-012-9655-6","relation":{},"ISSN":["0271-9142","1573-2592"],"issn-type":[{"value":"0271-9142","type":"print"},{"value":"1573-2592","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,2,12]]}}}